3-MeOARh-NTR is an activatable imaging probe characterized by high selectivity and stability, offering a high signal-to-noise ratio specifically for nitroreductase (NTR) detection. It serves as an efficient molecular tool for the identification of endogenous NTR [1].

3-MeOARh-NTR(10 μM, 30分钟) 在降低氧浓度后孵育12小时的HeLa细胞中产生明显荧光信号[1]。同样条件下，该化合物在小鼠肾组织中实现荧光成像(λex=488 nm；λem=510-590 nm)。3-MeOARh-NTR作为通过NTR活性评估肾脏缺氧状况的有效探针，显示其在生物学成像领域的应用潜力[1]。