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Targets Recommended: Histone Methyltransferase Antifolate Histamine Receptor

426

抑制剂 & 化合物

32

天然产物

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化合物库

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同位素标记化合物

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Cat. No. Product Name
L5900 血脑屏障通透化合物库

509 compounds
509 个 CNS-Penetrant 生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L3900 DNA 损伤和修复分子库

910 compounds
910 个与 DNA 损伤和修复紧密相关的化合物集合,是高通量筛选,高内涵筛选的良好载体;
L3980 DNA损伤/修复库Plus

667 compounds
667 种 DNA 损伤/修复靶向、结构新颖的化合物;
L7500 凝血与抗凝化合物库

144 compounds
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选;
L2540 肠道微生物代谢化合物库

614 compounds
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选;

化合物库

血脑屏障通透化合物库
Cat.No: L5900
Compounds: 509
DNA 损伤和修复分子库
Cat.No: L3900
Compounds: 910
DNA损伤/修复库Plus
Cat.No: L3980
Compounds: 667
凝血与抗凝化合物库
Cat.No: L7500
Compounds: 144
肠道微生物代谢化合物库
Cat.No: L2540
Compounds: 614
Cat. No. Product Name Target Signaling Pathways
T8548 Metoprine

Histone Methyltransferase; Antifolate; Histamine Receptor Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; Neuroscience
Metoprine 是一种有效的组胺 N-甲基转移酶抑制剂,具有抗肿瘤活性。它是一种二氨基嘧啶衍生物,可以透过血脑屏障,并通过抑制 HMT 增加脑组胺水平。
T2625 MK-0752

Beta Amyloid; Gamma-secretase Neuroscience; Proteases/Proteasome; Stem Cells
MK0752 是一种高效的、特异性的、可穿过血脑屏障的、口服活性的 γ-分泌酶(γ-secretase)抑制剂,对人 SH-SY5Y 细胞 Aβ40 呈剂量依赖性降低(IC50=5 nM)。它能够降低体内新生的中枢神经系统 Aβ。
T15108 DG-041

Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation
DG-041 是高亲和力,选择性的,有效的 EP3受体拮抗剂,在结合和 FLIPR 试验中,IC50分别为 4.6 nM 和 8.1 nM。DG-041通过抑制 PGE2促进血小板聚集。DG-041具有血脑屏障渗透性。
T22782 FGIN-1-27

Others Others
FGIN 1-27 是一种吲哚乙酰胺,是外周苯二氮卓受体的特异性的配体,Ki 为 5.0 nM。FGIN 1-27 可以透过血脑屏障。FGIN 1-27对异烟肼引起的抽搐发作具有抑制作用。
T24055 FAUC 213

FAUC213,FAUC-213

Dopamine Receptor GPCR/G Protein; Neuroscience
FAUC 213 是一种具有口服活性的‘、高度选择性的、可透过血脑屏障的多巴胺 D4受体完全拮抗剂,对 hD4.4的 Ki=2.2 nM。它对 D2和 D3受体的活性较低,对于 hD2、hD3的 Ki 分别为 3.4 μM、5.3 μM。它表现出非典型的抗精神病活性。
T1065 Baclofen

巴氯芬,Lioresal

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Baclofen (Lioresal) 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物,是可口服的选择性代谢型 GABA-B 受体激动剂,具有高血脑屏障渗透率,用于治疗因脊髓损伤和多发性硬化引起的痉挛。
T2009 SB-3CT

MMP Proteases/Proteasome
SB-3CT 是一种可透过血脑屏障的、竞争性的金属蛋白酶MMP-2和MMP-9抑制剂,Ki 分别为 13.9 nM、600 nM。他对明胶酶具有高选择性。它具有神经保护和抗癌作用。
T3119 JNJ-63533054

JNJ 63533054

GPR Endocrinology/Hormones; GPCR/G Protein
JNJ-63533054 是一种选择性的,具有口服活性的GPR139激动剂,对人GPR139的EC50为 16 nM。它可穿过血脑屏障,对 GPR139 的选择性高于其他 GPCR、离子通道和转运蛋白。
T19438 Myristyl nicotinate

Tetradecyl nicotinate,肉豆蔻醇烟酸酯

GPR Endocrinology/Hormones; GPCR/G Protein
Myristyl nicotinate (Tetradecyl nicotinate) 是 Nicotinic acid 的亲脂衍生物,是一种酯前药。它能够刺激光损伤的皮肤中的表皮分化,增加皮肤 NAD 含量并增强人皮肤屏障。它被开发用于将烟酸输送到皮肤中,以防止光化性角化病及其发展为皮肤癌。
T10760 Ceramides Mixture

神经酰胺混合物,神经酰胺

Telomerase DNA Damage/DNA Repair
Ceramides Mixture 是表皮渗透屏障的主要脂质成分,参与生长抑制,细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺,由含羟基和非羟基脂肪酸的神经酰胺组成。
T8778 TTK21

Epigenetic Reader Domain Chromatin/Epigenetic
TTK21 是 CBP/p300 组蛋白乙酰转移酶活性的激活剂,与葡萄糖基碳纳米球结合时,可通过血脑屏障,对成人大脑神经发生和长期记忆功能有益。
T9687 MAGL-IN-4

His121 ARG57

Lipase Metabolism
MAGL-IN-4 (His121 ARG57) 是选择性的、口服有效的、可透过血脑屏障的、可逆的单酰基甘油脂肪酶抑制剂,IC50=6.2 nM。它主要通过大脑中选择性抑制 MAGL 增加 2-花生四烯酰甘油水平来增强内源性大麻素信号。
T1993 J-147

J147

Epigenetic Reader Domain; Dopamine Receptor; Monoamine Oxidase Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂,可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体,EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
T0082 Domperidone

R33812,多潘立酮

Dopamine Receptor GPCR/G Protein; Neuroscience
Domperidone (R33812) 是多巴胺 2 受体拮抗剂,能够影响胃和小肠的化学感受器触发区和运动功能,具有止吐和促动力作用。
T12877L Seltorexant

JNJ-42847922

OX Receptor GPCR/G Protein; Neuroscience
Seltorexant (JNJ-42847922) 是一种可口服,高亲和性以及选择性的 orexin-2 受体(OX2R)拮抗剂,对人和大鼠中的 OX2R 的pKi 值分别为 8.0 和 8.1。它穿过血脑屏障,迅速占据大鼠大脑中的 OX2R 结合位点。
T12492 Pivagabine

CXB-722,匹伐加宾

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Pivagabine (CXB-722) 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。它可穿透大鼠的血脑屏障,拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
T2316 Omarigliptin

MK-3102,奥格列汀

Proteasome; DPP-4 Proteases/Proteasome; Ubiquitination
Omarigliptin (MK-3102) 是高效选择性 DPP4抑制剂,IC50=为1.6nM。
T21935L AMN082 free base

AMN082

GluR Neuroscience
AMN082 free base 是 mGluR7选择性激动剂,口服有活性,能够透过血脑屏障,可通过跨膜区的变构位点直接激活受体信号。在表达 mGluR7 的转染哺乳动物细胞上,它能够有效抑制 cAMP 积累并刺激 GTPγS 结合。它能够选择性针对 mGluR 的其他亚型及选择性离子型谷氨酸受体。具有抗抑郁活性。
T8526 Metformin

甲福明,二甲双胍,1,1-Dimethylbiguanide

Mitophagy; AMPK; Autophagy Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂,具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制,常用于 2 型糖尿病的研究。
T11861 LM11A-31 dihydrochloride

Others Others
LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物,能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂,是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。
T2684 JNJ-1661010

JNJ1661010,Takeda-25,JNJ 1661010

FAAH Metabolism; Neuroscience
JNJ-1661010 (Takeda-25) 是一种有效的、选择性的、可以穿透血脑屏障的脂肪酸酰胺水解酶 (FAAH) 抑制剂,对大鼠和人 FAAH 的 IC50分别为 34 和 33 nM,可用于缓解疼痛的研究。
T23394 SR 57227 hydrochloride

SR 57227A,SR57227盐酸盐,SR 57227 hydrochloride

5-HT Receptor GPCR/G Protein; Neuroscience
SR 57227 hydrochloride(SR 57227A ) 是一种有效的、具有口服活性和选择性的 5-HT3 受体激动剂,具有穿越血脑屏障的能力和抗抑郁作用。它对大鼠皮质膜和整个 NG 108-15 细胞或其膜上的 5-HT3 受体结合位点的亲和力,IC50在 2.8 至 250 nM 之间。
T2141 Mecamylamine hydrochloride

盐酸美加明,Inversine,Mevasin

AChR Neuroscience
Mecamylamine hydrochloride (Mevasin) 是一种易穿过血脑屏障的烟碱拮抗剂,用作高血压的神经节阻滞剂,具有抗神经疾病作用。
T21422 Methylnaltrexone bromide

Relistor,MOA-728,MOA 728,Methylnaltrexone,溴化甲基纳曲酮,MOA728

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Methylnaltrexone bromide (MOA-728) 是纳曲酮的四元衍生物,是可口服的外周作用 μ 阿片拮抗剂。它穿越血脑屏障的能力有限,可在胃肠道组织中发挥作用。
T8630 Baclofen hydrochloride

4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) 是一种 GAMMA-AMINOBUTYRIC ACID 衍生物,是一种特异性 GABA-B 受体激动剂。它用于治疗肌肉痉挛,尤其是由于脊髓损伤引起的肌肉痉挛。其治疗效果来自于脊髓和脊髓上部位的作用,通常是减少兴奋性传递。
T20570 Labetalol

Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne

Adrenergic Receptor GPCR/G Protein; Neuroscience
Labetalol (Apo-Labetalol) 是一种抗高血压药物,可用于心血管疾病的研究,如妊娠期高血压。它是一种口服具有活性的选择性 α1- 和非选择性 β-肾上腺素能受体 (adrenergic receptor) 竞争性拮抗剂。
T6438 Cefoselis Sulfate

FK 037 Sulfate,FK-037,硫酸头孢噻利

Antibacterial; Antibiotic Microbiology/Virology
Cefoselis Sulfate (FK 037 Sulfate) 是一种头孢菌素 β-内酰胺抗生素。它对多种革兰氏阳性和革兰氏阴性生物均表现出良好的活性。它可以透过血脑屏障。
T13664 DSP-4 hydrochloride

Neurotoxin DSP 4 (hydrochloride)

Others Others
DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) 是一种高选择性的神经毒素,主要是来自蓝斑 (LC) 的神经元,容易通过血脑屏障。它对成年和发育中大鼠去甲肾上腺素能神经元具有神经毒性作用,可用于中枢和外周去甲肾上腺素能神经元的暂时选择性降解。
T11571 HLY78

4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂,通过靶向通道中 Axin 的 DIX 域,增强 Axin-LRP6 交联,诱导 Wnt 信号转导。
T0740 Metformin hydrochloride

Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride

Mitophagy; AMPK; Autophagy Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 是一种抗糖尿病药物,抑制结肠、前列腺等多种 Y 细胞的增殖,具有作为抗 Y 药物的潜在功能。它可以透过血脑屏障,诱导自噬。
T7601L Carbetocin acetate

醋酸卡贝缩宫素,Carbetocin acetate(37025-55-1 free base),卡贝缩宫素醋酸盐

Oxytocin Receptor Endocrinology/Hormones; GPCR/G Protein
Carbetocin acetate 是催产素类似物,是催产素受体激动剂,Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力,Ki 为 1.17 μM。它能透过血脑屏障,可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性,具有用于产后出血的研究潜力。
T0825 Ebselen

SPI-1005,PZ-51,依布硒,CCG-39161

Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。
T1667 Tandutinib

MLN518,CT53518,NSC726292,坦度替尼

Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
Tandutinib (CT53518) 是一种选择性 FLT3抑制剂,其 IC50为 0.22 μM。它还抑制c-Kit 和PDGFR,其IC50分别为 0.17 μM 和 0.20 μM。它可穿透血脑屏障,用于急性骨髓性白血病。
T7601 Carbetocin

卡贝缩宫素,醋酸卡贝缩宫素

Oxytocin Receptor Endocrinology/Hormones; GPCR/G Protein
Carbetocin 是催产素类似物,是催产素受体激动剂,Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力,Ki 为 1.17 μM。它能透过血脑屏障,可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性,具有用于产后出血的研究潜力。
T21935 AMN082

AMN 082 dihydrochloride

GluR Neuroscience
AMN082 (AMN 082 dihydrochloride) 是可口服,可透过血脑屏障的选择性mGluR7激动剂,通过跨膜区的变构位点直接激活受体信号,具有抗抑郁作用。
T12017 Methyllycaconitine citrate

MLA

AChR Neuroscience
Methyllycaconitine citrate (MLA) 是一种可穿过血脑屏障的 α7 神经元烟碱乙酰胆碱受体(α7nAChR)拮抗剂,可用于研究神经系统疾病。
T6845 GNE-317

GNE317

PI3K; mTOR PI3K/Akt/mTOR signaling
GNE-317 是一种可透过血脑屏障 (BBB)的 PI3K/mTOR 抑制剂。
T12539L Prinomastat

KB-R9896,AG3340

MMP Proteases/Proteasome
Prinomastat (AG3340) 是一种可穿过血脑屏障且具有口服活性和选择性的金属蛋白酶 (MMP) 抑制剂,抗肿瘤活性,对金属蛋白酶具有广谱的抑制作用,对 MMP-1, MMP-3 和 MMP-9 的抑制作用较强。
T1612 Neostigmine methyl sulfate

Normastigmin,甲基硫酸新斯的明,甲硫酸新斯的明,Hodostin,Syntostigmin

AChR; AChE Neuroscience
Neostigmine methyl sulfate (Syntostigmin) 是一种乙酰胆碱酯酶的可逆抑制剂, 不能透过血脑屏障。
T2708 SL327

SL 327,SL-327

MEK; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK
SL327 是能通过血脑屏障运输的选择性 MEK1/2 抑制剂,IC50 分别为 0.18 和 0.22 μM。
T5518 N-acetylcysteine amide

Reactive Oxygen Species; ROS Immunology/Inflammation; Metabolism; NF-κB
N-Acetylcysteine amide 是一种硫醇抗氧化剂,也是一种神经保护剂,能够透过细胞膜和血脑屏障的,可降低ROS 的产生。
T17211 Vafidemstat

ORY-2001

Histone Demethylase; MAO Chromatin/Epigenetic; Metabolism; Neuroscience
Vafidemstat (ORY-2001) 是一种可透过血脑屏障且具有选择性、口服活性的赖氨酸-组蛋白去甲基化酶 (LSD1)/MAO-B 抑制剂,可用于研究神经系统疾病。
T35559 SAG 21k

Hedgehog/Smoothened GPCR/G Protein; Stem Cells
SAG 21k 是一种可透过血脑屏障且具有口服生物活性和有效性的 Hedgehog 信号激活剂,可用于研究软骨再生。
TQ0026 MDR-1339

DWK-1339

Beta Amyloid; Gamma-secretase Neuroscience; Proteases/Proteasome; Stem Cells
MDR-1339 是口服有效Aβ聚集抑制剂,可透过血脑屏障的。MDR-1339可用于阿尔兹海默症的研究。
T73494 TNG908

Histone Methyltransferase Chromatin/Epigenetic
TNG908 是一种可通过血脑屏障且具有口服活性和选择的 MTAP 协同 PRMT5 抑制剂,可杀死对MTAP缺失的癌症。
T15779 LP-533401 hydrochloride

5-HT Receptor GPCR/G Protein; Neuroscience
LP-533401 hydrochloride 是不能穿过血脑屏障的外周 Tph 抑制剂,抑制5-羟色胺合成,可用于研究牙周病和肝脂肪变性。
T7340 5'-N-Ethylcarboxamidoadenosine

NECA,5'-N-乙基酰胺基腺苷

Adenosine Receptor GPCR/G Protein; Neuroscience
5'-N-Ethylcarboxamidoadenosine (NECA) 是腺苷受体的激动剂,可增加荧光素和低分子量葡聚糖的脑外渗,与血脑屏障调节无关。
T9070 ASP2905

ASP-2905

Potassium Channel Membrane transporter/Ion channel
ASP-2905 是一种有效且选择性的钾通道 Kv12.2抑制剂。ASP2905 (ASP-2905) 可以穿越血脑屏障并具有抗精神病活性。
T33467 MOMIPP

PI3K PI3K/Akt/mTOR signaling
MOMIPP 是一种 PIKfyve 抑制剂,是一种巨胞饮作用的诱导剂,可穿过血脑屏障 (BBB)。
T10855 CO23

Thyroid hormone receptor(THR) Endocrinology/Hormones
CO23 是一种血脑屏障渗透剂和选择性甲状腺激素受体 α 激动剂,可用于生长发育调控研究。

化合物

Metoprine
Cat.No: T8548
Synonym:
Target: Histone Methyltransferase, Antifolate, Histamine Receptor
MK-0752
Cat.No: T2625
Synonym:
Target: Beta Amyloid, Gamma-secretase
DG-041
Cat.No: T15108
Synonym:
Target: Prostaglandin Receptor
FGIN-1-27
Cat.No: T22782
Synonym:
Target: Others
FAUC 213
Cat.No: T24055
Synonym: FAUC213,FAUC-213
Target: Dopamine Receptor
Baclofen
Cat.No: T1065
Synonym: 巴氯芬,Lioresal
Target: GABA Receptor
SB-3CT
Cat.No: T2009
Synonym:
Target: MMP
JNJ-63533054
Cat.No: T3119
Synonym: JNJ 63533054
Target: GPR
Myristyl nicotinate
Cat.No: T19438
Synonym: Tetradecyl nicotinate,肉豆蔻醇烟酸酯
Target: GPR
Ceramides Mixture
Cat.No: T10760
Synonym: 神经酰胺混合物,神经酰胺
Target: Telomerase
TTK21
Cat.No: T8778
Synonym:
Target: Epigenetic Reader Domain
MAGL-IN-4
Cat.No: T9687
Synonym: His121 ARG57
Target: Lipase
J-147
Cat.No: T1993
Synonym: J147
Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase
Domperidone
Cat.No: T0082
Synonym: R33812,多潘立酮
Target: Dopamine Receptor
Seltorexant
Cat.No: T12877L
Synonym: JNJ-42847922
Target: OX Receptor
Pivagabine
Cat.No: T12492
Synonym: CXB-722,匹伐加宾
Target: GABA Receptor
Omarigliptin
Cat.No: T2316
Synonym: MK-3102,奥格列汀
Target: Proteasome, DPP-4
AMN082 free base
Cat.No: T21935L
Synonym: AMN082
Target: GluR
Metformin
Cat.No: T8526
Synonym: 甲福明,二甲双胍,1,1-Dimethylbiguanide
Target: Mitophagy, AMPK, Autophagy
LM11A-31 dihydrochloride
Cat.No: T11861
Synonym:
Target: Others
JNJ-1661010
Cat.No: T2684
Synonym: JNJ1661010,Takeda-25,JNJ 1661010
Target: FAAH
SR 57227 hydrochloride
Cat.No: T23394
Synonym: SR 57227A,SR57227盐酸盐,SR 57227 hydrochloride
Target: 5-HT Receptor
Mecamylamine hydrochloride
Cat.No: T2141
Synonym: 盐酸美加明,Inversine,Mevasin
Target: AChR
Methylnaltrexone bromide
Cat.No: T21422
Synonym: Relistor,MOA-728,MOA 728,Methylnaltrexone,溴化甲基纳曲酮,MOA728
Target: Opioid Receptor
Baclofen hydrochloride
Cat.No: T8630
Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride
Target: GABA Receptor
Labetalol
Cat.No: T20570
Synonym: Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne
Target: Adrenergic Receptor
Cefoselis Sulfate
Cat.No: T6438
Synonym: FK 037 Sulfate,FK-037,硫酸头孢噻利
Target: Antibacterial, Antibiotic
DSP-4 hydrochloride
Cat.No: T13664
Synonym: Neurotoxin DSP 4 (hydrochloride)
Target: Others
HLY78
Cat.No: T11571
Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
Target: Wnt/beta-catenin
Metformin hydrochloride
Cat.No: T0740
Synonym: Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride
Target: Mitophagy, AMPK, Autophagy
Carbetocin acetate
Cat.No: T7601L
Synonym: 醋酸卡贝缩宫素,Carbetocin acetate(37025-55-1 free base),卡贝缩宫素醋酸盐
Target: Oxytocin Receptor
Ebselen
Cat.No: T0825
Synonym: SPI-1005,PZ-51,依布硒,CCG-39161
Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease
Tandutinib
Cat.No: T1667
Synonym: MLN518,CT53518,NSC726292,坦度替尼
Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit
Carbetocin
Cat.No: T7601
Synonym: 卡贝缩宫素,醋酸卡贝缩宫素
Target: Oxytocin Receptor
AMN082
Cat.No: T21935
Synonym: AMN 082 dihydrochloride
Target: GluR
Methyllycaconitine citrate
Cat.No: T12017
Synonym: MLA
Target: AChR
GNE-317
Cat.No: T6845
Synonym: GNE317
Target: PI3K, mTOR
Prinomastat
Cat.No: T12539L
Synonym: KB-R9896,AG3340
Target: MMP
Neostigmine methyl sulfate
Cat.No: T1612
Synonym: Normastigmin,甲基硫酸新斯的明,甲硫酸新斯的明,Hodostin,Syntostigmin
Target: AChR, AChE
SL327
Cat.No: T2708
Synonym: SL 327,SL-327
Target: MEK, DNA/RNA Synthesis
N-acetylcysteine amide
Cat.No: T5518
Synonym:
Target: Reactive Oxygen Species, ROS
Vafidemstat
Cat.No: T17211
Synonym: ORY-2001
Target: Histone Demethylase, MAO
SAG 21k
Cat.No: T35559
Synonym:
Target: Hedgehog/Smoothened
MDR-1339
Cat.No: TQ0026
Synonym: DWK-1339
Target: Beta Amyloid, Gamma-secretase
TNG908
Cat.No: T73494
Synonym:
Target: Histone Methyltransferase
LP-533401 hydrochloride
Cat.No: T15779
Synonym:
Target: 5-HT Receptor
5'-N-Ethylcarboxamidoadenosine
Cat.No: T7340
Synonym: NECA,5'-N-乙基酰胺基腺苷
Target: Adenosine Receptor
ASP2905
Cat.No: T9070
Synonym: ASP-2905
Target: Potassium Channel
MOMIPP
Cat.No: T33467
Synonym:
Target: PI3K
CO23
Cat.No: T10855
Synonym:
Target: Thyroid hormone receptor(THR)
Cat. No. Product Name Target Signaling Pathways
T0130 Physostigmine Salicylate

水杨酸依色林,水杨酸毒扁豆碱

AChR; AChE Neuroscience
Physostigmine salicylate 是一种可逆的乙酰胆碱酯酶抑制剂,也一种是抗胆碱能中毒的解毒剂。它可透过血脑屏障并刺激中枢胆碱能神经传递。它能逆转阿尔茨海默病转基因小鼠的记忆缺陷。
T0795 Rutin

Quercetin 3-O-rutinoside,芦丁,Rutoside

Beta Amyloid; Prostaglandin Receptor; Autophagy Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
Rutin (Quercetin 3-O-rutinoside) 属于黄酮类天然产物,具有血脑屏障渗透性。Rutin 具有广泛的生物活性,包括抗氧化、抗炎、抗肿瘤、降血糖、神经保护、抗菌、抗衰老等等。
T0848 L-DOPA

左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine

Dopamine Receptor; Endogenous Metabolite GPCR/G Protein; Metabolism; Neuroscience
L-DOPA (Levodopa) 是的神经递质多巴胺的代谢前体,具有口服活性。Levodopa 能够透过血脑屏障,并在大脑中转化为多巴胺。Levodopa 具有抗痛觉过敏作用。Levodopa 还具有帕金森氏病的研究潜力。
T22417 Rutin hydrate

芦丁,Rutoside,Sophorin,Quercetin-3-O-rutinoside

Beta Amyloid; Others; Autophagy Autophagy; Neuroscience; Others
Rutin hydrate (Sophorin) 是一种广泛存在于多种植物中的黄酮类天然产物,具有降糖、抗炎、抗氧化、神经保护、肾脏保护、肝脏保护和降低 Aβ 低聚物活性等多种生物活性。它能穿过血脑屏障,通过抑制细胞凋亡、线粒体功能紊乱和氧化应激抑制万古霉素诱导的肾小管细胞凋亡。
T0700 Ursodeoxycholic acid

熊去氧胆酸,UDCA,Ursodiol

Potassium Channel; Endogenous Metabolite Membrane transporter/Ion channel; Metabolism
Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂,通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收,用于溶解胆结石,并具有研究与肥胖相关的脂肪肝疾病的潜力。
TN6774 Emodin 6-O-β-D-glucoside

大黄素-6-O-β-D-葡萄糖苷,Glucoemodin

Others Others
Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性,可用于研究动脉粥样硬化及糖尿病并发症。
T29078 Ursodeoxycholic acid sodium

UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

FXR; Endogenous Metabolite; GPCR19 GPCR/G Protein; Metabolism
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸,具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子,通过与胆汁酸激活受体相互作用发挥其作用,包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。
T6S0119 Dauricine

蝙蝠葛碱

Apoptosis; Others; NF-κB Apoptosis; NF-κB; Others
Dauricine 是存在于北豆根粉末中的一种双苯异喹啉生物碱,具有抗炎活性。它通过抑制NF-κB 激活,剂量依赖性地抑制结肠癌细胞的增值和侵袭,并诱导凋亡。
T6S0444 Salvianolic acid A

丹酚酸 A,Dan Phenolic Acid A

MMP Proteases/Proteasome
Salvianolic acid A (Dan Phenolic Acid A) 能够提高抑制基质金属钛酶 9 和抗炎作用,进而保护血脑屏障。
T67710 3-Indoleacrylic acid

Endogenous Metabolite Metabolism
3-Indoleacrylic acid 是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid 对肠上皮屏障功能有有益作用,并减轻免疫细胞的炎症反应。
T4917 Dehydroascorbic acid

(L)-Dehydroascorbic acid,脱氢抗坏血酸,去氢抗坏血酸

Endogenous Metabolite Metabolism
Dehydroascorbic acid ((L)-Dehydroascorbic acid) 是维生素 C 的氧化型,能够透过血脑屏障,对中风具有有效的脑保护作用。
T0883 Tramiprosate

Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed,高牛黄酸

Beta Amyloid; GABA Receptor Membrane transporter/Ion channel; Neuroscience
Tramiprosate (Alzhemed) 是一种具有口服活性的、可透过血脑屏障的天然氨基酸,存在于各种红色海藻中,能够可溶性 Aβ 结合并以非原纤维形式维持 Aβ。它是一种 GABA 类似物,具有神经保护,抗惊厥和抗高血压的活性。
TN1236 3',4',7-Trihydroxyisoflavone

MAPK; JNK MAPK
3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物,是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂,具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用,可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能,可用于研究特应性皮炎。
T3851 Vicenin 2

Vicenin -2,维采宁 2,新西兰牡荆苷

RAAS Endocrinology/Hormones
Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂,IC50=43.83 μM。
T10196 7α-Hydroxy-4-cholesten-3-one

7-hydroxy-4-cholesten-3-one

Others Others
7α-Hydroxy-4-cholesten-3-one 是一种可穿过血脑屏障的胆汁酸前体,可作为肝胆汁酸合成的指标。7α-Hydroxy-4-cholesten-3-one 是一种孕烷 X 受体 (PXR) 激动剂。7α-Hydroxy-4-cholesten-3-one 可用于研究与胆汁酸生物合成缺陷有关的疾病。
T6S0721 Orientin

荭草苷,Lutexin,Luteolin-8-glucoside

Others Others
Orientin (Luteolin-8-glucoside) 是天然存在的生物活性类黄酮,是一种有前景的神经保护剂,具有多种生物特性,如抗炎、抗肿瘤、抗氧化、保护心脏等。它有用于神经性疼痛研究潜力。
T4S0878 Prunetin

樱黄素,Prunusetin

ERK; Dehydrogenase; NF-κB MAPK; Metabolism; NF-κB
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
T5S1632 Barlerin

8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

VEGFR; TNF; NF-κB; Akt; Caspase Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。
T3893 Forsythoside B

连翘酯苷 B,连翘脂苷B

TNF; NF-κB Apoptosis; NF-κB
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。
T4S0797 Berberine

小檗碱,Berberin,Umbellatine,黄连素

Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Berberine (Umbellatine) 属于生物碱类天然产物,可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
T4439 sn-Glycero-3-phosphocholine

Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC

Endogenous Metabolite; AChE Metabolism; Neuroscience
sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体,能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响,同时具有良好的耐受性和安全性,因此能够用于阿尔茨海默病和痴呆症的研究。
T1079 Metronidazole

Flagyl,Metronidazol,甲硝唑,Anagiardil

Apoptosis; NADPH; Hydrogenase; Antibacterial; Antibiotic; Parasite; Antifection Apoptosis; Metabolism; Microbiology/Virology
Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物,一种抗生素和抗原虫剂,具有口服活性和血脑屏障渗透性。Metronidazole 可用于治疗或预防厌氧菌引起的系统或局部感染。
T13493 3-Acetyldeoxynivalenol

Others Others
3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin.
T14114 Acivicin

阿西维辛,AT-125,U-42126

Others Others
Acivicin (AT-125) is a γ-glutamyl transpeptidase (GGT) inhibitor derived from the Streptomyces sviceus natural product. It possesses anti-cancer and anti-parasitic properties and can effectively cross the blood-brain barrier[1][2].
TN1793 Isorhamnetin 3-O-galactoside

异鼠李素-3-O-半乳糖苷,Cacticin

ERK; TNF; NF-κB Apoptosis; MAPK; NF-κB
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic for treatment of severe vascular inflammatory diseases.
TN1913 Marmin

Calcium Channel; Antifection; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.
T13680 Enniatin B1

恩镰孢菌素 B1

ERK MAPK
Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes.
T61171 Cyclo(his-pro) TFA

Others Others
Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone, has shown inhibitory effects on NF-κB nuclear accumulation. Additionally, it possesses the ability to cross the blood-brain barrier and impact various inflammatory and stress responses [1, 2].
T75571 Withaphysalin D

Others Others
Withaphysalin D 是一种选择性抑制含GluN2B的N-甲基-D-天冬氨酸受体(NMDAR)的化合物。该物质可从睡莲中提取,对神经保护有益,能穿过血脑屏障。
T77207 Acivicin hydrochloride

Others Others
Acivicin hydrochloride (AT-125 hydrochloride),一种猪链霉菌的天然产物,兼具透过血脑屏障的能力,是γ-谷氨酰转肽酶 (GGT) 的抑制剂,具有抗癌和抗寄生虫的特性。
TN5228 Vestitol

Antifection Microbiology/Virology
Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from 25-50 to 50-100 ug/mL and MBCs ranging from 25-50 to 50-100 ug/mL.Vestitol exerts a limited inhibitory effect on S. hermonthica germination, it can significantly inhibit seedling growth, it also contributes, at least in part, to the host's defence mechanism and acts as a chemica...
TN3364 Agrimonolide

Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
Agrimonolide 是一种来自异香豆素的化合物,主要存在于草药Agrimonia pilosa Ledeb 中,具有显著的生物活性。Agrimonolide 通过抑制脂多糖(LPS)诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平,可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1,对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是,Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制,同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡,同时增加活性氧(ROS)和总铁的水平。Agrimonolide 很容易穿过血脑屏障,表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Physostigmine Salicylate
Cat.No: T0130
Synonym: 水杨酸依色林,水杨酸毒扁豆碱
Target: AChR, AChE
Rutin
Cat.No: T0795
Synonym: Quercetin 3-O-rutinoside,芦丁,Rutoside
Target: Beta Amyloid, Prostaglandin Receptor, Autophagy
L-DOPA
Cat.No: T0848
Synonym: 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine
Target: Dopamine Receptor, Endogenous Metabolite
Rutin hydrate
Cat.No: T22417
Synonym: 芦丁,Rutoside,Sophorin,Quercetin-3-O-rutinoside
Target: Beta Amyloid, Others, Autophagy
Ursodeoxycholic acid
Cat.No: T0700
Synonym: 熊去氧胆酸,UDCA,Ursodiol
Target: Potassium Channel, Endogenous Metabolite
Emodin 6-O-β-D-glucoside
Cat.No: TN6774
Synonym: 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin
Target: Others
Ursodeoxycholic acid sodium
Cat.No: T29078
Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium
Target: FXR, Endogenous Metabolite, GPCR19
Dauricine
Cat.No: T6S0119
Synonym: 蝙蝠葛碱
Target: Apoptosis, Others, NF-κB
Salvianolic acid A
Cat.No: T6S0444
Synonym: 丹酚酸 A,Dan Phenolic Acid A
Target: MMP
3-Indoleacrylic acid
Cat.No: T67710
Synonym:
Target: Endogenous Metabolite
Dehydroascorbic acid
Cat.No: T4917
Synonym: (L)-Dehydroascorbic acid,脱氢抗坏血酸,去氢抗坏血酸
Target: Endogenous Metabolite
Tramiprosate
Cat.No: T0883
Synonym: Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed,高牛黄酸
Target: Beta Amyloid, GABA Receptor
3',4',7-Trihydroxyisoflavone
Cat.No: TN1236
Synonym:
Target: MAPK, JNK
Vicenin 2
Cat.No: T3851
Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷
Target: RAAS
7α-Hydroxy-4-cholesten-3-one
Cat.No: T10196
Synonym: 7-hydroxy-4-cholesten-3-one
Target: Others
Orientin
Cat.No: T6S0721
Synonym: 荭草苷,Lutexin,Luteolin-8-glucoside
Target: Others
Prunetin
Cat.No: T4S0878
Synonym: 樱黄素,Prunusetin
Target: ERK, Dehydrogenase, NF-κB
Barlerin
Cat.No: T5S1632
Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01
Target: VEGFR, TNF, NF-κB, Akt, Caspase
Forsythoside B
Cat.No: T3893
Synonym: 连翘酯苷 B,连翘脂苷B
Target: TNF, NF-κB
Berberine
Cat.No: T4S0797
Synonym: 小檗碱,Berberin,Umbellatine,黄连素
Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy
sn-Glycero-3-phosphocholine
Cat.No: T4439
Synonym: Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC
Target: Endogenous Metabolite, AChE
Metronidazole
Cat.No: T1079
Synonym: Flagyl,Metronidazol,甲硝唑,Anagiardil
Target: Apoptosis, NADPH, Hydrogenase, Antibacterial, Antibiotic, Parasite, Antifection
3-Acetyldeoxynivalenol
Cat.No: T13493
Synonym:
Target: Others
Acivicin
Cat.No: T14114
Synonym: 阿西维辛,AT-125,U-42126
Target: Others
Isorhamnetin 3-O-galactoside
Cat.No: TN1793
Synonym: 异鼠李素-3-O-半乳糖苷,Cacticin
Target: ERK, TNF, NF-κB
Marmin
Cat.No: TN1913
Synonym:
Target: Calcium Channel, Antifection, Histamine Receptor
Enniatin B1
Cat.No: T13680
Synonym: 恩镰孢菌素 B1
Target: ERK
Cyclo(his-pro) TFA
Cat.No: T61171
Synonym:
Target: Others
Withaphysalin D
Cat.No: T75571
Synonym:
Target: Others
Acivicin hydrochloride
Cat.No: T77207
Synonym:
Target: Others
Vestitol
Cat.No: TN5228
Synonym:
Target: Antifection
Agrimonolide
Cat.No: TN3364
Synonym:
Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK
Cat. No. Product Name Species Expression System
TMPH-01576 KRT16 Protein, Human, Recombinant (His & Myc)

KRT16,Keratin-16,Keratin, type I cytoskeletal 16,Cytokeratin...

Human E. coli
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
TMPH-02504 DEFA5 Protein, Mouse, Recombinant (GST)

Defa5,Alpha-defensin 5,Defensin-related cryptdin-5,Defcr5

Mouse E. coli
Probably contributes to the antimicrobial barrier function of the small bowel mucosa. DEFA5 Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.2 kDa and the accession number is P28312.
TMPK-00509 E-Cadherin/Cadherin-1 Protein, Cynomolgus, Recombinant (His)

E-Cadherin,Arc-1,L-CAM,E-CAD,Cadherin1,Cadherin-1,E Cadherin...

Cynomolgus HEK293 Cells
E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues.
TMPH-01706 Mucin-16/MUC16 Protein, Human, Recombinant (His)

Ovarian carcinoma antigen CA125,Ovarian cancer-related tumor...

Human HEK293 Cells
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Mucin-16/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30.5 kDa and the accession number is Q8WXI7.
TMPH-02503 DEFA1 Protein, Mouse, Recombinant (GST & His)

HP-1,HNP-1,Defensin, alpha 1,DEFA1,DEFA2,MRS,Neutrophil defe...

Mouse E. coli
Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium. DEFA1 Protein, Mouse, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 34.1 kDa and the accession number is P11477.
TMPH-00031 Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)

Hemolysin

Aeromonas sobria E. coli
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter.
TMPH-01578 KRT18 Protein, Human, Recombinant (His)

Keratin, type I cytoskeletal 18,KRT18,Cell proliferation-ind...

Human HEK293 Cells
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
TMPH-02861 Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO)

Wnt7b,Protein Wnt-7b

Mouse E. coli
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation.
TMPH-00761 Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant

Cutin hydrolase,CUTA,Cutinase

Neocosmosporum cucurbitae E. coli
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.4 kDa and the accession number is Q99174.
TMPY-03175 Claudin-11 Protein, Human, Recombinant (mFc)

claudin 11,OTM,OSP

Human HEK293 Cells
Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.Claudin-11 is a tight junction associated protein and is a major component of central ...
TMPK-01388 GUCY2C Protein, Canine, Recombinant (aa 21-430, His)

GC-C,GUCY2C,STAR,EC 4.6.1,STA receptor,GCC,MUCIL,Guanylyl cy...

Canine HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Canine, Recombinant (aa 21-430, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.6 kDa and the accession number is F1PAG3.
TMPH-00760 Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His)

Cutin hydrolase,CUTA,Cutinase

Neocosmosporum cucurbitae P. pastoris (Yeast)
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is Q99174.
TMPH-00424 Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO)

Cutinase,CUTA,Cutin hydrolase

Colletotrichum capsici E. coli
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.0 kDa and the accession number is P10951.
TMPK-00990 GUCY2C Protein, Mouse, Recombinant (His & Avi)

GC-C,STAR,DIAR6,GCC,GUC2CEC 4.6.1.2,STA receptor,MUCIL,GUCY2...

Mouse HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.01 kDa and the accession number is Q3UWA6-1.
TMPK-00991 GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated

EC 4.6.1,Guanylyl cyclase C,MUCIL,GUC2CEC 4.6.1.2,GUC2C,STA ...

Mouse HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.01 kDa and the accession number is Q3UWA6-1.
TMPK-01279 GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His)

GUC2CEC 4.6.1.2,GCC,Guanylyl cyclase C,STA receptor,MUCIL,GU...

Cynomolgus HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.2 kDa and the accession number is XP_005570270.1.
TMPK-00856 GUCY2C Protein, Human, Recombinant (His & Avi)

GCC,STAR,STA receptor,Guanylyl cyclase C,EC 4.6.1,GUC2C,MUCI...

Human HEK293 Cells
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 48.8 kDa and the accession number is P25092-1.
TMPK-00163 IL-33 Protein, Cynomolgus, Recombinant (His)

IL1F11,C9orf26 Z,C9ORF26,DV27,RP11-575C20.2,NFEHEV,IL33,DVS2...

Cynomolgus HEK293 Cells
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
TMPH-01577 KRT18 Protein, Human, Recombinant (E. coli, His)

Keratin-18,KRT18,Cytokeratin-18,Cell proliferation-inducing ...

Human E. coli
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. KRT18 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 52.0 kDa and the accession number is P05783.
TMPK-01194 IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated

IL-22,Cytokine Zcyto18,白细胞介素,IL-TIF,白介素,Interleukin-22,TIFIL...

Mouse E. coli
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 19.7 kDa and the accession number i...
TMPK-00661 IL-22 Protein, Cynomolgus, Recombinant (His)

TIFIL-23,IL-22,IL-D110,IL-TIF,TIFa,Interleukin-22,Cytokine Z...

Cynomolgus HEK293 Cells
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. IL-22 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 17.69 kDa and the accession number is G7PHZ7.
TMPH-03756 Wnt7b Protein, Human, Recombinant (His & Myc & SUMO)

Protein Wnt-7b,WNT7B

Human E. coli
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Wint7b Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 56.3 kDa and ...
TMPH-01751 Nephrin/NPHS1 Protein, Human, Recombinant (His)

Nephrin,Renal glomerulus-specific cell adhesion receptor,NPH...

Human E. coli
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Nephrin/NPHS1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.1 kDa and the accession number is O60500.
TMPK-01137 FAM3D Protein, Human, Recombinant (hFc)

OIT1,EF7,FAM3D

Human HEK293 Cells
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity t...
TMPH-01708 Mucin-2/MUC2 Protein, Human, Recombinant (His)

MUC2,Mucin-2,Intestinal mucin-2

Human E. coli
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Mucin-2/MUC2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa an...
TMPK-01153 PLVAP Protein, Human, Recombinant (His)

PV1,FELS

Human HEK293 Cells
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases...
TMPK-01158 Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)

SCTE,KLKL2,KLK5,KLK-L2,Klnc,Kallikrein c

Mouse HEK293 Cells
The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-...
TMPY-04780 VMO1 Protein, Human, Recombinant

vitelline membrane outer layer 1 homolog (chicken),PRO21055,...

Human HEK293 Cells
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. VMO1 is regulated by estrogen and target microRNAs and it is a potential diagnostic marker of ovarian cancer in laying hens. VMO1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted mole...
TMPY-00375 VMO1 Protein, Human, Recombinant (mFc)

ERGA6350,PRO21055,vitelline membrane outer layer 1 homolog (...

Human HEK293 Cells
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. VMO1 is regulated by estrogen and target microRNAs and it is a potential diagnostic marker of ovarian cancer in laying hens. VMO1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag....
TMPK-00710 Claudin-4 Protein-VLP, Human, Recombinant

Claudin4,CLDN4,Claudin-4,CPETR1,CPE-R,WBSCR8,CPE R

Human HEK293 Cells
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs in...
TMPH-01575 KRT10 Protein, Human, Recombinant (His)

Keratin, type I cytoskeletal 10,Keratin-10,Cytokeratin-10,KR...

Human E. coli
Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occu...
TMPH-01607 LCE3A Protein, Human, Recombinant (His)

Late envelope protein 13,LCE3A,Late cornified envelope prote...

Human E. coli
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. LCE3A Protein, Human, Recombinant (His) is expressed in E. coli expression system ...
TMPH-03753 MYLK Protein, Human, Recombinant (His)

MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase...

Human E. coli
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl...
TMPH-03373 SLC2A1 Protein, Rat, Recombinant (His & Myc)

Glucose transporter type 1, erythrocyte/brain,Solute carrier...

Rat E. coli
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. SLC2A1 ...
TMPH-02122 SLC2A1 Protein, Human, Recombinant (His & Myc)

Glucose transporter type 1, erythrocyte/brain,HepG2 glucose ...

Human E. coli
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. SLC2A1 ...
TMPJ-01456 Mucin-17/MUC17 Protein, Human, Recombinant (His)

Mucin-17, MUC-17, MUC17, MUC3, MUC-3

Human HEK293 Cells
Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients. And that p38 signalling is a key factor involved in MUC17-mediated inhibition of GC cell proliferation and protection against inflammatory stimulation, MUC17 upregulates the expression ...
TMPJ-00200 EpCAM/TROP1 Protein, Mouse, Recombinant (hFc)

17-1A,323/A3,TROP1,EGP314,ACSTD1,CD326,EGP-2,MOC31,EGP40,TAC...

Mouse HEK293 Cells
Epithelial Cellular Adhesion Molecule (Ep-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the EPCAM family. Its’ monomer subunit structure interacts with phosphorylated CLDN7. Ep-CAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection...
TMPY-00493 IL-19 Protein, Human, Recombinant (His)

interleukin 19,Interleukin-19,IL-10C,NG.1,ZMDA1,MDA1

Human Baculovirus Insect Cells
The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e...
TMPY-02129 Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)

transglutaminase 3,UHS2,TGE

Human Baculovirus Insect Cells
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutaminase 3 (TGM3) is a member of a family of Ca2+-dependent enzymes that catalyze covalent cross-linking reactions between proteins or peptides. TGM3 isoform is widely expressed and is important for epithelial barrier formation. It is a zymogen, requiring proteolysis for activity. Calc...
TMPY-01824 Caspase-14 Protein, Human, Recombinant (His)

caspase 14, apoptosis-related cysteine peptidase,ARCI12

Human E. coli
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Casp...
TMPY-04070 Citrate Synthase Protein, Human, Recombinant (His)

citrate synthase

Human Baculovirus Insect Cells
Chondroitin sulphate (CS) glycosaminoglycan chains on cell and extracellular matrix proteoglycans (PGs) can no longer be regarded as merely hydrodynamic space fillers. Overwhelming evidence over recent years indicates that sulphation motif sequences within the CS chain structure are a source of significant biological information to cells and their surrounding environment. CS sulphation motifs have been shown to interact with a wide variety of bioactive molecules, e.g. cytokines, growth factors, ...

重组蛋白

KRT16 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01576
Species: Human
Expression System: E. coli
DEFA5 Protein, Mouse, Recombinant (GST)
Cat.No: TMPH-02504
Species: Mouse
Expression System: E. coli
E-Cadherin/Cadherin-1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00509
Species: Cynomolgus
Expression System: HEK293 Cells
Mucin-16/MUC16 Protein, Human, Recombinant (His)
Cat.No: TMPH-01706
Species: Human
Expression System: HEK293 Cells
DEFA1 Protein, Mouse, Recombinant (GST & His)
Cat.No: TMPH-02503
Species: Mouse
Expression System: E. coli
Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)
Cat.No: TMPH-00031
Species: Aeromonas sobria
Expression System: E. coli
KRT18 Protein, Human, Recombinant (His)
Cat.No: TMPH-01578
Species: Human
Expression System: HEK293 Cells
Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-02861
Species: Mouse
Expression System: E. coli
Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant
Cat.No: TMPH-00761
Species: Neocosmosporum cucurbitae
Expression System: E. coli
Claudin-11 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-03175
Species: Human
Expression System: HEK293 Cells
GUCY2C Protein, Canine, Recombinant (aa 21-430, His)
Cat.No: TMPK-01388
Species: Canine
Expression System: HEK293 Cells
Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His)
Cat.No: TMPH-00760
Species: Neocosmosporum cucurbitae
Expression System: P. pastoris (Yeast)
Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO)
Cat.No: TMPH-00424
Species: Colletotrichum capsici
Expression System: E. coli
GUCY2C Protein, Mouse, Recombinant (His & Avi)
Cat.No: TMPK-00990
Species: Mouse
Expression System: HEK293 Cells
GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00991
Species: Mouse
Expression System: HEK293 Cells
GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His)
Cat.No: TMPK-01279
Species: Cynomolgus
Expression System: HEK293 Cells
GUCY2C Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00856
Species: Human
Expression System: HEK293 Cells
IL-33 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00163
Species: Cynomolgus
Expression System: HEK293 Cells
KRT18 Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01577
Species: Human
Expression System: E. coli
IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01194
Species: Mouse
Expression System: E. coli
IL-22 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00661
Species: Cynomolgus
Expression System: HEK293 Cells
Wnt7b Protein, Human, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-03756
Species: Human
Expression System: E. coli
Nephrin/NPHS1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01751
Species: Human
Expression System: E. coli
FAM3D Protein, Human, Recombinant (hFc)
Cat.No: TMPK-01137
Species: Human
Expression System: HEK293 Cells
Mucin-2/MUC2 Protein, Human, Recombinant (His)
Cat.No: TMPH-01708
Species: Human
Expression System: E. coli
PLVAP Protein, Human, Recombinant (His)
Cat.No: TMPK-01153
Species: Human
Expression System: HEK293 Cells
Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01158
Species: Mouse
Expression System: HEK293 Cells
VMO1 Protein, Human, Recombinant
Cat.No: TMPY-04780
Species: Human
Expression System: HEK293 Cells
VMO1 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-00375
Species: Human
Expression System: HEK293 Cells
Claudin-4 Protein-VLP, Human, Recombinant
Cat.No: TMPK-00710
Species: Human
Expression System: HEK293 Cells
KRT10 Protein, Human, Recombinant (His)
Cat.No: TMPH-01575
Species: Human
Expression System: E. coli
LCE3A Protein, Human, Recombinant (His)
Cat.No: TMPH-01607
Species: Human
Expression System: E. coli
MYLK Protein, Human, Recombinant (His)
Cat.No: TMPH-03753
Species: Human
Expression System: E. coli
SLC2A1 Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03373
Species: Rat
Expression System: E. coli
SLC2A1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02122
Species: Human
Expression System: E. coli
Mucin-17/MUC17 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01456
Species: Human
Expression System: HEK293 Cells
EpCAM/TROP1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00200
Species: Mouse
Expression System: HEK293 Cells
IL-19 Protein, Human, Recombinant (His)
Cat.No: TMPY-00493
Species: Human
Expression System: Baculovirus Insect Cells
Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)
Cat.No: TMPY-02129
Species: Human
Expression System: Baculovirus Insect Cells
Caspase-14 Protein, Human, Recombinant (His)
Cat.No: TMPY-01824
Species: Human
Expression System: E. coli
Citrate Synthase Protein, Human, Recombinant (His)
Cat.No: TMPY-04070
Species: Human
Expression System: Baculovirus Insect Cells
Cat. No. Product Name Target Signaling Pathways
T11067 VX-984

M9831

DNA-PK DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用,可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
T10118 3-O-Methyltolcapone D7

Ro 40-7591 D7

Transferase Metabolism
3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P
TMIJ-0312 L-Dopa-2,5,6-d3

L-Dopa-2,5,6-d3 是 L-Dopa 的氘代化合物。L-Dopa 的 CAS 号为 59-92-7。Levodopa 是的神经递质多巴胺的代谢前体,具有口服活性。Levodopa 能够透过血脑屏障,并在大脑中转化为多巴胺。Levodopa具有抗痛觉过敏作用。Levodopa还具有帕金森氏病的研究潜力。
T70808 Cabazitaxel-d6

Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
TMIH-0046 3-Indoleacrylic acid-d4

3-Indoleacrylic acid-d4 是 3-Indoleacrylic acid 的氘代化合物。3-Indoleacrylic acid 的 CAS 号为 1204-06-4。3-Indoleacrylic acid是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid对肠上皮屏障功能有有益作用,并减轻免疫细胞的炎症反应。
T71303 Flufenamic Acid-d4

Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...

同位素标记化合物

VX-984
Cat.No: T11067
Synonym: M9831
Target: DNA-PK
3-O-Methyltolcapone D7
Cat.No: T10118
Synonym: Ro 40-7591 D7
Target: Transferase
L-Dopa-2,5,6-d3
Cat.No: TMIJ-0312
Synonym:
Target:
Cabazitaxel-d6
Cat.No: T70808
Synonym:
Target:
3-Indoleacrylic acid-d4
Cat.No: TMIH-0046
Synonym:
Target:
Flufenamic Acid-d4
Cat.No: T71303
Synonym:
Target:
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