γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimental autoimmune encephalomyelitis (EAE) in murine models in vivo. This compound is relevant for research into multiple sclerosis (MS) and other neuroinflammatory disorders characterized by blood-brain barrier compromise and microglial activation [1].

γ-Fibrinogen377-395（200 μM）能够有效阻断纤维蛋白与Mac-1的相互作用，进而降低Mac-1过表达细胞对固定化纤维蛋白原的粘着能力。此外，该化合物还能抑制小胶质细胞的活化[1]。

γ-纤维蛋白原377-395（30 μg/小鼠；鼻内给药；每日一次，连续40天）能提升小鼠的运动功能，而不对外周免疫反应产生影响。该化合物不干预纤维蛋白原的凝血功能[1]。在实验性自身免疫性脑炎（EAE）诱导前，接种γ377-395肽的小鼠，在运动能力和协调性上均优于对照组[1]。