(S)-CE-123 is an innovative and highly selective atypical dopamine transporter (DAT) inhibitor, exhibiting an EC 50 of 2.76 μM in uptake inhibition assays performed in HEK293 cells with stable expression of human DAT isoforms. As a Modafinil analogue, (S)-CE-123 can cross the blood–brain barrier and enhances cognitive and motivational functions in experimental animals [1] [2].

(S)-CE-123（剂量为6.0、12.0、24.0 mg/kg；腹腔注射；测试前30分钟）有效抑制了TBZ（1.0 mg/kg）对杠杆按压和食物摄入的影响。独立使用(S)-CE-123时，其效果与对照组（接受媒介物处理的大鼠）相比无显著差异 [1]。实验模型：训练有素的雄性 Sprague-Dawley 大鼠 [1]。