Tubulin inhibitor 41

Name: Tubulin inhibitor 41
Brand: TargetMol
SKU: T87573
Rating: 4.5 (1 reviews)

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产品编号 T87573Cas号 2770273-12-4

Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].

Tubulin inhibitor 41

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产品编号 T87573Cas号 2770273-12-4

规格	价格	库存	数量
10 mg	询价	10-14周
50 mg	询价	10-14周

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产品描述	Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].
体外活性	Tubulin inhibitor 41 (Compd D19) 在U87癌细胞系中显示出显著的抗增殖效果，其IC 50 值为0.90 ± 0.03 μM。此外，该化合物能有效降解微管蛋白骨架 [1]。
体内活性	'Tubulin inhibitor 41 (Compd D19, 5 mg/kg 和 10 mg/kg) 剂量依赖性地抑制正位胶质瘤异种移植模型 (GL261-Luc) 的肿瘤生长，并显著延长小鼠的存活时间。'