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BD-Oligo作为一种有前景的荧光传感器,专门用于检测Aβ寡聚体。它不仅能够在体外监测纤维形成过程中的寡聚体动态,还展示了在阿尔茨海默病(AD)小鼠模型中对Aβ寡聚体的体内染色可能性。BD-Oligo通过π-π堆积作用以及BD-Oligo与Aβ寡聚体暴露的疏水区之间的氢键作用来实现传感过程,这一机制通过计算技术得以确定。此外,BD-Oligo能够穿越血脑屏障(BBB),在AD转基因小鼠模型的大脑中检测寡聚体而不产生毒性。
BD-Oligo作为一种有前景的荧光传感器,专门用于检测Aβ寡聚体。它不仅能够在体外监测纤维形成过程中的寡聚体动态,还展示了在阿尔茨海默病(AD)小鼠模型中对Aβ寡聚体的体内染色可能性。BD-Oligo通过π-π堆积作用以及BD-Oligo与Aβ寡聚体暴露的疏水区之间的氢键作用来实现传感过程,这一机制通过计算技术得以确定。此外,BD-Oligo能够穿越血脑屏障(BBB),在AD转基因小鼠模型的大脑中检测寡聚体而不产生毒性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | BD-Oligo is a promising fluorescent sensor designed for detecting Aβ oligomers. It effectively monitors the dynamics of these oligomers during fibril formation in vitro and shows potential for in vivo staining in Alzheimer's disease (AD) mouse models. The sensing mechanism is facilitated through π-π stacking interactions and hydrogen bonding between BD-Oligo and the exposed hydrophobic regions of Aβ oligomers, as confirmed by computational techniques. Furthermore, BD-Oligo can cross the blood-brain barrier (BBB) to detect oligomers in the brains of AD transgenic mice without causing toxicity. |
别名 | BoDipy-Oligomer, BDOligo, BD Oligo |
分子量 | 571.64 |
分子式 | C25H24BCl3F2N2O4 |
CAS No. | 1357578-02-9 |
存储 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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