CSF1R-IN-23 (Compound 7dri), a selective colony-stimulating factor-1 receptor (CSF1R) inhibitor, exhibits an IC50 of 36.1 nM. This compound acts as an antineuroinflammatory agent in a mouse model and is noted for its blood-brain barrier (BBB) permeability [1].

CSF1R-IN-23（0-10 μM，30分钟）抑制细胞RAW264.7和小胶质细胞EOC20中CSF1R的自磷酸化，且不显现明显细胞毒性[1]。Western Blot Analysis [1]。细胞系：EOC20和RAW264.7。浓度：0-10 μM。孵育时间：30分钟。结果：抑制了CSF1R的磷酸化。

CSF1R-IN-23于C57BL/6J小鼠模型中展现出显著的治疗效果，该小鼠模型通过脂多糖引发神经炎症。通过腹腔注射0.5 mg/kg的剂量，每两天一次，连续四次注射后，成功消除了海马、皮层和丘脑中76%的小胶质细胞 [1]。