JNJ-5207787

Name: JNJ-5207787
Brand: TargetMol
SKU: T15620
Rating: 4.5 (1 reviews)

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产品编号 T15620Cas号 683746-68-1

JNJ-5207787 is a penetrates the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. It is >100-fold selective versus human Y1, Y4, and Y5 receptors. JNJ-5207787 suppresses the binding of peptide YY with pIC50s of 7.0 and 7.1 for the human Y2 receptor and rat Y2 receptor, respectively.

JNJ-5207787

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产品编号 T15620Cas号 683746-68-1

规格	价格	库存	数量
1 mg	¥ 770	35日内发货
10 mg	¥ 5,180	35日内发货

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产品描述	JNJ-5207787 is a penetrates the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. It is >100-fold selective versus human Y1, Y4, and Y5 receptors. JNJ-5207787 suppresses the binding of peptide YY with pIC50s of 7.0 and 7.1 for the human Y2 receptor and rat Y2 receptor, respectively.
靶点活性	Y2 receptor (rat):7.1 (pic50), Y2 receptor (human):7.0 (pic50)
体外活性	JNJ-5207787 (10 μM; 15 min) suppresses [125I]PYY labeling in the lateral septum, cerebellum, ventral tegmental area, substantia nigra, hippocampus, septum, amygdala, and hypothalamus. JNJ-5207787 (0.01, 0.1, 1, 10 μM) has antagonistic properties and suppresses the PYY-stimulated [35S]GTPγS binding to basal level with a p IC50 corr of 7.20 [1].
体内活性	JNJ-5207787 (i.p.; 30 mg/kg) penetrates the brain (Cmax=1351 ng/ml at 30 min) and occupies Y2 receptor binding sites[1].