首页工具

登录

搜索结果

Search Results for " cdk "

Targets Recommended: CDK CDK

344

抑制剂 & 化合物

11

天然产物

4

化合物库

24

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L3400	临床期小分子药物库		3404 compounds
	3404 个临床期化合物集合，可用于高通量筛选和高内涵筛选；
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L1600	激酶抑制剂库		2720 compounds
	2720 种激酶抑制剂/调节剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；

化合物库

临床期小分子药物库

Cat.No: L3400

Compounds: 3404

细胞周期化合物库

Cat.No: L8100

Compounds: 677

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

激酶抑制剂库

Cat.No: L1600

Compounds: 2720

Cat. No.	Product Name	Target	Signaling Pathways
TQ0078	CDK-IN-2 CDK inhibitor II	CDK	Cell Cycle/Checkpoint
	CDK-IN-2 (CDK inhibitor II) 是一种有效且特异性的 CDK9 抑制剂，IC50小于8 nM。
T60869	CDK-IN-10	CDK	Cell Cycle/Checkpoint
	CDK-IN-10 是一种细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗癌活性，可用于研究癌症。
T14916	CDK2-IN-4	CDK	Cell Cycle/Checkpoint
	CDK2-IN-4 是选择性的CDK2抑制剂，对 CDK2/cyclin A 的IC50值为 44 nM，选择性高出 CDK1/cyclin B 的 2,000 倍 (IC50=86 μM)。
T36741	CDK-IN-6	Others	Others
	CDK-IN-6, a pyrazolo[1,5-a]pyrimidine compound, exhibits potent anticancer activities as a CDK inhibitor[1].
T40290	CDK12-IN-5	CDK	Cell Cycle/Checkpoint
	CDK12-IN-5 是一种高效的 CDK12 抑制剂，具有潜在的抗癌抗肿瘤活性，可口用于研究乳腺癌和卵巢癌。
T39957	CDK4/6-IN-6	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-6 是CDK4/CDK6的有效抑制剂，结合CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 为 0.6 nM 和 13.9 nM。
T10742	CDK9-IN-10	CDK	Cell Cycle/Checkpoint
	CDK9-IN-10 是一种有效的 CDK9 抑制剂。CDK9-IN-10 是 PROTAC CDK9 degrader-2 的配体。
T10736	CDK4/6-IN-2	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。
T10740	CDK8-IN-1	CDK	Cell Cycle/Checkpoint
	CDK8-IN-1 是一个有效的、CDK8 的选择性抑制剂，其 IC50 值为 3 nM。
T10734	CDK ligand for PROTAC	Others	Others
	CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
T14914	Cdk1/2 Inhibitor III	CDK	Cell Cycle/Checkpoint
	Cdk1/2 Inhibitor III 是一种具有选择性的 Cdk1/2抑制剂，对 CDK1/cyclin B 的 IC50值为2.1μM。
T10745	CDK9-IN-7	CDK	Cell Cycle/Checkpoint
	CDK9-IN-7 (compound 21e) 是一种高效选择性的，具有口服活性的 CDK9/cyclin T 抑制剂 (IC50=11 nM)，与抑制其他 CDK 相比更有效 (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM)。CDK9-IN-7 具有抗癌活性并没有明显的毒性。CDK9-IN-7 诱导非小细胞肺癌 (NSCLC) 细胞凋亡，在 G2 期阻滞细胞周期，并具有抑制非小细胞肺癌干细胞特性。
T14918	CDK9-IN-2 N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺	Others; CDK	Cell Cycle/Checkpoint; Others
	CDK9-IN-2 是一种特异性CDK9抑制剂。它在 A2058 皮肤细胞系（72 小时）和 H929 多发性骨髓瘤细胞系（72小时）的IC50分别为 7 nM 和 5 nM。
T37207L	Cdk5 Substrate acetate	CDK	Cell Cycle/Checkpoint
	Cdk5 Substrate acetate 是一种丝氨酸/苏氨酸激酶，主要在神经元组织中具有活性。与 p25 或 p35 一起，Cdk5 磷酸化一系列蛋白质，包括组蛋白 H1 和 tau。它是一种合成肽 (PKTPKKAKKL)，对应于组蛋白 H1 的序列。它被 Cdk5 磷酸化，Km 值为 5 µM。
T10735	CDK4/6/1 Inhibitor Crozbaciclib	CDK	Cell Cycle/Checkpoint
	CDK4/6/1 Inhibitor (Crozbaciclib) 是一种 CDK4/6 抑制剂 (IC50s: 3 and 1 nM). CDK4/6抑制剂是一类用于治疗一些类型的激素受体阳性、her2阴性乳腺癌的化合物，可阻断了乳腺癌细胞分裂和繁殖的过程。
T36933	Cdk2 Inhibitor II Cdk2 Inhibitor II,CDK2-IN-3	CDK	Cell Cycle/Checkpoint
	Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂，50 为 60 nM。
T39752	CDK12-IN-2 CDK12 inhibitor 2,CDK12-IN-2	CDK	Cell Cycle/Checkpoint
	CDK12-IN-2 (CDK12 inhibitor 2) 是一种有效的选择性 CDK12 抑制剂，对 CDK12、CDK2、CDK7 和 CDK9 的 IC50 为 52 nM、>100 μM、>10 μM 和 16 μM。 CDK12-IN-2可用于研究CDK12的功能。
T10734L	CDK ligand for PROTAC hydrochloride	Others	Others
	CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
TP1875L	CDK2 acetate(255064-79-0 free base)	Others	Others
	CDK2 acetate(255064-79-0 free base) 是真核生物 S/T 蛋白激酶家族的成员，其功能是催化 ATP γ-磷酸磷酸基转移到蛋白质底物中的丝氨酸或苏氨酸羟基（表示为 S0/T0）。
T75127	CDK-IN-12	Others	Others
	CDK-IN-12 (Example 20) 是一种CDK 抑制剂。CDK-IN-12 抑制 CDK4/6 的IC50值小于 20 nM。
T62235	CDK-IN-9	Others	Others
	CDK-IN-9 (compound 24) 是一种 CDK 的有效抑制剂。CDK-IN-9 也是一种能够诱导 CDK12 和 DDB1 相互作用的分子胶，能够作用于 CDK2/E (IC50: 4 nM) 。CDK-IN-9 能够导致细胞周期蛋白 K (cyclin K) 的多泛素化及其随后的降解。CDK-IN-9 可以利用去磷酸化视网膜母细胞瘤蛋白和RNA 聚合酶 II，进而诱导细胞凋亡 (apoptosis)。
T61583	CDK/HDAC-IN-1	Others	Others
	CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.
T78906	CDK/HDAC-IN-3	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CDK/HDAC-IN-3 是一种口服活性的 HDAC/CDK 双重抑制剂，对 CDK9、CDK12、CDK13 及 HDAC1、HDAC2、HDAC3 表现出有效且选择性的抑制，IC50 值分别为 98.32 nM、98.85 nM、100 nM、62.12 nM、93.28 nM 和 82.87 nM。该化合物主要用于急性髓性白血病 (AML) 的相关研究。
T84917	CDK-IN-11	Others	Others
	CDK-IN-11，一种杂环化合物，可促进心肌细胞成熟。
T63664	CDK/HDAC-IN-2	Others	Others
	CDK/HDAC-IN-2 是有效的 HDAC/CDK 双重抑制剂，能够作用于 HDAC1 (IC50: 6.4 nM)、HDAC2 (IC50: 0.25 nM)、HDAC3 (IC50: 45 nM)、HDAC6,8 (IC50>1000 nM)、CDK1 (IC50: 8.63 nM)、CDK2 (IC50: 0.30 nM)、CDK4,6,7 (IC50>1000 nM)。CDK/HDAC-IN-2 能够将细胞周期停滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。CDK/HDAC-IN-2 具有优异的抗增殖效果，显示出显著的抗肿瘤作用。
T60025	Eciruciclib	CDK	Cell Cycle/Checkpoint
	Eciruciclib 是一种具有抗肿瘤特性的 CDK 抑制剂。
T37207	Cdk5 Substrate Cdk5 Substrate
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 μM.
T10746	CDK9-IN-8	CDK	Cell Cycle/Checkpoint
	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).
T40263	CDK5-IN-1 CDK5-IN-1	Others	Others
	CDK5-IN-1 is a highly potent inhibitor of CDK5, displaying an inhibitory activity of less than 10 nM. This potent compound is specifically employed in scientific investigations relating to kidney diseases.
T40289	CDK12-IN-6 CDK12-IN-6	Others	Others
	CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not exhibit any inhibitory effect on CDK2/Cyclin E (IC50 >20 μM) and CDK9/Cyclin T1 (IC50 >20 μM) when tested under the same high ATP conditions (2 mM) (WO2021116178A1).
T39247	CDK7-IN-5 CDK7-IN-5	Others	Others
	CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).
T5673	Senexin A	CDK	Cell Cycle/Checkpoint
	Senexin A 是一种有效且选择性的 CDK8 抑制剂，它还抑制 CDK19，Kd 值分别为0.83μM 和0.31μM。
T40160	CDK2-IN-7 CDK2-IN-7	Others	Others
	CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).
T40264	CDK7-IN-7 CDK7-IN-7	Others	Others
	CDK7-IN-7, a highly potent and selective inhibitor of CDK7 kinase, exhibits remarkable activity with an IC50 of less than 50 nM.
T39354	CDK9-IN-12 CDK9-IN-12	Others	Others
	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC 50 value of 5.41 nM.
T7789	DRB	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	DRB 是一种核苷类似物，对几种羧基末端结构域激酶（包括酪蛋白激酶 II 、细胞周期依赖性激酶）有抑制作用。它可诱导人类结肠腺癌细胞的 p53 依赖性凋亡，且不会诱发健康细胞遗传毒性应激。
T36743	CDK7/9 tide
	CDK7/9 tide is peptide substrate for CDK7 or CDK9[1]. [1]. Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27; 8:147.
T72029	CDK8-IN-13	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	CDK8-IN-13是一种 CDK8抑制剂（IC50：51.9 nM），具有强效性、选择性和口服活性。CDK8-IN-13能诱导细胞凋亡，降低了 p-STAT1 S727和p-STAT5 S726的表达。CDK8-IN-13表现出抗肿瘤活性。
T39943	CDK7-IN-6 CDK7-IN-6	Others	Others
	CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. This compound holds significant potential for cancer research purposes.
T39372	CDK7-IN-1 CDK7-IN-1	Others	Others
	CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound 215).
T40288	CDK12-IN-4 CDK12-IN-4	Others	Others
	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or CDK9/Cyclin T1 (IC50 > 20 μM) under the influence of high ATP (2 mM) levels (WO2021116178A1).
T36744	CDK9 Antagonist-1 CDK9 Antagonist-1	Others	Others
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9\|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
T9632	CDK9-IN-30	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	CDK9-IN-30 是 Tat 肽衍生物之一，可抑制 HIV-1 长末端重复激活转录。
T60619	CDK9-IN-15	CDK	Cell Cycle/Checkpoint
	CDK9-IN-15 是一种有效的小分子CDK9抑制剂，可通过降解、抑制 CDK9 来阻断正性转录延长因子 P-TEFb (positive transcription elongation factor b) 对 RNA Poly-II C末端区域的磷酸化，抑制转录，迅速降低细胞内 mRNA 水平，从而引起肿瘤细胞凋亡。
T64373	CDK1-IN-2 cdk1 inhibitor 2	CDK	Cell Cycle/Checkpoint
	CDK1-IN-2 (cdk1 inhibitor 2)是一种CDK1抑制剂，IC50为5.8μM。CDK1-IN-2的激酶谱显示了多种激酶的非选择性抑制。
T72048	CDK8-IN-12	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	CDK8-IN-12 是一种具有选择性、有效性和口服活性的 CDK8 抑制剂（Ki ： 14 nM），是一种抗癌剂。CDK8-IN-12 对 GSK-3α、GSK-3β、PCK-θ 具有抑制作用，Ki 分别为 13 nM、4 nM、109 nM。CDK8-IN-12对 MV4-11 细胞显示出抗增殖活性。
T2082	CDK4-IN-1	CDK	Cell Cycle/Checkpoint
	CDK4-IN-1 是一种新型的特异性 CDK4/Cyclin D1 抑制剂，IC50 为 10 nM；分别是 CDK1/Cyclin B (IC50>15 uM) 和 CDK2/Cyclin A (IC50=5.265 uM) 的 1500 倍和 500 倍。
T40047	CDK6/9-IN-1 CDK6/9-IN-1	Others	Others
	CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
T39956	CDK4/6-IN-5 CDK4/6-IN-5	Others	Others
	CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively (WO2019207463A1, example A93).
T5438	PROTAC CDK9 Degrader-1	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	PROTAC CDK9 Degrader-1 是一种选择性 CDK9 降解剂，是由Cereblon 配体和CDK 配体相连的PROTAC。

化合物

Cat.No: TQ0078

Synonym: CDK inhibitor II

Target: CDK

Cat.No: T60869

Target: CDK

Cat.No: T14916

Target: CDK

Cat.No: T36741

Target: Others

Cat.No: T40290

Target: CDK

Cat.No: T39957

Target: CDK

Cat.No: T10742

Target: CDK

Cat.No: T10736

Target: CDK

Cat.No: T10740

Target: CDK

CDK ligand for PROTAC

Cat.No: T10734

Target: Others

Cdk1/2 Inhibitor III

Cat.No: T14914

Target: CDK

Cat.No: T10745

Target: CDK

Cat.No: T14918

Synonym: N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺

Target: Others, CDK

Cdk5 Substrate acetate

Cat.No: T37207L

Target: CDK

CDK4/6/1 Inhibitor

Cat.No: T10735

Synonym: Crozbaciclib

Target: CDK

Cdk2 Inhibitor II

Cat.No: T36933

Synonym: Cdk2 Inhibitor II,CDK2-IN-3

Target: CDK

Cat.No: T39752

Synonym: CDK12 inhibitor 2,CDK12-IN-2

Target: CDK

CDK ligand for PROTAC hydrochloride

Cat.No: T10734L

Target: Others

CDK2 acetate(255064-79-0 free base)

Cat.No: TP1875L

Target: Others

Cat.No: T75127

Target: Others

Cat.No: T62235

Target: Others

CDK/HDAC-IN-1

Cat.No: T61583

Target: Others

CDK/HDAC-IN-3

Cat.No: T78906

Target: HDAC

Cat.No: T84917

Target: Others

CDK/HDAC-IN-2

Cat.No: T63664

Target: Others

Cat.No: T60025

Target: CDK

Cdk5 Substrate

Cat.No: T37207

Synonym: Cdk5 Substrate

Cat.No: T10746

Target: CDK

Cat.No: T40263

Synonym: CDK5-IN-1

Target: Others

Cat.No: T40289

Synonym: CDK12-IN-6

Target: Others

Cat.No: T39247

Synonym: CDK7-IN-5

Target: Others

Cat.No: T5673

Target: CDK

Cat.No: T40160

Synonym: CDK2-IN-7

Target: Others

Cat.No: T40264

Synonym: CDK7-IN-7

Target: Others

Cat.No: T39354

Synonym: CDK9-IN-12

Target: Others

Cat.No: T7789

Target: HIV Protease

Cat.No: T36743

Cat.No: T72029

Target: Apoptosis, CDK

Cat.No: T39943

Synonym: CDK7-IN-6

Target: Others

Cat.No: T39372

Synonym: CDK7-IN-1

Target: Others

Cat.No: T40288

Synonym: CDK12-IN-4

Target: Others

CDK9 Antagonist-1

Cat.No: T36744

Synonym: CDK9 Antagonist-1

Target: Others

Cat.No: T9632

Target: HIV Protease

Cat.No: T60619

Target: CDK

Cat.No: T64373

Synonym: cdk1 inhibitor 2

Target: CDK

Cat.No: T72048

Target: GSK-3, CDK

Cat.No: T2082

Target: CDK

Cat.No: T40047

Synonym: CDK6/9-IN-1

Target: Others

Cat.No: T39956

Synonym: CDK4/6-IN-5

Target: Others

PROTAC CDK9 Degrader-1

Cat.No: T5438

Target: CDK, PROTACs

Cat. No.	Product Name	Target	Signaling Pathways
T5S1467	Cucurbitacin E	CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint
	Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性，具有预防神经变性，具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。
T16324	Nimbolide	Apoptosis; NF-κB; CDK	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。
T2933	Wogonin Vogonin,汉黄芩素	Apoptosis; Wnt/beta-catenin; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Wogonin (Vogonin) 是一种具有细胞渗透性的口服类黄酮，具有抗炎和抗癌特性，能够抑制 CDK8和 Wnt 的活性。
TN1673	Garcinone C 伽升沃 C,伽升沃C	ATM/ATR; CDK; STAT; AChR; Antifection	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Garcinone C 是一种从 Garcinia oblongifolia Champ 中提取的黄酮衍生物，具有抗炎、收敛和促进肉芽的活性。 Garcinone C 是一种 AChE 抑制剂，对某些癌症具有潜在的细胞毒性作用。
T7444	6-(Dimethylamino)purine N,N-Dimethyladenine,6-二甲基氨基嘌呤	Serine/threonin kinase; CDK	Cell Cycle/Checkpoint; Metabolism
	6-(Dimethylamino)purine (N,N-Dimethyladenine) 是一种丝氨酸苏氨酸蛋白激酶和 CDK 抑制剂。
TN1299	Desmethylglycitein 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone	PI3K; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物，具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2，抑制 CDK1 和 CDK2 活性。
T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。
T25192	Butyrolactone I Olomoucin,丁酸内酯I	CDK	Cell Cycle/Checkpoint
	Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。
TN2080	Pinoresinol 松脂酚，松脂素,(+)-Pinoresinol	Apoptosis; NF-κB; CDK; p53	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素，具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调，抑制 NF-kappaB 和激活蛋白 1 。
T38441	Manzamine A hydrochloride	Others	Others
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].

天然产物

Cat.No: T5S1467

Target: CDK, Autophagy

Cat.No: T16324

Target: Apoptosis, NF-κB, CDK

Cat.No: T2933

Synonym: Vogonin,汉黄芩素

Target: Apoptosis, Wnt/beta-catenin, CDK, Autophagy

Cat.No: TN1673

Synonym: 伽升沃 C,伽升沃C

Target: ATM/ATR, CDK, STAT, AChR, Antifection

6-(Dimethylamino)purine

Cat.No: T7444

Synonym: N,N-Dimethyladenine,6-二甲基氨基嘌呤

Target: Serine/threonin kinase, CDK

Desmethylglycitein

Cat.No: TN1299

Synonym: 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

Butyrolactone I

Cat.No: T25192

Synonym: Olomoucin,丁酸内酯I

Target: CDK

Cat.No: TN2080

Synonym: 松脂酚，松脂素,(+)-Pinoresinol

Target: Apoptosis, NF-κB, CDK, p53

Manzamine A hydrochloride

Cat.No: T38441

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01173	CDK7 Protein, Human, Recombinant Cyclin-dependent kinase 7,Cell division protein kinase 7,Ser...	Human	E. coli
	CDK7 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01172	CDK7 Protein, Human, Recombinant (His) 39 kDa protein kinase,Cyclin-dependent kinase 7,CDK...	Human	Baculovirus Insect Cells
	CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPH-03456	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) CAK1,CIV1,Serine/threonine-protein kinase CAK1,CDK-...	Saccharomyces cerevisiae	Baculovirus Insect Cells
	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.1 kDa and the accession number is P43568.
TMPH-03457	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) Serine/threonine-protein kinase CAK1,CAK1,CDK-activ...	Saccharomyces cerevisiae	E. coli
	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.6 kDa and the accession number is P43568.
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-04450	CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST) P34CDC2 & CCNE1,CDC2,CDKN1,CDK1,CCNE,CDC28...	Human	Baculovirus Insect Cells
	CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 109.7 kDa and the accession number is NP_001777.1&NP_001229.1.
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPH-01171	CDK5 Protein, Human, Recombinant Serine/threonine-protein kinase PSSALRE,Cyclin-dependent-lik...	Human	E. coli
	CDK5 Protein, Human, Recombinant is expressed in E. coli.
TMPY-04556	CDK5 Protein, Human, Recombinant (GST) PSSALRE,cyclin-dependent kinase 5	Human	Baculovirus Insect Cells
	Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was jo...
TMPH-01167	CDK1 Protein, Human, Recombinant (His) p34 protein kinase,Cell division control protein 2 homolog,C...	Human	E. coli
	CDK1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01169	CDK4 Protein, Human, Recombinant (His) Cyclin-dependent kinase 4,CDK4,Cell division protei...	Human	E. coli
	CDK4 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-04549	CDK1 Protein, Human, Recombinant (GST) CDC2,P34CDC2,CDC28A,cyclin-dependent kinase 1	Human	Baculovirus Insect Cells
	CDK1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 60 kDa and the accession number is P06493-1.
TMPY-04775	CDK1 Protein, Mouse, Recombinant (His & GST) CDC2>,Cdc2,Cdc2a,p34<,cyclin-dependent kinase 1	Mouse	Baculovirus Insect Cells
	CDK1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 61.9 kDa and the accession number is P11440.
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His) DOC-1R,p14,cyclin-dependent kinase 2 associated protein 2	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative las...
TMPH-01170	CDK5R1 Protein, Human, Recombinant (His) CDK5 activator 1,CDK5R,NCK5A,CDK5...	Human	E. coli
	CDK5R1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-04449	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His) HCAK,CAK1,cyclin-dependent kinase 7,p39MO15,CDKN7,S...	Human	Baculovirus Insect Cells
	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 118.8 kDa and the accession number is P50613&P51946&P51948.
TMPJ-00963	CDKN2C Protein, Human, Recombinant (His) Cyclin-Dependent Kinase 4 Inhibitor C,p18-INK4c,CDK...	Human	E. coli
	Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis,...
TMPH-00081	CDKB1-2 Protein, Arabidopsis thaliana, Recombinant (His) CDKB1-2,CDKB1;2,Cyclin-dependent kinase B1...	Arabidopsis thaliana	P. pastoris (Yeast)
	Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage. CDKB1-2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 37.6 kDa and the accessio...
TMPY-04463	CDKL2 Protein, Human, Recombinant (His) KKIAMRE,P56,cyclin-dependent kinase-like 2 (CDC2-related kin...	Human	Baculovirus Insect Cells
	Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus, amygdala, and dorsal thalamus. The high expression in these brain regions suggests that Cdkl2 may have functions in congnition and emotion processes. Cdkl2 accumulates primarily in the cytoplasm, with lower levels in the nucleus.
TMPH-01168	CDKN2B Protein, Human, Recombinant (His & Myc) Multiple tumor suppressor 2,Cyclin-dependent kinase 4 inhibi...	Human	E. coli
	CDKN2B Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His) KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,C...	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ...
TMPY-02495	p19 INK4d Protein, Human, Recombinant (GST) p19-INK4D,INK4D,cyclin-dependent kinase inhibitor 2D (p19, i...	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His) G1/S-specific cyclin-D2,CCND2	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ...
TMPY-02796	KIAA0101 Protein, Human, Recombinant (His) L5,NS5ATP9,p15PAF,OEATC1,p15(PAF),OEATC,PAF,p15/PAF,OEATC-1,...	Human	E. coli
	KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell ...

重组蛋白

CDK7 Protein, Human, Recombinant

Cat.No: TMPH-01173

Species: Human

Expression System: E. coli

CDK7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01172

Species: Human

Expression System: Baculovirus Insect Cells

CAK1 Protein, S. cerevisiae, Recombinant (His & Myc)

Cat.No: TMPH-03456

Species: Saccharomyces cerevisiae

Expression System: Baculovirus Insect Cells

CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03457

Species: Saccharomyces cerevisiae

Expression System: E. coli

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04450

Species: Human

Expression System: Baculovirus Insect Cells

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

CDK5 Protein, Human, Recombinant

Cat.No: TMPH-01171

Species: Human

Expression System: E. coli

CDK5 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04556

Species: Human

Expression System: Baculovirus Insect Cells

CDK1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01167

Species: Human

Expression System: E. coli

CDK4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01169

Species: Human

Expression System: E. coli

CDK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04549

Species: Human

Expression System: Baculovirus Insect Cells

CDK1 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04775

Species: Mouse

Expression System: Baculovirus Insect Cells

CDK2AP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02921

Species: Human

Expression System: E. coli

CDK5R1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01170

Species: Human

Expression System: E. coli

CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04449

Species: Human

Expression System: Baculovirus Insect Cells

CDKN2C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00963

Species: Human

Expression System: E. coli

CDKB1-2 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00081

Species: Arabidopsis thaliana

Expression System: P. pastoris (Yeast)

CDKL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04463

Species: Human

Expression System: Baculovirus Insect Cells

CDKN2B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01168

Species: Human

Expression System: E. coli

CDKN1B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00972

Species: Human

Expression System: E. coli

p19 INK4d Protein, Human, Recombinant (GST)

Cat.No: TMPY-02495

Species: Human

Expression System: E. coli

CCND2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00936

Species: Human

Expression System: E. coli

KIAA0101 Protein, Human, Recombinant (His)

Cat.No: TMPY-02796

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼