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CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 19,400 | 10-14周 | |
50 mg | ¥ 25,800 | 10-14周 | |
100 mg | ¥ 33,500 | 10-14周 |
产品描述 | CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM. |
靶点活性 | CDK6:2.2 nM (ki), CDK4:0.3 nM (ki), CDK1:110 nM (ki) |
体外活性 | CDK4/6-IN-3 inhibits MCF7 and BT549 cell lines proliferation (EC50s: 30 nM and 2.1 μM). |
分子量 | 462.57 |
分子式 | C25H31FN8 |
CAS No. | 2366237-37-6 |
密度 | 1.41 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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