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Cat. No. | Product Name | ||
---|---|---|---|
L6750 | 活血化瘀中药单体库 | 580 compounds | |
580种来源于常见活血化瘀中药的单体化合物,是药物开发、药理研究等领域的有效工具。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8441 |
Lerisetron
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Lerisetron 是5-HT3拮抗剂,与 5-HT3受体具有高亲和力(pKi:9.2)。它对尿烷麻醉大鼠的 5-HT 引发的反射性心率过缓具有抑制作用。 | |||
T3474 |
RO 46-8443
|
Endothelin Receptor | GPCR/G Protein |
Ro 46-844 是选择性非肽内皮素受体拮抗剂。它对ETB(IC50: 34-69 nM) 的选择性比ETA 受体 (IC50: 6800 nM) 高的100倍以上。 | |||
T1752 |
NS6180
|
Potassium Channel | Membrane transporter/Ion channel |
NS6180是一种高效的KCa3.1离子通道选择性抑制剂,IC50值9nM。NS6180阻止T 细胞活化和炎症反应。 | |||
T2626 |
SBC-115076
SBC115076 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-115076 是前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(PCSK9)抑制剂。其中PCSK9 是一种前蛋白转化酶,在 LDL 受体代谢中的重要物质。 | |||
T35317 |
Zopolrestat
CP 73850,CP73850,CP-73850,唑泊司他,Zopolrestatum |
Reductase | Endocrinology/Hormones; Metabolism |
Zopolrestat (CP 73850) 是口服有效的醛糖还原酶抑制剂,IC50为3.1 nM。Zopolrestat (CP 73850) 在糖尿病并发症方面有研究的价值。 | |||
T5194 |
SPHINX31
|
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
SPHINX31 是丝氨酸/富含精氨酸的蛋白激酶1的选择性抑制剂,其IC50值为 5.9 nM。它有效抑制丝氨酸/丰富精氨酸的剪接因子1 磷酸化,有用于局部新生血管性眼病的研究潜力。 | |||
T8405 |
Vardenafil hydrochloride
伐地那非,盐酸伐地那非 |
PDE | Metabolism |
Vardenafil hydrochloride 是口服具有活性的、高效的、选择性的磷酸二酯酶 5抑制剂。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它能够非竞争性地抑制环磷酸鸟苷水解,提高 cGMP 水平。它可用于勃起功能障碍的研究。 | |||
T5329 |
Trandolapril
|
Angiotensin-converting Enzyme (ACE) | Metabolism |
Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂,在高血压和充血性心力衰竭及心肌梗死领域有研究价值。 | |||
T0096 |
Vardenafil
伐地那非,Vivanza,Levitra,Vardenafil hydrochloride |
PDE | Metabolism |
Vardenafil (Vivanza) 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。 | |||
T0293 |
Metyrapone
美替拉酮,甲吡酮,NSC-25265,Su-4885 |
Others; P450; Dehydrogenase; Autophagy | Autophagy; Metabolism; Others |
Metyrapone (NSC-25265) 是 STEROID 11-BETA-MONOOXYGENASE 酶抑制剂。 它被用作库欣综合征诊断中下丘脑-垂体反馈机制的测试。 | |||
T3046 |
BMY 7378 dihydrochloride
BMY7378 HCl |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
BMY 7378 dihydrochloride (BMY7378 HCl) 是选择性 α1D 肾上腺素受体拮抗剂,也是5-HT1A 受体部分激动剂。它同表达克隆大鼠 α1D-AR 的膜结合的亲和力 (Ki=2 nM) 是同克隆大鼠 α1A-AR (Ki=800 nM) 或仓鼠 α1B-AR (Ki=600 nM) 结合的亲和力 的100 以上。 | |||
T29112 |
VPC171
(2-氨基-4-(3-(三氟甲基)苯基)噻吩-3-基)(苯基)甲酮,VPC 171,VPC-171 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
VPC171 是一种新型腺苷 A1 受体正变构调节剂 (PAM)。 | |||
T4097 |
Vardenafil hydrochloride trihydrate
Vardenafil HCl Trihydrate,BAY38-9456,盐酸瓦地那非三水合物 |
PDE | Metabolism |
Vardenafil hydrochloride trihydrate (BAY38-9456) 是一种新型 PDE 抑制剂,对 PDE5 和 PDE1 的 IC50 分别为 0.7 和 180 nM。 | |||
T0031L |
Ziprasidone hydrochloride
盐酸齐拉西酮,齐拉西酮盐酸盐,CP-88059 hydrochloride,CP-88059,Ziprasidone HCl |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Ziprasidone hydrochloride (CP-88059 hydrochloride) 是一种联合 5-HT(5-羟色胺)和多巴胺受体拮抗剂,具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。 | |||
T23044 |
N,N'-Dicyclohexylurea
DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲 |
Epoxide Hydrolase | Metabolism |
N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。 | |||
T20419 |
Raloxifene
Pharoxifene,雷洛昔芬,Raloxifenum,Keoxifene,LY-139481 |
Estrogen Receptor/ERR; Others | Endocrinology/Hormones; Others |
Raloxifene (LY-139481) 是一种苯并噻吩类化合物,是一种选择性雌激素受体 (estrogen receptor) 调节剂 (SERM),对骨、血脂有雌激素激动作用,对乳腺和子宫有雌激素拮抗作用。它用于乳腺癌和骨质疏松症研究。 | |||
T4480 |
Vardenafil dihydrochloride
Levitra,Vardenafil Hydrochloride,二盐酸伐地那非 |
PDE | Metabolism |
Vardenafil dihydrochloride (Levitra) 是一种新型 PDE 抑制剂,对 PDE5 和 PDE1 的 IC50 分别为 0.7 和 180 nM。 | |||
T34435 |
RU 47213
RU-47213,Itameline,RU47213 |
Others | Others |
RU 47213 可用于抑制东莨菪碱诱导的大鼠工作记忆障碍。 | |||
T26010 |
Quinacainol
PK-10139,RP-54272,RP 54272,PK 10139,PK10139 |
Others | Others |
Quinacainol (RP 54272)是一种新的抗心律失常化合物,在大鼠中具有I类抗心律失常作用。 | |||
T36520 |
COR659
|
Cannabinoid Receptor; GABA Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。 | |||
T5628 |
p-cumylphenol
|
Others | Others |
p-cumylphenol 可治疗新生大鼠肾小管囊肿形成。 | |||
T28009 |
ME-3221
ME 3221,ME3221 |
RAAS | Endocrinology/Hormones |
ME-3221是一种血管紧张素AT1受体拮抗剂,可预防老年中风易发性高血压大鼠的高血压并发症。 | |||
T37637 |
4,4-Dimethoxy-2-butanone
|
Endogenous Metabolite | Metabolism |
4,4-Dimethoxy-2-butanone 对大鼠实验中显示出亚急性口服毒性。 | |||
T24821 |
Spizofurone
Espizofurona,AG-629 |
Others | Others |
Spizofurone (Espizofurona) 具有抗溃疡活性,对大鼠胃黏膜具有保护作用,可增加分离的牛蛙十二指肠粘膜中的碱性分泌。 | |||
T22840 |
HexylHIBO
|
GluR | Neuroscience |
HexylHIBO 是一种 I 型 mGluR 拮抗剂,对 mGlu1a 和 mGlu5a 具有抑制作用, Kb 值分别为 140 和110 μM。HexylHIBO 降低大鼠 sEPSC。 | |||
T16329 |
Nitroflurbiprofen
NO-flurbiprofen,Nitroxybutyl flurbiprofen,硝基氟比洛芬,HCT 1206 |
COX | Immunology/Inflammation; Neuroscience |
Nitroflurbiprofen (Nitroxybutyl flurbiprofen) 是一种释放 NO 的环氧合酶抑制剂,可调节门脉高压性肝硬化大鼠肝内血管张力的增加。 | |||
T19338 |
Gelucire 44/14
Gelucire 14/44 |
Others | Others |
Gelucire 44/14 (Gelucire 14/44) 可作为非离子表面活性赋形剂,可改善脂肪分解受损大鼠的脂肪吸收。 | |||
T26613L |
Ambazone
Ambazon,Primal,安巴腙 |
Others | Others |
Ambazone (Primal) 被发现对小鼠和大鼠的各种可移植肿瘤具有活性。 | |||
T2264 |
AM281
1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-4-吗啉基-1H-吡唑-3-甲酰胺 |
Cannabinoid Receptor | GPCR/G Protein |
AM281 是选择性CB1受体拮抗剂,IC50=9.91 nM。它抑制 CB2 受体,IC50=13000 nM。 | |||
T17101 |
Tiopinac
RS40974,RS-40974,RS 40974 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Tiopinac (RS 40974) 具有抗炎镇痛活性和抗血小板聚集特性,在肾上腺切除大鼠中表现出抗燃活性。Tiopinac 抑制前列腺素合成,可用于研究类风湿性关节炎。 | |||
T19864 |
Xenalipin
BW 207U |
Others | Others |
Xenalipin (BW 207U) 具有降血脂作用。它可以降低大鼠的血液胆固醇和甘油三酯。 | |||
T16140 |
MRS 1754
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
MRS 1754 是A2B 腺苷受体选择性拮抗剂,对人和大鼠的 A1和 A3受体的亲和力非常低。 | |||
T13919 |
Terbufibrol
|
Others | Others |
Terbufibrol 降低正常和高胆固醇血症雄性大鼠的血清总胆固醇水平。 | |||
T25276 |
Crilvastatin
PMD387,PMD 387,PMD-387 |
HMG-CoA Reductase | Metabolism |
Crilvastatin (PMD 387) 是一种新型非竞争性羟甲基戊二酰辅酶 A 还原酶抑制剂,具有降胆固醇活性,可抑制遗传性高胆固醇血症大鼠的胆固醇吸收。 | |||
T35367 |
Thioacetamide
TAA,硫代乙酰胺 |
Others | Others |
Thioacetamide 是一种肝毒剂,广泛用于诱导实验性肝损伤,在大鼠中引起肝细胞坏死和随后的炎症(主要是 M1-/M2-巨噬细胞,没有中性粒细胞浸润)。 | |||
T16783 |
Rolziracetam
罗拉西坦,CI-911 |
Others | Others |
Rolziracetam (CI-911) 是 racetam 家族的益智药物之一,能够改善老鼠和猴子的有效记忆。 | |||
T7809L |
Ipamorelin 2 Pivalic acid
NNC-26-0161 |
Others | Others |
Ipamorelin 2 Pivalic acid (NNC-26-0161) 是一种生长激素释放肽,可诱导大鼠纵向骨生长。 | |||
T70722 |
N 0861
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
N 0861 是选择性腺苷A1受体拮抗剂,减轻大鼠腺苷控制低血压期间肾功能不全。 | |||
T7580 |
CX546
苯并二氧六环-6-(1-哌啶基)甲酰胺 |
Autophagy; iGluR | Autophagy; Membrane transporter/Ion channel; Neuroscience |
CX546 是一种 AMPA 受体调节剂。 它增强大鼠的认知功能,具有抗精神病的作用。 | |||
T28232 |
Oleoylestrone
Estrone 3-oleate,MP 101,MP-101,MP101 |
Antioxidant | oxidation-reduction |
Oleoylestrone (MP-101) 存在于血浆和脂肪组织中,具有潜在的抗氧化作用,可诱导大鼠体内脂肪的流失,可用于减肥。 | |||
T32160 |
Indolidan
LY 195115 |
Others | Others |
Indolidan (LY 195115) 诱导费舍尔344大鼠的心血管和肾上腺增生性病变。 Indolidan 可增加心血管疾病的风险。 | |||
T5987 |
Potassium oxonate
Oxonic Acid (potassium salt),氧嗪酸钾,Potassium otastat,Potassium azaorotate |
Others | Others |
Potassium oxonate (Potassium azaorotate) 是用作尿酸酶抑制剂,都5-FU 磷酸化为5-fluorouridine-5'-monophosphate 具有抑制作用。 | |||
T13331 |
WAY127093B racemate
|
PDE | Metabolism |
WAY127093B racemate 是WAY127093 B 的外消旋体。WAY127093B 是一种磷酸二酯酶IV 抑制剂,在大鼠和豚鼠中具有口服活性。 | |||
T7555 |
Piperidolate hydrochloride
|
AChR | Neuroscience |
Piperidolate hydrochloride 是一种抗毒蕈碱药,可抑制乙酰胆碱引起的异常活性,能抑制大鼠和狗的肠痉挛。 | |||
T10923 |
CYP17-IN-1
|
P450 | Metabolism |
CYP17-IN-1 是一种有效的 CYP17 口服抑制剂,可抑制大鼠和人类的 CYP17,IC50 分别为 15.8 和 20.1 nM。 | |||
T13452 |
(S)-MCPG
(+)-MCPG |
GluR | Neuroscience |
(S)-MCPG ((+)-MCPG) 是一种 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂,可阻断大鼠的空间学习和体内齿状回的长期增强,可用于研究神经系统疾病。 | |||
T68058 |
Dulozafone
F1933 |
Others | Others |
Dulozafone (F1933) 具有抗在脑杏仁核点燃模型中显示出抗惊厥活性,可保护完全点燃的大鼠免受全身性癫痫发作。 | |||
T72038 |
YM-58790
YM-58790 free base |
AChR | Neuroscience |
YM-58790 free base 是一种高效的 mAChR 拮抗剂。YM-58790 free base 对 M1 mAChR、M2 mAChR 和 M3 mAChR具有抑制作用, Ki 值分别为 28 nM ,260 nM ,和 15 nM 。YM-58790 free base 通过抑制膀胱加压来抑制大鼠的反射性节律性膀胱收缩。 | |||
TP1070L |
PACAP (1-27), human, ovine, rat acetate
PACAP 1-27 acetate,PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base) |
PACAP | GPCR/G Protein |
PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate)(127317-03-7 free base) 是一种新的神经肽,最初从牛下丘脑中分离出来,也存在于人和大鼠中。 | |||
T9379 |
L-Threonic acid magnesium salt
|
Others | Others |
L-Threonic acid magnesium salt 可增加老年大鼠和晚期阿尔茨海默病 (AD) 模型小鼠的突触密度和记忆能力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13903 |
Stearoylethanolamide
N-(2-Hydroxyethyl)octadecanamide |
Apoptosis | Apoptosis |
Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) 是一种存在于人、大鼠和小鼠大脑中的大麻素类化合物,具有促细胞凋亡活性。 | |||
T3875 |
CLINODISIDE A
|
Others | Others |
Clinodiside A 是来自中草药Clinopodium chinensis 中。 | |||
TN3651 |
Cichoriin
|
Others | Others |
Cichoriin 对SARS-CoV-2有明显活性,是治疗重症COVID-19的潜在候选物质。 | |||
T3697 |
3',6-Disinapoylsucrose
Disinapoyl sucrose,3,6'-Disinapoyl sucrose,3,6'-二芥子酰基蔗糖 |
BCL; Epigenetic Reader Domain | Apoptosis; Chromatin/Epigenetic |
3',6-Disinapoylsucrose (Disinapoyl sucrose) 是远志的指标成分,表现出显著的抗氧化活性和抗抑郁效果。 | |||
TN7217 |
4,6-Benzilidine-D-Glucose
|
Others | Others |
4,6-Benzilidine-D-Glucose 是一种临床抗肿瘤化合物,在化学诱导肝细胞癌大鼠中显示出抗肿瘤活性。 | |||
T2793 |
Tetrahydropalmatine
DL-Tetrahydropalmatine,四氢帕马丁,延胡索乙素,Rotundine |
Apoptosis; Others; Dopamine Receptor | Apoptosis; GPCR/G Protein; Neuroscience; Others |
Tetrahydropalmatine (DL-Tetrahydropalmatine) 通过抑制大鼠杏仁核的多巴胺释放来抑制癫痫发作,用于缓解疼痛的研究。 | |||
T7912 |
(−)-Myrtenal
(1R)-(-)-桃金娘烯醛,桃金娘烯醛,(1R)-(−)-Myrtenal |
Others | Others |
(−)-Myrtenal 是一种具有口服活性及抗肿瘤活性的萜烯。(-)-Myrtenal 作用于糖尿病大鼠的骨骼肌和肝脏,利用 Akt 增强 GLUT2 ,进而改善高血糖症。 | |||
T2750 |
Ginkgolide C
银杏内酯C,BN-52022 |
MMP; Sirtuin; Endogenous Metabolite; AMPK | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ginkgolide C (BN-52022) 是从银杏叶中分离到的一种黄酮类天然产物,可增强体内大鼠的心脏功能,具有减少血小板聚集,改善阿尔兹海默症等作用。 | |||
TN6764 |
Simmondsin
|
Others | Others |
Simmondsin 是一种来自Simmondsia chinensis——荷荷巴的天然产物。它减少了大鼠的食物摄入量和体重,而没有明显的负面影响。 | |||
T4S0176 |
Alnustone
(4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one,桤木酮 |
Others | Others |
Alnustone ((4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one) 是一种非酚双苯庚烷类化合物,在草药和香料中发现,是姜黄的成分之一,具有抗吐、抗炎作用。 | |||
T5S2178 |
Fargesin
辛夷脂素,(+/-)-Fargesin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Fargesin ((+/-)-Fargesin) 是一种活性新木脂素,从木兰植物中分离得到,具有抗高血压和抗炎活性。 | |||
T5781 |
taraxasteryl acetate
蒲公英甾醇醋酸酯,醋酸蒲公英酯 |
Antibacterial | Microbiology/Virology |
Taraxasteryl acetate 是分离自矢状疟原虫中,具有广谱的抗炎活性。它能够改善右旋糖酐、酵母聚糖及花生四烯酸诱导的大鼠后爪水肿。它可用于研究局部炎症。 | |||
T6S1294 |
Nicotiflorin
Nictoflorin,Kaempferol-3-O-Rutinoside,山奈酚-3-O-芸香糖苷,Nicotifloroside |
Others | Others |
Nicotiflorin (Kaempferol-3-O-Rutinoside) 是一种黄酮苷,从传统中药Flos Carthami 中提取得到。它有抗糖化活性和神经保护作用。 | |||
TN1238 |
3,4-O-Isopropylidene-shikimic acid
3,4-O-异亚丙基莽草酸,3,4-O-Isopropylidene shikimic acid |
NOS; NO Synthase | Immunology/Inflammation |
3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) 是一种从Hypericum wightianum 中提取得到的天然产物。它具有抗炎症和抗氧化作用。 | |||
TJS0928 |
Calenduloside E
去葡萄糖竹节参皂苷,Silphioside F |
Others | Others |
Calenduloside E (Silphioside F) 是从辽东楤木中提取的一种五环三萜皂苷。它靶向热休克蛋白90 (Hsp90) ,具有抗凋亡作用。 | |||
T3804 |
Neomangiferin
Mangiferin 7-glucoside,新芒果苷 |
Phosphatase | Metabolism |
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。 | |||
T0632 |
3,4,5-Trimethoxybenzoic acid
Gallic acid trimethyl ether,Eudesmic acid,3,4,5-三甲氧基苯甲酸,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid,没食子酸三甲醚 |
Antioxidant | oxidation-reduction |
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) 是一种苯甲酸衍生物,可用作医药和有机合成中的砌块。 | |||
T3753 |
Sinapinic Acid
Sinapic acid,芥子酸,Synapoic acid |
Apoptosis; RAAS; Reactive Oxygen Species; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。 | |||
T20754 |
Deltamethrin
Butoss,RU-22974,Esbecythrin,溴氰菊酯,K-Othrin,Decamethrin,RU 22974 |
Others | Others |
Deltamethrin (RU 22974) 是一种具有神经毒性的拟除虫菊酯杀虫剂,在大鼠中能够产生一系列可逆的运动症状(如包括后肢僵硬、舞蹈性关节炎)。 | |||
T7050 |
alpha-Tocopherolquinone
托可醌,Metarene |
Antioxidant | oxidation-reduction |
alpha-Tocopherolquinone (Metarene) 会下调线粒体的呼吸活动。在还原为生育酚氢醌后,它还显示出抗氧化活性。在大鼠缺氧期间,已发现它的水平升高。 | |||
T37152 |
3-Methyl-2-cyclopenten-1-one
|
Endogenous Metabolite | Metabolism |
3-Methyl-2-cyclopenten-1-one 可作为食品添加剂,在 2-5 ppm 下可改善肉类和肉制品的风味。添加3-Methyl-2-cyclopenten-1-one 在对雄性Wistar 大鼠口服给药时显示出胃细胞保护活性。 | |||
T2946 |
Tanshinone IIA sulfonate sodium
丹参酮IIA磺酸盐,丹参酮IIA-磺酸钠,Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium |
CaMK; P450; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) 是从丹参中提取的丹参酮IIA 的水溶性衍生物,是SOCE 抑制剂,用于心血管疾病的研究。 | |||
T4S2128 |
Bilobetin
白果双黄酮,白果素 |
PKA; PPAR | DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors |
Bilobetin 是银杏的活性成分,可改善胰岛素抵抗,增加肝脏对脂质的吸收和氧化,降低极低密度脂蛋白甘油三酯分泌和血液甘油三酯水平,增强组织中 β-氧化的酶的表达和活性,并减弱甘油三酯及其代谢产物的积累。它还增加了 PPARα的磷酸化,核转位和活性,并伴随着 cAMP 水平和 PKA 活性的升高。 | |||
T8769 |
Harmaline hydrochloride
Harmidine hydrochloride |
Others | Others |
Harmaline hydrochloride (Harmidine hydrochloride) 是一种荧光吲哚生物碱,来自 harmala 生物碱和 β-咔啉。它是 harmine 的部分氢化形式。 Harmaline 通过诱导下橄榄神经元的节律性放电在正常大鼠中产生全身性震颤。 | |||
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
T2795 |
Amygdalin
苦杏仁苷,Laetrile |
Others | Others |
Amygdalin (Laetrile) 是一种植物葡萄糖苷,分离自蔷薇果实的果核中,如杏,桃,杏仁,樱桃和李子。 | |||
T2768 |
Saikosaponin A
柴胡皂苷A,柴胡皂苷 A |
NF-κB; Antibacterial; Liver X Receptor | Metabolism; Microbiology/Virology; NF-κB |
Saikosaponin A 是银柴胡中的主要活性成分,有抗炎活性,可上调 LXRα的表达。 | |||
T4010 |
Juglone
5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin |
DNA/RNA Synthesis; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料,有抗菌作用。 | |||
T5S1889 |
Yunaconitine
Guayewuanine B,滇乌头碱 |
Others | Others |
Yunaconitine (Guayewuanine B) 是一种乌头类生物碱,具有剧毒。 | |||
T3676 |
Sesamol
1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分,具有抗氧化和抗肿瘤活性。它是一种自由基清除剂,在 DPPH 实验中,IC50为 5.95±0.56 μg/mL。 | |||
T3388 |
Calycosin-7-O-β-D-glucoside
毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside |
MMP; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome |
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮,从黄芪中分离得到。它具有多种生物活性,包括心脏保护、神经保护、抗炎和抗氧化作用。 | |||
T40615 |
N,N'-Dimethylthiourea
N,N-二甲基硫脲,DMTU |
Antioxidant | oxidation-reduction |
N,N'-Dimethylthiourea (DMTU) 是一种分离自黑蒜的化合物。N,N'-Dimethylthiourea 具有口服活性的羟基自由基 (•OH) 的清除剂,通过活化的中性粒细胞在体外阻止 •OH 的产生。N,N'-Dimethylthiourea 通过发挥 •OH 清除和抗炎作用,防止水浸限制应激诱导的大鼠胃粘膜损伤。 | |||
T6S0653 |
Linarin
Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷 |
TNF; AChE | Apoptosis; Neuroscience |
Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂,从薄荷花提取物中分离得到。 | |||
T3849 |
Kinsenoside
金线莲苷,(+)-Kinsenoside |
Apoptosis; Nrf2 | Apoptosis; Immunology/Inflammation |
Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分,以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力,防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。 | |||
TCS0102 |
Pulegone
胡薄荷酮,(+)-Pulegone,蒲勒酮,胡薄荷酮,长叶薄荷酮 |
Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分,也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道,并在高浓度下抑制前者但不抑制后者。 | |||
T3976 |
Cytosporone B
Csn-B,Dothiorelone G |
Others | Others |
Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。 | |||
T3S1553 |
trans-Cinnamaldehyde
Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein |
COX; Endogenous Metabolite | Immunology/Inflammation; Metabolism; Neuroscience |
trans-Cinnamaldehyde (Phenylacrolein) 是一种能够用于合成反式肉桂醛-β-环糊精复合物,一种能够食用的抗菌涂层,能够延长鲜切水果的保质期。它是一种能够通过烷基异氰化物与乙炔二羧酸二烷基酯的反应来合成高度多官能的呋喃环。 | |||
T4S21320 |
ISOGINKGETIN
异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮 |
MMP; Others | Others; Proteases/Proteasome |
ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂,也是一种Pre-mRNA Splicing 抑制剂。 | |||
T4S1962 |
beta-Asarone
β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin |
NF-κB; JNK | MAPK; NF-κB |
beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分,具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障,能够预防帕金森病。 | |||
TJS1779 |
Protosappanin A
原苏木素A,PTA |
NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells |
Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物,通过下调 JAK2和 STAT3的磷酸化,抑制 JAK2/STAT3依赖的炎症通路。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
T6S1699 |
Shogaol
[6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol |
Lipoxygenase; Autophagy | Autophagy; Metabolism |
6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物,具有抗癌、抗炎和抗氧化的多种生物活性。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
T3123 |
Allicin
|
ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection | Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome |
Allicin 具有抗氧化、杀菌、抗癌、抗炎活性,对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移,这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压,它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。 | |||
TN1853 |
Lariciresinol
(+)-落叶松树脂醇 |
VEGFR; Antifection | Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Lariciresinol 是一种肠木脂素前体,它通过破坏真菌质膜具有杀真菌活性,并具有作为治疗人类真菌感染性疾病的新型抗真菌剂的治疗潜力。膳食 lariciresinol 可以减缓乳腺肿瘤的生长并降低人 MCF-7 乳腺癌异种移植物和致癌物诱导的大鼠乳腺肿瘤的血管密度。 | |||
T36585 |
Isodeoxycholic Acid
isoDCA |
Chloride channel; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology |
Isodeoxycholic Acid 是一种胆汁酸,由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚,这表明它的去污活性降低了,而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid(0.1%)能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发,并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中,血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。 | |||
T3826 |
Polygalasaponin F
异牡荆苷,瓜子金皂苷己 |
NF-κB; TLR; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 属于生物碱类天然产物,可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。 | |||
T3S2259 |
Methyl eugenol
4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01100 |
GPT2 Protein, Rat, Recombinant (His)
glutamic pyruvate transaminase (alanine aminotransferase) 2 |
Rat | Baculovirus Insect Cells |
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. As a key enzyme for gluconeogenesis, Gpt is a widely-used serum marker for liver injury. Two ALT isoenzymes have been identified, ALT1 and ALT2 (GPT1 and GPT2), which are encoded by separate genes and share ... | |||
TMPY-02843 |
GPX7 Protein, Human, Recombinant (hFc)
GSHPx-7,UNQ469/PRO828,NPGPx,CL683,glutathione peroxidase 7,G... |
Human | HEK293 Cells |
GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to differ by overlapping exons with different boundaries. GPX7 is an enzyme. It has molecular functions (glutathione peroxidase activity, oxidoreductase activity) and to localize in various compartments (extracellular space, extracellular region). GPX7 gene has been proposed to part... | |||
TMPH-00227 |
Beta-casein Protein, Bovine, Recombinant (His & Myc)
CSN2,Beta-casein |
Bovine | E. coli |
Important role in determination of the surface properties of the casein micelles.; Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.; Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.; Antioxidant peptide has antioxidant activity. Beta-casein Protein, Bovine, Recomb... | |||
TMPY-02433 |
APE1/APEX1 Protein, Human, Recombinant (His)
APEX,HAP1,APX,APE,APEX nuclease (multifunctional DNA repair ... |
Human | E. coli |
The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the... | |||
TMPY-03963 |
CALCB Protein, Human, Recombinant (mFc)
CGRP-II,calcitonin-related polypeptide β,calcitonin-related ... |
Human | HEK293 Cells |
CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ... | |||
TMPY-02579 |
NRN1 Protein, Human, Recombinant (His)
NRN,dJ380B8.2,MGC44811,neuritin 1 |
Human | Baculovirus Insect Cells |
Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF), and NT-3. Purified rec... | |||
TMPY-01771 |
Latexin Protein, Mouse, Recombinant (His)
latexin |
Mouse | E. coli |
Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI, and LXN, is a cytoplasm protein that belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in the heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional spe... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11152 |
Edaravone-d5
MCI-186 D5 |
Others | Others |
Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits. | |||
T71065 |
Quinapril-d5
|
||
Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con... | |||
T36537 |
Nitrofurantoin-13C3
Nitrofurantoin-13C3 |
||
Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1In vivo, nitrofurantoin (25-100 mg/kg) reducesE. colireplication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates ofP. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as ca... | |||
T35521 |
Aflatoxin G2-13C17
Aflatoxin G2-13C17 |
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Aflatoxin G2-13C17is intended for use as an internal standard for the quantification of aflatoxin G2by GC- or LC-MS. Aflatoxin G2is a mycotoxin that has been found inAspergillus.1It is lethal to ducklings (LD50= 2.83 mg/kg) but is non-toxic to rats when administered at a dose of 200 mg/kg.2 1.Bennett, J.W., and Klich, M.MycotoxinsClin. Microbiol. Rev.16(3)497-516(2003) 2.Wogan, G.N., Edwards, G.S., and Newberne, P.M.Structure-activity relationships in toxicity and carcinogenicity of aflatoxins a... | |||
T35591 |
Guanfacine-13C,15N3
Guanfacine-13C,15N3 |
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Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin... | |||
TMIJ-0466 |
Acephate-d3 (acetyl-d3)
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Acephate-d3 (acetyl-d3) 是 Acephate 的氘代化合物。Acephate 的 CAS 号为 30560-19-1。Acephate 是能产生胆碱毒性的抗胆碱酯酶杀虫剂。它能够有效抑制蟑螂的AChE,但对大鼠 AChE 的抑制作用较弱。 | |||
T71286 |
Guaifenesin-d3
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Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner. Guaifenesin increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing ... | |||
T71145 |
Racecadotril-d5
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Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-indu... | |||
T71205 |
Fosinopril-d7 sodium salt
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Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti... | |||
T35519 |
Aflatoxin B2-13C17
Aflatoxin B2-13C17 |
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Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen... | |||
T37608 |
Riluzole-13C,15N2
Riluzole-13C,15N2 |
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Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a... | |||
T70990 |
ADMA-d6
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NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da... | |||
T70174 |
Pirlindole-d4 HCl
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Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru... | |||
T71305 |
Clofibric Acid-d4
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Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxal... | |||
T70883 |
Moexipril-d5
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Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ... | |||
T35520 |
Aflatoxin G1-13C17
Aflatoxin G1-13C17 |
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Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase... | |||
TMID-0041 |
Menaquinone-9-d7
Vitamin K2-MK9-d7 |
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Menaquinone-9-d7 是 Menaquinone-9 的氘代化合物。Menaquinone-9 的 CAS 号为 523-39-7。Menaquinone 9 (MK-9) 是一种维生素 K2 类似物,已在包括大肠杆菌在内的各种细菌中发现。Menaquinone 9 对紫外线敏感,可与细菌电子传输链的一种成分可溶性硝酸还原酶结合。 | |||
T71327 |
Paraxanthine-d6
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Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni... | |||
T69598 |
Isoproterenol-d7 HCl
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Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom... | |||
T70186 |
Methazolamide-d6
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Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re... | |||
T71212 |
Lornoxicam-d4
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Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e... | |||
T69600 |
Spermidine-d6
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Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki... | |||
TMIJ-0342 |
Aniline-d5
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Aniline-d5 是 Aniline 的氘代化合物。Aniline 的 CAS 号为 62-53-3。Aniline 通过铁过载和通过血红素加氧酶 1 上调诱导氧化应激对脾脏产生毒性。它会导致 p-IKKα 和 p-IKKβ 显着增加,进而增加 NF-κB 和 AP-1 结合活性。 | |||
T69966 |
Roxadustat-d5
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Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ... | |||
T71142 |
Tebuconazole-d9
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Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per... | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
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Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... | |||
T36055 |
Nitisinone-13C6
Nitisinone-13C6 |
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Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F... |