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顶部生物活性化学信息储存和溶解信息计算器

Biperiden Hydrochloride

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产品编号 T14614Cas号 1235-82-1
别名 盐酸比哌立登, KL 373 (Hydrochloride)

Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker and it is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Target: M1 receptors Biperiden is an antiparkinsonian agent of the anticholinergic type. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate and it also has a prominent central blocking effect on M1 receptors[2]. Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty. Whereas biperiden and procyclidine did not [3]. Clinical indications: parkinsonism FDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness

Biperiden Hydrochloride
其他形式的 “Biperiden Hydrochloride”:

Biperiden Hydrochloride

Rating icon 还可以
产品编号 T14614 别名 盐酸比哌立登, KL 373 (Hydrochloride)Cas号 1235-82-1

Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker and it is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Target: M1 receptors Biperiden is an antiparkinsonian agent of the anticholinergic type. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate and it also has a prominent central blocking effect on M1 receptors[2]. Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty. Whereas biperiden and procyclidine did not [3]. Clinical indications: parkinsonism FDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness

规格价格库存数量
10 mg¥ 2,69035日内发货
50 mg¥ 11,50035日内发货
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产品介绍

生物活性
产品描述
Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker and it is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Target: M1 receptors Biperiden is an antiparkinsonian agent of the anticholinergic type. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate and it also has a prominent central blocking effect on M1 receptors[2]. Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty. Whereas biperiden and procyclidine did not [3]. Clinical indications: parkinsonism FDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness
别名盐酸比哌立登, KL 373 (Hydrochloride)
化学信息
分子量347.92
分子式C21H30ClNO
CAS No.1235-82-1
密度1.31g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
H2O: 5 mg/mL (14.37 mM), Sonication is recommended.
溶液配制表
H2O
1mg5mg10mg50mg
1 mM2.8742 mL14.3711 mL28.7422 mL143.7112 mL
5 mM0.5748 mL2.8742 mL5.7484 mL28.7422 mL
10 mM0.2874 mL1.4371 mL2.8742 mL14.3711 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments 一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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关键词

KL 373KL-373Biperiden HydrochlorideKL373

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