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Wasabi Receptor Toxin TFA (WaTx TFA)为Wasabi Receptor Toxin的TFA盐形态,属于细胞穿透性蝎毒素.该化合物能激活TRPA1离子通道 (TRPA1 ion channel),具有纳摩尔级的EC50,可增加通道的开放时间,同时降低Ca2+的通透性.此外,Wasabi Receptor Toxin TFA在大鼠体内可诱发热超敏反应和机械性异常疼痛,但不会导致神经源性炎症.
Wasabi Receptor Toxin TFA (WaTx TFA)为Wasabi Receptor Toxin的TFA盐形态,属于细胞穿透性蝎毒素.该化合物能激活TRPA1离子通道 (TRPA1 ion channel),具有纳摩尔级的EC50,可增加通道的开放时间,同时降低Ca2+的通透性.此外,Wasabi Receptor Toxin TFA在大鼠体内可诱发热超敏反应和机械性异常疼痛,但不会导致神经源性炎症.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin. This compound functions as a cell-permeable scorpion toxin and serves as an activator of the TRPA1 ion channel (TRPA1 ion channel), exhibiting its potency with an EC50 at the nanomolar level. It effectively prolongs the channel opening time while reducing Ca2+ permeability. Additionally, WaTx TFA induces thermal hyperalgesia and mechanical allodynia in rats without causing neurogenic inflammation. |
别名 | WaTx TFA |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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