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TMPH-02875
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ROMO1 Protein, Mouse, Recombinant (His)
Protein MGR2 homolog,Romo1,Reactive oxygen species modul...
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Mouse
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E. coli
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Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. |
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TMPY-03991
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DBI Protein, Human, Recombinant (His)
diazepam binding inhibitor (GABA receptor modulator...
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Human
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E. coli
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The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine receptor and facilitates transport of cholesterol to the inner membrane to stimulate steroid synthesis. Through this action, DBI indirectly modulates gamma-aminobutyric acid (GABA)-mediated inhibitory neurotransmission. DBI can be postulated as a candidate gene for psychiatric phenot... |
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TMPH-03177
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RhlR Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO)
Elastase modulator,rhlR,Regulatory protein RhlR,HTH...
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Pseudomonas aeruginosa
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E. coli
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Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone). RhlR Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.6 kDa and the accession n... |
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TMPH-03367
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SOSTDC1 Protein, Rat, Recombinant (His & Myc)
Sostdc1,Sclerostin domain-containing protein 1,Wnt-signaling...
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Rat
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HEK293 Cells
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Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. SOSTDC1 Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 24.6 kDa and the accession number is Q642G2. |
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TMPH-02053
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RBM14 Protein, Human, Recombinant (His & SUMO)
RNA-binding protein 14,RRM-containing coactivator activator/...
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Human
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E. coli
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RBM14 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
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TMPY-04544
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MEK2 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase kinase 2,FLJ26075,MKK2,CFC4...
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Human
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Baculovirus Insect Cells
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Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ... |
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TMPH-01953
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SSX1 Protein, Human, Recombinant (His & SUMO)
SSX1,Synovial sarcoma, X breakpoint 1,Cancer/testis antigen ...
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Human
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E. coli
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Could act as a modulator of transcription. SSX1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.9 kDa and the accession number is Q16384. |
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TMPH-01954
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SSX2 Protein, Human, Recombinant (His & SUMO)
SSX2,Protein SSX2,SSX2B,Synovial sarcoma, X breakpoint 2,Can...
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Human
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E. coli
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Could act as a modulator of transcription. SSX2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.6 kDa and the accession number is Q16385. |
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TMPH-02694
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GNG12 Protein, Mouse, Recombinant (His & Myc)
Gng12,Guanine nucleotide-binding protein G(I)/G(S)/G(O) subu...
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Mouse
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E. coli
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Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
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TMPK-00070
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BAFFR/TNFRSF13C Protein, Human, Recombinant (His & Avi), Biotinylated
CD268,TNFRSF13C,BAFFR,BR3,BROMIX,prolixin,CVID4
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Human
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HEK293 Cells
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BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF. |
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TMPK-01254
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BAFFR/TNFRSF13C Protein, Cynomolgus, Recombinant (His)
CVID4,prolixin,TNFRSF13C,CD268,BROMIX,BAFFR,BR3
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Cynomolgus
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HEK293 Cells
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BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA / TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF. |
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TMPH-03204
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GHR Protein, Rabbit, Recombinant (His & Myc)
GHR,Somatotropin receptor,Growth hormone receptor
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Rabbit
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E. coli
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Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. GHR Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.6 kDa and the accession number is P19941. |
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TMPH-03112
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GHR Protein, Pig, Recombinant (His)
Growth hormone receptor,GHR,Somatotropin receptor
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Sus scrofa (Pig)
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E. coli
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Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. GHR Protein, Pig, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 30.3 kDa and the accession number is P19756. |
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TMPH-02440
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GHR Protein, Rhesus macaque, Recombinant (His)
GHR,Somatotropin receptor,Growth hormone receptor
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Rhesus
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E. coli
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Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. GHR Protein, Rhesus macaque, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 30.2 kDa and the accession number is P79194. |
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TMPH-02032
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GPRC5A Protein, Human, Recombinant (GST)
G-protein coupled receptor family C group 5 member A,GPRC5A,...
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Human
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E. coli
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Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. GPRC5A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 37.0 kDa and the accession number i... |
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TMPK-00500
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CD83 Protein, Cynomolgus, Recombinant (His)
CD83,HB15,CD83 molecule,BL11
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Cynomolgus
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HEK293 Cells
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CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). While CD83 is emerging as a promising immune modulator with therapeutic potential, some important aspects such as its ligand/s, intracellular signaling pathways and modulators of its expression are unclear. |
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TMPK-01030
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LRRN1 Protein, Mouse, Recombinant (His)
Neuronal leucine-rich repeat protein 1,LRN,NLRR1,NLRR-1,FIGL...
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Mouse
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HEK293 Cells
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Lrrn1 is required for the formation of MHB--loss of function leads to a loss of the morphological constriction and loss of Fgf8. Cells overexpressing Lrrn1 violate the boundary and result in a loss of cell restriction between midbrain and hindbrain compartments. Lrrn1 also regulates the glycosyltransferase Lunatic Fringe, a modulator of Notch signalling, maintaining its expression in midbrain cells which is instrumental in MHB boundary formation. |
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TMPJ-01336
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SENP2 Protein, Human, Recombinant
Sentrin/SUMO-specific protease SENP2,Axam2,SMT3-specific iso...
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Human
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E. coli
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SENP2 is an enzyme that belongs to the peptidase C48 family. SENP2 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SUMO1 is a small ubiquitin-like protein that can be covalently conjugated to other proteins. It has been implicated as a down-regulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. |
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TMPJ-00297
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SHPK Protein, Human, Recombinant (His)
Carbohydrate kinase-like protein,SHPK,CARKL,Sedoheptulokinas...
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Human
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HEK293 Cells
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Sedoheptulokinase (SHPK) belongs to the FGGY kinase family, and is mainly located in cytoplasm. SHPK is strongly expressed in liver, kidney and pancreas. It is expressed at lower levels in placenta and heart, and very weakly expressed in lung and brain. SHPK catalyzes the chemical reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphatecan, It can transform sedoheptulose to sedoheptulose 7-phosphate in the condition of ATP, and acts as a modulator of macrophage activation through control ... |
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TMPJ-01129
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SMAD1 Protein, Human, Recombinant (GST)
hSMAD1,Transforming Growth Factor-Beta-Signaling Protein 1,T...
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Human
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E. coli
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SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated ... |
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TMPH-01699
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SMAD2 Protein, Human, Recombinant (His & SUMO)
JV18-1,SMAD2,SMAD family member 2,Mothers against decapentap...
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Human
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E. coli
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Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3... |
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TMPY-02394
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IMPA1 Protein, Human, Recombinant (His)
IMPA,inositol(myo)-1(or 4)-monophosphatase 1,IMP
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Human
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E. coli
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IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene. This gene encodes an enzyme that dephosphorylates Myo-inositol monophosphate to generate free Myo-inositol, a precursor of phosphatidylinositol, and is, therefore, an important modulator of intracellular signal transduction via the production of the second messenger's myoinositol 1,4,5-trisphosphate and diacylglycerol. Despite its many physiological functions, no clinical phenotype has been assigned to this gene dysfunction to date. Ad... |
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TMPY-01451
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MESDC2 Protein, Human, Recombinant (His)
MESD,mesoderm development candidate 2,BOCA
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Human
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HEK293 Cells
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MESD (Mesoderm Development LRP Chaperone) is a Protein Coding gene. LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61, and MESDC2, is a member of the MESD family. It is widely expressed in the thyroid, placenta, and other tissues. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity reside... |
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TMPJ-01322
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TWSG1 Protein, Human, Recombinant (His)
TSG,Twisted Gastrulation Protein Homolog 1,TWSG1
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Human
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HEK293 Cells
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Twisted Gastrulation Protein Homolog 1 (TWSG1) is a 22 kDa secreted protein that belongs to the twisted gastrulation protein family. Human TWSG1 is synthesized as a 223 aa precursor that contains a 25 aa signal peptide and a 198 aa mature chain. TWSG1 may be involved in dorsoventral axis formation. TWSG1 seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors.TWSG1 can inhibit BMP activity by binding directly to B... |
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TMPY-02805
|
GNGT1 Protein, Human, Recombinant (His)
guanine nucleotide binding protein (G protein), γ transducin...
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Human
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E. coli
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GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the ... |
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TMPJ-00271
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SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD 3,Mothers against DPP homolog 3,hMAD-3,MADH3,JV15-2,SMA...
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Human
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E. coli
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Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated... |
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TMPY-02602
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PTPMT1 Protein, Human, Recombinant (His)
protein tyrosine phosphatase, mitochondrial 1,MOSP,FLJ46081,...
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Human
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E. coli
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PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an a... |
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TMPH-02638
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HSPA5 Protein, Mouse, Recombinant (E. coli, His)
Hspa5,Heat shock protein 70 family protein 5,Endoplasmic ret...
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Mouse
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E. coli
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Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ER... |
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TMPY-04388
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BLK Protein, Human, Recombinant (GST)
MODY11,BLK proto-oncogene, Src family tyrosine kinase
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Human
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Baculovirus Insect Cells
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Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and... |
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TMPY-02802
|
GNG13 Protein, Human, Recombinant (His)
G(gamma)13,h2-35,G(γ)13,guanine nucleotide binding protein (...
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Human
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E. coli
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GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. Each G protein is composed of an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding... |
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TMPJ-00067
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BAFFR/TNFRSF13C Protein, Human, Recombinant (His)
BR3,BAFFR,CD268,TNFRSF13C,BAFF R
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Human
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HEK293 Cells
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Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF... |
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TMPY-04562
|
GRK2 Protein, Human, Recombinant (His & GST)
β,adrenergic, beta, receptor kinase 1
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Human
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Baculovirus Insect Cells
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G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor... |
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