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VU6000918
还可以产品编号 T39543Cas号 2101737-32-8
VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.
VU6000918
还可以产品编号 T39543Cas号 2101737-32-8
VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 1,380 | 5日内发货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,480 | 5日内发货 |
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| 产品描述 | VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor. |
| 靶点活性 | M4 (human):19 nM (EC50) |
| 体外活性 | VU6000918 demonstrates statistically significant AHL reversal (18%) from a low oral dose of 0.03 mg/kg and reaches maximal reversal (74%) from a 3 mg/kg dose, with a resulting in vivo plasma EC 50 of 74 nM (0.66 nM unbound) based on terminal concentrations measured in the study animals (1.5 hr post-administration of 17j)[1]. |
| 分子量 | 389.42 |
| 分子式 | C18H17F2N5OS |
| CAS No. | 2101737-32-8 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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