24(S)-hydroxy Cholesterol

Name: 24(S)-hydroxy Cholesterol
Brand: TargetMol
SKU: T21562
Rating: 4.5 (1 reviews)

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产品编号 T21562Cas号 474-73-7

别名 Cerebrosterol, 24S-OHC, 24S-HC, 24(S)-羟基胆固醇

24(S)-hydroxy Cholesterol (24S-OHC) 是神经组织中胆固醇消除途径的过表达终末产物，是 LXR 激动剂和选择性 NMDARs 阳性变构调节剂，可作为作为 NPD 生物标志物，诱导小鼠认知能力下降，可用于研究神经系统疾病。

还可以

产品编号 T21562 别名 Cerebrosterol, 24S-OHC, 24S-HC, 24(S)-羟基胆固醇Cas号 474-73-7

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产品介绍

生物活性

产品描述	24(S)-hydroxy Cholesterol (24S-OHC) is the terminal product of the cholesterol elimination pathway in neural tissues. It is an LXR agonist and a selective positive allosteric modulator of NMDARs. It can serve as a biomarker for NPD, induce cognitive decline in mice, and is useful for studying neurological diseases.
体外活性	24(S)-hydroxy Cholesterol (1, 10, 30 μM) 能够有效保护离体大鼠视网膜，防止静水压力升高所导致的损伤。[1]
别名	Cerebrosterol, 24S-OHC, 24S-HC, 24(S)-羟基胆固醇

化学信息

分子量	402.65
分子式	C₂₇H₄₆O₂
CAS No.	474-73-7
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CC[C@@H](C(C)C)O)C)[H])[H]
密度	1.03g/cm3

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

Ethanol: 16.00 mg/mL (39.74 mM), Sonication is recommended.

DMSO: 10.00 mg/mL (24.84 mM), Sonication is recommended.

溶液配制表

DMSO/Ethanol