methyltetrazine-peg-4-ss-peg4-methyltetrazine

Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit polyethylene glycol (PEG) linker, employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。

Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

N-Boc-4-pentyne-1-amine 是一种基于烷基链的PROTAC连结剂，用于PROTAC MG-277[1]的合成。

DSPE-PEG-OH (MW 2000) 是一种基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。

m-PEG7-4-nitrophenyl carbonate 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。

BSJ-4-116 是一种高效的选择性 CDK12 降解剂，IC50 为 6 nM，是由 Cereblon 配体和 CDK 配体相连的 PROTAC。它通过提前终止转录来下调 DDR 基因，主要是通过增加聚腺苷酸化，具有抗增殖作用。

N-Boc-cis-4-hydroxy-L-proline methyl ester为不可降解(non-cleavable)的ADC linker，用于抗体药物偶联体(ADCs)合成。该化合物同时作为基于烷基链(alkyl chain)的PROTAC linker，适用于PROTAC合成。

Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker，是合成的 E3 连接酶配体-linker 偶联物，可应用于 PROTAC 技术。

Amine-PEG-CH2COOH (MW 2000) 是一种基于 PEG 的 PROTAC 接头，可用于合成 PROTAC。

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。它可用于 PROTAC 的合成分子。

Pomalidomide 4'-PEG2-azide 是由E3 连接酶配体和linker 组成的偶联物，包括基于 Pomalidomide 的 cereblon 配体和linker。

Methyltetrazine-SS-PEG4-Biotin is a cleavable four-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Methyltetrazine-PEG4-SS-NHS ester is a cleavable, four-unit polyethylene glycol (PEG) linker commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1].

1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- 在生命科学相关研究中具有广泛的应用。

Lenalidomide-4-aminomethyl is a CRBN ligand derived from Lenalidomide, which is utilized for the recruitment of CRBN protein. By linking Lenalidomide-4-aminomethyl to the ligand, a PROTAC can be formed.

PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9, thereby modulating transcriptional activity.

PROTACAR Degrader-4 包含IAP 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于cIAP1的降解剂也被称为SNIPER。

Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).

cis-4-Hydroxy-D-proline hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66933，CAS号为 77449-94-6。

D-Proline, 4-hydroxy-, methyl ester hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65606，CAS号为 114676-59-4。

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Thiol-PEG-CH2COOH (MW 5000) is a Polyethylene glycol (PEG) derived link molecule, commonly utilized in the construction of PROTACs, which are bifunctional compounds designed for targeted protein degradation [1].

Amine-PEG-amine (MW 35000), a PEG-based PROTAC linker, is utilized for the synthesis of PROTACs[1].

Methyltetrazine-acid is an alkyl chain-derived linker employed for PROTAC synthesis[1].

Mal-PEG-mal (MW 3400) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG-triethoxysilane (MW 2000) is a polyethylene glycol (PEG) based linker compound, specifically designed for the purpose of synthesizing proteolysis-targeting chimeras (PROTACs)[1].

m-PEG-triethoxysilane (MW 1000) is a polyethylene glycol (PEG) derivative functionalized with triethoxysilane. It acts as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs), a class of compounds used for targeted protein degradation[1].

Biotin-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

m-PEG-Lys-NHS ester (MW 20000) is an alkyl ether-based PROTAC linker commonly employed in PROTAC synthesis[1].

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker suitable for synthesizing PROTACs[1].

Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) derived linker compound, specifically designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].

Aminooxy-PEG-OH (MW 2000) serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Amine-PEG-CH2COOH (MW 3400) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

m-PEG-acrylate (MW 2000) is a polyethylene glycol (PEG) derivative linker, which serves as a crucial component in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

PC Methyltetrazine-PEG4-NHS carbonate ester is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Azide-PEG-azide (MW 20000) is a polyethylene glycol (PEG)-based linker compound utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

m-PEG-NHS ester (MW 5000) serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Biotin-PEG4-methyltetrazine is a PEG-derived linker utilized for synthesizing PROTACs[1], a type of molecule employed in targeted protein degradation.

m-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker, suitable for synthesizing PROTACs[1].

Amine-PEG-amine (MW 3400) is a polyethylene glycol (PEG) -based linker used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

PROTAC ER Degrader-4 is a PROTAC degrader of the estrogen receptor (ER) with an IC50 of 0.8 nM.

m-PEG-NH2 (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Methyltetrazine-PEG24-NH-Boc is a PEG-derived linker for PROTAC synthesis[1].

Acrylate-PEG-OH (MW 5000) is a Polyethylene Glycol (PEG)-based linker compound primarily utilized in PROTAC synthesis[1].