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AP-III-a4 hydrochloride (1177827-73-4 free base)
产品编号 T6759L
别名 ENOblock hydrochloride, AP-III-a4 hydrochloride
AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. IC50 value: 0.576 uM [1] Target: enolase Enolase is a component of the glycolysis pathway and a "moonlighting" protein, with important roles in diverse cellular processes that are not related to its function in glycolysis. However, small molecule tools to probe enolase function have been restricted to crystallography or enzymology. ENOblock is the first reported enolase inhibitor that is suitable for biological assays. This new chemical tool may also be suitable for further study as a cancer and diabetes drug candidate.
AP-III-a4 hydrochloride (1177827-73-4 free base)
产品编号 T6759L 别名 ENOblock hydrochloride, AP-III-a4 hydrochloride
AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. IC50 value: 0.576 uM [1] Target: enolase Enolase is a component of the glycolysis pathway and a "moonlighting" protein, with important roles in diverse cellular processes that are not related to its function in glycolysis. However, small molecule tools to probe enolase function have been restricted to crystallography or enzymology. ENOblock is the first reported enolase inhibitor that is suitable for biological assays. This new chemical tool may also be suitable for further study as a cancer and diabetes drug candidate.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 970 | 5日内发货 | |
| 5 mg | ¥ 1,820 | 5日内发货 | |
| 10 mg | ¥ 2,925 | 5日内发货 | |
| 25 mg | ¥ 5,985 | 5日内发货 | |
| 50 mg | ¥ 8,450 | 5日内发货 | |
| 100 mg | 询价 | 5日内发货 | |
| 200 mg | 询价 | 5日内发货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 2,515 | 5日内发货 |
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| 产品描述 | AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. IC50 value: 0.576 uM [1] Target: enolase Enolase is a component of the glycolysis pathway and a "moonlighting" protein, with important roles in diverse cellular processes that are not related to its function in glycolysis. However, small molecule tools to probe enolase function have been restricted to crystallography or enzymology. ENOblock is the first reported enolase inhibitor that is suitable for biological assays. This new chemical tool may also be suitable for further study as a cancer and diabetes drug candidate. |
| 别名 | ENOblock hydrochloride, AP-III-a4 hydrochloride |
| 分子量 | 631.18 |
| 分子式 | C31H44ClFN8O3 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 53 mg/mL (83.97 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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