Prolyl-4-hydroxylase Inhibitor 11, a novel proline 4-hydroxylase inhibitor, shows protective effects against oxidative stress and Cu(II) toxicity in Chlorella vulgaris.

Prolyl hydroxylase:0.19 microM

In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). In vitro tests indicated that peroxidase-like complexes could be formed between Bpy-COOH and Cu(II). It could be concluded that the use of Bpy-COOH could significantly decrease Cu(II) toxicity to algal cells by forming peroxidase-like complexes.[1]
Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase. [2,2'-bipyridine]-5,5'-dicarboxylic acid (IC50 = 0.19 microM) is the most potent inhibitor of its type yet reported.[2]

In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). The in vivo experiments showed that the production of reactive oxygen species in C. pyrenoidosa treated by the addition of Bpy-COOH and Cu(II) in three orders were all significantly less than that in cases treated with only Cu(II).[1]