438
82
6
177
15
Cat. No. | Product Name | ||
---|---|---|---|
L5400 | 抗心血管疾病化合物库 | 1408 compounds | |
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; | |||
L1120 | AMPK靶向分子库 | 80 compounds | |
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选; | |||
L7500 | 凝血与抗凝化合物库 | 144 compounds | |
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2193 | 抗肝癌化合物库 | 1787 compounds | |
1787 种与肝癌相关的化合物,可以用于抗肝癌药物研发和药理研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12598 |
Pz-1
|
VEGFR; c-RET | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Pz-1 是 VEGFR2 和 RET 酪氨酸激酶的抑制剂,可阻断 RET 刺激生长所需的血液供应。 | |||
T9724 |
VEGFR2-IN-2
|
Others | Others |
VEGFR2-IN-2 具有抗炎和镇痛活性。 | |||
T2446 |
KI8751
|
EGFR; VEGFR; FGFR; PDGFR; c-Kit | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Ki8751 是一种有效的 VEGFR2 抑制剂,其 IC50=0.9 nM。 | |||
TQ0321 |
BIBF 1202
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
BIBF 1202是 BIBF 1120的羧酸盐代谢物。BIBF 1202抑制 VEGFR2激酶的 IC50值为62 nM。 | |||
T14349 |
Auristatin F
|
Microtubule Associated; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling |
Auristatin F 是一种有效的微管抑制剂和血管损伤剂。 Auristatin F 可用于抗体-药物偶联物。 | |||
T9979 |
VEGFR-2-IN-29
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-29是一种 VEGFR2抑制剂。 | |||
T9929 |
Ramucirumab
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Ramucirumab 是一种人 VEGFR-2 拮抗剂,具有抗实体瘤活性。它是人源化单克隆抗体,能够与 VEGFR-2 结合,阻碍 VEGFR 配体 VEGF-A,VEGF-C 和 VEGF-D 结合。 | |||
T2419 |
BMS-794833
|
VEGFR; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
BMS794833 是一种 VEGFR2 和 Met 的抑制剂,它们的 IC50值分别为 15 和 1.7 nM。 | |||
T8844 |
Diflapolin
|
Others; FLAP; Epoxide Hydrolase | Immunology/Inflammation; Metabolism; Others |
Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂,具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性,IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成,IC50分别为 30 和 170 nM。 | |||
TQ0041 |
Ningetinib Tosylate
|
VEGFR; c-Met/HGFR; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
Ningetinib Tosylate 是口服具有活力的、小分子酪氨酸激酶抑制剂,能够抑制 c-Met (IC50:6.7 nM),VEGFR2 (IC50:1.9 nM) 和 Axl (IC50<1.0 nM)。 | |||
T2456 |
Tivozanib
替沃扎尼,AV-951,KRN951 |
VEGFR; PDGFR; Ephrin Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂,它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。 | |||
T11520 |
GW806742X
|
MLK; VEGFR | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
GW806742X 是ATP 模拟物,是MLKL 抑制剂,可结合 MLKL 假激酶结构域,Kd 值为 9.3μM。它对VEGFR2的IC50为 2 nM,延缓 MLKL 膜移位并抑制坏死。 | |||
T6012 |
SAR131675
SAR 131675 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SAR131675 是一种选择性的VEGFR3抑制剂,其IC50=23 nM。 | |||
T4288 |
hVEGF-IN-1
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
hVEGF-IN-1 是一种喹唑啉衍生物,可以特异性结合内部核糖体进入位点 A 中富含 G 的序列,并会使 G-四链体结构不稳定。在 SPR 实验中,它与 IRES-A (WT) 结合的Kd 值为 0.928 μM。它能够抑制VEGF-A 蛋白表达,阻止肿瘤细胞迁移,抑制肿瘤生长。 | |||
T3638 |
Leukadherin-1
|
Integrin; Complement System | Cytoskeletal Signaling; Immunology/Inflammation |
Leukadherin-1 是 CD11b/CD18 的变构激活剂,可增加 CD11b/CD18 依赖性细胞对纤维蛋白原的粘附,减少白细胞运动和跨内皮迁移,具有抗炎作用。 | |||
T2642 |
PD173074
|
Apoptosis; EGFR; VEGFR; FGFR; IGF-1R; Src | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PD173074 是一种 FGFR1抑制剂,IC50为 25 nM。它也可抑制 VEGFR2活性,IC50值为 100-200 nM。 | |||
T0446 |
Naphazoline hydrochloride
盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物,是一种眼血管收缩剂。 | |||
T16975 |
TAK-593
|
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
TAK-593 是一种 VEGFR2 和 PDGFR 抑制剂,能够作用于VEGFR1 (IC50:3.2 nM)、VEGFR2 (IC50:0.95 nM)、VEGFR3 (IC50:1.1 nM)、PDFGRα (IC50:4.3 nM)、PDFGRβ (IC50:13 nM)。 | |||
T8157 |
Centhaquin
PMZ-2010,Centhaquine |
Others | Others |
Centhaquin (Centhaquine)e 是一种具有研究出血性休克的潜力的试剂。在出血模型中,它能够减少全身血管阻力。 | |||
T2064 |
Semaxinib
司马沙尼,SU5416 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Semaxinib (SU5416) 是一种选择性的 VEGFR(Flk-1/KDR) 抑制剂,其 IC50=1.23 μM。 | |||
T21445 |
Naphazoline
AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。 萘甲唑啉可用作血管收缩剂,当应用于粘膜时可快速减少肿胀。 | |||
T5475 |
ZD-4190
|
EGFR; VEGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
ZD-4190 是血管内皮细胞生长因子受体 2 (VEGFR2) 和表皮生长因子受体 (EGFR) 信号传导的抑制剂,用于治疗癌症。 | |||
T3566 |
SU5205
SU 5205 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU5205 是一种 VEGFR2 (FLK-1) 的抑制剂,其IC50=9.6 μM。 | |||
T2656 |
Fruquintinib
HMPL-013,呋喹替尼 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Fruquintinib (HMPL-013) 是一种选择性的VEGFR 1/2/3抑制剂,它们的IC50值分别为33 nM、0.5 nM、35 nM。 | |||
T6036 |
Brivanib
BMS-540215,布立尼布 |
EGFR; VEGFR; FGFR; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Brivanib (BMS-540215) 是一种针对 VEGFR2 的 ATP 竞争性抑制剂,IC50 为 25 nM。它对 VEGFR-1 和 FGFR-1 具有中等效力,对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。 | |||
T21712 |
BAY 41-8543
|
Others; Guanylate cyclase | GPCR/G Protein; Others |
BAY 41-8543 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 刺激剂,具有抗血小板作用。它在大鼠的肺和全身血管床中具有血管舒张活性,有用于心血管疾病的研究潜力。 | |||
T1656 |
Vandetanib
ZD6474,凡德他尼 |
Apoptosis; EGFR; VEGFR; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Vandetanib (ZD6474) 是一种具有口服活性的VEGFR2/KDR 酪氨酸激酶抑制剂,IC50值为40 nM。它也抑制VEGFR3/FLT4和EGFR/HER1,IC50值分别为110和500 nM。 | |||
T7945 |
SU14813
|
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
SU14813 是一种多靶点受体酪氨酸激酶抑制剂,能够抑制 VEGFR2 (IC50:50 nM),VEGFR1 (IC50:2 nM),PDGFRβ (IC50:4 nM),KIT (IC50:15 nM)。 | |||
T9928 |
Ranibizumab
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Ranibizumab 是一种人源化单克隆抗体片段,旨在靶向和抑制血管内皮生长因子 (VEGF),包括 VEGF110、VEGF121 和 VEGF165。 Ranibizumab 选择性靶向和中和 VEGF-A 同工型的能力使其成为湿性年龄相关性黄斑变性 (AMD) 研究和治疗策略的重要组成部分。 | |||
T3691 |
(Rac)-SAR131675
SAR131675 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
(Rac)-SAR131675 是一种有效的、选择性的VEGFR3抑制剂,其IC50=23 nM。 | |||
T0993 |
Methoxamine hydrochloride
Methoxamine HCl,盐酸甲氧明 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Methoxamine hydrochloride (Methoxamine HCl) 是一种 alpha1 肾上腺素能受体的选择性激动剂。它通过 Prazosin 敏感机制在兔肺动脉显著增加 ATP、ADP 和 AMP 的溢出,但不增加腺苷的溢出。它引起血管收缩和外周血管阻力增加。 | |||
T3569 |
SU5214
SU 5214 |
VEGFR; Tyrosinase | Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
SU5214 (SU 5214) 是 VEGFR2 抑制剂,IC50值为 14.8 µM(FLK-1) 和 36.7 µM (EGFR)。 | |||
T5458 |
Darusentan
Lu-135252,达卢生坦 |
Endothelin Receptor | GPCR/G Protein |
Darusentan (Lu-135252) 是内皮素受体 A (ET-A) 受体选择性拮抗剂,能够作用于 ET-A 受体(Ki:1.4 nM)及ET-B 受体(Ki:184 nM),对 ETA 受体的选择性大于 ETB 受体的100以上。它在大鼠主动脉血管平滑肌细胞膜中竞争结合放射性标记的内皮素(Ki:13 nM)。 | |||
T6517 |
Golvatinib
E-7050,戈伐替尼 |
VEGFR; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。 | |||
T3599 |
BFH772
BFH-722 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
BFH772 是 VEGFR2抑制剂(IC50:3 nM),具有口服活性。 | |||
T5466 |
Tyrosine kinase-IN-1
|
VEGFR; FGFR; FLT; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂,能够抑制KDR (IC50:4 nM),Flt-1 (IC50:20 nM),FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。 | |||
T6996 |
SU 5402
SU5402 |
VEGFR; FGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU 5402 是多靶点受体酪氨酸激酶抑制剂,能够抑制VEGFR2 (IC50:20 nM),FGFR1 (IC50:30 nM),PDGFRβ (IC50:510 nM)。 | |||
T21593 |
AAL-993
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
AAL-993 是口服有效的VEGFR 选择性抑制剂,抑制 VEGFR1、VEGFR2 和 VEGFR3 的IC50分别为 130 nM、23 nM 和 18 nM,对其他酪氨酸激酶的抑制作用较弱。AAL-993 具有抗血管生成和抗肿瘤的活性。 | |||
T9473 |
4SC-203
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
4SC-203 是一种具有潜在的抗肿瘤活性的多激酶抑制剂。它对 FLT3/STK1、 FLT3 的突变形式以及 VEGFRs 具有选择性抑制作用。 | |||
T4425 |
JK-P3
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
JK-P3 是广谱 VEGFR2抑制剂。它能够抑制 VEGF-A 刺激的 VEGFR2 激活和细胞内信号转导,也可阻碍内皮单层细胞迁移和血管生成,影响成纤维细胞生长因子受体激酶在体外的活性。它具有抗血管生成的作用。 | |||
T1449 |
Hydrochlorothiazide
HCTZ,双氢氯噻嗪,氢氯噻嗪 |
Potassium Channel; Carbonic Anhydrase; TGF-beta/Smad | Membrane transporter/Ion channel; Metabolism; Stem Cells |
Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药,可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能,减少纤维化并具有降压作用。 | |||
T7123 |
AMG-47a
|
VEGFR; p38 MAPK; JAK; Src | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
AMG-47a 是具有口服活性的 Lck 抑制剂,IC50值为 0.2 nM。它具有抗炎作用,对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。 | |||
T0145 |
Felodipine
非洛地平,CGH-869 |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Felodipine (CGH-869) 是一种长效的 1, 4-二氢吡啶钙通道抑制剂,可跨越血脑屏障,可诱导自噬,具有抗高血压活性。它通过选择性作用于血管平滑肌,尤其是阻力血管来降低血压。 | |||
T4026 |
SU5408
VEGFR2 Kinase Inhibitor I |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU5408 (VEGFR2 Kinase Inhibitor I) 是一种可渗透细胞的VEGFR2激酶抑制剂,其IC50=70 nM。 | |||
T1754 |
ZM 306416
CB 676475 |
VEGFR; Bcr-Abl; Src | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
ZM 306416 (CB 676475) 是一种 VEGFR 的有效抑制剂,能够抑制 KDR (IC50:0.1 μM) 和 Flt (IC50:2 μM),也是一种 EGFR 的抑制剂(IC50<10 nM)。 | |||
TQ0317 |
R1530
R-1530,R 1530 |
VEGFR; FGFR; FLT; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
R1530 是一种多激酶抑制剂,具有抗肿瘤和抗血管生成活性。它是具有口服活性的有丝分裂/血管生成高效双重作用抑制剂, 抑制 VGFR2、FGFR1作用的 IC50分别为 10 nM 和 28 nM。 | |||
T2288 |
Motesanib
AMG 706,莫特塞尼,莫替沙尼 |
VEGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Motesanib (AMG 706) 是有效的、ATP 竞争性的 VEGFR1/2/3 的抑制剂,其IC50值为 2 nM/3 nM/6 nM,与对 Kit 的选择性相似,是 PDGFR 和 Ret 的 10 倍多。 | |||
T22459 |
Xanthinol Nicotinate
Angioamin,烟酸占替诺,Complamin |
Others | Others |
Xanthinol Nicotinate (Complamin) 是血管扩张剂,可直接作用于小动脉和毛细血管的平滑肌,能够扩大血管,改善血液流变学并降低外周血管阻力。 | |||
T7611 |
ODM-203
|
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
ODM-203 是 FGFR 和 VEGFR 家族的抑制剂,具有显著的抗肿瘤活性,能够诱导抗肿瘤免疫。 | |||
T15185 |
Lucitanib
E-3810,德立替尼 |
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Lucitanib (E-3810) 是 VEGFR 和 FGFR 的双重抑制剂,有效和选择性地抑制VEGFR1 (IC50:7 nM),VEGFR2 (IC50:25 nM),VEGFR3 (IC50:10 nM),FGFR1 (IC50:17.5 nM),FGFR2 (IC50:82.5 nM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8198 |
Visnagin
|
Others | Others |
Visnagin 是一种抗氧化剂呋喃香豆素衍生物。它具有预防Cerulein 诱导的急性胰腺炎的潜力。它在血管平滑肌中具有良好的血管扩张作用。它具有抗炎作用,可用于缓解疼痛的研究。 | |||
T8213 |
Isolinderalactone
|
NOS; STAT | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Isolinderalactone 具有抗炎和抗癌能力,具有中等的 iNOS 抑制活性,IC50 值为 0.30 uM。 | |||
T8206 |
Cycleanine
|
Others | Others |
Cycleanine 是一种高效血管选择性Ca- 拮抗剂,具有缓解疼痛、肌肉松弛和抗炎作用。它还具有有效的抗菌、抗真菌、抗疟原虫和细胞毒活性。 | |||
T4A2456 |
Gamabufotalin
Gamabufagin,日本蟾蜍毒苷元 |
COX | Immunology/Inflammation; Neuroscience |
Gamabufotalin (Gamabufagin) 是一种蟾蜍甾烯,存在于蟾酥中。它稳定性高,毒性低,被广泛用于癌症的研究。 | |||
T17280 |
(Z)-Guggulsterone
|
Apoptosis; VEGFR; Akt | Angiogenesis; Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
(Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul 的成分,可通过引起细胞凋亡来抑制人前列腺癌细胞的生长,还可通过抑制VEGF-VEGF-R2-Akt 信号传导轴来抑制血管生成。 | |||
T3S1591 |
Notoginsenoside Fc
三七皂苷 FC,三七皂苷Fc |
Others; Autophagy | Autophagy; Others |
Notoginsenoside Fc 是从三七叶中分离得到的原卟啉二醇型皂苷,可通过促进自噬促进糖尿病大鼠血管损伤后的内皮细胞再生,具有抗血小板聚集的作用。 | |||
T1431 |
Khellin
凯林,Amicardine,Methafrone,Visammin |
EGFR; Others | Angiogenesis; JAK/STAT signaling; Others; Tyrosine Kinase/Adaptors |
Khellin (Methafrone) 是从阿米芹中提取得到的一种呋喃并色酮,是EGFR 抑制剂,IC50为 0.15 µM。它体外具有抗增殖活性,还具有抗痉挛和冠状动脉舒张作用。 | |||
T0853 |
Adenosine
腺苷,D-Adenosine,Adenine riboside |
Apoptosis; Nucleoside Antimetabolite/Analog; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Adenosine (D-Adenosine) 是一种核糖核苷,由与核糖结合的腺嘌呤组成,具有血管扩张、抗心律失常和镇痛作用。 | |||
T3S0153 |
Xanthatin
苍耳亭,叶黄制菌素 |
Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors |
Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物,可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL,对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。 | |||
T2906 |
Tanshinone IIA
丹参酮IIA,Tanshinone B,Dan Shen ketone |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tanshinone IIA (Tanshinone B) 是红根丹参根系中的一种主要组合物。它能够利用靶向 VEGF/VEGFR2的蛋白激酶结构域,抑制血管生成。 | |||
T3S0364 |
L-Arginine
L-精氨酸,L-Arg,(S)-(+)-Arginine |
IL Receptor; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞,并被代谢成一氧化氮、多胺或 L-脯氨酸。 | |||
T19180 |
Adrenic Acid
二十二碳四烯酸,廿二碳四烯酸,cis-7,10,13,16-Docosatetraenoic acid |
Endogenous Metabolite | Metabolism |
Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) 是一种天然的多不饱和脂肪酸,主要存在于肾上腺,肾脏,大脑和脉管系统中。Adrenic Acid 能够调节肾上腺皮质血管的血管紧张度。Adrenic Acid 也是非酒精性脂肪肝疾病的炎症增强剂。 | |||
T7203 |
Oglufanide
奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH |
VEGFR; HCV Protease; Endogenous Metabolite | Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
TN2019 |
Orobol
3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮 |
BCL; Caspase; PI3K | Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K,对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。 | |||
T1152 |
Albendazole
SKF-62979,阿苯达唑 |
HIF/HIF Prolyl-Hydroxylase; Microtubule Associated; Antibiotic; Parasite | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Albendazole (SKF-62979) 是一种广谱抗寄生虫剂,具有高效,低宿主毒性的特点。 它用于研究人类和动物的胃肠道寄生虫。 | |||
T13108 |
Pamufetinib
H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115 |
VEGFR; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Pamufetinib (TAS-115) 是VEGFR 和c-Met/HGFR 抑制剂,能够抑制 rVEGFR2 (IC50:30 nM)和 rMET (IC50:32 nM)的活性。 | |||
T1205 |
Chloramphenicol
Chlornitromycin,Levomycetin,Chloromycetin,氯霉素 |
ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Chloramphenicol (Chloromycetin) 是一种广谱抗生素,有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基,对肽基转移酶有活性,抑制肽键的形成。 | |||
T0070 |
Pentoxifylline
Oxpentifylline,PTX,己酮可可碱,BL-191 |
HIV Protease; PDE; Adenosine Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂,具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。 | |||
TWA2417 |
Sodium taurocholate
牛黄胆酸钠(牛胆酸钠,牛胆酸钠盐,牛磺膽酸鈉,牛磺胆酸钠,牛磺胆酸钠盐,牛胆酸钠水合物,水合牛磺胆酸钠,牛胆酸钠(混合物),牛黄胆酸钠(水合),牛磺胆酸钠(标准品)),Taurocholate Sodium |
Others | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应,例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。 | |||
T14055 |
5Z-7-Oxozeaenol
FR148083,L783279,LL-Z 1640-2 |
VEGFR; FLT; MEK; MAPK; PDGFR; Antibiotic; Src | Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors |
5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂,不可逆的选择性抑制 TAK1和 VEGF-R2,IC50值分别为 8 nM 和 52 nM。 | |||
T6S1373 |
Casticin
Quercetagetin 3,6,7,4'-Tetramethyl Ether,Vitexicarpin,蔓荆子黄素 |
STAT | JAK/STAT signaling; Stem Cells |
Casticin (Vitexicarpin) 是从蔓荆子中得到的一种甲氧基黄酮,可抑制STAT3的活化,具有抗有丝分裂和抗炎活性。 | |||
T8178 |
Acetagastrodin
乙酰天麻素,Acegastrodine |
Others | Others |
Acetagastrodin (Acegastrodine) 是一种抗氧化剂,也是合成 DBPG 的中间体。 | |||
T3S1816 |
Parishin B
|
Others | Others |
Parishin B 是一种分离自天麻中的 Parishin 衍生物,可能具有抗氧化活性。 | |||
T6S0721 |
Orientin
荭草苷,Lutexin,Luteolin-8-glucoside |
Others | Others |
Orientin (Luteolin-8-glucoside) 是天然存在的生物活性类黄酮,是一种有前景的神经保护剂,具有多种生物特性,如抗炎、抗肿瘤、抗氧化、保护心脏等。它有用于神经性疼痛研究潜力。 | |||
TN1683 |
Gentisin
龙胆根素,龍膽根素 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Gentisin 是一种提取于 Gentianae radix (Gentianaceae) 的天然化合物,具有诱变活性。 | |||
T19711 |
Desmosterol
Desmesterol,24-Dehydrocholesterol |
Endogenous Metabolite | Metabolism |
Desmosterol(24-Dehydrocholesterol) 是一种胆固醇生物合成中间体,抑制巨噬细胞炎症小体活化,防止血管炎症和动脉粥样硬化。 | |||
T6S1367 |
Procyanidin B2
原花青素 B2,Proanthocyanidin B2 |
Reactive Oxygen Species; NOD | Immunology/Inflammation; Metabolism; NF-κB |
Procyanidin B2 (Proanthocyanidin B2) 是天然黄酮类物质,具有抗肿瘤,抗氧化等活性。 | |||
T0878 |
Diosmin
Venosmine,Diosmil,Barosmin,地奥司明,地奥司明(7-芸香糖甙) |
Aryl Hydrocarbon Receptor; Norepinephrine | Immunology/Inflammation; Neuroscience |
Diosmin (Venosmine) 是在各种柑橘类水果中发现的类黄酮,也是芳烃受体激动剂,有增强血管壁的作用。 | |||
T5S0833 |
Astragaloside III
|
Antioxidant | oxidation-reduction |
Astragaloside III 是一种分离自黄芪中的一种天然产物。 | |||
T5684 |
Ethyl 3,4-dihydroxybenzoate
|
Apoptosis; Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; NO Synthase; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others |
Ethyl 3,4-dihydroxybenzoate 是从花生种子的种皮中发现的脯氨酰羟化酶抑制剂,是一种抗氧化剂。它是胶原蛋白合成抑制剂,具有骨骼保护作用。它通过激活 NO 合酶并产生线粒体 ROS 来保护心肌,可诱导 ESCC 细胞自噬和凋亡。 | |||
T4S0999 |
(2S)-Isoxanthohumol
Isoxanthohumol,(2S)-异黄腐酚,异黄腐醇 |
Virus Protease; HSV | Microbiology/Virology |
(2S)-Isoxanthohumol 是一种由啤酒花原异戊烯基二氢黄酮 Isoxanthohumol 的微生物转化代谢物。 | |||
T0530 |
Flavanone
2-Phenyl-4-chromanone,4-Flavanone,2,3-Dihydroflavone,黄烷酮,2-Phenylchroman-4-one |
Others; Aromatase | Endocrinology/Hormones; Others |
Flavanone (2-Phenylchroman-4-one) 是天然的黄酮类化合物,对人类雌激素合成酶芳香化酶具有抑制作用。 | |||
TN1567 |
Delphinidin chloride
|
Estrogen Receptor/ERR; VEGFR | Angiogenesis; Endocrinology/Hormones; Tyrosine Kinase/Adaptors |
Delphinidin chloride 是一种花青素,是一种可从浆果和红酒中分离得到的天然植物色素,是某些花青素的前体。Delphinidin chloride 诱导血管内皮释放一氧化氮,引起血管松弛。在1 ~ 40 μM 剂量下,对上皮生长因子受体的信号传导和雌激素受体α的表达有抑制作用,与细胞凋亡和自噬有关。Delphinidin chloride 能调节 JAK/STAT3 和 MAPKinase 信号传导。Delphinidin 还能抑制 p300/CBP 的组蛋白乙酰转移酶活性(IC50 在约为30 μM) | |||
T6S0655 |
Corynoxeine
|
ERK | MAPK |
Corynoxeine 是从钩藤中分离的一种天然产物,是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的 ERK1/ERK2抑制剂。 | |||
TN1996 |
Nothofagin
|
ERK; IL Receptor; TNF | Apoptosis; Immunology/Inflammation; MAPK |
Nothofagin 具有抗氧化和抗血栓活性,它通过抑制高渗透性、CAMs 的表达以及白细胞的粘附和迁移具有抗炎活性,从而支持其作为血管炎症性疾病的治疗作用。 | |||
TN1087 |
Deoxypodophyllotoxin
脱氧鬼臼毒素,去氧鬼臼毒素 |
Apoptosis; Microtubule Associated; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling |
Deoxypodophyllotoxin 是从桃儿七根茎分离的一种木酚素,是鬼臼毒素衍生物,具有抗有丝分裂和抗病毒特性。它是血管生成抑制剂,作为靶向微管药物,在肿瘤学中具有重大影响。它引起 DRG 神经元细胞内 Ca2+浓度增加,诱导细胞自噬和凋亡。 | |||
T4S1102 |
Liensinine diperchlorate
莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate |
Mitophagy; Others; Autophagy | Autophagy; Others |
Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬,具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。 | |||
T3427 |
Polydatin
Piceid,虎杖苷,Polydotin Peceid |
Apoptosis; Mitophagy; NF-κB; Autophagy | Apoptosis; Autophagy; NF-κB |
Polydatin (Piceid) 是从传统中药虎杖根中提取的一种天然产物,在多个实验模型中具有抗炎作用。它可抑制 G6PD,并诱导氧化和内质网应激。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 属于生物碱类天然产物,是一种神经递质,一种肾上腺素能受体 (AR) 的激动剂,对 α1、α2 和 β1 AR 具有激活活性。Norepinephrine 被用作抗休克的血管活性剂。 | |||
T6S1784 |
Brazilin
Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素 |
Apoptosis; Others; AMPK; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
Brazilin (Braziletto) 是来自几种热带硬木的心材的一种红色染料前体,有软骨保护和抗炎活性。它抑制细胞增殖,促进细胞凋亡并通过 AMPK/mTOR 途径诱导自噬。 | |||
TN1969 |
N-(p-Coumaroyl) serotonin
|
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
N-(p-Coumaroyl) Serotonin 是从红花种子中分离出来的多酚,具有抗氧化、抗动脉粥样硬化和抗炎作用,常用于动脉粥样硬化的研究。它可改善动脉粥样硬化和主动脉壁膨大。它可降低肌浆网中 PDGF 诱导的对中PDGFR 酪氨酸磷酸化和 Ca2+释放的作用。 | |||
TN1042 |
Chebulic acid
|
Others | Others |
Chebulic acid 是一种分离自Terminalia chebula 中的酚羧酸化合物,具有显著的抗氧化作用,它能够打破由晚期糖基化终产物 (AGEs) 诱导的蛋白质交联,阻碍 AGEs 的形成。它能够有效控制代谢参数升高、氧化应激和肾损害,支持其在糖尿病肾病中的有益作用。 | |||
T2520 |
Desloratadine
Sch34117,地氯雷他定,NSC 675447 |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
T3403 |
Glabridin
光甘草定,Q-100692,KB-289522,LS-176045 |
Reactive Oxygen Species; Tyrosinase; GABA Receptor; Antibacterial; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Glabridin (KB-289522) 能够结合并激活PPARγ,EC50值为 6115 nM,是一种从Glycyrrhiza glabra 中分到的异黄烷类天然产物。它具有抗炎、抗菌、抗肾炎、抗氧化、抗肿瘤、抗糖尿病、抗骨质疏松、保护神经、保护心血管、清除自由基等作用。 | |||
T5S1889 |
Yunaconitine
Guayewuanine B,滇乌头碱 |
Others | Others |
Yunaconitine (Guayewuanine B) 是一种乌头类生物碱,具有剧毒。 | |||
T3794 |
Pentagalloylglucose
Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖 |
Influenza Virus | Microbiology/Virology |
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。 | |||
T6S1418 |
Praeruptorin C
|
Antioxidant; Calcium Channel | Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Praeruptorin C 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.7。 | |||
T6429 |
Caffeic Acid Phenethyl Ester
Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE |
Apoptosis; NF-κB | Apoptosis; NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯,是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活,具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。 | |||
TN2354 |
Methylnissolin
3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷 |
ERK; PDGFR | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
Methylnissolin 是从黄芪中分离的一种天然产物,可抑制血小板衍生生长因子 (PDGF)-BB 诱导的细胞增殖,IC50为 10 μM。。它通过抑制ERK1/2MAP 激酶级联反应抑制 PDGF-BB 诱导的血管平滑肌细胞增殖。它还抑制 PDGF-BB 诱导的细胞外信号调节激酶 1/2 (ERIC1/2) 丝裂原活化蛋白 (MAP) 激酶的磷酸化,具有抗菌和抗癌作用。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03156 |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His)
vascular endothelial growth factor C |
Mouse,Rat | HEK293 Cells |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.5 kDa and the accession number is P97953-1. | |||
TMPY-01677 |
VE-Cadherin Protein, Human, Recombinant (His & hFc)
cadherin 5, type 2 (vascular endothelium),CD144,7B4 |
Human | HEK293 Cells |
VE-Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 92 kDa and the accession number is P33151-1. | |||
TMPJ-00865 |
VEGF121 Protein, Human, Recombinant (His)
VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生... |
Human | HEK293 Cells |
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel... | |||
TMPY-01830 |
VCAM-1 Protein, Mouse, Recombinant (His)
Vcam-1,CD106,vascular cell adhesion molecule 1 |
Mouse | HEK293 Cells |
VCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 75.8 kDa and the accession number is Q3UPN1. | |||
TMPY-03698 |
VEGF121b Protein, Human, Recombinant
MVCD1,VEGF,VPF,vascular endothelial growth factor A |
Human | HEK293 Cells |
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9. | |||
TMPY-02432 |
VEGF164 Protein, Rat, Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Rat | Baculovirus Insect Cells |
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2. | |||
TMPY-04911 |
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated
vascular endothelial growth factor A,血管内皮生长因子 |
Human,Cynomolgus | HEK293 Cells |
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4. | |||
TMPY-00947 |
VCAM-1 Protein, Human, Recombinant (hFc)
INCAM-100,CD106,VCAM-1,vascular cell adhesion molec... |
Human | HEK293 Cells |
VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1. | |||
TMPY-01717 |
VEGF164 Protein, Mouse, Recombinant
vascular endothelial growth factor A,Vpf,Vegf,血管内皮生... |
Mouse | Baculovirus Insect Cells |
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2. | |||
TMPJ-00412 |
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,V... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... | |||
TMPY-01008 |
VEGFD Protein, Human, Recombinant (His)
VEGFD,c-fos induced growth factor (vascular endothe... |
Human | HEK293 Cells |
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915. | |||
TMPJ-00864 |
VEGF165 Protein, Human, Recombinant
Vascular Endothelial Growth Factor Isoform 165,血管内皮... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul... | |||
TMPY-01007 |
VEGFC Protein, Human, Recombinant (His)
血管内皮生长因子,LMPH1D,VEGF-C,Flt4-L,vascular endothelial ... |
Human | HEK293 Cells |
VEGFC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is P49767. | |||
TMPJ-00603 |
TL1A/TNFSF15 Protein, Mouse, Recombinant
TNFSF15,Tumor Necrosis Factor Ligand Superfamily Member 15,V... |
Mouse | E. coli |
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ... | |||
TMPH-03131 |
VEGFA Protein, Pig, Recombinant (His)
Vascular endothelial growth factor A,VEGFA,Vasc... |
Sus scrofa (Pig) | E. coli |
VEGFA Protein, Pig, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.2 kDa and the accession number is P49151. | |||
TMPY-03155 |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc)
vascular endothelial growth factor C |
Mouse,Rat | HEK293 Cells |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 41.5 kDa and the accession number is O35757. | |||
TMPJ-00930 |
VCAM-1 Protein, Mouse, Recombinant (hFc)
Vascular cell adhesion protein 1,Vcam1 |
Mouse | HEK293 Cells |
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interac... | |||
TMPY-03305 |
VE-Cadherin Protein, Rat, Recombinant (His)
cadherin 5, type 2 (vascular endothelium) |
Rat | HEK293 Cells |
VE-Cadherin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 65.1 kDa and the accession number is A6JXX3. | |||
TMPH-03398 |
VCAM-1 Protein, Rat, Recombinant (His)
Vcam1,Vascular cell adhesion protein 1 |
Rat | E. coli |
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM-1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 77.4 ... | |||
TMPY-01144 |
VCAM-1 Protein, Mouse, Recombinant (His & hFc)
vascular cell adhesion molecule 1,Vcam-1,CD106 |
Mouse | HEK293 Cells |
VCAM-1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 102 kDa and the accession number is Q3UPN1. | |||
TMPJ-00844 |
ANXA8 Protein, Human, Recombinant
Vascular Anticoagulant-β,Annexin-8,Annexin A8,VAC-B... |
Human | E. coli |
Annexin A8 (ANXA8) belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Annexin A8 contains 4 annexin repeats separated by linking sequences of variable lengths. A pair of annexin repeats may form one binding site for calcium and phospholipid. ANXA8 is preferentially expressed in acute promyelocytic leukemia (APL) cells, which suggests its participation in hematopoietic cell differentiation. In addition, ANXA8 is an anticoagulant protein that acts as an indirect i... | |||
TMPY-03200 |
VEGFD Protein, Rat, Recombinant (hFc)
c-fos induced growth factor (vascular endothelial g... |
Rat | HEK293 Cells |
VEGFD Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.6 kDa and the accession number is O35251. | |||
TMPY-03080 |
VEGF165 Protein, Danio rerio (zebrafish), Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Danio rerio (zebrafish) | Baculovirus Insect Cells |
VEGF165 Protein, Danio rerio (zebrafish), Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is O73682. | |||
TMPY-03705 |
VEGF164 Protein, Canine, Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Canine | HEK293 Cells |
VEGF164 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9MYV3-3. | |||
TMPY-05616 |
VCAM-1 Protein, Human, Recombinant (hFc), Biotinylated
CD106,vascular cell adhesion molecule 1,INCAM-100,V... |
Human | HEK293 Cells |
VCAM-1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P19320-1. | |||
TMPY-06916 |
VCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated
vascular cell adhesion molecule 1,INCAM-100,CD106,V... |
Human | HEK293 Cells |
VCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 77.36 kDa and the accession number is NP_001069.1. | |||
TMPY-04327 |
VEGFB Protein, Human, Recombinant (hFc)
VRF,血管内皮生长因子,vascular endothelial growth factor B,V... |
Human | HEK293 Cells |
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang I... | |||
TMPY-00948 |
VCAM-1 Protein, Human, Recombinant (His)
vascular cell adhesion molecule 1,CD106,INCAM-100,V... |
Human | HEK293 Cells |
VCAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76 kDa and the accession number is P19320-1. | |||
TMPH-02011 |
PTPRB Protein, Human, Recombinant (His & SUMO)
PTPRB,Receptor-type tyrosine-protein phosphatase beta,Va... |
Human | E. coli |
PTPRB Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02303 |
Vasculin Protein, Human, Recombinant (His & SUMO)
GC-rich promoter-binding protein 1,Vasculin,GPBP1,Vascul... |
Human | E. coli |
Functions as a GC-rich promoter-specific transactivating transcription factor. Vasculin Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 36.8 kDa and the accession number is Q86WP2. | |||
TMPJ-00377 |
VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated
INCAM-100,Vascular cell adhesion protein 1,V-CAM 1,... |
Human | HEK293 Cells |
VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. It's important function is a recognition of cell-cell. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation。 | |||
TMPY-03150 |
VEGFD Protein, Mouse, Recombinant (His)
VEGF-D,Vegfd,AI325264,c-fos induced growth factor (vascu... |
Mouse | HEK293 Cells |
VEGFD Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is P97946. | |||
TMPY-02589 |
VEGFD Protein, Mouse, Recombinant (hFc)
c-fos induced growth factor (vascular endothelial g... |
Mouse | HEK293 Cells |
VEGFD Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P97946. | |||
TMPY-01237 |
VE-Cadherin Protein, Mouse, Recombinant (His)
VECD,VE-Cad,Cd144,7B4,Vec,VEcad,cadherin 5, type 2 (vasc... |
Mouse | HEK293 Cells |
VE-Cadherin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.5 kDa and the accession number is P55284. | |||
TMPH-02010 |
PTPRB Protein, Human, Recombinant (His)
Vascular endothelial protein tyrosine phosphatase,P... |
Human | P. pastoris (Yeast) |
PTPRB Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPY-01656 |
VEGF183 Protein, Human, Recombinant
血管内皮生长因子,VEGF165,VPF,VEGF,vascular endothelial grow... |
Human | Baculovirus Insect Cells |
VEGF183 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 21 kDa and the accession number is P15692-3. | |||
TMPH-00949 |
APOLD1 Protein, Human, Recombinant (His)
Vascular early response gene protein,APOLD1,VERGE,A... |
Human | E. coli |
May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. APOLD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 33.4 kDa and the accession number is Q96LR9. | |||
TMPY-05798 |
VEGF145 Protein, Human, Recombinant
血管内皮生长因子,vascular endothelial growth factor A,VPF,M... |
Human | HEK293 Cells |
VEGF145 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.92 kDa and the accession number is P15692-6. | |||
TMPH-03272 |
Complement factor D Protein, Rat, Recombinant (His)
Adipsin,Df,Adn,C3 convertase activator,Complement factor D,E... |
Rat | P. pastoris (Yeast) |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. | |||
TMPH-03271 |
Complement factor D Protein, Rat, Recombinant (His & Myc)
Adn,C3 convertase activator,Properdin factor D,Complement fa... |
Rat | HEK293 Cells |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038. | |||
TMPJ-00379 |
AOC3 Protein, Human, Recombinant (hFc)
SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas... |
Human | HEK293 Cells |
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam... | |||
TMPJ-00380 |
AOC3 Protein, Human, Recombinant (His)
Membrane primary amine oxidase,HPAO,VAP-1,Semicarbazide-sens... |
Human | HEK293 Cells |
Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inf... | |||
TMPJ-01030 |
JAM-B Protein, Human, Recombinant (hFc)
JAM-B,JAM2,Junctional Adhesion Molecule B,C21orf43,JAM-2,Jun... |
Human | HEK293 Cells |
JAM-B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-75 KDa and the accession number is P57087. | |||
TMPJ-01031 |
JAM-B Protein, Human, Recombinant (His)
C21orf43,VE-JAM,Junctional Adhesion Molecule 2,VEJAM,JAM-2,J... |
Human | HEK293 Cells |
JAM-B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-39 KDa and the accession number is P57087. | |||
TMPJ-00414 |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
Protein-tyrosine kinase receptor flk-1,KDR,Kinase insert dom... |
Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 120-150 KDa and the accession number is P35968. | |||
TMPJ-00593 |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
KDR,Fetal liver kinase 1,VEGFR-2,Kinase insert domain recept... |
Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa and the accession number is AAI31823.1. | |||
TMPK-00823 |
VEGF165 Protein, Human, Recombinant (His & Avi)
血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA,VEGFMGC70609,VPF,... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4. | |||
TMPK-00810 |
tPA Protein, Mouse, Recombinant (His)
PLAT,Reteplase,t-PA,tPA,Alteplase |
Mouse | HEK293 Cells |
Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism. | |||
TMPY-01075 |
Von Willebrand Factor/vWF Protein, Human, Recombinant (His)
von Willebrand factor,VWD,F8VWF |
Human | CHO Cells |
Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thr... | |||
TMPY-04644 |
PDGFB Protein, Human, Recombinant (His)
platelet-derived growth factor beta polypeptide,SSV,c-sis,SI... |
Human | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0124 |
Brivanib Alaninate-d4
|
||
Brivanib Alaninate-d4 是 Brivanib Alaninate 的氘代化合物。Brivanib Alaninate 的 CAS 号为 649735-63-7。Brivanib alaninate 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐,IC50值为 25 nM,具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制,对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。 | |||
TMID-0021 |
Fruquintinib-d3
|
||
Fruquintinib-d3 是 Fruquintinib 的氘代化合物。Fruquintinib 的 CAS 号为 1194506-26-7。Fruquintinib 是一种选择性的VEGFR 1/2/3抑制剂,它们的IC50值分别为33 nM、0.5 nM、35 nM。 | |||
TMID-0001 |
Vitamin K1-d4
|
||
Vitamin K1-d4 是 Vitamin K1 的氘代化合物。Vitamin K1 的 CAS 号为 84-80-0。Vitamin K1 (Phylloquinone) 是天然存在的维生素。Vitamin K1是血液凝固,骨和血管代谢所必须的。 | |||
TMIH-0497 |
Riociguat-13C-d6
|
||
Riociguat-13C-d6 是 Riociguat 的 13C 和氘代化合物。Riociguat 的 CAS 号为 625115-55-1。Riociguat 是一种鸟苷酸环化酶的刺激剂,可导致血管平滑肌松弛,用于治疗严重的肺动脉高压。 | |||
TMIJ-0077 |
Clevidipine-d7
|
||
Clevidipine-d7 是 Clevidipine 的氘代化合物。Clevidipine 的 CAS 号为 167221-71-8。Clevidipine butyrate 是一种二氢吡啶 L 型钙通道阻滞剂,IC50为7.1 nM。它对血管平滑肌有选择性,可用于降低血压。 | |||
TMIJ-0095 |
Nimodipine-d7
|
||
Nimodipine-d7 是 Nimodipine 的氘代化合物。Nimodipine 的 CAS 号为 66085-59-4。Nimodipine 是一种具有口服活性,耐受性良好的光敏二氢吡啶钙拮抗剂。它可研究脑血管疾病。 | |||
TMIJ-0497 |
Lacidipine-d10
|
||
Lacidipine-d10 是 Lacidipine 的氘代化合物。Lacidipine 的 CAS 号为 103890-78-4。Lacidipine 是一种L型钙离子通道阻断剂。 | |||
TMIJ-0251 |
Nicergoline-13C-d3
|
||
Nicergoline-13C-d3 是 Nicergoline 的 13C 和氘代化合物。Nicergoline 的 CAS 号为 27848-84-6。Nicergoline 是一种有效的,选择性的、具有口服活性的α1A-肾上腺素能受体拮抗剂,是一种溴烟碱酸的麦角林衍生物。它具有血管舒张作用,可以改善阿尔茨海默症小鼠的认知功能。 | |||
TMIJ-0117 |
rac-Clopidogrel-d4 Hydrogen Sulfate
|
||
rac-Clopidogrel-d4 Hydrogen Sulfate 是 rac-Clopidogrel Hydrogen Sulfate 的氘代化合物。rac-Clopidogrel Hydrogen Sulfate 的 CAS 号为 135046-48-9。(±) Clopidogrel hydrogen sulfate是一种在药理学和结构上类似于ticlopidine的抗血小板药物,用于抑制脑血管疾病、外周血管疾病和冠状动脉疾病等各种疾病中的血栓。 | |||
TMID-0070 |
Amiodarone-d10 Hydrochloride
|
||
Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
TMID-0069 |
Amiodarone-d4 HCl
|
||
Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
TMIJ-0202 |
Desloratadine-d5
|
||
Desloratadine-d5 是 Desloratadine 的氘代化合物。Desloratadine 的 CAS 号为 100643-71-8。Desloratadine 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
TMIJ-0342 |
Aniline-d5
|
||
Aniline-d5 是 Aniline 的氘代化合物。Aniline 的 CAS 号为 62-53-3。Aniline 通过铁过载和通过血红素加氧酶 1 上调诱导氧化应激对脾脏产生毒性。它会导致 p-IKKα 和 p-IKKβ 显着增加,进而增加 NF-κB 和 AP-1 结合活性。 | |||
TMIJ-0317 |
Nadolol-d9 (Mixture of Diastereomers)
|
||
Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 | |||
TMIJ-0272 |
Sarpogrelate-d3 HCl
|
||
Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。 |