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Search Results for " oxygen "

Targets Recommended: Reactive Oxygen Species Indoleamine 2,3-Dioxygenase (IDO) Lipoxygenase Others

321

抑制剂 & 化合物

209

天然产物

12

化合物库

61

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L2910	抗氧化化合物库		1314 compounds
	氧化应激（Oxidative Stress，OS）是指体内氧化与抗氧化作用失衡的一种状态。氧化应激导致活性氧（ROS）大量积累，氧化程度超出抗氧化物的清除能力，从而引起氧化损伤，氧化应激损伤是许多疾病发生的基础，不同程度的氧化应激造成的细胞效应与心脑血管疾病、神经退行性病变、炎症和肿瘤密切相关。抗氧化剂是一类能够对抗氧化应激，降低氧化损伤的一类化合物。 TargetMol 抗氧化化合物库是1314 种对氧化应激具有抑制作用的小分子特有集合，是研究氧化应激的有用工具，可以用于高通量筛选和高内涵筛选。
L2160	抗癌活性化合物库		3188 compounds
	3188 种具有抗肿瘤活性的化合物的特有集合，用于高通量、高内涵筛选；
L2150	抗癌药物库		3080 compounds
	3080 个具有抗癌活性小分子的独特集合，生物活性已经临床前实验证实，可用于高通量、高内涵筛选；
L2120	抗癌临床化合物库		2545 compounds
	2545 个具有抗癌活性小分子的独特集合，可用于高通量高内涵筛选。
L2100	抗癌化合物库		7234 compounds
	7234 种肿瘤相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L4800	血管生成库		1353 compounds
	1353 个高潜力的抑制或促进血管生成的小分子集合，可用于药物靶点开发、血管生成机理研究的高通量筛选，高内涵筛选；
L2110	抗癌上市药物库		1779 compounds
	1779 个具有抗癌活性小分子的独特集合，所有化合物都经过了严格的临床前研究和临床试验，由FDA、EMA 或NMPA 批准上市，可用于高通量、高内涵筛选。
L2180	抗肿瘤库Plus		1468 compounds
	1468 种抗肿瘤相关、结构新颖的化合物；
L1300	PI3K/Akt/mTOR 化合物库		420 compounds
	420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合，用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选；
L5300	线粒体靶向库		812 compounds
	812 种具有潜在或确定线粒体靶向活性的化合物，以促进针对线粒体的药物研究；
L2521	糖酵解化合物库		555 compounds
	555 种糖酵解相关的活性化合物，可用于高通量和高内涵筛选
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

抗氧化化合物库

Cat.No: L2910

Compounds: 1314

抗癌活性化合物库

Cat.No: L2160

Compounds: 3188

抗癌药物库

Cat.No: L2150

Compounds: 3080

抗癌临床化合物库

Cat.No: L2120

Compounds: 2545

抗癌化合物库

Cat.No: L2100

Compounds: 7234

血管生成库

Cat.No: L4800

Compounds: 1353

抗癌上市药物库

Cat.No: L2110

Compounds: 1779

抗肿瘤库Plus

Cat.No: L2180

Compounds: 1468

PI3K/Akt/mTOR 化合物库

Cat.No: L1300

Compounds: 420

线粒体靶向库

Cat.No: L5300

Compounds: 812

糖酵解化合物库

Cat.No: L2521

Compounds: 555

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
TP1344	Luciferase	Others	Others
	Luciferase 是一种在生物发光细菌中发现的依赖黄素的单加氧酶。 Luciferase 是识别和表征功能变体的宝贵工具，可用于研究基因表达、细胞内信号传导、转录因子、受体活性和蛋白质折叠。
T16951	Sulcotrione	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Sulcotrione 属于β-三酮类除草剂，对羟基苯基丙酮酸双加氧酶有抑制作用。
T5426	DMNQ	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	DMNQ 是氧化还原循环剂，以浓度依赖性方式在细胞内产生超氧化物和过氧化氢，能够诱导ROS 增加。
T1710	Trolox	Apoptosis; Antioxidant; Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Trolox 是一种维生素 E 的衍生物，具有细胞渗透性和水溶性。Trolox 是一种膜损伤抑制剂，具有强大的抗氧化活性。
T32648	Leptophos oxon Leptophos OA,Leptophos oxygen analog,Phosvel oxon,Velsicol VCS O-analog	Others	Others
	Leptophos oxon is a phosvel analog-oxygen substituting sulfur.
T9045	Bemotrizinol	Others	Others
	Bemotrizinol 是紫外线 (UV) 滤光片，已被证实可用它接受N-氧化物光氧化产生的原子氧。
T3952	TPEN TPEDA	Apoptosis; Reactive Oxygen Species; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	TPEN (TPEDA) 是一种特定的细胞可渗透的重金属螯合剂，对 Zn2+具有高亲和力，但对 Mg2+和 Ca2+具有较低的亲和力。它诱导 DNA 损伤并增加细胞内ROS 的产生，还抑制细胞增殖并诱导凋亡。
T15030	CycLuc1	Others	Others
	CycLuc1 是一种荧光素酶底物，具有血脑屏障渗透性。
T5116	Iprodione	Others; Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Others
	Iprodione 是一种二甲酰亚胺类的高度特异性杀菌剂，能通过产生自由氧自由基引起氧化损伤。
T3496	Buprofezin 噻嗪酮,NNI 750,Applaud,Buprofezine	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Buprofezin (Applaud) 是一种杀虫剂，通过抑制几丁质合成起作用，在体外还可以剂量依赖性地增加活性氧的产生。
T19428	Mito-TEMPO	Reactive Oxygen Species; Mitochondrial Metabolism	Immunology/Inflammation; Metabolism; NF-κB
	Mito-TEMPO 是一种线粒体靶向超氧化物歧化酶的模拟物。Mito-TEMPO 可以清除超氧化物和烷基自由基，防止线粒体的氧化、坏死和凋亡。
T5966	Hexaconazole 己唑醇,(-)-Hexaconazol	Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Hexaconazole ((-)-Hexaconazol) 是一种广谱三唑类杀菌剂，通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成，从而导致真菌细胞膜的破坏和细胞死亡。
TD0102	1,3-Diphenylisobenzofuran DPBF	Others	Others
	1,3-Diphenylisobenzofuran (DPBF) 是一种荧光探针，对单线态氧(1O2) 的具有高特异性，可形成内过氧化物并分解成 1,2-dibenzoylbenzene，可用于活性氧生成的检测。
T5518	N-acetylcysteine amide	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	N-Acetylcysteine amide 是一种硫醇抗氧化剂，也是一种神经保护剂，能够透过细胞膜和血脑屏障的，可降低ROS 的产生。
T4168	Visomitin SKQ1	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Visomitin (SKQ1) 是一种靶向线粒体的抗氧化剂，表现出高效的线粒体穿透能力和有效的抗氧化能力。
T8370	GSK5182	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	GSK5182 是高效选择性，具有口服活性的 ERRγ反向激动剂，其 IC50=79 nM，且不与其他核受体相互作用，包括 ERRα 和 ERα。它还能增加肝癌细胞中 reactive oxyen species (ROS)的产生。
T7703	PK11007	Reactive Oxygen Species; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	PK11007 是一种温和的硫醇烷基化剂，具有抗癌活性。它通过两个表面暴露的半胱氨酸的选择性烷基化来稳定 p53。它通过增加活性氧水平诱导突变的 p53癌细胞死亡。
T15433	GSK2795039	Apoptosis; Reactive Oxygen Species; ROS; NADPH	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	GSK2795039 是一种 NADPH 氧化酶 2 抑制剂，可抑制活性氧产生和 NADPH 消耗，同时可减少细胞凋亡。
T38155	N-Acetyl-D-cysteine	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	N-Acetyl-D-cysteine 具有抗氧化活性，机制是通过与巯基反应清除ROS。N-Acetyl-D-cysteine 不能进入谷胱甘肽代谢途径。
T2090	Lexibulin CYT-997	Apoptosis; Reactive Oxygen Species; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂，可诱导细胞凋亡，并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M，在体内外具有高细胞毒性和血管增生阻断作用。
T13189	TP-10	PDE	Metabolism
	TP-10 是 PDE10A 对其他 PDE 的特异性抑制剂，IC50 为 0.8 nM。
T13019	Succinyl phosphonate trisodium salt 琥珀酰膦酸盐	Dehydrogenase; Reactive Oxygen Species; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB
	Succinyl phosphonate trisodium salt 是 α-酮戊二酸脱氢酶（KGDHC）抑制剂，能够有效抑制肌肉，脑，人成纤维细胞，细菌中的 KGDHC。Succinyl phosphonate trisodium salt 抑制 2-氧代戊二酸脱氢酶，以细胞特异性代谢依赖性方式抑制癌细胞的活力。Succinyl phosphonate trisodium salt 抑制谷氨酸诱导的海马神经元中ROS 的产生。
T0756	Ethoxyquin Santoquin,Quinol,Santoflex,乙氧基喹啉	HSP; Reactive Oxygen Species	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	Ethoxyquin (Santoflex) 是一种热休克蛋白 90 抑制剂，是一种用于动物饲料的抗氧化剂。
T4287	Succinobucol Probucol monosuccinate,AGI-1067	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Succinobucol (Probucol monosuccinate) 是酚类抗氧化剂，具有抗炎、抗血小板聚集活性。
T17250	W-54011	ROS; Complement System	Immunology/Inflammation
	W-54011 是口服有效的非肽 C5a 受体拮抗剂，抑制125I 标记的 C5a 与人嗜中性白细胞的结合，Ki 为 2.2 nM。它还抑制C5a 诱导的人嗜中性粒细胞的细胞内 Ca2+动员，趋化性和ROS 的生成，IC50分别为 3.1 nM、2.7 nM 和1.6 nM。
T0418	Allylthiourea 阿利硫脲,N-Allylthiourea,Thiosinamine,烯丙基硫脲	MAO; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Allylthiourea (Thiosinamine) 是一种代谢抑制剂，专门抑制氨氧化。
T8377	Mesotrione 甲基磺草酮,硝磺草酮	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Mesotrione 是一种苯甲酰环己二酮类除草剂，是一种竞争性羟基苯基丙酮酸双加氧酶酶抑制剂。它对玉米作物具有选择性，它在易感作物中代谢速度快，耐受性较高。
T38423	CL097 CL097	Reactive Oxygen Species; TLR	Immunology/Inflammation; Metabolism; NF-κB
	CL097 是 TLR7 和 TLR8 的有效激动剂。 CL097 诱导巨噬细胞中的促炎细胞因子和 NADPH 氧化酶引发，从而增加 fMLF 刺激的 ROS 产生。
T6699	Tempol TMPN,Tanol,4-Hydroxy-TEMPO,阻聚剂701	Reactive Oxygen Species; ROS; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Tempol (Tanol) 是一种超氧化物歧化酶类似物，可有效中和活性氧，具有抗炎、神经保护和镇痛作用。
T11580	Heme Oxygenase-1-IN-1 HO-1-IN-1	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Heme Oxygenase-1-IN-1 (HO-1-IN-1) 是一种血红素加氧酶 1 (HO-1) 抑制剂，IC50=250 nM。
T0163	Nisoldipine 尼索地平,BAY-k 5552	Calcium Channel; Reactive Oxygen Species	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Nisoldipine (BAY-k 5552) 是一种高效特异的L 型Cav1.2通道阻断剂，IC50=10 nM。
T8320	J14 J-14	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	J14 是一种可逆的 sulfiredoxin 抑制剂，IC50=8.1 μM。它能够抑制sulfiredoxin 诱导氧化应激，使细胞内ROS 积累，导致细胞毒性和癌细胞死亡。
T6482	Efaproxiral Sodium 乙丙昔罗钠,RSR13 sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Efaproxiral Sodium (RSR13 sodium) 是血红蛋白 (Hb) 合成变构调节剂，能够减少血红蛋白氧 (O2) 的结合亲和力。
T21233	Dihydrolipoic acid Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid,二氢硫辛酸	Antioxidant	oxidation-reduction
	Dihydrolipoic acid (USAF XR-12) 是高效的抗氧化剂，对所有以氧为中心的自由基都有很强的清除能力。它在多种疾病中表现出抗炎特性。在 LPS 诱导的疾病行为大鼠中，它通过 ERK/Nrf2/HO-1/ROS/NLRP3 通路发挥预防作用。它还可以可用于抑郁症的研究。
T7191	Diphenyleneiodonium chloride 二苯基氯化碘盐,DPI	NOS; Reactive Oxygen Species; NADPH; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Diphenyleneiodonium chloride (DPI) 是 NADPH 氧化酶抑制剂，也是 TRPA1激活剂，EC50为 1 - 3 μM 。它选择性抑制胞内活性氧。
T21807	INCA-6 Triptycene-1,4-quinone	Others	Others
	INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点，有效抑制calcineurin (CN)-NFAT 信号传导。
T4172	Methoxy-PMS 1-Methoxyphenazine methosulfate,1-Methoxy PMS	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Methoxy-PMS (1-Methoxyphenazine methosulfate) 是一个稳定的电子传递中介，是一种活性氧生成的诱导剂。
T40612	Manganese(salen) chloride EUK-8	Others	Others
	Manganese(salen) chloride (EUK-8) 是超氧化物歧化酶和过氧化氢酶的一种模拟物，具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。
T9211	Mito-LND Mito-Loidamine	OXPHOS; Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Mito-LND (Mito-Loidamine) 是一种有口服活性和靶向线粒体的氧化磷酸化抑制剂。它抑制线粒体生物能，刺激活性氧的形成，并诱导肺癌细胞自噬细胞死亡。
T15213	Emeramide BDTH2,N,N'-二(2-巯基乙基)间苯二甲酰胺	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Emeramide (BDTH2) 是一种硫醇氧化还原抗氧化剂，也是一种重金属螯合剂。
T5030	Zofenopril calcium SQ26991,佐芬普利钙,Zofenopril (calcium)	RAAS; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Zofenopril calcium (SQ26991) 是一种抗氧化剂和血管紧张素转化酶 (ACE) 抑制剂。
T6201	Disufenton sodium Cerovive,NXY059,OKN007,NXY-059,NXY 059	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Disufenton sodium (NXY-059) 是一种神经保护剂 phenylbutynitrone 的衍生物，具有强大的自由基清除能力。
T7717	Sodium 2-oxopropanoate Sodium pyruvate,丙酮酸钠	Reactive Oxygen Species; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB
	Sodium 2-oxopropanoate (Sodium pyruvate) 是 pyruvate 的钠盐形式。pyruvate 是葡萄糖的三碳代谢物，是一种在糖酵解途径中产生的化合物，它是一种能够清除 ROS 的自由基清除剂。
T2587	Ecabet Sodium TA-2711E,TA-2711,伊卡倍特钠	Reactive Oxygen Species; Antibacterial	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Ecabet Sodium (TA-2711) 可通过抑制活性氧的产生，促进幽门螺杆菌的根除，可用于胃肠道疾病的相关研究。
T12059L	Mitoquinone mesylate MitoQ mesylate,米托蒽醌甲磺酸盐,MitoQ10 mesylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Mitoquinone mesylate (MitoQ10 mesylate) 是可防止氧化损伤的抗氧化剂，靶向TPP 的线粒体。
T21011	Buspirone Buspirone free base,Ansial,丁螺环酮	5-HT Receptor	GPCR/G Protein; Neuroscience
	Buspirone (Buspirone free base) 是一种azaspiro 化合物，具有抗焦虑药、镇静剂、血清素能激动剂和EC 3.4.21.26(脯氨酸寡肽酶)抑制剂的作用。
T1057	Azilsartan TAK-536,阿齐沙坦	RAAS	Endocrinology/Hormones
	Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。
T50099	HIF-2α-IN-4	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	HIF-2a translation inhibitor 是一种有效的HIF-2α翻译抑制剂，IC50=5 μM，能够抑制组成型和缺氧诱导的 HIF-2α 蛋白表达。其中 HIF-2α-IN-4 将 5'UTR 铁响应元件与氧传感联系起来。
T3103	L67 DNA Ligase Inhibitor	DNA; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L67 (DNA Ligase Inhibitor) 是一种竞争性人类 DNA 连接酶抑制剂，抑制 DNA 连接酶 I 和 III，IC50为10μM。
T15458	H2DCFDA 2',7'-二氯荧光素二乙酸酯,2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	H2DCFDA (DCFH-DA) 属于绿色荧光染料，是一种检测细胞内活性氧 (ROS) 的探针 (Ex/Em=488/525 nm)，具有细胞膜渗透性。

化合物

Cat.No: TP1344

Target: Others

Cat.No: T16951

Target: Reactive Oxygen Species

Cat.No: T5426

Target: Reactive Oxygen Species, ROS

Cat.No: T1710

Target: Apoptosis, Antioxidant, Ferroptosis, Reactive Oxygen Species

Cat.No: T32648

Synonym: Leptophos OA,Leptophos oxygen analog,Phosvel oxon,Velsicol VCS O-analog

Target: Others

Cat.No: T9045

Target: Others

Cat.No: T3952

Synonym: TPEDA

Target: Apoptosis, Reactive Oxygen Species, Autophagy

Cat.No: T15030

Target: Others

Cat.No: T5116

Target: Others, Reactive Oxygen Species, Antifungal

Cat.No: T3496

Synonym: 噻嗪酮,NNI 750,Applaud,Buprofezine

Target: Reactive Oxygen Species

Cat.No: T19428

Target: Reactive Oxygen Species, Mitochondrial Metabolism

Cat.No: T5966

Synonym: 己唑醇,(-)-Hexaconazol

Target: Reactive Oxygen Species, Antifungal

1,3-Diphenylisobenzofuran

Cat.No: TD0102

Synonym: DPBF

Target: Others

N-acetylcysteine amide

Cat.No: T5518

Target: Reactive Oxygen Species, ROS

Cat.No: T4168

Synonym: SKQ1

Target: Reactive Oxygen Species

Cat.No: T8370

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Reactive Oxygen Species

Cat.No: T7703

Target: Reactive Oxygen Species, p53

Cat.No: T15433

Target: Apoptosis, Reactive Oxygen Species, ROS, NADPH

N-Acetyl-D-cysteine

Cat.No: T38155

Target: Reactive Oxygen Species

Cat.No: T2090

Synonym: CYT-997

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated

Cat.No: T13189

Target: PDE

Succinyl phosphonate trisodium salt

Cat.No: T13019

Synonym: 琥珀酰膦酸盐

Target: Dehydrogenase, Reactive Oxygen Species, Endogenous Metabolite

Cat.No: T0756

Synonym: Santoquin,Quinol,Santoflex,乙氧基喹啉

Target: HSP, Reactive Oxygen Species

Cat.No: T4287

Synonym: Probucol monosuccinate,AGI-1067

Target: Antioxidant, Reactive Oxygen Species

Cat.No: T17250

Target: ROS, Complement System

Cat.No: T0418

Synonym: 阿利硫脲,N-Allylthiourea,Thiosinamine,烯丙基硫脲

Target: MAO, Reactive Oxygen Species

Cat.No: T8377

Synonym: 甲基磺草酮,硝磺草酮

Target: Reactive Oxygen Species

Cat.No: T38423

Synonym: CL097

Target: Reactive Oxygen Species, TLR

Cat.No: T6699

Synonym: TMPN,Tanol,4-Hydroxy-TEMPO,阻聚剂701

Target: Reactive Oxygen Species, ROS, Autophagy

Heme Oxygenase-1-IN-1

Cat.No: T11580

Synonym: HO-1-IN-1

Target: Reactive Oxygen Species

Cat.No: T0163

Synonym: 尼索地平,BAY-k 5552

Target: Calcium Channel, Reactive Oxygen Species

Cat.No: T8320

Synonym: J-14

Target: Reactive Oxygen Species

Efaproxiral Sodium

Cat.No: T6482

Synonym: 乙丙昔罗钠,RSR13 sodium

Target: Reactive Oxygen Species

Dihydrolipoic acid

Cat.No: T21233

Synonym: Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid,二氢硫辛酸

Target: Antioxidant

Diphenyleneiodonium chloride

Cat.No: T7191

Synonym: 二苯基氯化碘盐,DPI

Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel

Cat.No: T21807

Synonym: Triptycene-1,4-quinone

Target: Others

Cat.No: T4172

Synonym: 1-Methoxyphenazine methosulfate,1-Methoxy PMS

Target: Reactive Oxygen Species

Manganese(salen) chloride

Cat.No: T40612

Synonym: EUK-8

Target: Others

Cat.No: T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat.No: T15213

Synonym: BDTH2,N,N'-二(2-巯基乙基)间苯二甲酰胺

Target: Reactive Oxygen Species

Zofenopril calcium

Cat.No: T5030

Synonym: SQ26991,佐芬普利钙,Zofenopril (calcium)

Target: RAAS, Reactive Oxygen Species

Disufenton sodium

Cat.No: T6201

Synonym: Cerovive,NXY059,OKN007,NXY-059,NXY 059

Target: Reactive Oxygen Species

Sodium 2-oxopropanoate

Cat.No: T7717

Synonym: Sodium pyruvate,丙酮酸钠

Target: Reactive Oxygen Species, Endogenous Metabolite

Cat.No: T2587

Synonym: TA-2711E,TA-2711,伊卡倍特钠

Target: Reactive Oxygen Species, Antibacterial

Mitoquinone mesylate

Cat.No: T12059L

Synonym: MitoQ mesylate,米托蒽醌甲磺酸盐,MitoQ10 mesylate

Target: Reactive Oxygen Species

Cat.No: T21011

Synonym: Buspirone free base,Ansial,丁螺环酮

Target: 5-HT Receptor

Cat.No: T1057

Synonym: TAK-536,阿齐沙坦

Target: RAAS

Cat.No: T50099

Target: Others, HIF/HIF Prolyl-Hydroxylase

Cat.No: T3103

Synonym: DNA Ligase Inhibitor

Target: DNA, DNA/RNA Synthesis

Cat.No: T15458

Synonym: 2',7'-二氯荧光素二乙酸酯,2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA

Target: Reactive Oxygen Species

Cat. No.	Product Name	Target	Signaling Pathways
T3S1692	Octahydrocurcumin	Anti-infection; NF-κB; Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Octahydrocurcumin 是一种姜黄素的氢化衍生物，是姜黄素的代谢物。
TQ0212	Glucoraphanin	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Glucoraphanin 是一种硫代葡萄糖苷，存在于十字花科蔬菜中，是 Nrf2 诱导剂 sulforaphane 的前体，sulforaphane 有抗氧化、抗炎、抗癌作用。
T1716	Echinacoside	Reactive Oxygen Species; Wnt/beta-catenin	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells
	Echinacoside 是一种从Cistanche salsa 中分离的苯乙醇类化合物，抑制Wnt/β-catenin 信号通路。它能够激活 Trk 受体及其下游信号通路而起到神经保护作用，还具有显著的抗骨质疏松作用。
TQ0288	Hexahydrocurcumin	Reactive Oxygen Species; ROS; COX	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Hexahydrocurcumin 是一种选择性口服活性COX-2抑制剂，对 COX-1 无活性，是姜黄素的主要代谢产物之一，。它具有抗氧化，抗癌和抗炎作用。
T2866	Echinocystic acid	Apoptosis; Antioxidant; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Echinocystic acid 是从皂角的果实中提取出来的一种五环三萜，有抗氧化，抗炎症和抗肿瘤作用。
T16747	Riboflavin Tetrabutyrate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Riboflavin Tetrabutyrate 是一种亲脂性黄素衍生物，具有抗氧化和脂质过氧化物去除活性。
TN1403	Arjunolic acid	IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE	Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB
	Arjunolic acid 是分离自蓝莓的皂苷，具有抗氧化、抗菌和抗炎症等多种生物活性，在保护细胞和组织免受活性氧的有害作用中发挥重要作用。
T3399	Psoralidin	Others; Estrogen/progestogen Receptor; Reactive Oxygen Species; Lipoxygenase; Gamma-secretase; Akt; COX; Antibacterial	Cytoskeletal Signaling; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Psoralidin 是COX-2和5-LOX 的抑制剂，有抗癌，抗菌和抗炎作用。它显著下调NOTCH1信号传导，还极大地诱导活化氧产生。
T6S2038	Ziyuglycoside II	Apoptosis; Antioxidant; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Ziyuglycoside II 是从地榆中提取的一种三萜皂苷，可诱导活性氧产生和凋亡，具有抗炎和抗癌作用。
T2818	Methyl Vanillate	Reactive Oxygen Species; Wnt/beta-catenin; Endogenous Metabolite	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells
	Methyl vanillate 是一种枳椇属植物中的提取物，是Wnt/β-catenin 信号通路活化剂，是一种香草酸的甲酯。它具有抗氧化作用。
T9057	norbergenin	IL Receptor; TNF; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Norbergenin 是一种 bergenin 的邻去甲基衍生物，可从白芍的根茎中分离得到，具有中等的抗氧化活性。
T8033	Sodium Thiocyanate	Others; Reactive Oxygen Species; Interleukin	Immunology/Inflammation; Metabolism; NF-κB; Others
	Sodium thiocyanate 能够减少促炎细胞因子 IL-6水平，并增强抗炎细胞因子 IL-10水平，并显著减少 ROS 形成。
TN2167	Rutaevin	Reactive Oxygen Species; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	Rutaevin 从Euodia rutaecarpa 中分离。它对 Raw 264.7 巨噬细胞中 LPS 诱导的NO 产生具有抑制作用。
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
T10668	Camalexin	Reactive Oxygen Species; ROS; Antibacterial; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Camalexin 是从Camelina sativa 和Arabidopsis 中分离出来的一种植物抗毒素，可诱导活性氧的产生，具有抗菌、抗真菌、抗增殖和抗癌活性。
TN1674	Garcinone D 伽升沃 D	Reactive Oxygen Species; Nrf2; STAT	Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Stem Cells
	Garcinone D 是来自山竹的一种呫吨酮，可促进 C17.2 神经干细胞的增殖。它以浓度和时间依赖的方式增加磷酸化信号转导和转录激活因子 3 (p-STAT3)、Cyclin D1 和核因子红细胞 2 相关因子 (Nrf2)、以及血红素加氧酶-1 (HO-1) 的蛋白质水平。
TN1058	Pelargonidin chloride	NOS; Reactive Oxygen Species; Nrf2; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	Pelargonidin chloride 是一种氧化氮自由基的清除剂，具有抗氧化作用。
TN6735	Bigelovin	Apoptosis; Reactive Oxygen Species; Retinoid Receptor; Autophagy; RAR/RXR	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Bigelovin 是从海百合中分离得到的一种倍半萜内酯，是选择性视黄素 X 受体 α 激动剂。它通过抑制ROS 的生成来调节 mTOR 信号通路。它诱导凋亡和自噬，有抗肿瘤活性。
T36735	3,5-Di-tert-butylphenol	Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	3,5-Di-tert-butylphenol 诱导活性氧物质的积累。 3,5-Di-tert-butylphenol 具有抗生物膜和抗真菌活性。
T8347	Rifamycin S	Reactive Oxygen Species; ROS; Antibacterial; Antibiotic	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Rifamycin S 是一种 DNA 依赖性 RNA 聚合酶抑制剂，是一种醌和一种针对革兰氏阳性细菌的抗生素试剂。它是涉及两个电子的可逆氧化还原系统的氧化形式。它能产生活性氧并抑制微粒体脂质过氧化，可研究肺结核和麻风病。
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
TN5634	Aureusidin Auresudidin,金鱼草素,Auresidin	Antioxidant; Reactive Oxygen Species; Lipoxygenase	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Aureusidin (Auresidin) 具有抗氧化和脂氧合酶抑制活性，具有抗炎作用。
T4902	Isotrifoliin Isoquercetin,Isoquercitroside,槲皮素-3-氧葡萄糖甙	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Isotrifoliin (Isoquercitroside) 是一种抗氧化剂，也是一种嗜酸性炎症抑制剂。
T0465	Ellagic acid 鞣花酸,Gallogen,Elagostasine	Hedgehog/Smoothened; Casein Kinase; Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; PKA; Syk; PKC; Carbonic Anhydrase	Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Ellagic acid (Gallogen) 是从 Eucalyptus maculata Hook 和 E. Hemipholia F. Muell 的 kino 中分离出来的稠合四环天然产物，是一种有效的，ATP 竞争性的CK2抑制剂，IC50和Ki 值分别为 40 nM 和 20 nM。
T2174	Quercetin 槲皮素,Sophoretin	Apoptosis; Mitophagy; Reactive Oxygen Species; PI3K; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Quercetin 属于黄酮类天然产物，是 SIRT1 的激动剂；Quercetin 也是一种 PI3K 抑制剂，抑制 PI3Kγ、PI3Kδ 和 PI3Kβ (IC50=2.4/3.0/5.4 μM)。Quercetin 作为公认的热休克蛋白抑制剂，也可通过下调Hsp70或Hsp90来显著减少TII模型中的外泌体释放。
T8306	Epiberberine chloride	Antioxidant; BACE; AChR; AChE	Neuroscience; oxidation-reduction
	Epiberberine chloride 是一种来自Coptis chinensis Franch.的天然原小檗碱，是 AChE、 BChE 和 BACE1 抑制剂，IC50 值分别为 1.07，6.03 和 8.55 μM。Epiberberine chloride 具有抗氧化作用，抑制Ca9-22和FaDu细胞系的运动，可用于研究高脂血症、阿尔滋海默症和糖尿病。
T3861	Isobavachalcone Corylifolinin,Isobacachalcone,补骨脂乙素	Apoptosis; Others; Reactive Oxygen Species; Akt; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Others; PI3K/Akt/mTOR signaling
	Isobavachalcone (Corylifolinin) 是来源于补骨脂的一种Akt 信号通路抑制剂，可诱导人类癌细胞凋亡，以IC50值为 7.92 μM 抑制 OVCAR-8 癌细胞生长，具有抗癌和抗增殖活性。它还能诱导 OVCAR-8 细胞中活性氧的产生。
T2864	Lycopene 番茄红素,ψ,ψ-Carotene	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	Lycopene (ψ,ψ-Carotene) 是一种番茄及其产品和其他红色水果和蔬菜中天然存在的类胡萝卜素，具有抗氧化活性。
T2834	Nobiletin Hexamethoxyflavone,川陈皮素,川皮苷	Apoptosis; MMP; Reactive Oxygen Species; ROR; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Nobiletin (Hexamethoxyflavone) 是一种来自柑橘皮的聚甲氧基黄酮，是RORs 激动剂，可改善记忆力丧失。它可降低分化的 C2C12 肌管中的ROS 水平，并具有抗炎，抗癌，抗血管生成，抗增殖，抗转移和诱导细胞凋亡作用。
TN1651	Furanodiene	Apoptosis; PARP; Reactive Oxygen Species; Caspase; CDK; P-gp	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Proteases/Proteasome
	Furanodiene 是从姜黄中提取的一种萜类天然产物，可抑制外排转运蛋白Pgp 功能并降低 Pgp 蛋白水平。它通过抗血管生成和诱导ROS 产生，DNA 链断裂和细胞凋亡发挥抗癌作用。
T6S1653	Albiflorin Alibiflorin,芍药内酯苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分，是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。
T4518	Licochalcone D	ERK; NF-κB	MAPK; NF-κB
	Licochalcone D 是一种 NF-κB p65的有效抑制剂，是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物，具有抗氧化、抗炎、抗癌等作用。
T6947	Piperlongumine PPLGM,荜茇酰胺,Piplartine	Apoptosis; ERK; Ferroptosis; Reactive Oxygen Species; ROS; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology; NF-κB
	Piperlongumine (Piplartine) 属于生物碱类天然产物，具有抗肿瘤、抗炎、抗氧化、抗血管生成等生物活性。Piperlongumine 可以增强 ROS 水平，诱导肿瘤细胞凋亡。
T3429	Protopine 原阿片碱,Macleyine,Hypercorine,Corydinine,Biflorine,Fumarine	Reactive Oxygen Species; Platelet aggregation; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; Others
	Protopine (Fumarine) 是一种常存在于亚洲东北部的一些植物中的异喹啉类生物碱，常用于抗肿瘤、抗炎活性的研究。
T3240	Citronellol dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Citronellol ((±)-β-Citronellol) 是一种单萜类化合物，从头状天竺葵中分离到。它可通过上调 TNF-α，RIP1/RIP3 的活性，下调 caspase-3/caspase-8 的活性，以及增加活性氧 (ROS) 的聚集来诱导肿瘤细胞的坏死性凋亡。
T8072	S-Methyl-L-cysteine S-甲基-L-半胱氨酸,S-Methylcysteine	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	S-Methyl-L-cysteine (S-Methylcysteine) 是一种催化抗氧化系统中甲硫氨酸硫氧化物还原酶 A 的作用底物，是一种天然产物，具有抗氧化、神经保护及减肥的功效。
T3744	Veratric acid Veratrumenoic acid,藜芦酸,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species; COX	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Veratric acid (3,4-Dimethoxybenzoic acid) 是从蔬菜和水果中得到的一种可口服多酚，具有抗氧化、保护心血管和抗炎活性。当细胞受到 UVB 辐射时，它能够减少上调的 COX-2 表达，降低 PGE2 和 IL-6 水平。
T41358	2-Hydroxybenzylamine	Others	Others
	2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂，可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。
T0480	Doxofylline Doxophylline,多索茶碱	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Doxofylline (Doxophylline) 是腺苷 A1 受体拮抗剂，且能抑制磷酸二酯酶 IV，用于治疗哮喘。
T7781	Reynoutrin Reinutrin,Quercetin-3-D-xyloside,槲皮素-3-D-木糖甙	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Reynoutrin (Reinutrin) 是一种黄酮类化合物，从草莓番石榴中得到，具有抗氧化清除自由基的活性。
TN1141	Isodeoxyelephantopin 异去氧苦地胆素,异去氧苦地胆苦素	NF-κB; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Isodeoxyelephantopin 是从地胆草中分离得到的一种倍半萜烯内酯，能调节 LncRNA 的表达，有抗乳腺癌的作用。它可诱导活性氧的生成，抑制 NF-κB 的激活。
T2796	Coenzyme Q10 Ubiquinone-10,辅酶Q10,CoQ10	Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Coenzyme Q10 (CoQ10)是来自藤仓赤霉菌的一种天然产物，在线粒体呼吸链中充当电子载体。
T5852	Canthaxanthin all-trans-Canthaxanthin,E 161g,角黄素,斑蝥黄	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Canthaxanthin (E 161g) 是具有多种生物活性的红橙色类胡萝卜素，如抗氧化、抗肿瘤活性。它属于叶黄素组，是存在于细菌、藻类和一些真菌中的天然色素。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T1660	Silibinin 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Silibinin (Silybin) 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。
T6S1367	Procyanidin B2 原花青素 B2,Proanthocyanidin B2	Reactive Oxygen Species; NOD	Immunology/Inflammation; Metabolism; NF-κB
	Procyanidin B2 (Proanthocyanidin B2) 是天然黄酮类物质，具有抗肿瘤，抗氧化等活性。
T3785	11-oxo-mogroside V 11-oxo Mogroside V,11-氧罗汉果苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	11-oxo-mogroside V (11-oxo Mogroside V) 是一种天然甜味剂，具有显著的抗氧化作用。它对活性氧物质具有显著的抑制作用，作用于O2-，H2O2和*OH，EC50分别为 4.79，16.52 和 146.17 μg/mL。
T0928	L-Ascorbic acid 维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate	Apoptosis; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	L-Ascorbic acid (Vitamin C) 属于天然产物，是一种强效的还原剂和抗氧化剂。L-Ascorbic acid 具有抗细菌感染、解毒反应和胶原蛋白形成的作用。L-Ascorbic acid 被用于治疗坏血病。
T5A2461	Bufotalin 蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵	Apoptosis; Others; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Others
	Bufotalin (Bufotaline) 是一种从蟾酥中分离的类固醇内酯，可诱导癌细胞凋亡，也诱导内质网应激的激活，具有强大的抗肿瘤活性。
T1717	alpha-Mangostin α-倒捻子素,α-Mangostin,Mangostin	Apoptosis; Virus Protease; Dehydrogenase; Reactive Oxygen Species; Antibacterial; Antifungal	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	alpha-Mangostin (Mangostin) 是有多种生物活性的膳食呫吨酮。它是一种IDH1突变体的抑制剂，Ki 值为 2.85 μM。
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天然产物

Octahydrocurcumin

Cat.No: T3S1692

Target: Anti-infection, NF-κB, Reactive Oxygen Species, ROS

Cat.No: TQ0212

Target: Antioxidant, Reactive Oxygen Species

Cat.No: T1716

Target: Reactive Oxygen Species, Wnt/beta-catenin

Hexahydrocurcumin

Cat.No: TQ0288

Target: Reactive Oxygen Species, ROS, COX

Echinocystic acid

Cat.No: T2866

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Riboflavin Tetrabutyrate

Cat.No: T16747

Target: Reactive Oxygen Species

Cat.No: TN1403

Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE

Cat.No: T3399

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Ziyuglycoside II

Cat.No: T6S2038

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Methyl Vanillate

Cat.No: T2818

Target: Reactive Oxygen Species, Wnt/beta-catenin, Endogenous Metabolite

Cat.No: T9057

Target: IL Receptor, TNF, Reactive Oxygen Species

Sodium Thiocyanate

Cat.No: T8033

Target: Others, Reactive Oxygen Species, Interleukin

Cat.No: TN2167

Target: Reactive Oxygen Species, NO Synthase

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

Cat.No: T10668

Target: Reactive Oxygen Species, ROS, Antibacterial, Antifungal

Cat.No: TN1674

Synonym: 伽升沃 D

Target: Reactive Oxygen Species, Nrf2, STAT

Pelargonidin chloride

Cat.No: TN1058

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Cat.No: TN6735

Target: Apoptosis, Reactive Oxygen Species, Retinoid Receptor, Autophagy, RAR/RXR

3,5-Di-tert-butylphenol

Cat.No: T36735

Target: Reactive Oxygen Species, Antifungal

Cat.No: T8347

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Cat.No: TN5634

Synonym: Auresudidin,金鱼草素,Auresidin

Target: Antioxidant, Reactive Oxygen Species, Lipoxygenase

Cat.No: T4902

Synonym: Isoquercetin,Isoquercitroside,槲皮素-3-氧葡萄糖甙

Target: Reactive Oxygen Species

Cat.No: T0465

Synonym: 鞣花酸,Gallogen,Elagostasine

Target: Hedgehog/Smoothened, Casein Kinase, Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, PKA, Syk, PKC, Carbonic Anhydrase

Cat.No: T2174

Synonym: 槲皮素,Sophoretin

Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy

Epiberberine chloride

Cat.No: T8306

Target: Antioxidant, BACE, AChR, AChE

Isobavachalcone

Cat.No: T3861

Synonym: Corylifolinin,Isobacachalcone,补骨脂乙素

Target: Apoptosis, Others, Reactive Oxygen Species, Akt, Autophagy

Cat.No: T2864

Synonym: 番茄红素,ψ,ψ-Carotene

Target: Reactive Oxygen Species, ROS

Cat.No: T2834

Synonym: Hexamethoxyflavone,川陈皮素,川皮苷

Target: Apoptosis, MMP, Reactive Oxygen Species, ROR, Autophagy

Cat.No: TN1651

Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp

Cat.No: T6S1653

Synonym: Alibiflorin,芍药内酯苷

Target: Reactive Oxygen Species

Cat.No: T4518

Target: ERK, NF-κB

Cat.No: T6947

Synonym: PPLGM,荜茇酰胺,Piplartine

Target: Apoptosis, ERK, Ferroptosis, Reactive Oxygen Species, ROS, Antibacterial, Autophagy

Cat.No: T3429

Synonym: 原阿片碱,Macleyine,Hypercorine,Corydinine,Biflorine,Fumarine

Target: Reactive Oxygen Species, Platelet aggregation, Histamine Receptor

Cat.No: T3240

Synonym: dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol

Target: Reactive Oxygen Species

S-Methyl-L-cysteine

Cat.No: T8072

Synonym: S-甲基-L-半胱氨酸,S-Methylcysteine

Target: Antioxidant, Reactive Oxygen Species

Cat.No: T3744

Synonym: Veratrumenoic acid,藜芦酸,3,4-Dimethoxybenzoic acid

Target: Reactive Oxygen Species, COX

2-Hydroxybenzylamine

Cat.No: T41358

Target: Others

Cat.No: T0480

Synonym: Doxophylline,多索茶碱

Target: PDE, Adenosine Receptor

Cat.No: T7781

Synonym: Reinutrin,Quercetin-3-D-xyloside,槲皮素-3-D-木糖甙

Target: Reactive Oxygen Species

Isodeoxyelephantopin

Cat.No: TN1141

Synonym: 异去氧苦地胆素,异去氧苦地胆苦素

Target: NF-κB, Reactive Oxygen Species, Autophagy

Cat.No: T2796

Synonym: Ubiquinone-10,辅酶Q10,CoQ10

Target: Ferroptosis, Reactive Oxygen Species, Endogenous Metabolite

Cat.No: T5852

Synonym: all-trans-Canthaxanthin,E 161g,角黄素,斑蝥黄

Target: Reactive Oxygen Species

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Cat.No: T1660

Synonym: 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I

Target: Reactive Oxygen Species, Autophagy

Cat.No: T6S1367

Synonym: 原花青素 B2,Proanthocyanidin B2

Target: Reactive Oxygen Species, NOD

11-oxo-mogroside V

Cat.No: T3785

Synonym: 11-oxo Mogroside V,11-氧罗汉果苷

Target: Reactive Oxygen Species

L-Ascorbic acid

Cat.No: T0928

Synonym: 维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite

Cat.No: T5A2461

Synonym: 蟾蜍他灵,Bufotaline,蟾毒它灵,蟾蜍他灵

Target: Apoptosis, Others, Reactive Oxygen Species

alpha-Mangostin

Cat.No: T1717

Synonym: α-倒捻子素,α-Mangostin,Mangostin

Target: Apoptosis, Virus Protease, Dehydrogenase, Reactive Oxygen Species, Antibacterial, Antifungal

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02875	ROMO1 Protein, Mouse, Recombinant (His) Protein MGR2 homolog,Romo1,Reactive oxygen species ...	Mouse	E. coli
	Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
TMPH-02803	NRROS Protein, Mouse, Recombinant (His) Negative regulator of reactive oxygen species,Trans...	Mouse	E. coli
	Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 acti...
TMPH-02230	NRROS Protein, Human, Recombinant (His & Myc) Leucine-rich repeat-containing protein 33,Negative regulator...	Human	Baculovirus Insect Cells
	NRROS Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 73.5 kDa and the accession number is Q86YC3.
TMPH-02231	NRROS Protein, Human, Recombinant (E. coli, His & Myc) Transforming growth factor beta activator LRRC33,Leucine-ric...	Human	E. coli
	NRROS Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 74.5 kDa and the accession number is Q86YC3.
TMPY-03553	15 Lipoxygenase 2 Protein, Human, Recombinant arachidonate 15-lipoxygenase, type B,ALOX15B,15-LOX...	Human	Baculovirus Insect Cells
	15 Lipoxygenase 2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 76 kDa and the accession number is AAH35217.1.
TMPH-00026	Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His) Equinatoxin-2,EqTII,DELTA-AITX-Aeq1a,Equinatoxin II,DELTA-ac...	Actinia equina	E. coli
	Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.9 kDa and the accession number is P61914.
TMPY-03462	15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST) ALOX15B,arachidonate 15-lipoxygenase, type B,15-LOX...	Human	Baculovirus Insect Cells
	15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 103.7 kDa and the accession number is AAH35217.1.
TMPY-02481	ACOX1 Protein, Human, Recombinant (His) PALMCOX,ACOX,SCOX,acyl-CoA oxidase 1, palmitoyl	Human	Baculovirus Insect Cells
	Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a...
TMPJ-00753	Myoglobin Protein, Human, Recombinant (His) MGC13548,PVALB,MB,Myoglobin	Human	E. coli
	Myoglobin(MB) is a cytoplasmic protein expressed in myocytes of the heart and skeletal muscle that reversibly binds oxygen. It belongs to the globin family. Functions of myoglobin include oxygen storage and transport, as well as scavenging of NO and reactive oxygen species. MB serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Myoglobin also serves as a sensitive marker for muscle injury resulting from cardiac infarction. Surprisingly, mice in which myogl...
TMPH-01318	SOD3 Protein, Human, Recombinant SOD3,Extracellular superoxide dismutase [Cu-Zn]	Human	E. coli
	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. SOD3 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24.1 kDa and the accession number is P08294.
TMPH-02795	Myoglobin Protein, Mouse, Recombinant (His & Myc) Mb,Nitrite reductase MB,Myoglobin,Pseudoperoxidase MB	Mouse	HEK293 Cells
	Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Myoglobin Protein, Mouse, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 21.9 kDa and the accession number is P04247.
TMPH-01317	SOD3 Protein, Human, Recombinant (His) SOD3,Extracellular superoxide dismutase [Cu-Zn]	Human	E. coli
	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. SOD3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.1 kDa and the accession number is P08294.
TMPH-00772	Leghemoglobin C2 Protein, Glycine max, Recombinant (His) Leghemoglobin C2	Glycine max	E. coli
	Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation.
TMPJ-01248	Cytoglobin/CYGB Protein, Human, Recombinant (His) Stellate Cell Activation-Associated Protein,Cytoglobin,CYGB,...	Human	E. coli
	Cytoglobin is a ubiquitously globin protein that belongs to the globin family. The highest expressed in heart, stomach, bladder and small intestine. CYGB acts a protector under conditions of oxidative stress. CYGB may be involved in intracellular oxygen storage or transfer, modulates oxygen and nitric oxide metabolism or scavenging free radicals within a cell.
TMPH-02618	CYP2E1 Protein, Mouse, Recombinant (His) Cyp2e1,Cytochrome P450 2E1,Cytochrome P450-J,4-nitrophenol 2...	Mouse	E. coli
	A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be invo...
TMPH-03275	Cytoglobin Protein, Rat, Recombinant (His & Myc) Stellate cell activation-associated protein,Stap,CYGB,Cytogl...	Rat	E. coli
	May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Plays a role in the development of liver fibrosis. Has a peroxidase activity.
TMPH-02140	CYP21A2 Protein, Human, Recombinant (E. coli, His) Cytochrome P-450c21,Cytochrome P450-C21B,CYP21,21-OHase,Cyto...	Human	E. coli
	A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via...
TMPH-00396	TrhO Protein, Chlamydophila felis, Recombinant (His) trhO,tRNA uridine(34) hydroxylase,tRNA hydroxylation protein...	Chlamydia felis	E. coli
	Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. TrhO Protein, Chlamydophila felis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 43.6 kDa and the accession number is Q252M0.
TMPH-03134	Leghemoglobin Lb120-8 Protein, Pisum sativum, Recombinant (His) Leghemoglobin Lb120-8	Pisum sativum	E. coli
	Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation. Leghemoglobin Lb120-8 Protein, Pisum sativum, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.9 kDa and the accession number is Q9SAZ1.
TMPH-02141	CYP21A2 Protein, Human, Recombinant (His) Cytochrome P450 21,CYP21A2,Cytochrome P450-C21B,Cytochrome P...	Human	P. pastoris (Yeast)
	A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via...
TMPH-02198	TXNRD2 Protein, Human, Recombinant (His & SUMO) TR-beta,Thioredoxin reductase 2, mitochondrial,Thioredoxin r...	Human	E. coli
	Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
TMPJ-00800	BPGM Protein, Human, Recombinant (His) 3-Diphosphoglycerate Mutase,2,DPGM,Bisphosphoglycerate Mutas...	Human	E. coli
	Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Deficiency of BPGM increases the affinity of cells...
TMPH-00575	GlpD Protein, E. coli, Recombinant (His) glpD,Aerobic glycerol-3-phosphate dehydrogenase	E. coli	E. coli
	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor. GlpD Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 60.8 kDa and the accession number is P13035.
TMPH-03092	Leghemoglobin A Protein, Phaseolus vulgaris, Recombinant (His & Myc) Leghemoglobin A	Phaseolus vulgaris	E. coli
	Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation. Leghemoglobin A Protein, Phaseolus vulgaris, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 22.9 kDa and the accession number is P02234.
TMPH-01434	Hemoglobin subunit delta/HBD Protein, Human, Recombinant (GST & His) HBD,Hemoglobin delta chain,Hemoglobin subunit delta,Delta-gl...	Human	E. coli
	Involved in oxygen transport from the lung to the various peripheral tissues. Hemoglobin subunit delta/HBD Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 47.5 kDa and the accession number is P02042.
TMPJ-01274	ERO1L Protein, Human, Recombinant (His) ERO1-L-Alpha,ERO1-L-α,Oxidoreductin-1-L-α,Endoplasmic Oxidor...	Human	HEK293 Cells
	ERO1-Like Protein α (ERO1L) is an enzyme that belongs to the EROs family. ERO1L is expressed at high level in esophagus and upper digestive tract. ERO1L is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. ERO1L acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It associates with ERP44, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. It...
TMPH-02617	COX5A Protein, Mouse, Recombinant (His & SUMO) Cytochrome c oxidase subunit 5A, mitochondrial,COX5A,Cytochr...	Mouse	E. coli
	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over t...
TMPH-02233	P4HTM Protein, Human, Recombinant (His & SUMO) Transmembrane prolyl 4-hydroxylase,P4HTM,Hypoxia-inducible f...	Human	E. coli
	Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
TMPH-01280	EGLN1 Protein, Human, Recombinant (His & Myc) HPH-2,EGLN1,PHD2,SM-20,HIF-prolyl hydroxylase 2,HIF-PH2,C1or...	Human	E. coli
	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquiti...
TMPH-02106	SH3PXD2A Protein, Human, Recombinant (His & Myc) SH3PXD2A,SH3 multiple domains protein 1,SH3 and PX domain-co...	Human	E. coli
	Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
TMPH-00099	NDK1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) Nucleoside diphosphate kinase 1,NDK1,Nucleoside diphosphate ...	Arabidopsis thaliana	P. pastoris (Yeast)
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Plays a role in response to reactive oxygen species (ROS) stress. NDK1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in yeast with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P39207.
TMPH-02139	CYP17A1 Protein, Human, Recombinant (GST) Cytochrome P450 17A1,CYPXVII,CYP17A1,CYP17,S17AH,Cytochrome ...	Human	E. coli
	A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, follow...
TMPH-02104	Sestrin-3/SESN3 Protein, Human, Recombinant (His & Myc) Sestrin-3,SESN3	Human	E. coli
	May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.
TMPY-02044	SOD2 Protein, Human, Recombinant superoxide dismutase 2, mitochondrial,IPOB,MNSOD,MVCD6	Human	E. coli
	Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. Mitochondrial superoxide dismutase [SOD; manganese SOD (MnSOD) or SOD2] neutralizes highly reactive superoxide radical (O•-2), the first member in the plethora of mitochondrial reactive oxygen species.
TMPK-00493	OSMR Protein, Cynomolgus, Recombinant (His) OSMR,IL-31R-β,PLCA1,IL-31RB,OSMRBMGC150626,IL-31R subunit β,...	Cynomolgus	HEK293 Cells
	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death. OSMR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted ...
TMPJ-00105	SOD2 Protein, Human, Recombinant (His) Superoxide Dismutase [Mn] Mitochondrial,SOD2	Human	HEK293 Cells
	Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. It is reported that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential ...
TMPY-01577	ORP150 Protein, Human, Recombinant (His) hypoxia up-regulated 1,HSP12A,Grp170,ORP-150,ORP150,GRP-170	Human	HEK293 Cells
	Hypoxia up-regulated protein 1, also known as 15 kDa oxygen-regulated protein, 17 kDa glucose-regulated protein, ORP-15, GRP-17, and HYOU1, is a member of the heat shock protein 7 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP15), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP6), and several isoforms of the two testis-specific HSP7 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic re...
TMPH-03751	CYBB Protein, Human, Recombinant (His) NADPH oxidase 2,Heme-binding membrane glycoprotein gp91phox,...	Human	E. coli
	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
TMPK-00571	OSMR Protein, Canine, Recombinant (His) OSMRB,IL-31R-β,OSMR,OSMRBMGC150626,OSMR β,IL-31R subunit β,I...	Canine	HEK293 Cells
	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death. OSMR Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted mole...
TMPJ-00946	TALDO1 Protein, Human, Recombinant (His) Transaldolase,TALDO1,TAL,TALDOR,TALDO	Human	HEK293 Cells
	Transaldolase (TALDO1) belongs to the transaldolase family of Type 1 subfamily. TALDO1 is expressed selectively in oligodendrocytes of the brain. TALDO1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. TALDO1 deficiency results in telangiectases of the sk...
TMPY-02271	TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His) thioredoxin reductase 1,TR1,TXNR,TR,TRXR1,GRIM-12	Human	E. coli
	Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor th...
TMPJ-00797	LDHB Protein, Human, Recombinant (His) LDH-B,Renal Carcinoma Antigen NY-REN-46,LDH-H,LDH Heart Subu...	Human	E. coli
	L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver....
TMPH-01080	Ceruloplasmin Protein, Human, Recombinant (His & Myc) CP,Ceruloplasmin,Ferroxidase ceruloplasmin,Cuproxidase cerul...	Human	E. coli
	Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Ceruloplasmin Protein, Human, Recombinant (His & Myc) is expressed in E. co...
TMPH-01512	HIF1AN Protein, Human, Recombinant (His) Hypoxia-inducible factor asparagine hydroxylase,Hypoxia-indu...	Human	P. pastoris (Yeast)
	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and severa...
TMPJ-00104	SOD2 Protein, Human, Recombinant (E. coli, His) SOD2,Superoxide Dismutase [Mn] Mitochondrial	Human	E. coli
	Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6), idiopathic cardiomyopathy (IDC), sporadic motor neuron dis...
TMPJ-00931	Serpin A4 Protein, Human, Recombinant (His) Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein Inhibitor,S...	Human	HEK293 Cells
	Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition,...
TMPJ-00933	PRDX5 Protein, Human, Recombinant (His) Antioxidant enzyme B166,Alu corepressor 1,Peroxiredoxin-5,PL...	Human	HEK293 Cells
	Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Peroxiredoxins is overexpressed in breast cancer tissues to a great extent suggesting that they has a proliferative effect and may be related to cancer development or progression. Peroxiredoxin 5 (PRDX5) is a thioredoxin peroxidase that belongs to the atypical 2-Cys class of the TSA/a...
TMPJ-00848	NCF1 Protein, Human, Recombinant (His) Nox-organizing protein 2/SH3 and PX domain-containing protei...	Human	E. coli
	Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and ...
TMPJ-00830	UROIIIS Protein, Human, Recombinant (His) Hydroxymethylbilane Hydrolyase [Cyclizing],Uroporphyrinogen-...	Human	E. coli
	Uroporphyrinogen-III Synthase is an enzyme which belongs to the uroporphyrinogen-III synthase family. Uroporphyrinogen-III Synthase is ubiquitous and it is involved in Porphyrin metabolism. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as Methionine synthesis (Vitamin B12) or oxygen transport (Heme). Uroporphyrinogen-III Synthase can catalyze cyclization of the linear Tetrapyrrole, Hydroxymethylbilane, to the Macrocyclic Uroporphy...
TMPY-03511	COX5B Protein, Human, Recombinant (His) COXVB,cytochrome c oxidase subunit Vb	Human	E. coli
	Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nucl...
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重组蛋白

ROMO1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02875

Species: Mouse

Expression System: E. coli

NRROS Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02803

Species: Mouse

Expression System: E. coli

NRROS Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02230

Species: Human

Expression System: Baculovirus Insect Cells

NRROS Protein, Human, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-02231

Species: Human

Expression System: E. coli

15 Lipoxygenase 2 Protein, Human, Recombinant

Cat.No: TMPY-03553

Species: Human

Expression System: Baculovirus Insect Cells

Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His)

Cat.No: TMPH-00026

Species: Actinia equina

Expression System: E. coli

15 Lipoxygenase 2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03462

Species: Human

Expression System: Baculovirus Insect Cells

ACOX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02481

Species: Human

Expression System: Baculovirus Insect Cells

Myoglobin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00753

Species: Human

Expression System: E. coli

SOD3 Protein, Human, Recombinant

Cat.No: TMPH-01318

Species: Human

Expression System: E. coli

Myoglobin Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02795

Species: Mouse

Expression System: HEK293 Cells

SOD3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01317

Species: Human

Expression System: E. coli

Leghemoglobin C2 Protein, Glycine max, Recombinant (His)

Cat.No: TMPH-00772

Species: Glycine max

Expression System: E. coli

Cytoglobin/CYGB Protein, Human, Recombinant (His)

Cat.No: TMPJ-01248

Species: Human

Expression System: E. coli

CYP2E1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02618

Species: Mouse

Expression System: E. coli

Cytoglobin Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03275

Species: Rat

Expression System: E. coli

CYP21A2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02140

Species: Human

Expression System: E. coli

TrhO Protein, Chlamydophila felis, Recombinant (His)

Cat.No: TMPH-00396

Species: Chlamydia felis

Expression System: E. coli

Leghemoglobin Lb120-8 Protein, Pisum sativum, Recombinant (His)

Cat.No: TMPH-03134

Species: Pisum sativum

Expression System: E. coli

CYP21A2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02141

Species: Human

Expression System: P. pastoris (Yeast)

TXNRD2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02198

Species: Human

Expression System: E. coli

BPGM Protein, Human, Recombinant (His)

Cat.No: TMPJ-00800

Species: Human

Expression System: E. coli

GlpD Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00575

Species: E. coli

Expression System: E. coli

Leghemoglobin A Protein, Phaseolus vulgaris, Recombinant (His & Myc)

Cat.No: TMPH-03092

Species: Phaseolus vulgaris

Expression System: E. coli

Hemoglobin subunit delta/HBD Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01434

Species: Human

Expression System: E. coli

ERO1L Protein, Human, Recombinant (His)

Cat.No: TMPJ-01274

Species: Human

Expression System: HEK293 Cells

COX5A Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02617

Species: Mouse

Expression System: E. coli

P4HTM Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02233

Species: Human

Expression System: E. coli

EGLN1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01280

Species: Human

Expression System: E. coli

SH3PXD2A Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02106

Species: Human

Expression System: E. coli

NDK1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

Cat.No: TMPH-00099

Species: Arabidopsis thaliana

Expression System: P. pastoris (Yeast)

CYP17A1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02139

Species: Human

Expression System: E. coli

Sestrin-3/SESN3 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02104

Species: Human

Expression System: E. coli

SOD2 Protein, Human, Recombinant

Cat.No: TMPY-02044

Species: Human

Expression System: E. coli

OSMR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00493

Species: Cynomolgus

Expression System: HEK293 Cells

SOD2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00105

Species: Human

Expression System: HEK293 Cells

ORP150 Protein, Human, Recombinant (His)

Cat.No: TMPY-01577

Species: Human

Expression System: HEK293 Cells

CYBB Protein, Human, Recombinant (His)

Cat.No: TMPH-03751

Species: Human

Expression System: E. coli

OSMR Protein, Canine, Recombinant (His)

Cat.No: TMPK-00571

Species: Canine

Expression System: HEK293 Cells

TALDO1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00946

Species: Human

Expression System: HEK293 Cells

TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)

Cat.No: TMPY-02271

Species: Human

Expression System: E. coli

LDHB Protein, Human, Recombinant (His)

Cat.No: TMPJ-00797

Species: Human

Expression System: E. coli

Ceruloplasmin Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01080

Species: Human

Expression System: E. coli

HIF1AN Protein, Human, Recombinant (His)

Cat.No: TMPH-01512

Species: Human

Expression System: P. pastoris (Yeast)

SOD2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-00104

Species: Human

Expression System: E. coli

Serpin A4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00931

Species: Human

Expression System: HEK293 Cells

PRDX5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00933

Species: Human

Expression System: HEK293 Cells

NCF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00848

Species: Human

Expression System: E. coli

UROIIIS Protein, Human, Recombinant (His)

Cat.No: TMPJ-00830

Species: Human

Expression System: E. coli

COX5B Protein, Human, Recombinant (His)

Cat.No: TMPY-03511

Species: Human

Expression System: E. coli

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Cat. No.	Product Name	Target	Signaling Pathways
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re...
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....

同位素标记化合物

Methazolamide-d6

Cat.No: T70186

Cat.No: T71328

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