802
1000+
6
21
23
Cat. No. | Product Name | ||
---|---|---|---|
L3200 | 自噬库 | 1248 compounds | |
1248 种细胞自噬相关的生物活性小分子化合物的特有集合,用于自噬相关的研究,用于高通量、高内涵筛选; | |||
L6001 | Mini真菌代谢天然产物筛选库 | Inquiry | |
L6150 | 天然产物共价化合物库 | 583 compounds | |
提供产品的生物学信息和药物学信息,为筛选提供理论方向和研究基础; | |||
L4600 | 植物来源化合物库 | 3048 compounds | |
3048 个植物来源天然产物的独特集合,来自277类植物的精心之选; | |||
L6620 | 抗寄生虫天然产物库 | 253 compounds | |
253 个抗寄生虫相关的天然产物集合,是药物开发、药理研究的有效工具; | |||
L6400 | 海洋天然产物库 | 144 compounds | |
144 种海洋来源的单体化合物,是药物开发、药理研究等领域的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14326 |
AS-35
|
Leukotriene Receptor | GPCR/G Protein |
AS-35 是一种可口服且具有选择性和高效性的 leukotrienes 拮抗剂,抑制 LTC4,LTD4 和 LTE4 诱导的回肠收缩。AS-35 具有抗过敏作用,抑制白三烯合成。 | |||
T60097 |
Methyl (E)-sinapate
|
Others | Others |
methyl (E)-sinapate 从 Polygala sibirica L.var. megalopha Fr 中分离得到。 | |||
T30503 |
BMS-195270
UNII-20UM0T170J,BMS 195270,BMS195270,CHEMBL13637,SCHEMBL5754043 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
BMS-195270 是一种具有组织特异性的大鼠膀胱肌张力和自发收缩抑制剂,能够在膀胱离体模型中抑制离体大鼠膀胱组织条的 Carbachol 引发的张力,抑制钙离子通量。 | |||
T26016 |
R 56865
R-56865,R56865 |
Sodium Channel | Membrane transporter/Ion channel |
R 56865 是一种弱电位操作通道抑制剂,抑制人分离心肌细胞的晚期钠电流。 | |||
T38699 |
Piperafizine A
|
Others | Others |
Piperafizine A 是从 Streptoverticillium aspergilloides 中分离得到的,可增强 vincristine 的抗肿瘤效力。 | |||
TP1745L |
Ceratotoxin A acetate
Ceratotoxin A acetate(150671-04-8 Free base) |
Antibacterial | Microbiology/Virology |
Ceratotoxin A acetate 是从副腺分泌液中分离出来的,具有抗菌作用。 | |||
T84295 |
Valeramide
|
||
Valeramide 是从 Ottonia anisum Spreng 根部分离得到的一种酰胺化合物。 | |||
TP1114L |
Leucokinin VIII acetate
Leucokinin 8 |
Others | Others |
Leucokinin VIII acetate (Leucokinin 8) 是一种从蟑螂头部提取物中分离的利尿八肽。 | |||
T21223 |
Isobutyl decanoate
Decanoic acid isobutyl ester |
Others | Others |
Isobutyl decanoate (Decanoic acid isobutyl ester) 可作为食管鳞状细胞癌和肺癌的一种生物标记物,可从葡萄酒中分离得到。 | |||
T7615L |
Xenopsin 2TFA(51827-01-1(free base)
|
Others | Others |
Xenopsin 2TFA(51827-01-1(free base) 是一种以前从两栖动物皮肤中分离出来的神经降压素样八肽。 | |||
T24821 |
Spizofurone
Espizofurona,AG-629 |
Others | Others |
Spizofurone (Espizofurona) 具有抗溃疡活性,对大鼠胃黏膜具有保护作用,可增加分离的牛蛙十二指肠粘膜中的碱性分泌。 | |||
T20603L |
Ranatensin acetate
|
Others | Others |
Ranatensin acetate 是一种从 Rana pipiens 皮肤中分离出来的十一肽,是一种天然存在的铃蟾肽样肽。 | |||
T77232 |
Heptacosanoic acid
|
Endogenous Metabolite | Metabolism |
Heptacosanoic acid 是从喜马拉雅永久冻土中分离的新型含油酵母Rhodosporidium kratochvilovae HIMPA1中提取的化合物。 | |||
T84296 |
4'-Hydroxyflavone
|
||
4'-Hydroxyflavone 是一种从黄芩根部分离得到的黄酮化合物,具有抗炎活性。 | |||
T9343 |
N-Cbz-DL-tryptophan
|
cholecystokinin | GPCR/G Protein |
N-Cbz-DL-tryptophan 是一种胆囊收缩素受体拮抗剂,可消除离体心脏对 CCK-8 的反应。 | |||
T38003 |
Levofloxacin N-oxide
|
Others | Others |
Levofloxacin N-oxide 是从左氧氟沙星中分离出来的杂质。 | |||
T20692L |
Schistoflrfamide acetate
Schistoflrfamide acetate(121801-61-4 Free base) |
Others | Others |
Schistoflrfamide acetate 是从蚱蜢 Schistocerca gregaria 中分离得到的。 Schistoflrfamide acetate 对昆虫乳白色小管腺细胞的基底膜电位产生直接影响。 | |||
T29345 |
2-Ethyl-5-methylphenol
|
Others | Others |
2-Ethyl-5-methylphenol 是一种烷基苯酚,可从金黄色青霉、疣状假单胞菌和绿色青霉中分离或鉴定的化合物。 | |||
T22928L |
Locustatachykinin I acetate
|
Others | Others |
Locustachykinin I acetate 是 Lacanobia 中脱酰胺酶的底物。它是一种从飞蝗中分离的昆虫速激肽相关肽。 | |||
T20166 |
Deltorphin
Deltorphin A,Dermenkephalin |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Deltorphin (Dermenkephalin) 是从亚马逊蛙 Phyllomedusa Sauvage 的皮肤中分离出来的。Deltorphin 对阿片受体也有亲和力。 | |||
TP1365L |
Parasin I acetate(219552-69-9 free base)
|
Antibacterial | Microbiology/Virology |
Parasin I acetate(219552-69-9 free base) 是一种从受伤鲶鱼 (Parasilurus asotus) 的皮肤粘液中分离出来的 19 个残基的强效抗菌肽。 | |||
T4701 |
Diclofop-methyl
|
Others | Others |
Diclofop-methyl 是常见的生后除草剂,普遍用于农业生产。它能够增强离体燕麦根液泡膜的质子通透性。 | |||
T28859 |
ß-Thujaplicinol
|
HBV | Microbiology/Virology |
ß-Thujaplicinol 是一种从西部红雪松心材中分离出的羟基化托泊酮,具有抗病毒活性,通过阻断病毒核糖核酸酶 H 活性来抑制乙型肝炎病毒复制,可用于研究病毒感染。 | |||
TP1019L |
Urechistachykinin I acetate(149097-03-0 free base)
Uru-TK I acetate |
Antibacterial | Microbiology/Virology |
Urechistachykinin I acetate(149097-03-0 free base) (Uru-TK I acetate) 是一种从类囊体线虫中分离出来的无脊椎动物加利宁相关肽 (TRP)。 | |||
T3073 |
PF-670462
PF670462 |
Casein Kinase | Metabolism; Stem Cells |
PF-670462 是一种选择性酪蛋白激酶 (CK1δ/ε)抑制剂,IC50值分别为 14 nM 和 7.7 nM。 | |||
TP1116L |
Kinetensin acetate(103131-69-7 free base)
Kinetensin (human) acetate |
Neurotensin Receptor | GPCR/G Protein |
Kinetensin acetate(103131-69-7 free base) 是从经胃蛋白酶处理的人血浆中分离出来的。它是一种神经降压素样肽。 | |||
T7902 |
Ozenoxacin
奥泽沙星,T-3912 |
Antibacterial | Microbiology/Virology |
Ozenoxacin (T-3912) 是一种非氟喹诺酮抗菌剂,对大多数从在皮肤和软组织感染中分离的微生物有活性。 | |||
T21331 |
SAR-020106
|
Chk | Cell Cycle/Checkpoint |
SAR-020106 是一种强效、ATP 竞争性和选择性 CHK1 抑制剂,IC50为 13.3 nM。它对 CHK2 具有良好的选择性,可通过选择抗癌药物增强抗肿瘤活性。 | |||
T2172 |
SQ22536
9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536 |
AChR | Neuroscience |
SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) 是一种腺苷酸环化酶抑制剂。 | |||
T126461 |
Aloenin B
|
||
Aloenin B 是一种从芦荟的叶和根中分离得到的化合物,对谷氨酸诱导的HT22细胞神经元死亡具有神经保护活性。 | |||
T6855 |
HA15
|
Apoptosis; GPR; Others; HSP; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others |
HA15 是一种高效特异性内质网伴侣蛋白BiP/GRP78/HSPA5抑制剂,抑制 BiP 的 ATP 酶活性,具有抗肿瘤活性。 | |||
TP1839L |
Dermaseptin acetate
|
Antibacterial | Microbiology/Virology |
Dermaseptin acetate 是一种从青蛙皮肤中分离出来的肽,在微摩尔浓度下表现出对细菌、真菌和原生动物的有效抗菌活性。 | |||
T7658 |
Dimethyl DL-Glutamate (hydrochloride)
|
Others | Others |
Dimethyl DL-Glutamate (hydrochloride) 是一种细胞渗透性谷氨酸衍生物,可在孤立的胰岛和糖尿病动物模型中增强胰岛素释放以响应葡萄糖。 | |||
T7037 |
7-Acetoxy-4-methylcoumarin
7-乙酰氧基-4-甲基香豆素,MU-Ac |
Others; GST | Others; oxidation-reduction |
7-Acetoxy-4-methylcoumarin 是羧酸酯酶的荧光底物,可作为一种 GST 的抑制剂,可从 Trigonella foenum graceum 中分离出来,抑制 AFB1-DNA 结合。 | |||
T37994 |
16-hydroxy Hexadecanoic Acid
Juniperic acid |
||
16-hydroxy Hexadecanoic Acid (Juniperic acid) 是从拟南芥叶和茎中分离出的化合物,可用于预防、缓解或治疗代谢性疾病。 | |||
T8182L |
Guan-fu base A hydrochloride(1394-48-5 free base)
|
P450 | Metabolism |
Guan-fu base A hydrochloride(1394-48-5 free base) 是一种从乌头中分离得到的抗心律失常生物碱。它是 一种 CYP2D6 人类、猴子和狗同工型的抑制剂。 | |||
TP1070L |
PACAP (1-27), human, ovine, rat acetate
PACAP 1-27 acetate,PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base) |
PACAP | GPCR/G Protein |
PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate)(127317-03-7 free base) 是一种新的神经肽,最初从牛下丘脑中分离出来,也存在于人和大鼠中。 | |||
T8802 |
2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-
2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-fur |
Serine Protease | Proteases/Proteasome |
2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- (Ulinastatin) 是胰蛋白酶抑制剂(人尿 urinastatin protein moiety),作为尿胰蛋白酶抑制剂(UTI),是一种从健康人尿液中分离或合成产生的糖蛋白。 | |||
TP1018L |
Urechistachykinin II acetate
Urechistachykinin II acetate(149097-04-1 free base),Uru-TK II acetate |
Others | Others |
Urechistachykinin II acetate (Uru-TK II acetate)(149097-04-1 free base) 是一种从类胡萝卜素蠕虫中分离出来的无脊椎动物快速激肽相关肽 (TRPs),显示出抗菌活性而没有溶血作用。 | |||
TP1192L |
Conopressin S acetate(111317-90-9 free base)
Con-S acetate |
Vasopressin Receptor | GPCR/G Protein |
Conopressin S acetate(111317-90-9 free base) (Con-S acetate) 是从 Conus striatus 中分离出来的天然产物,与加压素 V1b 受体 (AVPR1B) 具有高亲和力,Ki 为 8.3 nM。 | |||
T8958 |
PU-H54
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
PU-H54 是一种基于嘌呤的 Grp94 抑制剂。它是一种基于 Grp94 选择性间苯二酚的抑制剂,通过探测 Grp94 中 S2 亚袋的专有结合区而分离。 | |||
T14133 |
AEOL-10150 pentachloride
|
Others; Antioxidant | Others; oxidation-reduction |
AEOL-10150 pentachloride 是一种超氧化物歧化酶模拟物,也是一种金属卟啉催化抗氧剂,可保护肺免受辐射损伤。 | |||
T31931L |
Gizzerosine HCl
Gizzerosine HCl(89238-78-8 Free base) |
Others | Others |
Gizzerosine 2HCl是鱼粉热处理过程中产生的一种物质,可诱导的肉鸡雏鸡组织病理学病变,可提高离体鸡原产鸡的细胞内环腺苷-3',5'-单磷酸水平。 | |||
TP1472 |
Tyroserleutide
|
Others | Others |
Tyroserleutide 是一种可从猪脾脏的降解产物中分离得到的小分子三肽,在体内外均对肿瘤生长具有抑制作用。 | |||
TN7044 |
S-(4-Hydroxybenzyl)glutathione
|
GluR | Neuroscience |
L-γ-Glutamyl-S-[(4-hydroxyphenyl)methyl] 是一种谷胱甘肽衍生物,能够抑制红藻氨酸与脑谷氨酸受体的体外结合(IC50:2 μM)。 | |||
TNU0430 |
N6-(p-Methoxybenzyl)adenosine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
N6-(p-Methoxybenzyl)adenosine 是一种腺嘌呤核苷类似物,在 U87MG 神经胶质瘤细胞中显示出体外抗增殖活性,在来自受刺激外周血单核细胞 (PBMC) 的离体 γδ T 细胞中表现出免疫原性。 | |||
TP1281L1 |
Bombesin acetate(31362-50-2 free base)
|
Bombesin Receptor | GPCR/G Protein |
Bombesin acetate(31362-50-2 free base) 是一种 14 个氨基酸的肽,是从欧洲火腹蟾蜍 (Bombina bombina) 的皮肤中分离出来的。它在哺乳动物中有两个已知的同源物,称为神经调节蛋白 B 和胃泌素释放肽。 | |||
T3631 |
PF-8380
|
PDE | Metabolism |
PF8380 是有效的autotaxin 抑制剂,在体外酶实验和人类全血细胞实验中的IC50分别为 2.8 nM 和 101 nM。 | |||
T30249 |
AZD 7009
AZD-7009,AZD7009 |
Sodium Channel | Membrane transporter/Ion channel |
AZD 7009是一种新型抗心律失常化合物,对CHO K1细胞中 hNav1.5的钠电流具有抑制作用,IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用,对e -4031诱导的动作电位持续时间延长具有抑制作用,促使浦肯野纤维的早期后去极化(EADs)。 | |||
T77245 |
Mannan
|
Endogenous Metabolite | Metabolism |
Mannan 是从藻类、蘑菇、酵母和高等植物中分离出的,可作为免疫调节剂。Mannan 抑制肝脏巨噬细胞(M1谱系)的促炎活性对许多肝脏病变(例如坏死或脂肪变性)具有保护作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1902 |
Magnocurarine
|
Others | Others |
Magnocurarine 是一种提取自Tiliacora racemosa 中的天然产物。 | |||
TN1855 |
Laurolitsine
去甲异波尔定,(+)-Norboldine |
Others | Others |
Laurolitsine ((+)-Norboldine) 是一种生物碱,从 Peumus boldusMolina 叶子中分离得到。 | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T2969 |
Lawsone
Hennotannic acid,指甲花醌,2-hydroxy-1,4-naphthoquinone |
Others; Antifungal | Microbiology/Virology; Others |
Lawsone (Hennotannic acid) 是一种从Lawsonia inermis 的叶片中分离得到的萘醌染料,具有抗菌和抗氧化活性。 | |||
T6395 |
Astragaloside A
Astragalin A,黄芪甲苷,Astramembrannin I |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Astragaloside A (Astramembrannin I) is the primary pure saponin isolated from Astragalus membranaceus. | |||
T20504 |
Alanylphenylalanine
NSC89630,Ala-phe,H-Ala-Phe-OH,NSC 89630,L-Alanyl-L-phenylalanine,NSC-89630 |
Endogenous Metabolite | Metabolism |
Alanylphenylalanine (Ala-phe) 是一种从小牛脑干中分离出的化合物。 | |||
TN3243 |
7-O-Methyleriodictyol
|
AChR | Neuroscience |
7-O-Methyleriodictyol 是一种从单乳蒿中分离出的黄烷酮,对大鼠分离的平滑肌有生物学作用。 | |||
TN1552 |
7,8-Dimethoxycoumarin
7,8-dimethoxychromen-2-one,Daphnetin dimethyl ether |
Others | Others |
7,8-Dimethoxycoumarin 是一种从 Artemisia caruifolia 和 Wikstroemia indica 中分离出来的天然产物。 | |||
TN1014 |
Saikosaponin E
|
Others | Others |
Saikosaponin E 是一种从柴胡中分离出来的天然产物。 | |||
T5S1649 |
Mudanpioside C
|
Others | Others |
Mudanpioside C 分离自芍药类植物。 | |||
TN6789 |
Neosalvianen
|
Others | Others |
Neosalvianen 是从丹参中分离出来的。 | |||
TN7026 |
Acorus gramineus, ext.
|
Others | Others |
Acorus gramineus, ext. | |||
T8272 |
Trierucin
|
Others; Endogenous Metabolite | Metabolism; Others |
Trierucin 是一种从种子油中提取的三芥酸甘油三酯。 | |||
TN5225 |
Verbasoside
脱咖啡酰基毛蕊糖苷,Decaffeoyl acteoside |
Others | Others |
Verbasoside (Decaffeoyl acteoside) 是一种从 Rehmannia glutinosa (Gaertn.) DC 的根中分离出来的苯丙烷类天然产物。 | |||
T4244 |
Methylophiopogonone A
|
Others | Others |
Methylophiopogonone A 是一种异黄酮,从Ophiopogon japonicas根部分离得到,具有抗炎作用。 | |||
T6S1879 |
Indaconitine
|
Others | Others |
Indaconitine 可分离自乌头植物根茎。 | |||
TN6767 |
ACETOXYVALERENIC ACID
|
Others | Others |
Acetoxyvalerenic acid 是从 valerian 中提取的天然产物。 | |||
T2O2770 |
Agarotetrol
|
Others | Others |
Agarotetrol 是一种色酮衍生物,从沉香中分离得到。 | |||
T4394 |
Methyl Isoferulate
|
Others | Others |
Methyl Isoferulate 从毛竹叶中分离纯化。 | |||
T13761 |
Luteolin 7-diglucuronide
|
Others | Others |
Luteolin 7-diglucuronide 是一种从马鞭草 Verbena officinalis 和三叶草 Aloysia triphylla 中提取的类黄酮。 | |||
T13776 |
Mogroside II-A
|
Others | Others |
Mogroside II-A 是从罗汉果Siraitia grosvenorii 中分离出来的。 | |||
TN1528 |
Cotoin
|
AChE | Neuroscience |
Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性,可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。 | |||
T13738 |
(+)-Isomenthone
|
Others | Others |
(+)-Isomenthone 是分离自Ziziphora clinopodioidesLam. 的异薄荷酮,是 L-Menthone 的异构体。 | |||
T19431 |
Moluccanin
|
Others | Others |
Moluccanin 是来自 Aleurites moluccana 的香豆素类。 | |||
T8210 |
Saikosaponin B4
|
Others | Others |
Saikosaponin B4 是一种柴胡皂苷,分离自柴胡的根。Saikosaponin B4选择性地抑制 ACTH 诱导的脂解作用。 | |||
T12014 |
Methyl carnosate
|
Antioxidant; Antibiotic | Microbiology/Virology; oxidation-reduction |
Methyl carnosate 是一种从鼠尾草或迷迭香中分离出具有抗氧化和抗菌活性的二萜化合物。 | |||
TN2029 |
p-Hydroxy-5,6-dehydrokawain
4'-Hydroxydehydrokawain,4'-羟基-5,6-脱氢醉椒素 |
Others | Others |
p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) 是一种分离自 Kawain 的天然产物。 | |||
TQ0226 |
Jionoside B1
|
Glucosidase | Metabolism |
Jionoside B1 是从熟地黄(Gaertn.)的根中分离出来的,抑制 α-葡萄糖苷酶。 | |||
T5761 |
Notoginsenoside Ft1
三七皂苷FT1,三七皂甙 Ft1 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Notoginsenoside Ft1 是一种植物分离的三七皂苷,具有刺激血管生成的作用。 | |||
TN4704 |
Oleaside A
|
Others | Others |
Oleaside A 是从夹竹桃中分离出来的。 | |||
TJS0328 |
Nordalbergin
6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素 |
Others | Others |
Nordalbergin 是一种香豆素,分离自Dalbergia sissoo的木皮中。 它能够显著性的诱导 HL-60 细胞的分化。 | |||
TN6738 |
Orthosphenic acid
|
Others | Others |
Orthosphenic acid 是一种从 M. triflora 中分离出来的天然产物。 | |||
T3S1149 |
Ganoderic acid G
|
Others | Others |
Ganoderic acid G 分离自灵芝菌管层表面。 | |||
TN7056 |
11-Methoxyyangonin
Trimethylhispidin,NSC212503,11-甲氧基醉椒素 |
Others | Others |
11-Methoxyyangonin (Trimethylhispidin) 是一种天然的卡瓦内酯。 | |||
TN7253 |
Torachrysone gentiobioside
|
||
Torachrysone gentiobioside 是一种从决明子中分离出来的酚苷类化合物。 | |||
T5790 |
1,1,1,1-Kestohexaose
1,1,1,1-Kestohexose,蔗果六糖 |
Others | Others |
1,1,1,1-Kestohexaose (1,1,1,1-Kestohexose) 是一种寡聚果糖,分离自Poa ampla 中。 | |||
TN1579 |
Dihydrocucurbitacin B
二氢葫芦素 B,23,24-dihydrocucurbitacin B |
IL Receptor; TNF; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Dihydrocucurbitacin B (23,24-dihydrocucurbitacin B) 是从 Cayaponia tayuya 的根中分离得到的,具有抗癌活性。 | |||
T3S1457 |
Palmaturbine
Palmatrubin,巴马亭红碱,Palmatrubine |
Others | Others |
Palmaturbine 从T. sinensis中分离,有抗肿瘤活性。 | |||
TN1519L |
(-)-Coclaurine hydrochloride
(-)-Coclaurine hydrochloride (486-39-5 Free base) |
AChR | Neuroscience |
(-)-Coclaurine hydrochloride 是从 Sarcopetalum harveyanum 中分离出来的,是一种 nAChR 拮抗剂。 | |||
TN4419 |
Lasiodonin
|
Others | Others |
Lasiodonin 是一种二萜化合物,提取自 Isodon lasiocarpus 中。 | |||
T10993 |
δ-Amyrenone
Delta-Amyrone,Α-香树脂酮 |
Others | Others |
δ-Amyrenone (Delta-Amyrone) 分离自 S. lineare,具有抗炎作用。 | |||
T5S2309 |
Hosenkoside K
凤仙萜四醇苷K,(+)-Hosenkoside K |
Others | Others |
Hosenkoside K 是一种糖苷,分离自凤仙花种子。 | |||
TN1539 |
Cussosaponin C
|
Others | Others |
Cussosaponin C 是从 Pulsatilla koreana Nakai 中分离得到的天然产物。 | |||
T12016 |
Methyl L-pyroglutamate
L-Pyroglutamic acid methyl ester,L-焦谷氨酸甲酯,(S)-Methyl 5-oxopyrrolidine-2-carboxylate |
Others | Others |
Methyl L-pyroglutamate (L-Pyroglutamic acid methyl ester) 分离自甘蓝中分离,显示出抗炎活性。 | |||
T11398 |
Ginsenoside Ra3
人参皂苷 RA3,人参皂苷RA3 |
Others | Others |
Ginsenoside Ra3 是分离自人参中,具有抗癌作用。 | |||
T13816 |
(+)-Peusedanol
(+)-白花前胡醇,白花前胡醇 |
Others | Others |
(+)-Peusedanol 是一种香豆素,从滨海前胡中分离出来。 | |||
TN1626 |
Eugenin
|
Others | Others |
Eugenin 是一种色酮,分离自滨海前胡,能够抗血小板聚集。 | |||
TN2366 |
Triglochinic acid
|
Others | Others |
Triglochinic acid 是一种分离自半夏块茎中的单体成分。 | |||
T4S1387 |
Isoescin IA
七叶皂苷C,异七叶皂苷 IA |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Isoescin IA 是一种从七叶树种子中分离出来的三萜皂苷。它具有抗HIV-1蛋白酶活性。 | |||
TN1278 |
4'-Methoxypuerarin
4'-甲氧基葛根素,4'-O-甲基葛根素 |
Others | Others |
4'-Methoxypuerarin 是分离于 Pueraria lobata 的一种异黄酮二甘醇。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00807 |
Osteopontin Protein, Mouse, Recombinant (His)
ETA-1,SPP1,OPN,Bone sialoprotein 1,BNSP,SPP-1,Osteopontin,Ne... |
Mouse | HEK293 Cells |
Secreted phosphoprotein 1 (SPP1) expression in TAMs isolated from lung adenocarcinoma tissues and PMA-treated THP-1 cells were measured. Macrophage polarization was identified by flow cytometric analysis. Cell migration and apoptosis were assessed by Transwell migration assays and flow cytometric analysis, respectively. SPP1 is highly expressed in tumor tissues and TAMs isolated from patients with an advanced TNM stage, and also in PMA-treated THP-1 cells. | |||
TMPY-04483 |
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas... |
Human | Baculovirus Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... | |||
TMPH-03329 |
Mcpt2 Protein, Rat, Recombinant (His & Myc)
Mast cell protease 2,Mcpt2,Mast cell protease II,Group-speci... |
Rat | E. coli |
This enzyme, isolated from small intestine, specifically inactivates the apo forms of a certain group of intracellular pyridoxal phosphate-requiring enzymes. It has chymotrypsin-like specificity towards small substrates. Mcpt2 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 30.5 kDa and the accession number is P00770. | |||
TMPK-01165 |
MCEMP1 Protein, Mouse, Recombinant (hFc)
MGC132456,C19orf59,MCEMP1 |
Mouse | HEK293 Cells |
A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). MCEMP1 in T lymphocytes isolated from sepsis mice were up- or downregulated by exogenous transfection in an attempt to investigate their effects on the release of inflammatory factors, the expression of immunoglobulins, the activity of T cell subsets and natural killer (NK) cells, as well as T lymphocyte apoptosis. | |||
TMPJ-00516 |
OBhFc1 Protein, Human, Recombinant (His)
Suppressor of Cdc Thirteen Homolog,CST Complex Subunit STN1,... |
Human | E. coli |
CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has prob... | |||
TMPY-00585 |
Annexin A8 Protein, Human, Recombinant (His)
ANX8,annexin A8 |
Human | E. coli |
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ... | |||
TMPY-01346 |
Psoriasin/S100A7 Protein, Human, Recombinant
S100 calcium binding protein A7,PSOR1,S100A7c |
Human | E. coli |
Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role... | |||
TMPJ-00798 |
ACYP1 Protein, Human, Recombinant (His)
ACYPE,Acylphosphate phosphohydrolase 1,erythrocyte isozyme,o... |
Human | E. coli |
ACYP1, also known as Acylphosphatase-1, Acylphosphatase, erythrocyte isozyme, Acylphosphatase, organ-common type isozyme, Acylphosphate phosphohydrolase 1 and ACYPE, is a small cytosolic enzyme which catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates.ACYP1 is a protein which belongs to the acylphosphatase family and contains 1 fibrinogen C-terminal domain. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of thei... | |||
TMPJ-00704 |
SCO1 Protein, Human, Recombinant (GST)
Protein SCO1 Homolog Mitochondrial,SCOD1,SCO1 |
Human | E. coli |
Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4... | |||
TMPJ-00474 |
CPA1 Protein, Human, Recombinant (His)
CPA,Carboxypeptidase A1,CPA1 |
Human | HEK293 Cells |
Carboxypeptidase A1 (CPA1) is secreted as a pancreatic peptidase that comes from the precursor form of inactive procarboxypeptidase. CPA1 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. It has a free C-terminal carboxyl group, with the preference of residues with aromatic or branched aliphatic side chains. CPA1 cleaves the C-terminal amide or ester bond of peptides and involves in zymogen inhibition. Three different forms of hu... | |||
TMPY-01847 |
REG3D Protein, Mouse, Recombinant (His)
Reg3d,regenerating islet-derived 3 delta,Ingaprp,MGC130575,I... |
Mouse | HEK293 Cells |
Regenerating islet-derived 3 delta (REG3D) is a member of the secreted Reg superfamily and contains one typical C-type lectin domain. Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family, which consists of four subtypes (types I, II, III, IV) based on t... | |||
TMPJ-00602 |
CPA2 Protein, Human, Recombinant (His)
CPA2,Carboxypeptidase A2 |
Human | HEK293 Cells |
Carboxypeptidase A2 (CPA) is a secreted pancreatic procarboxy-peptidase that cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group. The hydrolytic action of CPA2 was identified with a preference towards long substrates with aromatic amino acids in their C-terminal end, particularly tryptophan. CPA2 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. Three different forms of human pancreat... | |||
TMPY-02376 |
BNIP3L Protein, Human, Recombinant
BCL2/adenovirus E1B 19kDa interacting protein 3-like,NIX,BNI... |
Human | E. coli |
The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to... | |||
TMPY-02599 |
MDH1 Protein, Rat, Recombinant (His)
malate dehydrogenase 1, NAD (soluble) |
Rat | E. coli |
Malate dehydrogenases 1(MDH1 / MDHA) is a soluble form of malate dehydrogenases. Malate dehydrogenases (MDH) is a group of multimeric enzymes consisting of identical subunits usually organized as either dimer or tetramers with subunit molecular weights of 30-35 kDa. MDH has been isolated from different sources including archaea, eubacteria, fungi, plants, and mammals. MDH catalyzes the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in... | |||
TMPY-02796 |
KIAA0101 Protein, Human, Recombinant (His)
L5,NS5ATP9,p15PAF,OEATC1,p15(PAF),OEATC,PAF,p15/PAF,OEATC-1,... |
Human | E. coli |
KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell ... | |||
TMPY-02704 |
PTMA Protein, Human, Recombinant (GST)
prothymosin, α,prothymosin, alpha,TMSA |
Human | E. coli |
PTMA (prothymosin, alpha, N-GST chimera) is a small, 12.4 kDa protein. It is a 109-111 amino acid long polypeptide as the precursor of thymosin a1. Thymosins are named becaues they were originally isolated from the thymus. But now in many other tissues, thymosins also can be detected. Thymosins have diverse biological activities, and two in particular, thymosins a1 and _4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In gen... | |||
TMPY-04374 |
MST4 Protein, Human, Recombinant (GST)
serine/threonine protein kinase 26,MST4,MASK |
Human | Baculovirus Insect Cells |
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently ... | |||
TMPY-01953 |
CALML5 Protein, Human, Recombinant (His & GST)
calmodulin like 5,CLSP |
Human | E. coli |
Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily a... | |||
TMPY-04357 |
RSK4 Protein, Human, Recombinant (GST)
RSK4,ribosomal protein S6 kinase, 90kDa, polypeptide 6,PP90R... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2... | |||
TMPY-01406 |
REG3G Protein, Human, Recombinant (His)
UNQ429,PAP-1B,LPPM429,REG-III,regenerating islet-derived 3 γ... |
Human | HEK293 Cells |
Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family, which consists of four subtypes (types I, II, III, IV) based on the primary structures of the encoded proteins of the genes, which are associated with tissue repair and have been directly implicated ... | |||
TMPY-01027 |
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1 |
Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40376 |
L-Phenylalanine-15N
L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。 | |||
T71141 |
Fenspiride-d5
|
||
Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ... | |||
T71300 |
Pentoxifylline-d6
|
||
Pentoxifylline-d6 is intended for use as an internal standard for the quantification of pentoxifylline by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent. It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 µM. Pentoxifylline (1, 2, and 3 mM) inhibits ADP-induced platelet aggregation in isolated human whole blood. It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5, 10, and 20 mg/... | |||
TMIH-0130 |
Butylphthalide-d7
NBP-d7 |
||
Butylphthalide-d7 是 Butylphthalide 的氘代化合物。Butylphthalide 的 CAS 号为 6066-49-5。Butylphthalide 是一种抗脑缺血药物,最初分离自芹菜种中,对中风动物模型有效。 | |||
TMIJ-0105 |
3-Butylphthalide-d9
|
||
3-Butylphthalide-d9 是 3-Butylphthalide 的氘代化合物。3-Butylphthalide 的 CAS 号为 6066-49-5。Butylphthalide 是一种抗脑缺血药物,最初分离自芹菜种中,对中风动物模型有效。 | |||
TMIH-0418 |
Ozenoxacin-d3
|
||
Ozenoxacin-d3 是 Ozenoxacin 的氘代化合物。Ozenoxacin 的 CAS 号为 245765-41-7。Ozenoxacin是一种新型喹诺酮类抗生素,能够抵抗大多数从在皮肤和软组织感染中分离的微生物。 | |||
T71326 |
1,3,7-Trimethyluric Acid-d9
|
||
1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes. | |||
TMIJ-0194 |
Tetramethylpyrazine-d12
|
||
Tetramethylpyrazine-d12 是 Tetramethylpyrazine 的氘代化合物。Tetramethylpyrazine 的 CAS 号为 1124-11-4。Tetramethylpyrazine 是从Ligusticum wallichii中提取的一种烷基吡嗪,常在薯条、面包、茶、乳制品、豆制品等食物中作为香精。它对大鼠具有潜在的抗神经和抗炎活性。 | |||
TMID-0018 |
Paclitaxel-d5
|
ADC Cytotoxin | Antibody-drug Conjugate/ADC Related |
Paclitaxel-d5 是 Paclitaxel 的氘代化合物。Paclitaxel 的 CAS 号为 33069-62-4。Paclitaxel 是一种从太平洋紫杉树皮中分离出来的环癸烷。 它以聚合形式稳定微管,导致细胞死亡。 | |||
T71302 |
Norfluoxetine-d5 HCl
|
||
Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewa... | |||
T71329 |
Theophylline-d6
|
||
Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F... | |||
T71211 |
Rizatriptan-d6 benzoate salt
|
||
Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors. Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries. In vivo, rizatriptan reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in a Cacna1a mutant transgenic mou... | |||
TMID-0258 |
(±)-Atropine-d3 (N-methyl-d3)
|
||
(±)-Atropine-d3 (N-methyl-d3) 是 (±)-Atropine 的氘代化合物。(±)-Atropine 的 CAS 号为 51-55-8。Atropine 是竞争性的毒蕈碱乙酰胆碱受体拮抗剂,有抗近视效果。它是一种从颠茄植物中分离出来的天然生物碱,可阻断乙酰胆碱对心率和收缩力的抑制作用。 | |||
T71143 |
Ambroxol-d5
|
||
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous part... | |||
T69598 |
Isoproterenol-d7 HCl
|
||
Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom... | |||
TMIH-0301 |
Levolansoprazole-d4
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Levolansoprazole-d4 是 Levolansoprazole 的氘代化合物。Levolansoprazole 的 CAS 号为 138530-95-7。Levolansoprazole 是一种质子泵抑制剂,不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50:82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性,具有相似的效力。 | |||
TMIJ-0050 |
Butyricacid-d7
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Butyricacid-d7 是 Butyricacid 的氘代化合物。Butyricacid 的 CAS 号为 107-92-6。Butyric acid 是一种从许多乳制品中分离出来的脂肪酸,具有抗癌活性。 它抑制组蛋白去乙酰化酶 (HDAC) 并诱导胶质瘤细胞凋亡和 G1 期细胞周期停滞。此外,它在低剂量时刺激上皮细胞增殖,在高剂量时抑制增殖。 | |||
T71981 |
Gliclazide-d4
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Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin... | |||
T71402 |
Nicorandil-d4
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Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =... | |||
T70313 |
Indoxyl Sulfate-d5 potassium salt
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Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ... | |||
T71142 |
Tebuconazole-d9
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Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per... | |||
T35520 |
Aflatoxin G1-13C17
Aflatoxin G1-13C17 |
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Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase... | |||
T35519 |
Aflatoxin B2-13C17
Aflatoxin B2-13C17 |
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Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen... |