Helodormin, a vasoactive intestinal peptide (VIP) helodermin-like peptide, is isolated from the venom of the Mexican beaded lizard (Heloderma suspectum). It modulates intracellular signaling by activating adenylyl cyclase, thereby influencing various cellular functions. This compound is used in research to explore the evolution and functions of the helodermin-like and VIP peptide families.