Helospectin I, a neuropeptide belonging to the vasoactive intestinal peptide (VIP) family, exhibits vasodilatory and antihypertensive properties, effectively reducing blood pressure. It was initially isolated from the salivary gland venom of the lizard Heloderma suspectum [1] [2].

Helospectin I（0.03-2 nmol/kg，左颈静脉注入100 μL）能够降低大鼠的血压[2]。同一化合物（0.1-0.8 nmol/kg，静脉注射）则提升小鼠血浆中胰高血糖素的水平[3]。