Myosin-IN-1 (compound F10), a specific inhibitor of cardiac myosin, acts by stabilizing the cardiac myosin motor domain in its closed biochemical and structural state. It reduces myocardial force production and calcium sensitivity, functioning as a negative inotropic agent. In isolated Langendorff-perfused rat hearts, Myosin-IN-1 decreases stress in myofilaments and diminishes the development of left ventricular pressure. This compound is applicable in heart failure research [1].
化学信息
分子量
296.41
分子式
C12H16N4OS2
CAS No.
849011-39-8
储存&溶解度
存储
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