|
TMPY-01442
|
DMBT1 Protein, Human, Recombinant (His)
GP340,deleted in malignant brain tumors 1,muclin
|
Human
|
HEK293 Cells
|
|
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo... |
|
TMPH-01650
|
PRAME Protein, Human, Recombinant (E. coli, His)
Opa-interacting protein 4,Preferentially expressed antigen o...
|
Human
|
E. coli
|
|
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role... |
|
TMPH-01651
|
PRAME Protein, Human, Recombinant (His)
Melanoma antigen preferentially expressed in tumors...
|
Human
|
P. pastoris (Yeast)
|
|
PRAME Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 59.9 kDa and the accession number is P78395. |
|
TMPY-04153
|
RNF43 Protein, Human, Recombinant (His)
ring finger protein 43,URCC,RNF43,RNF124
|
Human
|
HEK293 Cells
|
|
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and t... |
|
TMPY-05033
|
5T4/TPBG Protein, Human, Recombinant (aa 60-345, His)
5T4AG,trophoblast glycoprotein,WAIF1,M6P1,5T4
|
Human
|
HEK293 Cells
|
|
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Human, Recombinant (aa 60-345, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.1 kDa and the accession number is Q13641. |
|
TMPK-00008
|
CCL5 Protein, Mouse, Recombinant (hFc)
D17S136E,RANTES,SCYA5,SIS-δ,Ccl5,SISd,eoCP,MuRantes,TCP228,S...
|
Mouse
|
HEK293 Cells
|
|
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is P30882. |
|
TMPY-00021
|
PADI4 Protein, Human, Recombinant (His)
PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI...
|
Human
|
Baculovirus Insect Cells
|
|
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres... |
|
TMPJ-00090
|
FGF-9 Protein, Human, Recombinant
Fibroblast Growth Factor 9,Heparin-Binding Growth Factor 9,F...
|
Human
|
E. coli
|
|
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial c... |
|
TMPJ-00258
|
TGF beta 2 Protein, Human, Recombinant
Glioblastoma-derived T-cell suppressor factor,TGF-β-2,Transf...
|
Human
|
HEK293 Cells
|
|
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be... |
|
TMPY-04779
|
BTN3A2 Protein, Human, Recombinant (His)
BTF3,BT3.2,BTF4,BTN3.2,CD277,butyrophilin subfamily 3 member...
|
Human
|
HEK293 Cells
|
|
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted... |
|
TMPY-03407
|
NQO1 Protein, Human, Recombinant (His)
NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...
|
Human
|
E. coli
|
|
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex... |
|
TMPY-00117
|
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16
|
Human,Cynomolgus
|
Baculovirus Insect Cells
|
|
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... |
|
TMPJ-01011
|
FGF-9 Protein, Mouse, Recombinant (His)
heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f...
|
Mouse
|
E. coli
|
|
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v... |
|
TMPY-04552
|
AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,...
|
Human
|
Baculovirus Insect Cells
|
|
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... |
|
TMPY-00150
|
IGF2/IGF-II Protein, Human, Recombinant
PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2
|
Human
|
P. pastoris (Yeast)
|
|
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br... |
|
TMPK-00280
|
B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated
NCR3LG1,B7H6,DKFZp686O24166,B7-H6,DKFZp686I21167,B7 Homolog ...
|
Human
|
HEK293 Cells
|
|
B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins. which is a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues. |
|
TMPK-00690
|
EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
LEGFR,ERBB1,EGFR,HER1,PIG61,NISBD2,EC 2.7.10,ERBB,EC 2.7.10....
|
Human
|
HEK293 Cells
|
|
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled is exp... |
|
TMPK-01051
|
BLOC1S2 Protein, Human, Recombinant
BLOS2,CEAP11,CEAP,BLOC-1 subunit 2
|
Human
|
E. coli
|
|
BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. On the subcellular level, BLOC1S2 is expressed in an organellar-like pattern and co-localizes with mitochondria. |
|
TMPK-01444
|
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Tetramer Protein, Human, MHC (His & Avi)
MZ2-E,MAGE1A,MAGE-1 antigen,MAGE A1,MAGE-A1,MAGE-1,MAGE1,CT1...
|
Human
|
HEK293 Cells
|
|
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. |
|
TMPK-01446
|
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi)
MAGE1,MAGE1A,MAGE-1 antigen,MAGE-A1,MAGE A1,CT1.1,MZ2-E,MAGE...
|
Human
|
HEK293 Cells
|
|
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. |
|
TMPK-00691
|
EGFRVIII Protein, Human, Recombinant (His & Avi)
EGFR,ErbB,mENA,HER1,LEGFR,EC 2.7.10.1,PIG61,EC 2.7.10,ERBB1,...
|
Human
|
HEK293 Cells
|
|
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi) is expressed in HEK2... |
|
TMPK-01445
|
HLA-A*02:01&B2M&MAGE-A1 (KVLEYVIKV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CT1.1,MAGE1,MAGE-1,MAGE-A1,MAGE-1 antigen,MAGE A1,MAGE1A,MZ2...
|
Human
|
HEK293 Cells
|
|
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. |
|
TMPK-01455
|
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi)
OIP4,PRAME,OIP-4,MAPE
|
Human
|
HEK293 Cells
|
|
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. |
|
TMPK-00692
|
EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
EC 2.7.10.1,PIG61,NISBD2,HER1,mENA,LEGFR,ErbB,EC 2.7.10,ERBB...
|
Human
|
HEK293 Cells
|
|
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated is exp... |
|
TMPK-00689
|
EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
EC 2.7.10.1,EC 2.7.10,ERBB1,EGFR,mENA,NISBD2,HER1,ErbB,PIG61...
|
Human
|
HEK293 Cells
|
|
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled is expre... |
|
TMPJ-01207
|
UPP1 Protein, Human, Recombinant (His)
UPP1,Uridine Phosphorylase 1,UPP1 Protein
|
Human
|
E. coli
|
|
Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in human solid tumors than in adjacent normal tissues. The high level of UPP1 expression in some tumors makes it a potential prognosticfactor for some cancers, such as oral squamous cell carcinoma. UPP1 is important for the homeostatic regulation of intracellular and plasma uridine c... |
|
TMPK-01406
|
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
MAPE,OIP4,OIP-4,PRAME
|
Human
|
HEK293 Cells
|
|
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. |
|
TMPK-01454
|
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Tetramer Protein, Human, MHC (His & Avi)
MAPE,OIP4,OIP-4,PRAME
|
Human
|
HEK293 Cells
|
|
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. |
|
TMPK-01441
|
HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Monomer Protein, Human, MHC (His & Avi)
OIP-4,PRAME,MAPE,OIP4
|
Human
|
HEK293 Cells
|
|
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. |
|
TMPK-01447
|
HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Monomer Protein, Human, MHC (His & Avi), Biotinylated
OIP4,MAPE,PRAME,OIP-4
|
Human
|
HEK293 Cells
|
|
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumors is limited. |
|
TMPK-00009
|
CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated
RANTES,SIS-δ,D17S136E,TCP228,eoCP,SIS-delta,SCYA5,CCL5,SISd,...
|
Human
|
E. coli
|
|
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 10.89 kDa and the accession number is P13501. |
|
TMPY-04764
|
PCK2 Protein, Human, Recombinant (His & GST)
PEPCK-M,PEPCK2,PEPCK,phosphoenolpyruvate carboxykinase 2 (mi...
|
Human
|
Baculovirus Insect Cells
|
|
PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors. |
|
TMPK-00742
|
PRL-3/PTP4A3 Protein, Human, Recombinant (His)
PRL-R,PRLR,PRL3,PTP4A3,PRL-3
|
Human
|
E. coli
|
|
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors. |
|
TMPK-00377
|
DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
DPP4,DPPIV,ADCP2,CD26,ADABP,TP103,EC 3.4.14.5
|
Cynomolgus,Rhesus
|
HEK293 Cells
|
|
CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express DPPIV/CD26 to a variable extent. |
|
TMPY-06317
|
5T4/TPBG Protein, Human, Recombinant (aa 1-355, His)
trophoblast glycoprotein,WAIF1,5T4AG,M6P1,5T4
|
Human
|
HEK293 Cells
|
|
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Human, Recombinant (aa 1-355, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.15 kDa and the accession number is NP_006661.1. |
|
TMPY-06191
|
5T4/TPBG Protein, Mouse, Recombinant (His)
trophoblast glycoprotein,WAIF1,5T4,AW495680
|
Mouse
|
HEK293 Cells
|
|
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9Z0L0. |
|
TMPY-06214
|
5T4/TPBG Protein, Mouse, Recombinant (hFc)
trophoblast glycoprotein,AW495680,5T4,WAIF1
|
Mouse
|
HEK293 Cells
|
|
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5 kDa and the accession number is Q9Z0L0. |
|
TMPK-01081
|
Glypican 2/GPC2 Protein, Mouse, Recombinant (His)
Cerebroglycan,2410016G05Rik,GPC2,Glypican-2
|
Mouse
|
HEK293 Cells
|
|
Glypicans can function as coreceptors for multiple signaling molecules known for regulating cell growth, motility, and differentiation. Some members of the glypican family, including glypican 2 (GPC2) and glypican 3 (GPC3), are expressed in childhood cancers and liver cancers, respectively. Antibody-based therapies targeting glypicans are being investigated in preclinical and clinical studies, with the goal of treating solid tumors that do not respond to standard therapies. |
|
TMPK-00721
|
CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated
Neurotactin,CXC3C,ABCD-3,Fkn,Fractalkine,NTT,Cx3cl1,SCYD1,Cx...
|
Mouse
|
HEK293 Cells
|
|
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma. |
|
TMPY-00483
|
Parvalbumin/PVALB Protein, Human, Recombinant (His)
parvalbumin,D22S749
|
Human
|
E. coli
|
|
Parvalbumins (PVALBs) are particularly abundant in the fast-contracting muscles and correlate positively with muscle relaxation speed in amphibians and fishes. The loss of PVALB plays a role in the pathogenesis of thyroid tumors. The mutations in the PVALB gene are not involved in GS patients who harbour a single or no mutant SLC12A3 allele. |
|
TMPK-00761
|
B2M/beta 2-Microglobulin Protein, Mouse, Recombinant (hFc)
B2M/β 2-Microglobulin,Beta-2-microglobulin,B2M,β-2-microglob...
|
Mouse
|
HEK293 Cells
|
|
The genetic and functional analysis of β2-microglobulin (B2M), a component of the HLA class-I complex.Acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX). Downregulation of B2M was also found in two additional PDXs established from ICI-resistant tumors. |
|
TMPY-01577
|
ORP150 Protein, Human, Recombinant (His)
hypoxia up-regulated 1,HSP12A,Grp170,ORP-150,ORP150,GRP-170
|
Human
|
HEK293 Cells
|
|
Hypoxia up-regulated protein 1, also known as 15 kDa oxygen-regulated protein, 17 kDa glucose-regulated protein, ORP-15, GRP-17, and HYOU1, is a member of the heat shock protein 7 family. Seven members from four different heat shock protein (HSP) families were identified including HYOU1 (ORP15), HSPC1 (HSP86), HSPA5 (Bip), HSPD1 (HSP6), and several isoforms of the two testis-specific HSP7 chaperones HSPA2 and HSPA1L. HYOU1 is highly expressed in tissues that contain well-developed endoplasmic re... |
|
TMPH-02188
|
Tenascin-X Protein, Human, Recombinant (His & Myc)
TNXB,Tenascin-X,Hexabrachion-like protein
|
Human
|
E. coli
|
|
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. Tenascin-X Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 81.5 kDa and the accession number is P22105. |
|
TMPK-00392
|
FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)
CD331,FGFR-1,FLT-2,BFGFR,N-sam,FGFR1 β (IIIc),bFGF-R-1
|
Human
|
HEK293 Cells
|
|
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession numb... |
|
TMPK-01530
|
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,LMP-2,PSMB9,LMP2,Macropain chain 7,Proteasome chain 7,RM...
|
Human
|
HEK293 Cells
|
|
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... |
|
TMPK-01534
|
Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi)
RING12,PSMB9,Proteasome chain 7,RMF,LMP-2,LMP2,MHC,Macropain...
|
Human & Mouse
|
HEK293 Cells
|
|
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... |
|
TMPK-01299
|
CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)
Carcinoembryonic,CEA,CEACD66e,DKFZp781M2392,CEACAM-5,CD66e,M...
|
Cynomolgus
|
HEK293 Cells
|
|
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. |
|
TMPY-03521
|
DcR3 Protein, Human, Recombinant (hFc)
DCR3,tumor necrosis factor receptor superfamily member 6b,M6...
|
Human
|
Baculovirus Insect Cells
|
|
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tu... |
|
TMPK-00592
|
Latexin Protein, Human, Recombinant (His)
ECI,TCI,LXN,MUM
|
Human
|
E. coli
|
|
Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells. |
|
TMPJ-00784
|
Alkaline Phosphatase Protein, Human, Recombinant (aa 23-506, His)
Alkaline phosphatase Regan isozyme,placental type,Placental ...
|
Human
|
HEK293 Cells
|
|
ALPP is a membrane protein and exits as a homodimer. ALPP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It has been shown to play a role in a number of processes including cell signaling, long-term potentiation, and cell adhesion, however, the best known and most commonly studied role is implicated in Alzheimer's research. |
沪公网安备 31010602006700号