1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that serves as a cytotoxic agent and lysosomotropic detergent. It induces cell death through acid-dependent accumulation in lysosomes, which disrupts the lysosomal membrane and facilitates the release of cysteine proteases into the cytoplasm. Additionally, 1-Dodecylimidazole exhibits hypocholesterolemic and broad-spectrum antifungal activities.

1-Dodecylimidazole是一种酸激活型洗涤剂，pKa值为6.3，已被证实对培养中的细胞具有细胞毒性。1-Dodecylimidazole对EMT-6和MGH U1细胞展现出了依赖于细胞外pH值(pHe)的细胞毒性，细胞死亡是剂量依赖性的，并且在pHe 6.0时的细胞毒性比pHe 7.0时高出100倍[4]。

1-Dodecylimidazole 的降胆固醇活性部分源自于其在2,3-氧化鲨烷醇环化酶水平上抑制胆固醇生物合成。研究显示，每日通过胃管给予 1-Dodecylimidazole（150 mg/kg 体重；连续10天）的大鼠其血清胆固醇浓度低于对照组大鼠。