SBP-0636457

Name: SBP-0636457
Brand: TargetMol
SKU: T38857
Price: 255 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T38857Cas号 1422180-49-1

别名 SBP-0636457, SBI-0636457, SB1-0636457

SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for research in the fields of solid tumors and hematologic cancers.

SBP-0636457

还可以

产品编号 T38857 别名 SBP-0636457, SBI-0636457, SB1-0636457Cas号 1422180-49-1

规格	价格	库存	数量
25 mg	¥ 15,000	6-8周

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生物活性

产品描述	SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for research in the fields of solid tumors and hematologic cancers.
靶点活性	XIAP:0.27 μM (Ki)
体外活性	SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1]. SBP-0636457 (10-1000 nM; 20 h) is ef?cacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC 50 of 9 nM[1].
别名	SBP-0636457, SBI-0636457, SB1-0636457