785
129
2
35
14
Cat. No. | Product Name | ||
---|---|---|---|
L2192 | 抗胰腺癌化合物库 | 2238 compounds | |
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L4020 | NO PAINS 化合物库 | 9384 compounds | |
TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物,可用于新药研发,信号通路研究,老药新用等研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16432 |
Pan-RAS-IN-1
|
MAPK; Ras | GPCR/G Protein; MAPK |
Pan-RAS-IN-1是一种广谱的 Ras 抑制剂。Pan-RAS-IN-1破坏 Ras 蛋白及其作用子的相互作用。 | |||
T1982 |
3-AP
NSC663249,Triapine,PAN-811,OCX191 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
3-AP (Triapine) 是一种新型的核糖核苷酸还原酶 M2 亚基抑制剂,也是一种放射致敏剂。 | |||
T70956 |
JNJ-pan-AR
|
Others | Others |
JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. | |||
T68655 |
PAN12314
|
Others | Others |
PAN12314, also known as Compound 5a, is a 5-HT4R partial agonists that displayed cognition-enhancing properties in animal models. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming). | |||
T62621 |
pan-HER-IN-2
|
Others | Others |
pan-HER-IN-2 (Compound C6) 是一种口服具有活力的、可逆的广谱 HER 抑制剂,能够作用于 EGFR (IC50: 0.72 nM)、HER4 (IC50: 2.0 nM)、EGFRT790M (IC50: 8.2 nM) / L858R (IC50: 75.1 nM)。pan-HER-IN-2 可以诱导细胞凋亡 (apoptosis),具有抗肿瘤作用。 | |||
T64070 |
Pan-Trk-IN-3
|
Others | Others |
Pan-Trk-IN-3 是一种有效的广谱 Trk 及其耐药突变体抑制剂,能够作用于 TrkA (IC50: 2 nM)、TrkB (IC50: 3 nM)、TrkC (IC50: 2 nM)、TrkAG595R (IC50: 21 nM)、TrkAG667C (IC50: 26 nM)、TrkAG667S (IC50: 5 nM)、TrkAF589L (IC50: 7 nM) 和 TrkCG623R (IC50: 6 nM)。Pan-Trk-IN-3 能够诱导细胞凋亡 (apoptosis),具有显著的抗肿瘤效果。 | |||
T79800 |
pan-KRAS-IN-2
|
Ras | GPCR/G Protein; MAPK |
Pan-KRAS-IN-2(compound 6)是一种抑制剂,对KRAS WT及其多种突变体(G12D、G12C、G12V、G12S、G12A、Q61H)表现出极高的抑制活性,其IC50均不超过10 nM;然而对KRAS G13D的抑制活性较低,IC50超过10 μM。 | |||
T63386 |
Pan-RAF kinase inhibitor 1
|
Others | Others |
Pan-RAF kinase inhibitor 1 是 Pan-RAF 激酶对有效抑制剂, 能够抑制 RAF 激酶,调节 MAPK 信号传导,进而影响 RAS 突变肿瘤细胞的增殖。 Pan-RAF kinase inhibitor 1 对研究癌症疾病表现出研究潜力。 | |||
T79814 |
pan-KRAS-IN-3
|
Ras | GPCR/G Protein; MAPK |
Pan-KRAS-IN-3 (Example 84)为一款pan-KRAS抑制剂,适用于癌症研究领域。 | |||
T62047 |
pan-HER-IN-1
|
Others | Others |
pan-HER-IN-1 (Compound C5) 是不可逆的、口服有效的广谱HER 抑制剂。pan-HER-IN-1抑制EGFR、HER4、EGFRT790M/L858R 和HER2的活性,IC50分别为 0.38、1.6、2.2 和 3.5 nM。pan-HER-IN-1可以诱导细胞凋亡 (apoptosis),显示出抗肿瘤活性。 | |||
T63475 |
Pan-Trk-IN-2
|
Others | Others |
Pan-Trk-IN-2 是小分子 Trks 抑制剂,表现出良好的抗肿瘤效果。 | |||
T79799 |
pan-KRAS-IN-4
|
Ras | GPCR/G Protein; MAPK |
Pan-KRAS-IN-4 (compound 5) 为一种高效KRAS抑制剂,其IC50值分别为0.37 nM (Kras G12C) 和0.19 nM (Kras G12V)。 | |||
T74847 |
PROTAC pan-IAP degrader-1
|
Others | Others |
PROTACpan-IAP degrader-1 (Compound 9) 是一种 pan-IAPPROTAC 降解剂。PROTACpan-IAP degrader-1 在 MM.1S 细胞中降解 XIAP、cIAP1 和 cIAP2 的 DC50分别为 0.7、2.4 和 6.2 nM。 | |||
T8224 |
VU0119498
|
AChR | Neuroscience |
VU0119498 是泛 GqmAChR M1、M3和M5的正变构调节剂,具有抗糖尿病活性,EC50值分别为 6.04、6.38 和 4.08 µM。 | |||
T0987 |
Gimeracil
吉美嘧啶,吉莫斯特,Gimestat |
Autophagy | Autophagy |
Gimeracil (Gimestat) 是一种竞争性可逆的 DPYD(二氢嘧啶脱氢酶,DPD) 有效抑制剂,是口服氟嘧啶衍生物 S-1 的成分,能够抑制 DNA DSB 的修复。 | |||
T70954 |
SP-187 HCl
|
Others | Others |
SP-187, also known as N-9-DNJ and UV-4B, is an alpha-Glucosidase inhibitor potentially for the treatment of dengue fever and influenza infection. Proline-producing strains of Serratia marcescens were more osmotolerant than wild-type strains. Growth inhibition by proline analogs was significantly enhanced by increasing the osmotic stress of the medium. | |||
T7020 |
Z-VAD-FMK
Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD |
Caspase | Apoptosis; Proteases/Proteasome |
Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂。Z-VAD-FMK 可以与活化的 caspase 结合,从而抑制细胞凋亡。Z-VAD-FMK即使在高达 440μM 的浓度下也不会抑制 UCHL1 的活性。 | |||
T14998 |
Copanlisib dihydrochloride
库潘尼西盐酸,BAY 80-6946 dihydrochloride |
Apoptosis; PI3K; mTOR | Apoptosis; PI3K/Akt/mTOR signaling |
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) 是一种选择性和 ATP 竞争性的泛 I 类 PI3K 抑制剂。它具有优越的抗肿瘤活性,对除 mTOR 以外的其他脂质和蛋白激酶的选择性也超过 2,000 倍。 | |||
T50113 |
(4R)-3-[2-(4-chlorophenoxy)-2-methylpropanoyl]-1,3-thiazolidine-4-carboxylic acid
|
Others | Others |
(4R)-3-[2-(4-chlorophenoxy)-2-methylpropanoyl]-1,3-thiazolidine-4-carboxylic acid 可用于化学和生命科学领域的研究。 | |||
T9386 |
2-((Perfluoropropan-2-yl)oxy)isoindoline-1,3-dione
|
Others | Others |
2-(2,6-dioxopiperidin-3-yl)-4-((9-hydroxynonyl)oxy)isoindoline-1,3-dione 是一种 PROTAC 接头,可用于 PROTAC 的合成。 | |||
T22338 |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
GDC046 |
Others; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046) 是一种具有口服活性的选择性TYK2抑制剂,对 TYK2、JAK1、JAK2 和 JAK3 的Ki 分别为 4.8、0.7、0.7 和 0.4 nM。 | |||
T7717 |
Sodium 2-oxopropanoate
Sodium pyruvate,丙酮酸钠 |
Reactive Oxygen Species; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB |
Sodium 2-oxopropanoate (Sodium pyruvate) 是 pyruvate 的钠盐形式。pyruvate 是葡萄糖的三碳代谢物,是一种在糖酵解途径中产生的化合物,它是一种能够清除 ROS 的自由基清除剂。 | |||
T1692 |
3-(3,4-Dimethoxyphenyl)propanoic acid
3,4-Dimethoxyhydrocinnamic acid,3,4-二甲氧基苯丙酸,3-(3,4-二甲氧基苯)丙酸 |
Aromatase | Endocrinology/Hormones |
3-(3,4-Dimethoxyphenyl)propanoic acid (3,4-Dimethoxyhydrocinnamic acid) 是一种口服具有活力的的短链脂肪酸 (SCFAs)。它在体内能够促进 γ 球蛋白基因表达和促红细胞生成,可用于 β 血红蛋白病和其他贫血症。 | |||
T10339 |
Antitrypanosomal agent 1
|
Parasite | Microbiology/Virology |
Antitrypanosomal agent 1 是一种有效的选择性锥虫硫酮还原酶抑制剂,IC50为 3.3 μM。它抑制谷胱甘肽还原酶,IC50为 64.8 μM,抑制布氏锥虫,EC50为 1 μM。 | |||
T6930 |
Pazopanib Hydrochloride
GW786034,Pazopanib HCl,GW786034 HCl,盐酸帕唑帕尼,Votrient HCl,Armala |
c-Fms; VEGFR; FGFR; PDGFR; c-Kit; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
Pazopanib Hydrochloride (Votrient HCl) 是一种多靶点抑制剂,抑制 VEGFR1、VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。 | |||
T76861 |
Cinpanemab
BIIB054 |
Others | Others |
Cinpanemab (BIIB054) 是一种新型人源单克隆抗体,对 α-突触核蛋白 1-10 位残基具有亲和力。Cinpanemab 可用于研究帕金森及其相关疾病。 | |||
T8687 |
diaminohydroxypropanetetraacetic acid
|
Others | Others |
diaminohydroxypropanetetraacetic acid 已被研究用于治疗血管疾病、冠状动脉疾病、心肌缺血、冠状动脉再狭窄和冠状动脉疾病等。 | |||
T0161 |
Pantoprazole Sodium Hydrate
SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis; Potassium Channel; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑,是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T6322 |
Copanlisib
BAY 80-6946,可泮利塞,库潘尼西 |
Apoptosis; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
Copanlisib (BAY 80-6946) 是一种选择性的和 ATP 竞争性的泛 I 类PI3K 抑制剂,具有抗肿瘤活性,对PI3Kα,PI3Kδ,PI3Kβ和PI3Kγ的IC50分别为 0.5 nM、0.7 nM、3.7 nM 和 6.4 nM。 | |||
T6929 |
Pantoprazole sodium
Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc |
Apoptosis; Others; Proton pump; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others |
Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂,是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,IC50为 6.8 μM。它可以改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T7587 |
Tenapanor
RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722 |
Sodium Channel | Membrane transporter/Ion channel |
Tenapanor (RDX 5791) 是钠氢离子交换NHE3的有效抑制剂, 对人和大鼠NHE3的IC50分别是5和10 nM。 | |||
T16126 |
Monepantel
AAD1566,PPL-1 |
AChR | Neuroscience |
Monepantel (AAD1566) 是一种有机驱虫剂,也是来自蛔虫和食管造口的烟碱乙酰胆碱受体拮抗剂,广泛用于农牧业除虫。 | |||
T9527 |
Span-85
Sorbitan trioleate,司盘85 |
Others | Others |
Span-85 (Sorbitan trioleate) 是一种合成的非离子乳化剂,由山梨糖醇或山梨糖醇与食品级棕榈酸部分酯化而成。粘度低,HLB 值最小,亲油性最强。它是一种优良的油包水(w/O)乳化剂和 O/w 型辅助乳化剂。 | |||
T0536 |
Cyclopropanecarbonitrile
Cyclopropanenitrile,Cyclopropylnitrile,环丙基腈 |
Others | Others |
Cyclopropanecarbonitrile (Cyclopropylnitrile) 是带有氰基的最小碳环分子。它主要用于微波光谱、光解和旋转光谱的实验。 | |||
T65636 |
BIS-TRIS propane
BTP |
Others | Others |
BIS-TRIS propane (BTP) 是镍基和钴基自旋团簇的新型多齿配体,是一种金属螯合剂。Bis-tris propane 常作为两性离子缓冲液使用,可用于PCR、蛋白质结晶研究和MgATPase 酶活力研究。 | |||
T60125 |
(2S,3S)-3-Hydroxy-2-methyl-3-phenylpropanoic acid
|
Others | Others |
(2S,3S)-3-Hydroxy-2-methyl-3-phenylpropanoic acid 是化学合成中间体。 | |||
T9927 |
Panitumumab
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Panitumumab 是一种重组全人源 IgG2 单克隆抗体,可与表皮生长因子(EGFR)结合,具有抗肿瘤活性。 | |||
T77670 |
(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid
|
Somatostatin | GPCR/G Protein |
(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid 是一种潜在的SSTR4激动剂。 | |||
T33876L1 |
Panomifene TFA
Panomifene TFA(77599-17-8 Free base),EGIS5650 TFA,GYKl13504 TFA |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Panomifene TFA(GYKl13504 TFA)是一种小分子 ERs 拮抗剂,具有抗癌活性,可用于研究乳腺癌和肌肉骨骼疾病。 | |||
T40709 |
3-Diethylamino-1-propanol
|
Others | Others |
3-Diethylamino-1-propanol 具有抗惊厥作用。 | |||
T8682 |
Vazegepant hydrochloride
Vazegepant HCl |
CGRP Receptor | GPCR/G Protein; Neuroscience |
Vazegepant hydrochloride (Vazegepant HCl) 是一种用于偏头痛的鼻用 gepant,是一种高度亲和性CGRP 受体拮抗剂 (hCGRPKi=0.023 nM)。它可能有助于有效管理 COVID-19 相关肺部炎症。 | |||
T1242 |
Alvimopan
爱维莫潘 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂,IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中,可用于术后肠梗阻的研究。 | |||
T4460 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate |
SGLT | GPCR/G Protein |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体,是竞争性葡萄糖协同转运蛋白2 抑制剂,可促进尿液中葡萄糖的排泄,可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。 | |||
T9437 |
1-methoxycyclopropanecarboxylic acid
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
1-methoxycyclopropanecarboxylic acid 是游离脂肪酸受体 3 (FFAR3, human) 的激动剂。 | |||
T34609 |
Selurampanel
BGG-492,BGG 492,BGG492 |
iGluR | Membrane transporter/Ion channel; Neuroscience |
Selurampanel (BGG492) 是一种具有口服活性和选择性的竞争性 AMPA 谷氨酸受体拮抗剂,是一种喹唑啉二酮磺酰胺。Selurampanel 可用于研究癫痫、偏头痛和耳鸣。 | |||
T20413L |
Spantide acetate
Spantide acetate(91224-37-2 Free base) |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Spantide acetate 是 NK1 受体的特异性拮抗剂,对 NK1 和 NK2 的 Kis 分别为 230 nM 和 8150 nM。 | |||
TP1137L |
Pancreatic Polypeptide (human) acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽,可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。 | |||
T17877 |
VH032-cyclopropane-F
VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101 |
Others; Ligand for E3 Ligase | Others; PROTAC |
VH032-cyclopropane-F 是基于 VH032 的 VHL 配体。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子,如 PROTAC 1。PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。 | |||
T9189 |
Iptacopan hydrochloride
Iptacopan HCl,LNP023 hydrochloride |
Complement System | Immunology/Inflammation |
Iptacopan hydrochloride (LNP023 hydrochloride) 是一种可口服、高效和高选择性的因子 B 抑制剂,IC50 为 10 nM。 LNP023 显示与人因子 B 的直接、可逆和高亲和力结合,KD 为 7.9 nM。 | |||
T50052 |
1,2-diphenylpropan-2-amine
|
Others | Others |
1,2-diphenylpropan-2-amine 是Remacemide 的(S,R)-异构体单盐酸盐代谢产物。1,2-diphenylpropan-2-amine 具有抗惊厥作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3009 |
3-Nitropropanoic acid
3-NP acid,Bovinocidin,3-NP,3-硝基丙酸,β-Nitropropionic acid |
Apoptosis; Dehydrogenase; Antibacterial | Apoptosis; Metabolism; Microbiology/Virology |
3-Nitropropanoic acid (Bovinocidin) 是一种琥珀酸脱氢酶的不可逆抑制剂。它对分枝杆菌有很强的抗菌活性,MIC 值为 3.3μM。 | |||
T13589 |
Caesappanin C
|
Others | Others |
Caesappanin C 是一种联苯二聚体,提取自印度尼西亚 Caesalpinia sappan L. 的心材中,具有刺激骨形成和再生的潜力。它在体外显示出对原代成骨细胞的强增殖刺激活性。 | |||
TN5924 |
3-Hydroxy-1-(4-hydroxyphenyl)propan-1-one
3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone,3-羟基-1-(4-羟基苯基)丙烷-1-酮 |
Others | Others |
3-Hydroxy-1-(4-hydroxyphenyl)propan-1-one (3-Hydroxy-1-(4-hydroxyphenyl)-1-propanone) 是植物来源的天然产物。 | |||
TWO2727 |
Propane-1,2,3-triyl tripalmitate
Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) 是内源性代谢产物的一种。 | |||
T19129 |
3-(3,4,5-Trimethoxyphenyl)propanoic acid
|
Endogenous Metabolite | Metabolism |
3-(3,4,5-Trimethoxyphenyl)propanoic acid 是Piper longum(长胡椒) 和Piper retrofractum(爪哇长胡椒) 的成分,存在于草药和香料中。 | |||
T9513 |
Methyl 3-phenylpropanoate
3-Phenylpropionic acid methyl ester,3-苯丙酸甲酯 |
Endogenous Metabolite | Metabolism |
Methyl 3-phenylpropanoate (3-Phenylpropionic acid methyl ester) 是内源性代谢产物的一种。 | |||
T5619 |
(±)-1,2-Propanediol
1,2-Propanediol,Propylene glycol,1,2-Dihydroxypropane,Methyl ethyl glycol,丙二醇 |
Others | Others |
(±)-1,2-Propanediol 是一种脂肪族醇,具有多种作用,可作为防腐剂和防冻剂,在食品工业和护肤品行业应用广泛。 (±)-1,2-Propanediol 是一种天然抑菌剂,能够在一定程度上抑制细菌的生长和繁殖 | |||
T4752 |
1-Aminocyclopropane-1-carboxylic acid
1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC |
Endogenous Metabolite; NMDAR | Metabolism; Neuroscience |
1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。 | |||
T2804 |
Panaxatriol
人参三醇,Panaxtriol |
Others | Others |
Panaxatriol (Panaxtriol) 是一种能够减轻由于辐射损伤造成的骨髓抑制的天然产物。 | |||
T9218 |
Andrograpanin
19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE,新穿心莲内酯苷元 |
p38 MAPK | MAPK |
Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) 是来自穿心莲的一种天然产物,具有抗炎和抗感染活性。 | |||
T2763 |
Panaxadiol
人参二醇,20(R)-Panaxadiol |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Panaxadiol (20(R)-Panaxadiol) 是从人参根中获得,具有神经保护和抗肿瘤作用,能够抑制程序性细胞死亡配体-1(PD-L1)的表达和肿瘤增殖。 | |||
TJS1779 |
Protosappanin A
原苏木素A,PTA |
NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells |
Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物,通过下调 JAK2和 STAT3的磷酸化,抑制 JAK2/STAT3依赖的炎症通路。 | |||
T7450 |
1-Phenylpropane-1,2-dione
1-Phenyl-1,2-propanedione,Acetyl benzoyl,1-苯基-1,2-丙二酮 |
Others | Others |
1-Phenylpropane-1,2-dione (Acetyl benzoyl) 是麻黄素生物碱的生物合成前体,分离自从嫩麻黄中。 | |||
T3738 |
3-(4-Hydroxyphenyl)-1-propanol
|
LTR | Immunology/Inflammation |
3-(4-Hydroxyphenyl)-1-propanol 能够用于合成 (-)-centrolobine。 | |||
TN4893 |
Rapanone
拉帕酮,2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone,2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione,酸藤子醌 |
Apoptosis; Phospholipase; Antibacterial; Parasite | Apoptosis; Metabolism; Microbiology/Virology |
Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) 是一种具有广泛生物活性的天然苯醌,如抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫活性。它还是选择性人滑膜 PLA2抑制剂,IC50值为 2.6 μM。 | |||
T6480 |
D-Pantothenic acid
vitamin B5,pantothenate,D-泛酸 |
Others | Others |
D-Pantothenic acid (vitamin B5) 是必需的微量营养素,是辅酶 A 的前体,在很多生物过程中发挥关键作用,如调节碳水化合物,脂质,蛋白和核酸代谢。 | |||
T0978 |
Pantethine
LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine |
Endogenous Metabolite | Metabolism |
D-Pantethine (Pantomin) 是泛酸的二聚体形式, 是生产辅酶 A 的中间体。D-Pantethine 能够作为膳食补充剂,用于改善血液胆固醇和研究痤疮。 | |||
T2799 |
(20S)-Protopanaxadiol
20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇 |
Apoptosis; Reactive Oxygen Species; P-gp | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) 是人参皂甙的代谢产物,是一种凋亡诱导剂,抑制Akt 活性并诱导多种肿瘤细胞凋亡。 | |||
T3737 |
3-(2,4-Dihydroxyphenyl)propanoic acid
3-(2,4-二羟基苯)丙酸,Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid |
Tyrosinase | Proteases/Proteasome |
3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) 是竞争性酪氨酸酶 (tyrosinase) 抑制剂,可抑制 L-Tyrosine 和 DL-DOPA,IC50和 Ki 分别为 3.02 μM 和 11.5 μM。 | |||
T8097 |
Methyl 3-aminopropanoate hydrochloride
β-Alanine methyl ester hydrochloride,3-氨基丙酸甲酯盐酸盐 |
Others | Others |
Methyl 3-aminopropanoate hydrochloride (β-Alanine methyl ester hydrochloride) 是由 Β-Alanine (I) 酯化得到。它可用于合成双齿吡啶酸配体。 | |||
T4887 |
3-Amino-2-methylpropanoic acid
DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine |
Endogenous Metabolite | Metabolism |
3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物,是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。 | |||
TN1517 |
1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
剑叶龙血素A,Cochinchinenin A |
Others | Others |
1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) 是龙血镇痛作用的物质基础。 | |||
T40585 |
1,3-Propanediol
|
Others | Others |
1,3-Propanediol 是微生物经甘油发酵产生的化合物。 | |||
TN7246 |
3-Sulfopropanoic acid
3-SPA |
Drug Metabolite | Metabolism |
3-Sulfopropanoic acid 是曲吡罗酯及其前药ALZ-801的主要代谢产物,是存在于AD患者的脑脊液(CSF)中的内源性分子,可抑制 Aβ42 寡聚体的形成。 | |||
T4773 |
3-Ethoxy-3-oxopropanoic acid
Monoethyl malonic acid,Ethyl hydrogen malonate,丙二酸单乙酯 |
Others; Endogenous Metabolite | Metabolism; Others |
3-Ethoxy-3-oxopropanoic acid (Monoethyl malonic acid) 是内源性代谢产物的一种。 | |||
T5290 |
(S)-2-Hydroxy-3-phenylpropanoic acid
L-(−)-3-Phenyllactic acid,L-3-苯乳酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。 | |||
T5243 |
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate
DMPE,1,2-十四酰基磷脂酰乙醇胺,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE |
Others; Endogenous Metabolite | Metabolism; Others |
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) 是内源性代谢产物的一种。 | |||
T1390 |
DL-Panthenol
Panthenol,DL-泛醇,DL-Pantothenyl alcohol,DL-Pantothenol |
||
DL-Panthenol (DL-Pantothenyl alcohol) 是一种泛酸的醇类衍生物。它广泛应用于皮肤和毛发护理研究。它具有睫毛保护作用。 | |||
TMA1570 |
Sappanone A
|
NF-κB; Nrf2 | Immunology/Inflammation; NF-κB |
Sappanone A 是一种高异黄烷酮,通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。 | |||
T20312 |
3-Phenylpropanal
NSC-9271,Phenylpropyl aldehyde,NSC9271,NSC 9271 |
Others | Others |
3-Phenylpropanal (Phenylpropyl aldehyde) 是RIFM 香料成分,可用于制作香水。3-Phenylpropanal 是杀螨剂的主要成分。3-Phenylpropanal 可作为苍蝇引诱剂使用。 | |||
T6S1780 |
Protosappanin B
原苏木素B,Q-100961,FT-0689654 |
Apoptosis | Apoptosis |
Protosappanin B (Q-100961) 是从苏木中提取的一种多酚类天然产物,具有抗肿瘤作用。它通过激活 MDM2 依赖性泛素化过程诱导 p53 蛋白降解。它显著提高细胞活力,抑制细胞凋亡并上调生长相关蛋白 43 的表达。 | |||
T2810 |
(20S)-Protopanaxatriol
原人参三醇,20(S)-APPT,20 (S)-原人参三醇,g-PPT |
Apoptosis; Estrogen Receptor/ERR; Glucocorticoid Receptor; Estrogen/progestogen Receptor; Liver X Receptor | Apoptosis; Endocrinology/Hormones; Metabolism |
(20S)-Protopanaxatriol (g-PPT) 是人参皂苷的代谢物,通过糖皮质激素受体和雌激素受体起作用,同时为LXRα的抑制剂,具有广泛的抗癌活性。 | |||
T4755 |
2,3-Diaminopropanoic acid hydrochloride
DL-2,3-Diaminopropionic acid monohydroch,3-Amino-DL-alanine monohydrochloride,DL-2,3-二胺基丙酸盐酸盐 |
Others; Endogenous Metabolite | Metabolism; Others |
2,3-Diaminopropanoic acid hydrochloride (3-Amino-DL-alanine monohydrochloride) 是内源性代谢产物的一种。 | |||
T3917 |
Protopanaxatriol
20(R)-APPT,20(R)-Protopanaxatriol,原人参三醇,(20R)-Protopanaxatriol |
PPAR | DNA Damage/DNA Repair; Metabolism |
Protopanaxatriol (20(R)-APPT) 是天然的人参皂苷的糖苷配基,包括 Re,Rf,Rg1,Rg2 和 Rh。 | |||
T3S1513 |
(20R)-Protopanaxadiol
Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol |
Others; Antibacterial | Microbiology/Virology; Others |
(20R)-Protopanaxadiol ((20R)-Protopanaxdiol) 是黑参中20(R)-人参皂甙 Rg3的一种三萜皂苷代谢物。它抑制幽门螺杆菌的生长,有抗肿瘤活性和细胞毒性。 | |||
T3551 |
D-Pantothenic acid hemicalcium salt
泛酸钙,D-Pantothenic Acid Calcium,D-泛酸半钙,Calpanate,Calcium D-pantothenate,Vitamin B5 calcium salt,Calcium pantothenate,Calcium D-Panthotenate |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
D-Pantothenic acid hemicalcium salt (Calcium pantothenate) 是一种水溶性维生素,能够减少苹果汁中的棒曲霉素。 | |||
T2760 |
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate
Iodogorgoic acid,apothyrin,jodgorgon,3,5-Diiodotyrosine Dihydrate,双碘酪氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (jodgorgon) 是内源性代谢产物的一种。 | |||
T1437 |
D-Panthenol
D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol |
Endogenous Metabolite | Metabolism |
D-Panthenol (D-Pantothenyl alcohol) 是 D-pantothenic acid 和胆碱能剂的酒精类似物。D-Panthenol 作为乙酰化反应所必需的辅酶A的前体,参与乙酰胆碱的合成。虽然 D-Panthenol 作用的确切机制尚不清楚,但它可能增强乙酰胆碱的作用。D-Panthenol 作用于胃肠道,增加下肠蠕动。它也适用于局部皮肤,以缓解瘙痒和促进愈合。 | |||
T83582 |
(±)-Pantothenic acid
(±)-Vitamin B5,(±)-Pantothenate |
||
(±)-Pantothenic acid ((±)-Pantothenate) 作为 B 组维生素的一员,对于哺乳动物细胞中辅酶 A (CoA) 的生物合成是不可或缺的。此外,该化合物能防护丙戊酸 (VPA) 在 CD-1 小鼠中引起的神经管缺陷 (NTD)。 | |||
TN2775 |
2-Methoxystypandrone
|
MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant | |||
TN2702 |
2,3-dihydroxy-3-(4-hydroxyphenyl)propanoic acid
|
Others | Others |
2,3-dihydroxy-3-(4-hydroxyphenyl)propanoic acid 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2702,CAS号为 100201-57-8。 | |||
TN2827 |
25(S)-Hydroxyprotopanaxatriol
|
Others | Others |
25(S)-Hydroxyprotopanaxatriol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2827,CAS号为 113539-03-0。 | |||
TN4001 |
erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol
|
Others | Others |
erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4001,CAS号为 1280602-81-4。 | |||
TMA0897 |
Beta-Carboline-1-propanoic acid
|
Others | Others |
Beta-Carboline-1-propanoic acid 是一种参考标准化合物,也是一种合成前体化合物。它是吲哚的衍生物,已被用于合成其他吲哚衍生物,如吲哚-3-甲醛,也被用作合成多环芳香化合物的起始材料。它还被用于研究含吲哚化合物的构效关系,并被用作研究吲哚反应性的模型化合物。 | |||
TN2041 |
Pangelin
|
Others | Others |
Pangelin is a natural product | |||
TN2040 |
Panaxynol
|
BCL; Caspase; HIF | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Proteases/Proteasome |
Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. | |||
TN4736 |
Paniculidine B
|
Others | Others |
Paniculidine B是一种天然产物,属于芸香科九里香属,其产品编号为 TN4736,CAS号为 97399-94-5。Paniculidine B可用作对照参考。 | |||
TQ0073 |
Andropanolide
|
HIV Protease; NO Synthase; Parasite | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Andropanolide 是一种来自穿心莲的二帖类化合物,具有抗HIV、抗疟和抗癌活性,对 Lipopolysaccharides (LPS) 刺激的 RAW264.7 巨噬细胞中一氧化氮 (NO) 的过量产生有抑制作用。 | |||
TN5964 |
Adiantulupanone
|
||
Adiantulupanone 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5964,CAS号为 51511-05-8。 | |||
T38589 |
Neopanaxadiol
|
Others | Others |
Neopanaxadiol, an aglycone derived from protopanaxadiol type ginsenosides, exhibits promising potential for Alzheimer's disease research. | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03082 |
DEFB106A Protein, Pan troglodytes, Recombinant (His & KSI)
BD-6,cBD-6,DEFB6,DEFB106,DEFB106A,Defensin, beta 106,Beta-de... |
Chimpanzee | E. coli |
Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2. DEFB106A Protein, Pan troglodytes, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 20.4 kDa and the accession number is Q5IAB3. | |||
TMPY-03564 |
TSPAN8 Protein, Human, Recombinant (His)
CO-029,tetraspanin 8,TM4SF3 |
Human | HEK293 Cells |
TSPAN8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.4 kDa and the accession number is P19075. | |||
TMPY-03833 |
TM4SF2/TSPAN7 Protein, Cynomolgus, Recombinant (His)
tetraspanin 7 |
Cynomolgus | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-00318 |
TSPAN1 Protein, Human, Recombinant (mFc)
tetraspanin 1,TSPAN1,NET1,TM4C,TM4SF |
Human | HEK293 Cells |
TSPAN1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 38.4 kDa and the accession number is O60635. | |||
TMPH-00808 |
HBV-D subtype ayw (isolate Japan/JYW796/1988) Protein X (His)
Peptide X,Protein X,HBx,pX,X |
HBV-D | E. coli |
HBV-D subtype ayw (isolate Japan/JYW796/1988) Protein X (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 22.6 kDa and the accession number is Q9QMI3. | |||
TMPY-00029 |
TM4SF2/TSPAN7 Protein, Rat, Recombinant (His)
tetraspanin 7 |
Rat | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-01500 |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is A0FFY3. | |||
TMPY-02961 |
PANP/C12orf53 Protein, Human, Recombinant (hFc)
C12orf53,UNQ828/PRO1755,PILR α associated neural protein, |
Human | HEK293 Cells |
C12orf53 is mainly expressed in adult brain and cerebellum. It also can be detected in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. C12orf53 acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. Chromosome 12 encodes over 1,100 genes within 132 million bases. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan... | |||
TMPY-01135 |
Influenza A H2N2 (A/Japan/305/1957) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H2N2 | HEK293 Cells |
Influenza A H2N2 (A/Japan/305/1957) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is P03451. | |||
TMPY-03862 |
TM4SF2/TSPAN7 Protein, Human, Recombinant (His)
TM4SF2,A15,MXS1,tetraspanin 7,TALLA-1,CCG-B7,CD231,... |
Human | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPH-03083 |
CrtX Protein, Pantoea ananas, Recombinant (His & Myc)
Zeaxanthin glucosyltransferase,ugt101,crtX |
Pantoea ananas | Baculovirus Insect Cells |
Catalyzes the glycosylation reaction which converts zeaxanthin to zeaxanthin bis(beta-D-glucoside). The reaction proceeds in two steps with the monoglucoside as an intermediate. CrtX Protein, Pantoea ananas, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 51.1 kDa and the accession number is P21686. | |||
TMPH-02193 |
Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (His)
Cell surface glycoprotein A15,Membrane component chromosome ... |
Human | P. pastoris (Yeast) |
May be involved in cell proliferation and cell motility. Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 14.5 kDa and the accession number is P41732. | |||
TMPH-02191 |
Tetraspanin-2/TSPAN2 Protein, Human, Recombinant
Tetraspanin-2,TSPAN2,Tetraspan NE... |
Human | E. coli |
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. Tetraspanin-2/TSPAN2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.8 kDa and the accession number is O60636. | |||
TMPH-02364 |
Japanese encephalitis virus Genome polyprotein (His & SUMO)
Genome polyprotein |
JEV | E. coli |
Japanese encephalitis virus Genome polyprotein (His & SUMO) is expressed in E. coli. | |||
TMPY-03675 |
TSPAN8 Protein, Human, Recombinant (mFc)
TM4SF3,tetraspanin 8,CO-029 |
Human | HEK293 Cells |
TSPAN8 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 58 kDa and the accession number is P19075. | |||
TMPY-00567 |
Influenza A H2N2 (A/Japan/305/1957) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H2N2 | HEK293 Cells |
Influenza A H2N2 (A/Japan/305/1957) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.5 kDa and the accession number is Q6XU87. | |||
TMPY-03871 |
TM4SF2/TSPAN7 Protein, Mouse, Recombinant (His)
AI323365,Tm4sf2,PE31,A15,R74651,TALLA,Mxs1,Cd231,1200014P11R... |
Mouse | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPY-03409 |
TSPAN1 Protein, Human, Recombinant (aa 110-211, rFc)
tetraspanin 1,NET1,TSPAN1,TM4SF,TM4C |
Human | HEK293 Cells |
TSPAN1 Protein, Human, Recombinant (aa 110-211, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 39.1 kDa and the accession number is O60635. | |||
TMPH-00087 |
Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
Expansin-A1,Alpha-expansin-1,EXPA1,Ath-Exp... |
Arabidopsis thaliana | E. coli |
Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.2 kDa and the accession number is Q9C554. | |||
TMPY-03978 |
TSPAN31 Protein, Human, Recombinant (mFc)
tetraspanin 31,SAS |
Human | HEK293 Cells |
TSPAN31 is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN31 is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. | |||
TMPY-01622 |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is A0FFY3. | |||
TMPH-03650 |
Turnip mosaic virus (TuMV) (strain Japanese) Genome polyprotein (His & Myc)
|
TuMV | E. coli |
N/A. Turnip mosaic virus (TuMV) (strain Japanese) Genome polyprotein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 66.6 kDa and the accession number is Q9ICI2. | |||
TMPH-03084 |
CrtX Protein, Pantoea ananas, Recombinant (E. coli, His & Myc)
Zeaxanthin glucosyltransferase,crtX,ugt101 |
Pantoea ananas | E. coli |
Catalyzes the glycosylation reaction which converts zeaxanthin to zeaxanthin bis(beta-D-glucoside). The reaction proceeds in two steps with the monoglucoside as an intermediate. CrtX Protein, Pantoea ananas, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.7 kDa and the accession number is P21686. | |||
TMPH-00164 |
4'-phosphopantetheinyl transferase ffp Protein, Bacillus subtilis, Recombinant (His & Myc)
4'-phosphopantetheinyl transferase ffp,EC:2.7.8.-,F... |
Bacillus subtilis | E. coli |
May activate the peptidyl carrier protein (PCP) domains of fengycin synthase by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. 4'-phosphopantetheinyl transferase ffp Protein, Bacillus subtilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.0 kDa and the accession number is Q9F4F7. | |||
TMPH-00088 |
Expansin-B1 Protein, Arabidopsis thaliana, Recombinant (His)
EXPB1,Expansin-B1,Ath-ExpBeta-1.5,Beta-expan |
Arabidopsis thaliana | E. coli |
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. | |||
TMPH-02192 |
Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (E. coli, His)
Transmembrane 4 superfamily member 2,TSPAN7,Membran... |
Human | E. coli |
May be involved in cell proliferation and cell motility. Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.6 kDa and the accession number is P41732. | |||
TMPY-06038 |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA Protein (His), Biotinylated
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA Protein (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is A0FFY3. | |||
TMPY-06031 |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA1 Protein (His), Biotinylated
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) Hemagglutinin/HA1 Protein (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is A0FFY3. | |||
TMPY-03936 |
TSPAN1 Protein, Human, Recombinant (aa 110-211, His)
NET1,TM4C,tetraspanin 1,TM4SF,TSPAN1 |
Human | HEK293 Cells |
TSPAN1 Protein, Human, Recombinant (aa 110-211, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.1 kDa and the accession number is O60635. | |||
TMPY-03930 |
TM4SF2/TSPAN7 Protein, Cynomolgus, Recombinant (mFc)
tetraspanin 7 |
Cynomolgus | HEK293 Cells |
TALLA-1, also known as TSPAN7, is a member of the transmembrane 4 superfamily Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. TALLA-1 gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. TALLA-1 is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. TM4... | |||
TMPH-03648 |
Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc)
Cruzaine,Cruzipain,Major cysteine proteinase |
Trypanosoma cruzi | E. coli |
Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.; The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weig... | |||
TMPH-03649 |
HSP100 Protein, Trypanosoma cruzi, Recombinant (His & Myc)
Heat shock protein 100,HSP100,Protein CLP |
Trypanosoma cruzi | E. coli |
N/A. HSP100 Protein, Trypanosoma cruzi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 22.9 kDa and the accession number is O15885. | |||
TMPJ-01468 |
pro-Beta NGF Protein, Human, Recombinant
β-NGF,NGF,NGFB,Beta-NGF,Beta-Nerve Growth Factor,pro-Beta NG... |
Human | E. coli |
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration. | |||
TMPJ-00375 |
HGF Protein, Human, Recombinant (His)
Scatter factor,Hepatocyte growth factor,HGF,SF,Hepatopoietin... |
Human | HEK293 Cells |
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET. HGF regulates epithelia... | |||
TMPJ-00134 |
pro-BDNF Protein, Human, Recombinant
Brain-Derived Neurotrophic Factor,Abrineurin,BDNF |
Human | E. coli |
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regul... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0022 |
1,3-Distearoyl-2-chloropropanediol-d5
|
||
1,3-Distearoyl-2-chloropropanediol-d5 是 1,3-Distearoyl-2-chloropropanediol 的氘代化合物。 | |||
TMIH-0421 |
Pazopanib-d6
|
||
Pazopanib-d6 是 Pazopanib 的氘代化合物。 | |||
T64769 |
Propan-d7-2-amine hydrochloride
|
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Propan-d7-2-amine hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64769。 | |||
TMIH-0037 |
2-Methylpropanedioic acid-d3
methyl-d3-malonic acid |
||
2-Methylpropanedioic acid-d3 是 2-Methylpropanedioic acid 的氘代化合物。2-Methylpropanedioic acid 的 CAS 号为 516-05-2。Methylmalonic acid 是癌症患者缺乏维生素 B-12的指标。 | |||
TMIH-0425 |
Perampanel-d5
|
||
Perampanel-d5 是 Perampanel 的氘代化合物。Perampanel 的 CAS 号为 380917-97-5。 | |||
TMIJ-0397 |
1,3-Dichloro-2-propanol-d5
|
||
1,3-Dichloro-2-propanol-d5 是 1,3-Dichloro-2-propanol 的氘代化合物。1,3-Dichloro-2-propanol 的 CAS 号为 96-23-1。 | |||
TMIJ-0362 |
rac 1-Palmitoyl-3-Chloropropanediol-d5
|
||
rac 1-Palmitoyl-3-Chloropropanediol-d5 是 rac 1-Palmitoyl-3-Chloropropanediol 的氘代化合物。rac 1-Palmitoyl-3-Chloropropanediol 的 CAS 号为 30557-04-1。 | |||
TMIJ-0192 |
Pantoprazole-d6
|
||
Pantoprazole-d6 是 Pantoprazole 的氘代化合物。Pantoprazole 的 CAS 号为 102625-70-7。Pantoprazole 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。 | |||
TMIJ-0388 |
3-Chloro-1,2-Propanediol-d5
|
||
3-Chloro-1,2-Propanediol-d5 是 3-Chloro-1,2-Propanediol 的氘代化合物。3-Chloro-1,2-Propanediol 的 CAS 号为 96-24-2。 | |||
TMIJ-0450 |
2,3-Dichloro-1-propanol-d5
|
||
2,3-Dichloro-1-propanol-d5 是 2,3-Dichloro-1-propanol 的氘代化合物。2,3-Dichloro-1-propanol 的 CAS 号为 616-23-9。 | |||
TMIH-0050 |
3-phenylpropanoic-2,2-d2 acid
|
||
3-phenylpropanoic-2,2-d2 acid 是 3-phenylpropanoic-2,2 acid 的氘代化合物。 | |||
TMIJ-0395 |
2-Chloro-1,3-propanediol-d5
|
||
2-Chloro-1,3-propanediol-d5 是 2-Chloro-1,3-propanediol 的氘代化合物。2-Chloro-1,3-propanediol 的 CAS 号为 497-04-1。 | |||
TMIJ-0398 |
rac 1,2-Bis-palmitoyl-3-chloropropanediol-d5
|
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rac 1,2-Bis-palmitoyl-3-chloropropanediol-d5 是 rac 1,2-Bis-palmitoyl-3-chloropropanediol 的氘代化合物。rac 1,2-Bis-palmitoyl-3-chloropropanediol 的 CAS 号为 51930-97-3。 | |||
T26871 |
BMT-052
BMT052 |
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BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM). |