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Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,980 | 35日内发货 | |
5 mg | ¥ 7,880 | 35日内发货 |
产品描述 | Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively. |
靶点活性 | L-selectin:86 μM, P-selectin:20 μM, Eselectin:88 μM |
体外活性 | Bimosiamose (TBC-1269) inhibits cell recruitment. And it does not possess any cytotoxic effect on neutrophils. Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. |
体内活性 | Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion. It also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. |
别名 | TBC-1269 |
分子量 | 862.91 |
分子式 | C46H54O16 |
CAS No. | 187269-40-5 |
密度 | 1.417 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | 0.1 M NaOH: 25 mg/mL (28.97 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended. DMSO: 125 mg/mL (144.86 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
0.1 M NaOH/DMSO
DMSO
|
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