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-9384个剔除PAINS的化合物小分子活性化合物，可用于高通量筛选和高内涵筛选；
-靶点多样，覆盖度广；涵盖多个疾病研究领域，如癌症、代谢、免疫和心血管系统等；
-是老药新用、细胞诱导靶点筛选的有效工具；
-详细的说明书，化合物结构、靶点信息、活性描述等；
-结构多样，药效显著，可渗透细胞；
-NMR、HPLC/ LCMS多重检测，保证产品结构准确，纯度高，保障实验顺利进行。
NO PAINS 化合物库
NO PAINS Compound Library
很棒高通量筛选是药物研发中是一个重要的研究手段，可以通过快速测试大量化合物来发现靶标化合物，真正的药物能够精确作用于特定蛋白质的结合位点，从而抑制或激活蛋白质的功能，然而在高通量筛选实验中发现一些化合物并不是基于化合物与蛋白质之间特异性的作用并且在不同类型靶点筛选中均表现出“活性”的假阳性结果，这类化合物称为泛筛选干扰化合物（PAINS, Pan-assay interference compounds）。PAINS 化合物包括毒黄素、异噻唑酮、绕丹宁、烯酮类等。由于PAINS 的难成药性，给科学家带来了巨大的困扰，浪费了大量的人力和物力资源。 TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物，可用于新药研发，信号通路研究，老药新用等研究。
TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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化合物库相关信息
Excel
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NO PAINS 化合物库规格
- 1 mg
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
询价 & 定制
产品描述
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
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化合物库组成
Apoptosis
Autophagy
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Endogenous Metabolite
Antibiotic
5-HT Receptor
Parasite
AChR
Antifungal
COX
NF-κB
Adrenergic Receptor
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Potassium Channel
HIV Protease
Dopamine Receptor
CDK
Calcium Channel
PI3K
VEGFR
Reactive Oxygen Species
Cytochromes P450
EGFR
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Epigenetic Reader Domain
GABA Receptor
Influenza Virus
Dehydrogenase
PDE
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PPAR
Estrogen/progestogen Receptor
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GluR
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JAK
FLT
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E1/E2/E3 Enzyme
NOS
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transporter
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STING
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P2Y Receptor
PERK
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IRAK
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Liver X Receptor
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PAK
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GPCR19
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IDO
IAP
Myosin
DNA
Gap Junction Protein
cholecystokinin
ROS Kinase
PD-1/PD-L1
Monocarboxylate transporter
IFNAR
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PAD
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cAMP
ATP Citrate Lyase
Porcupine
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GST
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CRM1
Ligands for Target Protein for PROTAC
YAP
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GTPase
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GRK
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PI4K
Oxytocin Receptor
Platelet aggregation
p97
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Arrestin
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LIM Kinase
PYK2
LDL
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ACK1
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NPC1L1
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Cell Cycle Arrest
Glutaminase
Annexin A
FLAP
Adiponectin Receptor
PAFR
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ASK
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APC/C
Apelin receptor
Dynamin
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E3 Ligase Ligand-Linker Conjugate
Cell wall
Galectin
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SIK
MTH1
GlyT
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Molecular Glues
MAGL
PTEN
Thrombopoietin Receptor
Mucin
OXPHOS
PSMA
Decarboxylase
TSH Receptor
CRFR
Pyroptosis
MELK
Methionine Adenosyltransferase (MAT)
Hippo pathway
GPX
KLF
NADPH-oxidase
BMI-1
Melanin-concentrating Hormone Receptor (MCHR)
MALT
Piezo Channel
EBI2/GPR183
Sodium-dependent phosphate transporter
RAR/RXR
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PGC-1α
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Survivin
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Stemness kinase
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Motilin Receptor
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