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-9384个剔除PAINS的化合物小分子活性化合物，可用于高通量筛选和高内涵筛选；
-靶点多样，覆盖度广；涵盖多个疾病研究领域，如癌症、代谢、免疫和心血管系统等；
-是老药新用、细胞诱导靶点筛选的有效工具；
-详细的说明书，化合物结构、靶点信息、活性描述等；
-结构多样，药效显著，可渗透细胞；
-NMR、HPLC/ LCMS多重检测，保证产品结构准确，纯度高，保障实验顺利进行。
NO PAINS 化合物库
NO PAINS Compound Library
很棒高通量筛选是药物研发中是一个重要的研究手段，可以通过快速测试大量化合物来发现靶标化合物，真正的药物能够精确作用于特定蛋白质的结合位点，从而抑制或激活蛋白质的功能，然而在高通量筛选实验中发现一些化合物并不是基于化合物与蛋白质之间特异性的作用并且在不同类型靶点筛选中均表现出“活性”的假阳性结果，这类化合物称为泛筛选干扰化合物（PAINS, Pan-assay interference compounds）。PAINS 化合物包括毒黄素、异噻唑酮、绕丹宁、烯酮类等。由于PAINS 的难成药性，给科学家带来了巨大的困扰，浪费了大量的人力和物力资源。 TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物，可用于新药研发，信号通路研究，老药新用等研究。
TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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化合物库相关信息
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NO PAINS 化合物库规格
- 1 mg
- 30 μL x 10 mM (in DMSO)
- 50 μL x 10 mM (in DMSO)
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
询价 & 定制
产品描述
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
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化合物库组成
Apoptosis
Autophagy
Antibacterial
Endogenous Metabolite
Antibiotic
5-HT Receptor
Parasite
AChR
Antifungal
COX
NF-κB
Adrenergic Receptor
DNA/RNA Synthesis
Potassium Channel
HIV Protease
Dopamine Receptor
Calcium Channel
CDK
PI3K
VEGFR
Reactive Oxygen Species
P450
EGFR
Histamine Receptor
Sodium Channel
Epigenetic Reader Domain
Influenza Virus
GABA Receptor
Dehydrogenase
JAK
PDE
HDAC
Histone Methyltransferase
PPAR
Estrogen/progestogen Receptor
TRP/TRPV Channel
Ferroptosis
GluR
Microtubule Associated
p38 MAPK
FLT
Antioxidant
AChE
mTOR
TNF
Estrogen Receptor/ERR
ERK
PDGFR
Src
Opioid Receptor
Phosphatase
FGFR
RAAS
Akt
PARP
GPR
iGluR
AMPK
Topoisomerase
SARS-CoV
c-Kit
Caspase
PKC
STAT
Proteasome
HCV Protease
Raf
Prostaglandin Receptor
c-Met/HGFR
Adenosine Receptor
Wnt/beta-catenin
Glucocorticoid Receptor
Virus Protease
IL Receptor
MMP
ATPase
NO Synthase
Mitophagy
Bcr-Abl
NMDAR
TGF-beta/Smad
GSK-3
ALK
Androgen Receptor
Beta Amyloid
BCL
HSV
HBV
Mitochondrial Metabolism
Nucleoside Antimetabolite/Analog
HSP
TLR
Anti-infection
Tyrosinase
MEK
Aurora Kinase
Sirtuin
HIF/HIF Prolyl-Hydroxylase
JNK
MAO
Drug Metabolite
Phospholipase
ROS
Interleukin
Reverse Transcriptase
Ras
PKA
P-gp
DNA-PK
MAPK
IκB/IKK
Cannabinoid Receptor
Monoamine Oxidase
Integrin
Tyrosine Kinases
Serine/threonin kinase
ROCK
BTK
CCR
Lipoxygenase
HER
Serotonin Transporter
Antiviral
ADC Cytotoxin
Carbonic Anhydrase
E1/E2/E3 Enzyme
NOS
CXCR
CaMK
Nrf2
p53
Gamma-secretase
Casein Kinase
Histone Demethylase
Trk receptor
ribosome
c-RET
TAM Receptor
LPL Receptor
Serine Protease
P2X Receptor
HIF
Neurokinin receptor
Antifection
IGF-1R
FAK
Chloride channel
Norepinephrine
DUB
Retinoid Receptor
S6 Kinase
S1P Receptor
Cysteine Protease
ATM/ATR
Kras
Proton pump
Transferase
Amino Acids and Derivatives
Fatty Acid Synthase
Hedgehog/Smoothened
Histone Acetyltransferase
Progesterone Receptor
Glucagon Receptor
DPP-4
Indoleamine 2,3-Dioxygenase (IDO)
c-Fms
Thyroid hormone receptor(THR)
DNA Alkylator/Crosslinker
NADPH
FXR
Glucosidase
FAAH
Chk
PLK
HMG-CoA Reductase
Protease-activated Receptor
Reductase
RIP kinase
Ligand for E3 Ligase
Aryl Hydrocarbon Receptor
Guanylate cyclase
LRRK2
transporter
Thrombin
PROTACs
Smo
PDK
NOD
DNA Methyltransferase
Kinesin
PERK
GNRH Receptor
Acyltransferase
STING
Melanocortin Receptor
AhR
Mdm2
P2Y Receptor
MRP
Glucokinase
Neuropeptide Y Receptor
Endothelin Receptor
OX Receptor
Syk
Sigma receptor
NOD-like Receptor (NLR)
BACE
Lipase
Factor Xa
Rho
Antifolate
Immunology/Inflammation related
DNA Alkylation
Bradykinin Receptor
Epoxide Hydrolase
SGLT
CFTR
ROR
Glutathione Peroxidase
c-Myc
IRE1
Vasopressin Receptor
PGE Synthase
Complement System
DHFR
CSF-1R
DNA gyrase
PROTAC Linker
Beta-Secretase
Aminopeptidase
Ephrin Receptor
Aromatase
Hydroxylase
IRAK
LTR
ABC
Pim
Liver X Receptor
Isocitrate Dehydrogenase (IDH)
PAK
Stearoyl-CoA Desaturase (SCD)
GPCR19
ADC Linker
LPA Receptor
GHSR
Leukotriene Receptor
IDO
IAP
Myosin
DNA
Gap Junction Protein
ROS Kinase
PD-1/PD-L1
CAT
Monocarboxylate transporter
IFNAR
DYRK
NAMPT
Vitamin
Phosphorylase
PAD
Xanthine Oxidase
RSV
Acetyl-CoA Carboxylase
cholecystokinin
Arginase
Melatonin Receptor
Neurotensin Receptor
UGT
Monoamine Transporter
cAMP
ATP Citrate Lyase
Porcupine
PAI-1
Neprilysin
GST
Discoidin Domain Receptor (DDR)
MLK
CRM1
Ligands for Target Protein for PROTAC
YAP
Arrestin
Tie-2
GTPase
CaSR
GRK
Telomerase
Lipid
BCRP
MNK
PI4K
Oxytocin Receptor
Platelet aggregation
p97
Imidazoline Receptor
PKM
DprE1
Na+/Ca2+ Exchanger
CETP
OCT
LIM Kinase
PYK2
LDL
MT Receptor
Bombesin Receptor
ACK
Free radical scavengers
CRISPR/Cas9
CGRP Receptor
SGK
advanced glycation end products
Adenylyl cyclase
NPC1L1
NEDD8
TOPK
cell cycle arrest
Glutaminase
Annexin A
FLAP
Adiponectin receptor
PAFR
GlyT
APC
Somatostatin
OAT
cGAS
ASK
Carboxypeptidase
Adenosine deaminase
Apelin receptor
Piezo Channel
Dynamin
MyD88
E3 Ligase Ligand-Linker Conjugate
Cell wall
Galectin
Kisspeptin
SIK
MTH1
Hexokinase
Molecular Glues
MAGL
PTEN
Thrombopoietin Receptor
Mucin
OXPHOS
PSMA
Decarboxylase
TSH Receptor
CRFR
Pyroptosis
MELK
Methionine Adenosyltransferase (MAT)
Hippo pathway
GPX
KLF
BMI-1
Melanin-concentrating Hormone Receptor (MCHR)
MALT
EBI2/GPR183
Sodium-dependent phosphate transporter
RAR/RXR
VDA
VDAC
Hck
RANKL/RANK
Haspin Kinase
Na-K-Cl cotransporter
Integrase
HCN Channel
PGC-1α
KSP
Wee1
Glutathione reductase
Survivin
MRGPR
CD73
GluCls
Aquaporin
NADPH-oxidase
Amylin Receptor
lysosomal autophagy
Taste receptor
Transaminase
Hydrogenase
CD38
CYP19A1
aconitase
gp120/CD4
LHRH
N-Acetylglucosaminyltransferase
Stemness kinase
FOXO1
Amylase
Prolyl Endopeptidase (PREP)
Motilin Receptor
Fas/FasL
FABP
PACAP
AAK1 (AP2 associated kinase 1)
Anion Exchanger
Thioredoxin
hCE
ATTECs
Fer/FerT kinase
NMU2R
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