Propantheline is an orally active antagonist of muscarinic acetylcholine receptors (mAChRs), commonly employed to investigate smooth muscle dysfunction, hyperhidrosis, smooth muscle spasms or cramps in the stomach, intestines, or bladder, as well as involuntary urination [1] [2] [3].

Propantheline (10 μM-1 mM) decreases urinary bladder smooth muscle reactivity to Acetylcholine [1].

Propantheline (oral administration, 10-300 mg/kg) decreased the fecal pellet count and the incidences diarrhea in restraint stress-induced bowel dysfunction rats [3]. Animal Model: Restraint stress-induced bowel dysfunction models in rats [3] Dosage: 10-300 mg/kg Administration: Oral administration Result: Decreased the fecal pellet count with ED 50 values of 41 mg/kg. Dose-dependently decreased the incidences of diarrhea with ED50 values of 64 mg/kg.