811
82
2
193
6
Cat. No. | Product Name | ||
---|---|---|---|
L3700 | JAK-STAT 化合物库 | 252 compounds | |
252 个 JAK/STAT 靶点相关的小分子化合物的独特集合,用于高通量、高内涵筛选; | |||
L7500 | 凝血与抗凝化合物库 | 144 compounds | |
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39719 |
Nrf2 activator-1
Nrf2 activator-1 |
Nrf2 | Immunology/Inflammation |
Nrf2 activator-1 是一种有效的 NF-E2 相关因子 2 (Nrf2) 激活剂。Nrf2 activator-1 可用于研究包括哮喘、急性肺损伤 (ALI)、急性呼吸窘迫综合征 (ARDS) 和肺纤维化等 COPD 和其他呼吸系统疾病。 | |||
T67925 |
Nampt activator-1
|
NAMPT | Metabolism |
NAMPT activator-1 (compound 1) 是一种有效的、专用范围广泛的烟酰胺磷酸基转移酶 (NAMPT) 激活剂(EC50 为3.3-3.7 μM)。NAMPT activator-1能有效保护培养细胞免受 fk866介导的毒性,是神经保护的潜在化合物。 | |||
T39965 |
NF-κΒ activator 1
|
NF-κB | NF-κB |
NF-κΒ activator 1 可激活NF-κΒ基因,EC50 为 0.9 μM。NF-κB 作为一种调控细胞增殖和细胞存活的基因被真核细胞广泛应用。NF-κΒ activator 1 可诱导超氧化物歧化酶 (SOD)2 mRNA 表达。 | |||
T13345 |
Wnt pathway activator 2
|
Others; Wnt/beta-catenin | Cytoskeletal Signaling; Others; Stem Cells |
Wnt pathway activator 2 是一种有效的 Wnt 激活剂,IC50 为 13 nM。 | |||
T8652 |
CASP3 Activator 1541
|
Caspase | Apoptosis; Proteases/Proteasome |
CASP3 Activator 1541 是 caspase-3 酶原形式的激活剂,可诱导细胞死亡。 | |||
T9778 |
KCNQ1 activator-1
|
Potassium Channel | Membrane transporter/Ion channel |
KCNQ1 activator-1 是有效的 KCNQ1通道激活剂。它在研究长 QT 综合征中有研究的价值。 | |||
T39924 |
NF-κΒ activator 2
|
NF-κB | NF-κB |
NF-κΒ activator 2 是口服有效的 NF-ҡB 激活剂,EC50为 1.58 μM。它通过增加 NF-κB 的表达和激活来诱导 SOD2。它具有用于研究肌萎缩性侧索硬化症的价值。 | |||
T16873 |
SERCA2a activator 1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
SERCA2a activator 1 是一种肌肉/内质网 Ca2+ 依赖性 ATPase 2a 激活剂。 SERCA2a activator 1 降低受磷蛋白抑制并增强心脏的收缩和舒张功能。 | |||
T17256 |
Wnt pathway activator 1
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Wnt pathway activator 1 是Wnt 激活剂(EC50=28-29 nM)。 | |||
T1772 |
MDK83190
Apoptosis Activator 2 |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂,可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。 | |||
T9400 |
KCNQ2/3 activator-1
|
Others; Potassium Channel | Membrane transporter/Ion channel; Others |
KCNQ2/3 activator-1 是Kv7.2/Kv7.3(KCNQ2/3) 钾通道激活剂,详细信息来自专利 WO2021113757A1的化合物 A。 | |||
T60675L |
AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
AMPK activator 2 hydrochloride( 2410961-69-0 Free base) |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
AMPK activator 2 hydrochloride 是一种含氟氯胍衍生物,可上调 AMPK 信号通路并下调 mTOR/4EBP1/p70S6K。AMPK activator 2 hydrochloride 抑制人类癌细胞系 (UMUC3、T24、A549) 的增殖和迁移。 | |||
T4280 |
Gcase activator 1
LTI-291,LTI 291,LTI291 |
Glucosidase | Metabolism |
Gcase activator 1 (LTI-291) 是葡糖脑苷脂酶 (Gcase) 的激活剂。 | |||
T9853 |
STING activator Compound 53
|
STING | Immunology/Inflammation |
基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING(人 EC50 185 nM)的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。 | |||
T8055 |
TFEB activator 1
(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,(1E,4E)-1,5(2 -甲氧基苯基)-1,4-戊二烯-3-酮,RPN77612 |
Others; Autophagy | Autophagy; Others |
TFEB activator 1 (Curcumin analog compound C1) 是转录因子 EB 的一种激活剂,有望预防或治疗阿尔茨海默病。 | |||
T7674 |
Thrombin Receptor Activator for Peptide
|
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T14127 |
Adenosine A1 receptor activator T62
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine A1 receptor activator T62 是腺苷 A1 受体的变构增强剂,有镇痛作用。 | |||
T9347 |
EAAT2 activator 1
3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine |
transporter | Metabolism |
EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) 是兴奋性氨基酸转运蛋白 2(EAAT2) 的有效激活剂,以剂量依赖性方式增加 EAAT2 蛋白水平。 | |||
T10674 |
Potassium Channel Activator 1
钾离子通道激活剂1,ZINC34634569 |
Potassium Channel | Membrane transporter/Ion channel |
Potassium Channel Activator 1 可用于治疗多巴胺能系统被破坏的疾病或病症的研究,例如情绪障碍 ADHD、精神分裂症和其他精神病状态。 | |||
T24546 |
Nrf2-Activator-12G
Nrf2 Activator IV,Nrf2 Activator-IV |
Others | Others |
Nrf2-Activator-12G is a potent Nrf-2 activator. | |||
T3293 |
Apoptozole
Apoptosis Activator VII |
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
Apoptozole (Apoptosis Activator VII) 是一种Hsc70和Hsp70的 ATPase 结构域抑制剂,可诱导凋亡,Kd 值分别为 0.21 和 0.14 μM。 | |||
T77616 |
VU533
Nape-Pld activator |
Phospholipase | Metabolism |
VU533 (Nape-Pld activator) 是一种NAPE-PLD 激活剂,其 EC50 值为0.30 µM。VU533 可以提高 NAPE-PLD 活性,增加巨噬细胞的胞葬作用。VU533 可用于与心脏代谢相关的疾病。 | |||
T2065 |
Bioymifi
DR5 Activator |
Apoptosis; TNF | Apoptosis |
Bioymifi (DR5 Activator) 是一种 TRAIL 受体DR5激活剂,与DR5的胞外结构域结合,Kd 为 1.2 μM,它可诱导 DR5 聚集,导致细胞凋亡。 | |||
T62238 |
AMPK activator 4
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
AMPK activator 4 是一种有效且具有选择性的AMPK激活剂,不抑制线粒体复合物 I。AMPK activator 4 选择性地激活肌肉组织中的 AMPK且剂量依赖性地改善正常小鼠的糖耐量,显著降低 db/db 糖尿病小鼠的空腹血糖水平和改善胰岛素抵抗。AMPK activator 4 具有降血糖作用。 | |||
T16342 |
KL1333
NQO1 activator 1 |
NADPH; Mitochondrial Metabolism | Metabolism |
KL1333 (NQO1 activator 1) 是口服NAD+调节剂,与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。 | |||
T14080 |
AA147
ATF6-activator-147 |
Others | Others |
AA147 (ATF6-activator-147) 是小分子内质网蛋白稳态调节剂,能够选择性激活未折叠蛋白反应的 ATF6臂。 | |||
T23828 |
BtGH84 Activator I
4-EtOQz,BtGH-84 Activator I,4 EtOQz,4EtOQz,Bt-GH-84 Activator I |
Others | Others |
BtGH84 Activator I is a BtGH84 activator. It is the small molecule activator of a glycoside hydrolase. | |||
T72617 |
Nampt activator-2
|
P450; NAMPT | Metabolism |
Nampt activator-2 是一种 NAMPT 激活剂(EC50 : 0.023 μM)。 Nampt activator-2 对 CYP2C9、2D6、2C19 具有亲和力,亲和力数值分别为 0.060 μM、 0.41 μM 和 0.59 μM 。Nampt activator-2 可用来研究动脉粥样硬化,肥胖,II型糖尿病,胰岛素抵抗和I型糖尿病。 | |||
T62758 |
PKM2 activator 2
|
PKM | Metabolism |
PKM2 activator 2是一种丙酮酸激酶 M2(PKM2)激活剂,AC 50 值为 66 nM。PKM2 activator 2具有抗肿瘤增殖和缓解沃伯格效应的作用,通过激活 PKM2 使细胞的糖酵解代谢恢复正常。 | |||
T36935 |
PKUMDL-LC-101-D04
GPX4-Activator-1d4,PKUMDL-LC-101-D04 |
GPX | oxidation-reduction |
PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4(GPX4)的异位激活剂,是一种铁死亡的调节剂。 当在无细胞试验中使用浓度为20 μM 时,GPX4活性增加到对照水平的150%;在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时,GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04(200 μM)能减少胆固醇过氧化氢诱导的MEF 死亡。 | |||
T72771 |
p53 Activator 7
|
Apoptosis | Apoptosis |
p53 Activator 7 是一种高效性和细胞渗透性的 p53 突变 Y220C (MDM-2/p53) 激活剂,可诱导细胞凋亡 。 | |||
T78650 |
Nrf2 activator-3
|
Antioxidant; Nrf2 | Immunology/Inflammation; oxidation-reduction |
Nrf2 activator-3为一种高效 Nrf2 激活剂,具有潜在的抗炎抗氧化抗肿瘤活性,可用于研究神经系统疾病和免疫相关疾病。 | |||
T78791 |
AMPK activator 12
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
AMPK activator 12 是一种 AMPK 激活剂和 GDF15 诱导剂,能提升人肝细胞内GDF15蛋白的表达水平,可用于研究癌症。 | |||
T63016 |
Nrf2 activator-4
|
Reactive Oxygen Species; Nrf2 | Immunology/Inflammation; Metabolism; NF-κB |
Nrf2 activator-4 是一种具有口服活性的 Nrf2 激活剂(EC50: 0.63 μM),对小神经胶质细胞中活性氧的产生有抑制作用,用于治疗人类代谢功能障碍相关的脂肪肝病。 | |||
T77349 |
CCR1/5/8 activator 1
|
Phospholipase | Metabolism |
CCR1/5/8 activator 1 是胞质磷脂酶 A 抑制剂,具有抗真菌活性。 | |||
T72420 |
MTK458
Mitophagy activator 1,EP-0035985 |
PTEN | PI3K/Akt/mTOR signaling |
MTK458 (EP-0035985) 是一种具有口服活性和脑渗透性的 PINK1 激活剂,在PFF 接种模型中促进 α-突触核蛋白病理学的清除并降低 pUb。MTK458 通过刺激 PINK1/TOM 复合物的二聚化和稳定来诱导病理学的α-突触核蛋白清除。MTK458 可用于帕金森病的研究。 | |||
T67858 |
STIMA-1
2-Vinylquinazolin-4-ol,p53 Activator VII |
Others | Others |
STIMA-1 (2-Vinylquinazolin-4-ol) 是一种活性化合物,可以恢复 p63 的活性。STIMA-1 可以刺激角质形成细胞的增殖和分化。 | |||
T63321 |
20S Proteasome activator 1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
20S Proteasome activator 1 是一种 20S 蛋白酶激活剂,对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。 | |||
T22567 |
AMPK activator
|
Others | Others |
AMPK activator | |||
T7496 |
Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Thrombin Receptor Activator for Peptide |
Protease-activated Receptor | GPCR/G Protein |
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。 | |||
T10069 | AMPK activator 1 | Others | Others |
AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM). | |||
T11418 |
Glucokinase activator 1
|
Others | Others |
Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM). | |||
T70862 |
AMPK Activator SC4
|
Others | Others |
SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake. | |||
T11457 |
GPR40 Activator 2
|
Others | Others |
GPR40 Activator 2 is a highly effective activator of the GPR40 receptor. | |||
T12179 |
Nav1.1 activator 1
|
Others | Others |
Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration. | |||
T11456 |
GPR40 Activator 1
|
Others | Others |
GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes. | |||
T12251 |
NR1H4 activator 1
|
Others | Others |
NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR). | |||
T12498 |
PKR activator 2
|
Others | Others |
PKR activator 2 is a potent activator of pyruvate kinase-R (PKR). | |||
T12497 | PKR activator 1 | Others | Others |
PKR activator 1 is a potent activator of pyruvate kinase-R (PKR). | |||
T7625 |
TRAP-6
PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA) |
Protease-activated Receptor | GPCR/G Protein |
TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段,是选择性的蛋白酶激活受体 1 (PAR1) 激动剂,通过凝血酶受体激活人血小板。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN6729 |
Azadiradione
AZD |
Others | Others |
Azadiradione (AZD) 是 HSF1的一种,是由印楝树中提取得到,具有一定生物活性的柠檬苦素。 | |||
T3876 |
Loureirin B
龙血素B,龙血素 B |
PAI-1; ERK; Potassium Channel; JNK | MAPK; Membrane transporter/Ion channel; Metabolism |
Loureirin B 是从剑叶龙血树中分离到的一种黄酮,是 PAI-1抑制剂,IC50值为 26.10 μM。它抑制 KATP,以及 ERK 和 JNK 的磷酸化,具有抗糖尿病的功效。 | |||
T4S0592 |
Toddalolactone
(+)-Toddalolactone,飞龙掌血内酯,毛两面针素 |
PAI-1 | Metabolism |
Toddalolactone ((+)-Toddalolactone) 是一种Toddalia asiatica 的主要成分,能够抑制重组人纤溶酶原激活物抑制物-1(PAI-1)的活性, IC50=37.31 μM。 | |||
TN1731 |
Hernandezine
|
TNF; ROS; P-gp; AMPK | Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling |
Hernandezine 是 AMPK 激动剂的激动剂,也是癌细胞中 ABCB1 介导的 MDR 的特异性逆转剂。 | |||
T8036 |
6-Methylflavone
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
6-Methylflavone 是α1β2γ2L 和α1β2GABAA 受体激活剂。 | |||
T7327 |
7-Methoxyisoflavone
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
7-Methoxyisoflavone 是单磷酸腺苷活化蛋白激酶 (AMPK) 的激活剂,是异黄酮衍生物。 | |||
T10085 |
20(S)-Hydroxycholesterol
20α-Hydroxycholesterol |
Smo | Stem Cells |
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂。 | |||
T12514 |
Podocarpic acid
|
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Podocarpic acid 是一种天然产物,是一种新型 TRPA1 激活剂。 | |||
T6S1141 |
Ganoderic acid A
灵芝酸 A,灵芝酸A |
Apoptosis; NF-κB; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism; NF-κB |
Ganoderic acid A 能够抑制 JAK-STAT3信号通路,也能抑制细胞增殖,存活率和 ROS。 它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。 | |||
T2855 |
Icariin
淫羊藿苷,Ieariline,淫羊藿甙 |
PDE; PPAR; Autophagy | Autophagy; DNA Damage/DNA Repair; Metabolism |
Icariin (Ieariline) 是一种黄酮醇苷,可抑制PDE5和PDE4活性,IC50分别为 432 nM 和 73.50 μM。它也是PPARα激活剂。 | |||
T8155 |
Maltoheptaose
|
Phospholipase | Metabolism |
Maltoheptaose 是一种含有七个葡萄糖单元的麦芽低聚糖。它是一种磷酸化酶 B (phosphorylase B) 的活化剂,可用于 2-磷酸庚糖的制备。 | |||
T6871 |
L-Glutamic acid monosodium salt
Monosodium glutamate,谷氨酸单钠盐,Glutacyl,Glutavene,L-谷氨酸单钠盐,Ajinomoto,MSG |
Apoptosis; Ferroptosis; GluR; iGluR | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
L-Glutamic acid monosodium salt (MSG) 作为兴奋性氨基酸神经递质,是谷氨酸盐受体所有亚型的激动剂,对多巴胺从神经末梢释放的过程有激动作用。 | |||
T8363 |
DL-Serine
|
PKM | Metabolism |
DL-Serine 是 D-丝氨酸和 L-丝氨酸的混合物,是一种基础代谢物。它具有抗病毒作用,能抑制烟草花叶病毒的增殖。 | |||
T14149 |
AICAR phosphate
AICA Riboside phosphate,Acadesine phosphate |
Mitophagy; NOS; YAP; AMPK | Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells |
AICAR phosphate (Acadesine phosphate) 是 AMPK 激活剂且是自噬、YAP 和 mitophagy 抑制剂,也是一种腺苷类似物, 可调节糖代谢和脂代谢,抑制促炎细胞因子和 iNOS 的产生。 | |||
TQ0089 |
Juglanin
|
Apoptosis; JNK; Autophagy | Apoptosis; Autophagy; MAPK |
Juglanin 是来自金鸡脚的一种黄酮类天然产物,是一种 JNK 的激活剂,能诱导人乳腺癌细胞的凋亡和自噬,具有炎症和抗肿瘤活性。 | |||
T5891 |
D-ERYTHRO-SPHINGOSINE
trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇 |
Phosphatase; Endogenous Metabolite; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism |
D-erythro-Sphingosine (trans-4-Sphingenine) 是一种非常有效的p32激酶活化剂,EC50为 8 μM。它也是一种PP2A 激活剂,抑制蛋白激酶 C (PKC)。 | |||
T5S1569 |
AKBA
乙酰基-11-酮基-beta-乳香酸,3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid |
Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite | Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others |
AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) 是一种从乳香中分离的天然成分,是新颖的 Nrf2 的活化剂。 | |||
TN1543 |
Cynaropicrin
|
IL Receptor; Others; TNF | Apoptosis; Immunology/Inflammation; Others |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro- | |||
T2896 |
Alantolactone
土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor |
Apoptosis; STAT; TGF-beta/Smad | Apoptosis; JAK/STAT signaling; Stem Cells |
Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 | |||
TN6552 |
5,7-Dimethoxyluteolin
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
5,7-Dimethoxyluteolin 是 5,7-二甲基木犀草素的一种衍生物,可以活化多巴胺转运蛋白,EC50为 3.417 μM。 | |||
TN1047 |
Ingenol mebutate
Ingenol 3-Angelate,巨大戟醇甲基丁烯酸酯,PEP005 |
gp120/CD4; HIV Protease; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Ingenol mebutate (Ingenol 3-Angelate) 是 PKC 的有效激动剂,包括 PKC-α、PKC-β、PKC-γ、PKC-δ 和 PKC-ε,Kis 为 0.3、0.105、0.162、0.376 和 0.171 nM。 Ingenol mebutate 具有抗炎和抗肿瘤活性。 | |||
TQ0198 |
Phorbol 12-myristate 13-acetate
佛波醇12-十四酸酯13-乙酸酯,PMA |
NF-κB; S1P Receptor; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; NF-κB |
Phorbol 12-myristate 13-acetate (PMA) 属于佛波酯类天然产物,是一种 PKC、SphK、NF-κB 的激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP1 细胞分化。 | |||
T3912 |
Saikosaponin B1
柴胡皂苷B1,柴胡皂苷 B1 |
Others | Others |
Saikosaponin B1 是柴胡的生物活性成分,具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路,显著抑制髓母细胞瘤模型中的肿瘤生长。 | |||
T3863 |
Chikusetsusaponin IVa
竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Chikusetsusaponin IVa (Calenduloside F) 是一种三萜皂苷中主要的活性成分,是一种蛋白激酶的激活剂,对血栓及一些代谢性疾病具有抵抗作用。 | |||
TN1621 |
Eriodictyol-7-O-glucoside
|
Nrf2 | Immunology/Inflammation |
Eriodictyol-7-O-glucoside 是一种 Nrf2 激活剂,可防止顺铂诱导的毒性。 Eriodictyol-7-O-glucoside 是一种类黄酮和自由基清除剂,在开心果皮中具有抗氧化活性。 | |||
T1131 |
Ivermectin
MK-933,伊维菌素 |
Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂,具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入,还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。 | |||
T2O2668 |
Oleic acid
Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸 |
Apoptosis; ATPase; Others; Endogenous Metabolite | Apoptosis; Membrane transporter/Ion channel; Metabolism; Others |
Oleic acid (Glycon Wo) 属于天然产物,是一种常见的不饱和脂肪酸,在存在于多种动物、植物的脂肪和油脂中。Oleic acid 是一种 Na+/K+ATP 酶激活剂。 | |||
TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
TN1182 |
11-Keto-beta-boswellic acid
11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸 |
Leukotriene Receptor; NF-κB; Lipoxygenase | GPCR/G Protein; Metabolism; NF-κB |
11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸,具有抗炎活性和剂量依赖性心脏保护作用,主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。 | |||
T3092 |
Nigericin sodium salt
尼日利亚菌素,尼日利亚菌素钠盐 |
Potassium Channel; NOD-like Receptor (NLR); Antibacterial; Antibiotic; NOD | Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB |
Nigericin sodium salt 属于抗生素,是一种 NLRP3 激活剂,也是一种阳离子离子载体。Nigericin sodium 可以触发 NALP3 炎性体的激活,可抑制高尔基体功能并抑制革兰氏阳性菌的生长。 | |||
Fr16605 |
Lupinine
鲁冰花,羽扇豆碱 |
AChR; AChE | Neuroscience |
Lupinine 是一种能够抵消乙醇麻醉的生物碱。 Lupinine 是一种 AChE 和 BChE 抑制剂和潜在的 CD69 激活剂,存在于 Loranthus、Calia 和 Lupinus 物种中。它还可以抑制肝素。 | |||
T36390 |
Sodium oleate
Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt |
ATPase | Membrane transporter/Ion channel |
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。 | |||
TMA2474 |
δ-Tocotrienol
Delta-Tocotrienol,δ-生育三烯酚 |
ERK; BCL; VEGFR; Akt; PI3K; PDK; p53 | Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
δ-Tocotrienol (Delta-Tocotrienol) 是一种维生素 E,存在于蔬菜,水果,种子,坚果,谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂,可以降低胆固醇和其他脂质,保护心血管疾病。 | |||
T19384 |
Isovalerylcarnitine
|
Apoptosis; Cysteine Protease | Apoptosis; Proteases/Proteasome |
Isovalerylcarnitine (3-methylbutyrylcarnitine) 是 L-亮氨酸分解代谢和异戊酸的积累产生的小分子化合物,也是一种具有选择性和有效性的钙蛋白酶 (calpain) 激活剂,可促使细胞凋亡,与异戊酸血症有关,可作为异戊酸血症的标志。 | |||
T9143 |
D-Isoleucine
(2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine |
Others | Others |
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) 是一种异亮氨酸立体异构体,是 Asc-1 反转运蛋白的选择性激活剂。它能够释放内源性 D-丝氨酸,提高海马 CA1-CA3 的长期增效作用。 | |||
T2745 |
18α-Glycyrrhetinic acid
18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid |
Apoptosis; NF-κB; Proteasome | Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination |
18α-Glycyrrhetinic acid (Enoxolone) 是 NF-kB 的抑制剂和蛋白酶体的激活剂,在多细胞生物中起到促进长寿和抗聚集因子的作用。它诱导细胞凋亡。 | |||
T6S1302 |
Carnosol
|
Nrf2; Endogenous Metabolite; S6 Kinase | Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Carnosol 是 Nrf2激活剂,增加 Nrf2 的水平以及能促进血红素氧合酶 1(HMOX1) 表达。它是核糖体 S6激酶(RSK2)抑制剂,可用于胃癌相关研究,IC50值约为 5.5 μM。 | |||
T10086 |
24-Hydroxycholesterol
Cholest-5-ene-3beta,24-diol |
Liver X Receptor; NMDAR | Metabolism; Neuroscience |
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) 是一种氧甾醇化合物,是一种 n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂,可用于研究心血管生成和胰腺癌。 | |||
T3727 |
Methyl syringate
Syringic Acid Methyl Ester,丁香酸甲酯 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Methyl syringate (Syringic Acid Methyl Ester) 是水仙花蜜的化学标记物,是有效的细菌和真菌漆酶酚介质。它也是TRPA1激动剂。 | |||
T3254 |
PHYTOL
植醇,trans-Phytol,(E)-Phytol |
Antibacterial; PPAR; Parasite | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
PHYTOL (trans-Phytol) 是一种从叶绿素中提取的二萜醇,广泛应用于食品添加剂和医药领域,具有很好的抗血吸虫特性。它具有抗伤害、抗氧化、抗炎、抗过敏等作用。它对结核分枝杆菌和金黄色葡萄球菌具有抗菌活性。 | |||
T5S2017 |
Ingenol
(-)-Ingenol,巨大戟二萜醇,巨大戟醇 |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Ingenol ((-)-Ingenol) 是一种PKC 激活剂,Ki 值为 30 μM,具有抗肿瘤活性。 从 Ingenol 酯中配制新的衍生物可能是开发新的先导化合物以重新激活潜伏 HIV 的创新方法。Ingenol mebutate 是治疗光化性角化病的有效方法。 | |||
T16579 |
Pro-xylane
玻色因,Hydroxypropyl tetrahydropyrantriol |
Others | Others |
Pro-xylane (Hydroxypropyl tetrahydropyrantriol) 是一种在水介质中具有生物活性的 c- 糖苷 (C-glycoside),是粘多糖 (GAGs) 的生物合成活化剂,也是第一种应用于化妆品的“绿色”化学物质。 | |||
T2939 |
Forskolin
毛喉素,Coleonol,Colforsin |
FXR; Adenylyl cyclase; AChR; Autophagy | Autophagy; Metabolism; Neuroscience |
Forskolin (Coleonol) 属于天然产物,是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平,可以激活 PXR 和 FXR,也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用,具有血小板抗凝集和降压作用。 | |||
TN5770 |
Gingerenone A
|
Nrf2 | Immunology/Inflammation |
Gingerenone A 是一种有效的 Nrf2-Gpx4 激活剂,是从生姜里面分离出来的小分子化合物,具有抗癌活性,可延长癌细胞的细胞周期,可抑制右旋糖酐硫酸钠 (DSS) 诱导的结肠炎小鼠继发性肝损伤 (SLI) 中的铁死亡。 | |||
TL0007 |
Bisdemethoxycurcumin
双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin |
Epigenetic Reader Domain; Wnt/beta-catenin | Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells |
Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。 | |||
T2854 |
Phillyrin
Forsythin,连翘苷 |
P450; Influenza Virus; AMPK | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。 | |||
T4868 |
gamma-Linolenic acid
gamolenic acid,γ-Linolenic acid,γ-亚麻酸 |
Endogenous Metabolite | Metabolism |
gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6),18 碳 (18C-) 多不饱和脂肪酸 (PUFA),可以从人乳和植物种子油中提取。 | |||
T2174 |
Quercetin
槲皮素,Sophoretin |
Apoptosis; Mitophagy; Reactive Oxygen Species; PI3K; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Quercetin 属于黄酮类天然产物,是 SIRT1 的激动剂;Quercetin 也是一种 PI3K 抑制剂,抑制 PI3Kγ、PI3Kδ 和 PI3Kβ (IC50=2.4/3.0/5.4 μM)。Quercetin 作为公认的热休克蛋白抑制剂,也可通过下调Hsp70或Hsp90来显著减少TII模型中的外泌体释放。 | |||
T3889 |
Platycodin D
|
Prostaglandin Receptor; AMPK | Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling |
Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物,是AMPKα的激活剂,具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。 | |||
TN1013 |
Cucurbitacin D
|
Apoptosis | Apoptosis |
Cucurbitacin D 是一种从 Ecballium elaterium (L.)分离出来的三萜类化合物,具有抗癌抗肿瘤活性,抑制转移性 PrC 中的葡萄糖摄取和乳酸产生,诱导独立于 ERK1/2 激活的炎症小体激活。 Cucurbitacin D 是巨噬细胞中的一种新的炎症小体激活剂,通过调节 JAK/STAT3、PI3K/Akt/mTOR 和 MAPK 信号通路抑制 HepG2 细胞增殖并诱导细胞凋亡, 可用于研究宫颈癌、白血病和前列腺癌。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01257 |
uPAR/PLAUR Protein, Mouse, Recombinant (His)
uPAR,Cd87,u-PAR,plasminogen activator, urokinase re... |
Mouse | HEK293 Cells |
uPAR/PLAUR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is P35456-1. | |||
TMPY-02141 |
uPAR/PLAUR Protein, Human, Recombinant (His)
UPAR,CD87,plasminogen activator, urokinase receptor... |
Human | HEK293 Cells |
uPAR/PLAUR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q03405-1. | |||
TMPY-00904 |
Urokinase/uPA Protein, Human, Recombinant (His)
u-PA,QPD,BDPLT5,ATF,UPA,plasminogen activator, urok... |
Human | HEK293 Cells |
Urokinase/uPA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is A0A024QZM9. | |||
TMPJ-00662 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Receptor activator of nuclear factor kappa-B ligand... |
Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog... | |||
TMPY-06624 |
STAT3 Protein, Human, Recombinant (His)
ADMIO,signal transducer and activator of transcript... |
Human | E. coli |
STAT3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 65.31 kDa and the accession number is P40763-1. | |||
TMPY-02603 |
STAT6 Protein, Human, Recombinant (His)
STAT6C,IL-4-STAT,STAT6B,signal transducer and activator<... |
Human | Baculovirus Insect Cells |
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators... | |||
TMPJ-00607 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
Receptor activator of nuclear factor κ-B ligand,Ost... |
Mouse | HEK293 Cells |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1. | |||
TMPY-01474 |
PAI-1 Protein, Human, Recombinant (His)
PAI,SERPINE1,PAI-1,serpin peptidase inhibitor, clade E (nexi... |
Human | HEK293 Cells |
PAI-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is A0A024QYT5. | |||
TMPY-04504 |
Urokinase/uPA Protein, Rat, Recombinant (His)
plasminogen activator, urokinase |
Rat | HEK293 Cells |
Urokinase/uPA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.3 kDa and the accession number is A6KKR2. | |||
TMPJ-00332 |
tPA Protein, Human, Recombinant (His)
TPA,T-PA,t-plasminogen activator,Tissue plasminogen... |
Human | HEK293 Cells |
Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs to the peptidase S1 family. The main function of this protein is to convert plasminogen into biologically active plasmin. As a protease, PLAT plays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulating the post-tra... | |||
TMPH-01371 |
GM2A Protein, Human, Recombinant (His & SUMO)
GM2-AP,Cerebroside sulfate activator protein,Sphing... |
Human | E. coli |
GM2A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 33.6 kDa and the accession number is P17900. | |||
TMPY-00938 |
tPA Protein, Human, Recombinant
TPA,plasminogen activator, tissue,T-PA |
Human | HEK293 Cells |
tPA Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 28 kDa and the accession number is P00750-1. | |||
TMPH-00833 |
PAI-1 Protein, Horse, Recombinant
Serpin E1,Plasminogen activator inhibitor 1,PAI-1,E... |
Horse | P. pastoris (Yeast) |
PAI-1 Protein, Horse, Recombinant is expressed in yeast. The predicted molecular weight is 36.2 kDa and the accession number is Q8MI31. | |||
TMPH-02834 |
PAI-1 Protein, Mouse, Recombinant (His & SUMO)
Endothelial plasminogen activator inhibitor,Serpine... |
Mouse | E. coli |
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of ... | |||
TMPH-02833 |
PAI-1 Protein, Mouse, Recombinant (His)
Endothelial plasminogen activator inhibitor,Plasmin... |
Mouse | P. pastoris (Yeast) |
PAI-1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 44.9 kDa and the accession number is P22777. | |||
TMPJ-00625 |
Serpin E1 Protein, Mouse, Recombinant (His)
Pai1,Planh1,Plasminogen activator inhibitor 1,Serpi... |
Mouse | HEK293 Cells |
Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. | |||
TMPH-00832 |
PAI-1 Protein, Horse, Recombinant (E. coli)
Endothelial plasminogen activator inhibitor,PAI-1,P... |
Horse | E. coli |
PAI-1 Protein, Horse, Recombinant (E. coli) is expressed in E. coli expression system. The predicted molecular weight is 32.1 kDa and the accession number is Q8MI31. | |||
TMPH-00356 |
PAI-1 Protein, Feline, Recombinant
PAI-1,Endothelial plasminogen activator inhibitor,S... |
Feline | E. coli |
PAI-1 Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29.7 kDa and the accession number is A9NJ78. | |||
TMPY-02765 |
GM2A Protein, Human, Recombinant (His)
GM2 ganglioside activator,SAP-3,GM2-AP |
Human | Baculovirus Insect Cells |
GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexo... | |||
TMPY-03442 |
MOB4A/MOB1B Protein, Human, Recombinant (GST)
MOB kinase activator 1B,MOBKL1A,MATS2,MOB4A |
Human | E. coli |
MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO... | |||
TMPY-00937 |
tPA Protein, Human, Recombinant (hFc)
TPA,T-PA,plasminogen activator, tissue |
Human | HEK293 Cells |
tPA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.5 kDa and the accession number is P00750-1. | |||
TMPH-00657 |
NlpD Protein, E. coli, Recombinant (His & SUMO)
Murein hydrolase activator NlpD,nlpD |
E. coli | E. coli |
Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division. | |||
TMPH-03397 |
uPAR/PLAUR Protein, Rat, Recombinant (His)
Plaur,Urokinase plasminogen activator surface recep... |
Rat | E. coli |
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. uPAR/PLAUR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.1 kDa and the accession number is P49616. | |||
TMPH-01424 |
GUCA2B Protein, Human, Recombinant (His)
Guanylate cyclase activator 2B,GUCA2B |
Human | HEK293 Cells |
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661. | |||
TMPH-03722 |
Coagulase/fibrinolysin Protein, Yersinia pestis, Recombinant (His & Myc)
Plasminogen activator,Pla,Coagulase/fibrinolysin |
Yersinia pestis | E. coli |
Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius). Activates plasminogen by cleaving it. | |||
TMPK-00484 |
HGFA Protein (pro form), Cynomolgus, Recombinant (His)
MGC138397,Hgfac,HGF activator,HGFA,MGC138395 |
Cynomolgus | HEK293 Cells |
HGFA Protein (pro form), Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.47 kDa and the accession number is A0A2K5TZH3. | |||
TMPK-01219 |
HGFA Protein (pro form), Mouse, Recombinant (His)
HGF activator,MGC138395,MGC138397,Hgfac,HGFA |
Mouse | HEK293 Cells |
HGFA Protein (pro form), Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.9 kDa and the accession number is Q9R098. | |||
TMPJ-01003 |
STAT5B Protein, Human, Recombinant (His)
Signal Transducer and Activator of Transcription 5B... |
Human | E. coli |
Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adul... | |||
TMPU-00004 |
STAT5A Protein, Human, Recombinant (His)
MGF,Signal transducer and activator of transcriptio... |
Human | E. coli |
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. Many studies have indicated a key role of STAT5a in leukemia, breast, colon, head and neck, and prostate cancer. Until recently, the unique characteristics and function of STAT5a in these cancers have not been delineated from STAT5b, and more research into their differential behavior is warranted. Because of its integral role in immune cell development, STAT5a may contribute to tumor de... | |||
TMPH-01869 |
PAI-2 Protein, Human, Recombinant (His)
SERPINB2,Urokinase inhibitor,Placental plasminogen activ... |
Human | HEK293 Cells |
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. PAI-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 50.1 kDa and the accession number is P05120. | |||
TMPY-01017 |
uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc)
plasminogen activator, urokinase receptor,u-PAR,uPA... |
Mouse | HEK293 Cells |
uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 58 kDa and the accession number is P35456-1. | |||
TMPY-02898 |
tPA Protein, Mouse, Recombinant (hFc)
plasminogen activator, tissue,AU020998,tPA,AW212668... |
Mouse | HEK293 Cells |
tPA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.4 kDa and the accession number is P11214. | |||
TMPH-00280 |
PRKRA Protein, Bovine, Recombinant (His & Myc)
Protein kinase, interferon-inducible double-stranded RNA-dep... |
Bovine | E. coli |
PRKRA Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.4 kDa and the accession number is Q2HJ92. | |||
TMPY-06353 |
GUCA2B Protein, Mouse, Recombinant (His)
Ugn,AV066530,Gcap2,guanylate cyclase activator 2B (... |
Mouse | HEK293 Cells |
GUCA2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.55 kDa and the accession number is Q3UWA6-1. | |||
TMPY-02581 |
STAT4 Protein, Human, Recombinant (His)
signal transducer and activator of transcription 4,... |
Human | Baculovirus Insect Cells |
High expression of STAT4 in gastric cancer predicted a better clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after gastrectomy. Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype. | |||
TMPH-02385 |
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)
Minor nucleoprotein VP30,Transcriptional activator ... |
MARV | E. coli |
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene. | |||
TMPH-03729 |
Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)
Transcriptional activator VP30,EbolaVP30,Minor nucl... |
ZEBOV | E. coli |
Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists a... | |||
TMPY-03610 |
PSME2 Protein, Human, Recombinant (His)
REGβ,proteasome (prosome, macropain) activator subu... |
Human | E. coli |
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPH-00545 |
Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc)
Immediate-early protein Rta,Protein R,Replication and transc... |
EBV | E. coli |
Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor. Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.9 kDa and the accession number is Q3KS... | |||
TMPJ-01335 |
MOB1A Protein, Human, Recombinant (His)
C2orf6,MOB4B,Mob1A,MOBK1B,Mps One Binder Kinase Activato... |
Human | E. coli |
MOB Kinase Activator 1A (MOB1A) belongs to the MOB1/phocein family, which acts as an activator of LATS1/2 in the Hippo signaling pathway, plays a key role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MOBKL1B stimulates the kinase activity of STK38 and STK38L. MOBKL1B binds to and regulate downstream targets such as the NDR-family protein kinases and LATS1 kinase. | |||
TMPH-01170 |
CDK5R1 Protein, Human, Recombinant (His)
CDK5 activator 1,CDK5R,NCK5A,CDK5R1,Cyclin-dependen... |
Human | E. coli |
CDK5R1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-03612 |
PSME1 Protein, Human, Recombinant (His)
proteasome (prosome, macropain) activator subunit 1... |
Human | E. coli |
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPJ-00674 |
RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
Receptor activator of NF-KB,TNFRSF11A,Osteoclast di... |
Mouse | HEK293 Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br... | |||
TMPJ-00961 |
STAT1 Protein, Human, Recombinant
Transcription Factor ISGF-3 Components p91/p84,STAT1,Signal ... |
Human | E. coli |
Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul... | |||
TMPJ-00349 |
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)
CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O... |
Human | HEK293 Cells |
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive... | |||
TMPJ-01318 |
TACI Protein, Mouse, Recombinant (hFc)
CD267,Tumor necrosis factor receptor superfamily member 13B,... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI (transmembrane activator and CAML interactor), is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. | |||
TMPJ-01100 |
UBE2V1 Protein, Human, Recombinant (His)
TRAF6-Regulated IKK Activator 1 Beta Uev1A,P/OKcl.1... |
Human | E. coli |
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Ly... | |||
TMPH-00887 |
AHSA1 Protein, Human, Recombinant (GST)
C14orf3,p38,Activator of 90 kDa heat shock protein ... |
Human | E. coli |
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. AHSA1 Protein, Human, Recombinant (GST) is expressed i... | |||
TMPH-00215 |
SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)
Venombin A,Fibrinogen-clotting enzyme,Snake venom serine pro... |
Bothrops jararaca | E. coli |
Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and activates factor VIII (F8). SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is P81661. | |||
TMPJ-01365 |
SLAMF8 Protein, Human, Recombinant (His)
CD353,SLAM family member 8,BCM-like membrane protein,B-lymph... |
Human | HEK293 Cells |
SLAM family member 8 (SLAMF8) is a single-pass type I membrane protein and contains 1 Ig-like C2-type domain. SLAMF8 is a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27098 |
Ivacaftor-D9
deutivacaftor,CTP-656 |
||
CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis. | |||
T10279 |
Alfacalcidol-D6
|
Others | Others |
Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication. | |||
T13076 |
Tamoxifen-d5
ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5 |
HSP | Cytoskeletal Signaling; Metabolism |
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity. | |||
T11089 |
Doxercalciferol-D3
|
Others | Others |
Doxercalciferol-d3 is the deuterated form of Doxercalciferol and ACTS as vitamin D receptor activator (VDRA), which is a vitamin D2 analogue. | |||
T11152 |
Edaravone-d5
MCI-186 D5 |
Others | Others |
Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits. | |||
T71402 |
Nicorandil-d4
|
||
Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =... |