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Targets Recommended: Nrf2

811

抑制剂 & 化合物

82

天然产物

2

化合物库

193

重组蛋白

6

同位素标记化合物

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Cat. No. Product Name
L3700 JAK-STAT 化合物库

252 compounds
252 个 JAK/STAT 靶点相关的小分子化合物的独特集合,用于高通量、高内涵筛选;
L7500 凝血与抗凝化合物库

144 compounds
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选;

化合物库

JAK-STAT 化合物库
Cat.No: L3700
Compounds: 252
凝血与抗凝化合物库
Cat.No: L7500
Compounds: 144
Cat. No. Product Name Target Signaling Pathways
T39719 Nrf2 activator-1

Nrf2 activator-1

Nrf2 Immunology/Inflammation
Nrf2 activator-1 是一种有效的 NF-E2 相关因子 2 (Nrf2) 激活剂。Nrf2 activator-1 可用于研究包括哮喘、急性肺损伤 (ALI)、急性呼吸窘迫综合征 (ARDS) 和肺纤维化等 COPD 和其他呼吸系统疾病。
T67925 Nampt activator-1

NAMPT Metabolism
NAMPT activator-1 (compound 1) 是一种有效的、专用范围广泛的烟酰胺磷酸基转移酶 (NAMPT) 激活剂(EC50 为3.3-3.7 μM)。NAMPT activator-1能有效保护培养细胞免受 fk866介导的毒性,是神经保护的潜在化合物。
T39965 NF-κΒ activator 1

NF-κB NF-κB
NF-κΒ activator 1 可激活NF-κΒ基因,EC50 为 0.9 μM。NF-κB 作为一种调控细胞增殖和细胞存活的基因被真核细胞广泛应用。NF-κΒ activator 1 可诱导超氧化物歧化酶 (SOD)2 mRNA 表达。
T13345 Wnt pathway activator 2

Others; Wnt/beta-catenin Cytoskeletal Signaling; Others; Stem Cells
Wnt pathway activator 2 是一种有效的 Wnt 激活剂,IC50 为 13 nM。
T8652 CASP3 Activator 1541

Caspase Apoptosis; Proteases/Proteasome
CASP3 Activator 1541 是 caspase-3 酶原形式的激活剂,可诱导细胞死亡。
T9778 KCNQ1 activator-1 

Potassium Channel Membrane transporter/Ion channel
KCNQ1 activator-1 是有效的 KCNQ1通道激活剂。它在研究长 QT 综合征中有研究的价值。
T39924 NF-κΒ activator 2

NF-κB NF-κB
NF-κΒ activator 2 是口服有效的 NF-ҡB 激活剂,EC50为 1.58 μM。它通过增加 NF-κB 的表达和激活来诱导 SOD2。它具有用于研究肌萎缩性侧索硬化症的价值。
T16873 SERCA2a activator 1

Calcium Channel Membrane transporter/Ion channel; Metabolism
SERCA2a activator 1 是一种肌肉/内质网 Ca2+ 依赖性 ATPase 2a 激活剂。 SERCA2a activator 1 降低受磷蛋白抑制并增强心脏的收缩和舒张功能。
T17256 Wnt pathway activator 1

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
Wnt pathway activator 1 是Wnt 激活剂(EC50=28-29 nM)。
T1772 MDK83190

Apoptosis Activator 2

Apoptosis; Caspase Apoptosis; Proteases/Proteasome
MDK83190 (Apoptosis Activator 2) 是一种细胞凋亡激活剂,可诱导 caspase-3 激活、Apaf-1 寡聚化、PARP 切割和 DNA 片段化。
T9400 KCNQ2/3 activator-1

Others; Potassium Channel Membrane transporter/Ion channel; Others
KCNQ2/3 activator-1 是Kv7.2/Kv7.3(KCNQ2/3) 钾通道激活剂,详细信息来自专利 WO2021113757A1的化合物 A。
T60675L AMPK activator 2 hydrochloride( 2410961-69-0 Free base)

AMPK activator 2 hydrochloride( 2410961-69-0 Free base)

AMPK Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
AMPK activator 2 hydrochloride 是一种含氟氯胍衍生物,可上调 AMPK 信号通路并下调 mTOR/4EBP1/p70S6K。AMPK activator 2 hydrochloride 抑制人类癌细胞系 (UMUC3、T24、A549) 的增殖和迁移。
T4280 Gcase activator 1

LTI-291,LTI 291,LTI291

Glucosidase Metabolism
Gcase activator 1 (LTI-291) 是葡糖脑苷脂酶 (Gcase) 的激活剂。
T9853 STING activator Compound 53

STING Immunology/Inflammation
基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING(人 EC50 185 nM)的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。
T8055 TFEB activator 1

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,(1E,4E)-1,5(2 -甲氧基苯基)-1,4-戊二烯-3-酮,RPN77612

Others; Autophagy Autophagy; Others
TFEB activator 1 (Curcumin analog compound C1) 是转录因子 EB 的一种激活剂,有望预防或治疗阿尔茨海默病。
T7674 Thrombin Receptor Activator for Peptide

Protease-activated Receptor GPCR/G Protein
Thrombin Receptor Activator for Peptide 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。
T14127 Adenosine A1 receptor activator T62

Adenosine Receptor GPCR/G Protein; Neuroscience
Adenosine A1 receptor activator T62 是腺苷 A1 受体的变构增强剂,有镇痛作用。
T9347 EAAT2 activator 1

3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine

transporter Metabolism
EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) 是兴奋性氨基酸转运蛋白 2(EAAT2) 的有效激活剂,以剂量依赖性方式增加 EAAT2 蛋白水平。
T10674 Potassium Channel Activator 1

钾离子通道激活剂1,ZINC34634569

Potassium Channel Membrane transporter/Ion channel
Potassium Channel Activator 1 可用于治疗多巴胺能系统被破坏的疾病或病症的研究,例如情绪障碍 ADHD、精神分裂症和其他精神病状态。
T24546 Nrf2-Activator-12G

Nrf2 Activator IV,Nrf2 Activator-IV

Others Others
Nrf2-Activator-12G is a potent Nrf-2 activator.
T3293 Apoptozole

Apoptosis Activator VII

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
Apoptozole (Apoptosis Activator VII) 是一种Hsc70和Hsp70的 ATPase 结构域抑制剂,可诱导凋亡,Kd 值分别为 0.21 和 0.14 μM。
T77616 VU533

Nape-Pld activator

Phospholipase Metabolism
VU533 (Nape-Pld activator) 是一种NAPE-PLD 激活剂,其 EC50 值为0.30 µM。VU533 可以提高 NAPE-PLD 活性,增加巨噬细胞的胞葬作用。VU533 可用于与心脏代谢相关的疾病。
T2065 Bioymifi

DR5 Activator

Apoptosis; TNF Apoptosis
Bioymifi (DR5 Activator) 是一种 TRAIL 受体DR5激活剂,与DR5的胞外结构域结合,Kd 为 1.2 μM,它可诱导 DR5 聚集,导致细胞凋亡。
T62238 AMPK activator 4

AMPK Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
AMPK activator 4 是一种有效且具有选择性的AMPK激活剂,不抑制线粒体复合物 I。AMPK activator 4 选择性地激活肌肉组织中的 AMPK且剂量依赖性地改善正常小鼠的糖耐量,显著降低 db/db 糖尿病小鼠的空腹血糖水平和改善胰岛素抵抗。AMPK activator 4 具有降血糖作用。
T16342 KL1333

NQO1 activator 1

NADPH; Mitochondrial Metabolism Metabolism
KL1333 (NQO1 activator 1) 是口服NAD+调节剂,与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。
T14080 AA147

ATF6-activator-147

Others Others
AA147 (ATF6-activator-147) 是小分子内质网蛋白稳态调节剂,能够选择性激活未折叠蛋白反应的 ATF6臂。
T23828 BtGH84 Activator I

4-EtOQz,BtGH-84 Activator I,4 EtOQz,4EtOQz,Bt-GH-84 Activator I

Others Others
BtGH84 Activator I is a BtGH84 activator. It is the small molecule activator of a glycoside hydrolase.
T72617 Nampt activator-2

P450; NAMPT Metabolism
Nampt activator-2 是一种 NAMPT 激活剂(EC50 : 0.023 μM)。 Nampt activator-2 对 CYP2C9、2D6、2C19 具有亲和力,亲和力数值分别为 0.060 μM、 0.41 μM 和 0.59 μM 。Nampt activator-2 可用来研究动脉粥样硬化,肥胖,II型糖尿病,胰岛素抵抗和I型糖尿病。
T62758 PKM2 activator 2

PKM Metabolism
PKM2 activator 2是一种丙酮酸激酶 M2(PKM2)激活剂,AC 50 值为 66 nM。PKM2 activator 2具有抗肿瘤增殖和缓解沃伯格效应的作用,通过激活 PKM2 使细胞的糖酵解代谢恢复正常。
T36935 PKUMDL-LC-101-D04

GPX4-Activator-1d4,PKUMDL-LC-101-D04

GPX oxidation-reduction
PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4(GPX4)的异位激活剂,是一种铁死亡的调节剂。 当在无细胞试验中使用浓度为20 μM 时,GPX4活性增加到对照水平的150%;在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时,GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04(200 μM)能减少胆固醇过氧化氢诱导的MEF 死亡。
T72771 p53 Activator 7

Apoptosis Apoptosis
p53 Activator 7 是一种高效性和细胞渗透性的 p53 突变 Y220C (MDM-2/p53) 激活剂,可诱导细胞凋亡 。
T78650 Nrf2 activator-3

Antioxidant; Nrf2 Immunology/Inflammation; oxidation-reduction
Nrf2 activator-3为一种高效 Nrf2 激活剂,具有潜在的抗炎抗氧化抗肿瘤活性,可用于研究神经系统疾病和免疫相关疾病。
T78791 AMPK activator 12

AMPK Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
AMPK activator 12 是一种 AMPK 激活剂和 GDF15 诱导剂,能提升人肝细胞内GDF15蛋白的表达水平,可用于研究癌症。
T63016 Nrf2 activator-4

Reactive Oxygen Species; Nrf2 Immunology/Inflammation; Metabolism; NF-κB
Nrf2 activator-4 是一种具有口服活性的 Nrf2 激活剂(EC50: 0.63 μM),对小神经胶质细胞中活性氧的产生有抑制作用,用于治疗人类代谢功能障碍相关的脂肪肝病。
T77349 CCR1/5/8 activator 1

Phospholipase Metabolism
CCR1/5/8 activator 1 是胞质磷脂酶 A 抑制剂,具有抗真菌活性。
T72420 MTK458

Mitophagy activator 1,EP-0035985

PTEN PI3K/Akt/mTOR signaling
MTK458 (EP-0035985) 是一种具有口服活性和脑渗透性的 PINK1 激活剂,在PFF 接种模型中促进 α-突触核蛋白病理学的清除并降低 pUb。MTK458 通过刺激 PINK1/TOM 复合物的二聚化和稳定来诱导病理学的α-突触核蛋白清除。MTK458 可用于帕金森病的研究。
T67858 STIMA-1

2-Vinylquinazolin-4-ol,p53 Activator VII

Others Others
STIMA-1 (2-Vinylquinazolin-4-ol) 是一种活性化合物,可以恢复 p63 的活性。STIMA-1 可以刺激角质形成细胞的增殖和分化。
T63321 20S Proteasome activator 1

Proteasome Proteases/Proteasome; Ubiquitination
20S Proteasome activator 1 是一种 20S 蛋白酶激活剂,对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。
T22567 AMPK activator

Others Others
AMPK activator
T7496 Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Thrombin Receptor Activator for Peptide

Protease-activated Receptor GPCR/G Protein
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5),用于研究冠心病 (CHD)。
T10069 AMPK activator 1

Others Others
AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).
T11418 Glucokinase activator 1

Others Others
Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).
T70862 AMPK Activator SC4

Others Others
SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.
T11457 GPR40 Activator 2

Others Others
GPR40 Activator 2 is a highly effective activator of the GPR40 receptor.
T12179 Nav1.1 activator 1

Others Others
Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration.
T11456 GPR40 Activator 1

Others Others
GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
T12251 NR1H4 activator 1

Others Others
NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).
T12498 PKR activator 2

Others Others
PKR activator 2 is a potent activator of pyruvate kinase-R (PKR).
T12497 PKR activator 1

Others Others
PKR activator 1 is a potent activator of pyruvate kinase-R (PKR).
T7625 TRAP-6

PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)

Protease-activated Receptor GPCR/G Protein
TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段,是选择性的蛋白酶激活受体 1 (PAR1) 激动剂,通过凝血酶受体激活人血小板。

化合物

Nrf2 activator-1
Cat.No: T39719
Synonym: Nrf2 activator-1
Target: Nrf2
Nampt activator-1
Cat.No: T67925
Synonym:
Target: NAMPT
NF-κΒ activator 1
Cat.No: T39965
Synonym:
Target: NF-κB
Wnt pathway activator 2
Cat.No: T13345
Synonym:
Target: Others, Wnt/beta-catenin
CASP3 Activator 1541
Cat.No: T8652
Synonym:
Target: Caspase
KCNQ1 activator-1 
Cat.No: T9778
Synonym:
Target: Potassium Channel
NF-κΒ activator 2
Cat.No: T39924
Synonym:
Target: NF-κB
SERCA2a activator 1
Cat.No: T16873
Synonym:
Target: Calcium Channel
Wnt pathway activator 1
Cat.No: T17256
Synonym:
Target: Wnt/beta-catenin
MDK83190
Cat.No: T1772
Synonym: Apoptosis Activator 2
Target: Apoptosis, Caspase
KCNQ2/3 activator-1
Cat.No: T9400
Synonym:
Target: Others, Potassium Channel
AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
Cat.No: T60675L
Synonym: AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
Target: AMPK
Gcase activator 1
Cat.No: T4280
Synonym: LTI-291,LTI 291,LTI291
Target: Glucosidase
STING activator Compound 53
Cat.No: T9853
Synonym:
Target: STING
TFEB activator 1
Cat.No: T8055
Synonym: (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,(1E,4E)-1,5(2 -甲氧基苯基)-1,4-戊二烯-3-酮,RPN77612
Target: Others, Autophagy
Thrombin Receptor Activator for Peptide
Cat.No: T7674
Synonym:
Target: Protease-activated Receptor
Adenosine A1 receptor activator T62
Cat.No: T14127
Synonym:
Target: Adenosine Receptor
EAAT2 activator 1
Cat.No: T9347
Synonym: 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine
Target: transporter
Potassium Channel Activator 1
Cat.No: T10674
Synonym: 钾离子通道激活剂1,ZINC34634569
Target: Potassium Channel
Nrf2-Activator-12G
Cat.No: T24546
Synonym: Nrf2 Activator IV,Nrf2 Activator-IV
Target: Others
Apoptozole
Cat.No: T3293
Synonym: Apoptosis Activator VII
Target: Apoptosis, HSP
VU533
Cat.No: T77616
Synonym: Nape-Pld activator
Target: Phospholipase
Bioymifi
Cat.No: T2065
Synonym: DR5 Activator
Target: Apoptosis, TNF
AMPK activator 4
Cat.No: T62238
Synonym:
Target: AMPK
KL1333
Cat.No: T16342
Synonym: NQO1 activator 1
Target: NADPH, Mitochondrial Metabolism
AA147
Cat.No: T14080
Synonym: ATF6-activator-147
Target: Others
BtGH84 Activator I
Cat.No: T23828
Synonym: 4-EtOQz,BtGH-84 Activator I,4 EtOQz,4EtOQz,Bt-GH-84 Activator I
Target: Others
Nampt activator-2
Cat.No: T72617
Synonym:
Target: P450, NAMPT
PKM2 activator 2
Cat.No: T62758
Synonym:
Target: PKM
PKUMDL-LC-101-D04
Cat.No: T36935
Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04
Target: GPX
p53 Activator 7
Cat.No: T72771
Synonym:
Target: Apoptosis
Nrf2 activator-3
Cat.No: T78650
Synonym:
Target: Antioxidant, Nrf2
AMPK activator 12
Cat.No: T78791
Synonym:
Target: AMPK
Nrf2 activator-4
Cat.No: T63016
Synonym:
Target: Reactive Oxygen Species, Nrf2
CCR1/5/8 activator 1
Cat.No: T77349
Synonym:
Target: Phospholipase
MTK458
Cat.No: T72420
Synonym: Mitophagy activator 1,EP-0035985
Target: PTEN
STIMA-1
Cat.No: T67858
Synonym: 2-Vinylquinazolin-4-ol,p53 Activator VII
Target: Others
20S Proteasome activator 1
Cat.No: T63321
Synonym:
Target: Proteasome
AMPK activator
Cat.No: T22567
Synonym:
Target: Others
Thrombin Receptor Activator for Peptide 5 (TRAP-5)
Cat.No: T7496
Synonym: Thrombin Receptor Activator for Peptide
Target: Protease-activated Receptor
AMPK activator 1
Cat.No: T10069
Synonym:
Target: Others
Glucokinase activator 1
Cat.No: T11418
Synonym:
Target: Others
AMPK Activator SC4
Cat.No: T70862
Synonym:
Target: Others
GPR40 Activator 2
Cat.No: T11457
Synonym:
Target: Others
Nav1.1 activator 1
Cat.No: T12179
Synonym:
Target: Others
GPR40 Activator 1
Cat.No: T11456
Synonym:
Target: Others
NR1H4 activator 1
Cat.No: T12251
Synonym:
Target: Others
PKR activator 2
Cat.No: T12498
Synonym:
Target: Others
PKR activator 1
Cat.No: T12497
Synonym:
Target: Others
TRAP-6
Cat.No: T7625
Synonym: PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)
Target: Protease-activated Receptor
Cat. No. Product Name Target Signaling Pathways
TN6729 Azadiradione

AZD

Others Others
Azadiradione (AZD) 是 HSF1的一种,是由印楝树中提取得到,具有一定生物活性的柠檬苦素。
T3876 Loureirin B

龙血素B,龙血素 B

PAI-1; ERK; Potassium Channel; JNK MAPK; Membrane transporter/Ion channel; Metabolism
Loureirin B 是从剑叶龙血树中分离到的一种黄酮,是 PAI-1抑制剂,IC50值为 26.10 μM。它抑制 KATP,以及 ERK 和 JNK 的磷酸化,具有抗糖尿病的功效。
T4S0592 Toddalolactone

(+)-Toddalolactone,飞龙掌血内酯,毛两面针素

PAI-1 Metabolism
Toddalolactone ((+)-Toddalolactone) 是一种Toddalia asiatica 的主要成分,能够抑制重组人纤溶酶原激活物抑制物-1(PAI-1)的活性, IC50=37.31 μM。
TN1731 Hernandezine

TNF; ROS; P-gp; AMPK Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling
Hernandezine 是 AMPK 激动剂的激动剂,也是癌细胞中 ABCB1 介导的 MDR 的特异性逆转剂。
T8036 6-Methylflavone

GABA Receptor Membrane transporter/Ion channel; Neuroscience
6-Methylflavone 是α1β2γ2L 和α1β2GABAA 受体激活剂。
T7327 7-Methoxyisoflavone

AMPK Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
7-Methoxyisoflavone 是单磷酸腺苷活化蛋白激酶 (AMPK) 的激活剂,是异黄酮衍生物。
T10085 20(S)-Hydroxycholesterol

20α-Hydroxycholesterol

Smo Stem Cells
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂。
T12514 Podocarpic acid

Others; TRP/TRPV Channel Membrane transporter/Ion channel; Others
Podocarpic acid 是一种天然产物,是一种新型 TRPA1 激活剂。
T6S1141 Ganoderic acid A

灵芝酸 A,灵芝酸A

Apoptosis; NF-κB; Endogenous Metabolite; Autophagy Apoptosis; Autophagy; Metabolism; NF-κB
Ganoderic acid A 能够抑制 JAK-STAT3信号通路,也能抑制细胞增殖,存活率和 ROS。 它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。
T2855 Icariin

淫羊藿苷,Ieariline,淫羊藿甙

PDE; PPAR; Autophagy Autophagy; DNA Damage/DNA Repair; Metabolism
Icariin (Ieariline) 是一种黄酮醇苷,可抑制PDE5和PDE4活性,IC50分别为 432 nM 和 73.50 μM。它也是PPARα激活剂。
T8155 Maltoheptaose

Phospholipase Metabolism
Maltoheptaose 是一种含有七个葡萄糖单元的麦芽低聚糖。它是一种磷酸化酶 B (phosphorylase B) 的活化剂,可用于 2-磷酸庚糖的制备。
T6871 L-Glutamic acid monosodium salt

Monosodium glutamate,谷氨酸单钠盐,Glutacyl,Glutavene,L-谷氨酸单钠盐,Ajinomoto,MSG

Apoptosis; Ferroptosis; GluR; iGluR Apoptosis; Membrane transporter/Ion channel; Neuroscience
L-Glutamic acid monosodium salt (MSG) 作为兴奋性氨基酸神经递质,是谷氨酸盐受体所有亚型的激动剂,对多巴胺从神经末梢释放的过程有激动作用。
T8363 DL-Serine

PKM Metabolism
DL-Serine 是 D-丝氨酸和 L-丝氨酸的混合物,是一种基础代谢物。它具有抗病毒作用,能抑制烟草花叶病毒的增殖。
T14149 AICAR phosphate

AICA Riboside phosphate,Acadesine phosphate

Mitophagy; NOS; YAP; AMPK Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
AICAR phosphate (Acadesine phosphate) 是 AMPK 激活剂且是自噬、YAP 和 mitophagy 抑制剂,也是一种腺苷类似物, 可调节糖代谢和脂代谢,抑制促炎细胞因子和 iNOS 的产生。
TQ0089 Juglanin

Apoptosis; JNK; Autophagy Apoptosis; Autophagy; MAPK
Juglanin 是来自金鸡脚的一种黄酮类天然产物,是一种 JNK 的激活剂,能诱导人乳腺癌细胞的凋亡和自噬,具有炎症和抗肿瘤活性。
T5891 D-ERYTHRO-SPHINGOSINE

trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇

Phosphatase; Endogenous Metabolite; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
D-erythro-Sphingosine (trans-4-Sphingenine) 是一种非常有效的p32激酶活化剂,EC50为 8 μM。它也是一种PP2A 激活剂,抑制蛋白激酶 C (PKC)。
T5S1569 AKBA

乙酰基-11-酮基-beta-乳香酸,3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid

Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others
AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) 是一种从乳香中分离的天然成分,是新颖的 Nrf2 的活化剂。
TN1543 Cynaropicrin

IL Receptor; Others; TNF Apoptosis; Immunology/Inflammation; Others
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro-
T2896 Alantolactone

土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor

Apoptosis; STAT; TGF-beta/Smad Apoptosis; JAK/STAT signaling; Stem Cells
Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。
TN6552 5,7-Dimethoxyluteolin

Dopamine Receptor GPCR/G Protein; Neuroscience
5,7-Dimethoxyluteolin 是 5,7-二甲基木犀草素的一种衍生物,可以活化多巴胺转运蛋白,EC50为 3.417 μM。
TN1047 Ingenol mebutate

Ingenol 3-Angelate,巨大戟醇甲基丁烯酸酯,PEP005

gp120/CD4; HIV Protease; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
Ingenol mebutate (Ingenol 3-Angelate) 是 PKC 的有效激动剂,包括 PKC-α、PKC-β、PKC-γ、PKC-δ 和 PKC-ε,Kis 为 0.3、0.105、0.162、0.376 和 0.171 nM。 Ingenol mebutate 具有抗炎和抗肿瘤活性。
TQ0198 Phorbol 12-myristate 13-acetate

佛波醇12-十四酸酯13-乙酸酯,PMA

NF-κB; S1P Receptor; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; NF-κB
Phorbol 12-myristate 13-acetate (PMA) 属于佛波酯类天然产物,是一种 PKC、SphK、NF-κB 的激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP1 细胞分化。
T3912 Saikosaponin B1

柴胡皂苷B1,柴胡皂苷 B1

Others Others
Saikosaponin B1 是柴胡的生物活性成分,具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路,显著抑制髓母细胞瘤模型中的肿瘤生长。
T3863 Chikusetsusaponin IVa

竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA

AMPK Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Chikusetsusaponin IVa (Calenduloside F) 是一种三萜皂苷中主要的活性成分,是一种蛋白激酶的激活剂,对血栓及一些代谢性疾病具有抵抗作用。
TN1621 Eriodictyol-7-O-glucoside

Nrf2 Immunology/Inflammation
Eriodictyol-7-O-glucoside 是一种 Nrf2 激活剂,可防止顺铂诱导的毒性。 Eriodictyol-7-O-glucoside 是一种类黄酮和自由基清除剂,在开心果皮中具有抗氧化活性。
T1131 Ivermectin

MK-933,伊维菌素

Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome
Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂,具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入,还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。
T2O2668 Oleic acid

Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸

Apoptosis; ATPase; Others; Endogenous Metabolite Apoptosis; Membrane transporter/Ion channel; Metabolism; Others
Oleic acid (Glycon Wo) 属于天然产物,是一种常见的不饱和脂肪酸,在存在于多种动物、植物的脂肪和油脂中。Oleic acid 是一种 Na+/K+ATP 酶激活剂。
TN3209 3′,4′,7-Trihydroxyflavone 

ATPase; Others; p38 MAPK; NF-κB MAPK; Membrane transporter/Ion channel; NF-κB; Others
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。
TN1182 11-​Keto-​beta-​boswellic acid

11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Leukotriene Receptor; NF-κB; Lipoxygenase GPCR/G Protein; Metabolism; NF-κB
11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸,具有抗炎活性和剂量依赖性心脏保护作用,主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
T3092 Nigericin sodium salt

尼日利亚菌素,尼日利亚菌素钠盐

Potassium Channel; NOD-like Receptor (NLR); Antibacterial; Antibiotic; NOD Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
Nigericin sodium salt 属于抗生素,是一种 NLRP3 激活剂,也是一种阳离子离子载体。Nigericin sodium 可以触发 NALP3 炎性体的激活,可抑制高尔基体功能并抑制革兰氏阳性菌的生长。
Fr16605 Lupinine

鲁冰花,羽扇豆碱

AChR; AChE Neuroscience
Lupinine 是一种能够抵消乙醇麻醉的生物碱。 Lupinine 是一种 AChE 和 BChE 抑制剂和潜在的 CD69 激活剂,存在于 Loranthus、Calia 和 Lupinus 物种中。它还可以抑制肝素。
T36390 Sodium oleate

Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt

ATPase Membrane transporter/Ion channel
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。
TMA2474 δ-Tocotrienol

Delta-Tocotrienol,δ-生育三烯酚

ERK; BCL; VEGFR; Akt; PI3K; PDK; p53 Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
δ-Tocotrienol (Delta-Tocotrienol) 是一种维生素 E,存在于蔬菜,水果,种子,坚果,谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂,可以降低胆固醇和其他脂质,保护心血管疾病。
T19384 Isovalerylcarnitine

Apoptosis; Cysteine Protease Apoptosis; Proteases/Proteasome
Isovalerylcarnitine (3-methylbutyrylcarnitine) 是 L-亮氨酸分解代谢和异戊酸的积累产生的小分子化合物,也是一种具有选择性和有效性的钙蛋白酶 (calpain) 激活剂,可促使细胞凋亡,与异戊酸血症有关,可作为异戊酸血症的标志。
T9143 D-Isoleucine

(2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine

Others Others
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) 是一种异亮氨酸立体异构体,是 Asc-1 反转运蛋白的选择性激活剂。它能够释放内源性 D-丝氨酸,提高海马 CA1-CA3 的长期增效作用。
T2745 18α-Glycyrrhetinic acid

18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid

Apoptosis; NF-κB; Proteasome Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination
18α-Glycyrrhetinic acid (Enoxolone) 是 NF-kB 的抑制剂和蛋白酶体的激活剂,在多细胞生物中起到促进长寿和抗聚集因子的作用。它诱导细胞凋亡。
T6S1302 Carnosol

Nrf2; Endogenous Metabolite; S6 Kinase Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling
Carnosol 是 Nrf2激活剂,增加 Nrf2 的水平以及能促进血红素氧合酶 1(HMOX1) 表达。它是核糖体 S6激酶(RSK2)抑制剂,可用于胃癌相关研究,IC50值约为 5.5 μM。
T10086 24-Hydroxycholesterol

Cholest-5-ene-3beta,24-diol

Liver X Receptor; NMDAR Metabolism; Neuroscience
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) 是一种氧甾醇化合物,是一种 n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂,可用于研究心血管生成和胰腺癌。
T3727 Methyl syringate

Syringic Acid Methyl Ester,丁香酸甲酯

TRP/TRPV Channel Membrane transporter/Ion channel
Methyl syringate (Syringic Acid Methyl Ester) 是水仙花蜜的化学标记物,是有效的细菌和真菌漆酶酚介质。它也是TRPA1激动剂。
T3254 PHYTOL

植醇,trans-Phytol,(E)-Phytol

Antibacterial; PPAR; Parasite DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
PHYTOL (trans-Phytol) 是一种从叶绿素中提取的二萜醇,广泛应用于食品添加剂和医药领域,具有很好的抗血吸虫特性。它具有抗伤害、抗氧化、抗炎、抗过敏等作用。它对结核分枝杆菌和金黄色葡萄球菌具有抗菌活性。
T5S2017 Ingenol

(-)-Ingenol,巨大戟二萜醇,巨大戟醇

PKC Chromatin/Epigenetic; Cytoskeletal Signaling
Ingenol ((-)-Ingenol) 是一种PKC 激活剂,Ki 值为 30 μM,具有抗肿瘤活性。 从 Ingenol 酯中配制新的衍生物可能是开发新的先导化合物以重新激活潜伏 HIV 的创新方法。Ingenol mebutate 是治疗光化性角化病的有效方法。
T16579 Pro-xylane

玻色因,Hydroxypropyl tetrahydropyrantriol

Others Others
Pro-xylane (Hydroxypropyl tetrahydropyrantriol) 是一种在水介质中具有生物活性的 c- 糖苷 (C-glycoside),是粘多糖 (GAGs) 的生物合成活化剂,也是第一种应用于化妆品的“绿色”化学物质。
T2939 Forskolin

毛喉素,Coleonol,Colforsin

FXR; Adenylyl cyclase; AChR; Autophagy Autophagy; Metabolism; Neuroscience
Forskolin (Coleonol) 属于天然产物,是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平,可以激活 PXR 和 FXR,也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用,具有血小板抗凝集和降压作用。
TN5770 Gingerenone A

Nrf2 Immunology/Inflammation
Gingerenone A 是一种有效的 Nrf2-Gpx4 激活剂,是从生姜里面分离出来的小分子化合物,具有抗癌活性,可延长癌细胞的细胞周期,可抑制右旋糖酐硫酸钠 (DSS) 诱导的结肠炎小鼠继发性肝损伤 (SLI) 中的铁死亡。
TL0007 Bisdemethoxycurcumin

双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin

Epigenetic Reader Domain; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。
T2854 Phillyrin

Forsythin,连翘苷

P450; Influenza Virus; AMPK Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。
T4868 gamma-Linolenic acid

gamolenic acid,γ-Linolenic acid,γ-亚麻酸

Endogenous Metabolite Metabolism
gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6),18 碳 (18C-) 多不饱和脂肪酸 (PUFA),可以从人乳和植物种子油中提取。
T2174 Quercetin

槲皮素,Sophoretin

Apoptosis; Mitophagy; Reactive Oxygen Species; PI3K; Autophagy Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
Quercetin 属于黄酮类天然产物,是 SIRT1 的激动剂;Quercetin 也是一种 PI3K 抑制剂,抑制 PI3Kγ、PI3Kδ 和 PI3Kβ (IC50=2.4/3.0/5.4 μM)。Quercetin 作为公认的热休克蛋白抑制剂,也可通过下调Hsp70或Hsp90来显著减少TII模型中的外泌体释放。
T3889 Platycodin D

Prostaglandin Receptor; AMPK Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物,是AMPKα的激活剂,具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
TN1013 Cucurbitacin D

Apoptosis Apoptosis
Cucurbitacin D 是一种从 Ecballium elaterium (L.)分离出来的三萜类化合物,具有抗癌抗肿瘤活性,抑制转移性 PrC 中的葡萄糖摄取和乳酸产生,诱导独立于 ERK1/2 激活的炎症小体激活。 Cucurbitacin D 是巨噬细胞中的一种新的炎症小体激活剂,通过调节 JAK/STAT3、PI3K/Akt/mTOR 和 MAPK 信号通路抑制 HepG2 细胞增殖并诱导细胞凋亡, 可用于研究宫颈癌、白血病和前列腺癌。
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天然产物

Azadiradione
Cat.No: TN6729
Synonym: AZD
Target: Others
Loureirin B
Cat.No: T3876
Synonym: 龙血素B,龙血素 B
Target: PAI-1, ERK, Potassium Channel, JNK
Toddalolactone
Cat.No: T4S0592
Synonym: (+)-Toddalolactone,飞龙掌血内酯,毛两面针素
Target: PAI-1
Hernandezine
Cat.No: TN1731
Synonym:
Target: TNF, ROS, P-gp, AMPK
6-Methylflavone
Cat.No: T8036
Synonym:
Target: GABA Receptor
7-Methoxyisoflavone
Cat.No: T7327
Synonym:
Target: AMPK
20(S)-Hydroxycholesterol
Cat.No: T10085
Synonym: 20α-Hydroxycholesterol
Target: Smo
Podocarpic acid
Cat.No: T12514
Synonym:
Target: Others, TRP/TRPV Channel
Ganoderic acid A
Cat.No: T6S1141
Synonym: 灵芝酸 A,灵芝酸A
Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy
Icariin
Cat.No: T2855
Synonym: 淫羊藿苷,Ieariline,淫羊藿甙
Target: PDE, PPAR, Autophagy
Maltoheptaose
Cat.No: T8155
Synonym:
Target: Phospholipase
L-Glutamic acid monosodium salt
Cat.No: T6871
Synonym: Monosodium glutamate,谷氨酸单钠盐,Glutacyl,Glutavene,L-谷氨酸单钠盐,Ajinomoto,MSG
Target: Apoptosis, Ferroptosis, GluR, iGluR
DL-Serine
Cat.No: T8363
Synonym:
Target: PKM
AICAR phosphate
Cat.No: T14149
Synonym: AICA Riboside phosphate,Acadesine phosphate
Target: Mitophagy, NOS, YAP, AMPK
Juglanin
Cat.No: TQ0089
Synonym:
Target: Apoptosis, JNK, Autophagy
D-ERYTHRO-SPHINGOSINE
Cat.No: T5891
Synonym: trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇
Target: Phosphatase, Endogenous Metabolite, PKC
AKBA
Cat.No: T5S1569
Synonym: 乙酰基-11-酮基-beta-乳香酸,3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid
Target: Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite
Cynaropicrin
Cat.No: TN1543
Synonym:
Target: IL Receptor, Others, TNF
Alantolactone
Cat.No: T2896
Synonym: 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor
Target: Apoptosis, STAT, TGF-beta/Smad
5,7-Dimethoxyluteolin
Cat.No: TN6552
Synonym:
Target: Dopamine Receptor
Ingenol mebutate
Cat.No: TN1047
Synonym: Ingenol 3-Angelate,巨大戟醇甲基丁烯酸酯,PEP005
Target: gp120/CD4, HIV Protease, PKC
Phorbol 12-myristate 13-acetate
Cat.No: TQ0198
Synonym: 佛波醇12-十四酸酯13-乙酸酯,PMA
Target: NF-κB, S1P Receptor, PKC
Saikosaponin B1
Cat.No: T3912
Synonym: 柴胡皂苷B1,柴胡皂苷 B1
Target: Others
Chikusetsusaponin IVa
Cat.No: T3863
Synonym: 竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA
Target: AMPK
Eriodictyol-7-O-glucoside
Cat.No: TN1621
Synonym:
Target: Nrf2
Ivermectin
Cat.No: T1131
Synonym: MK-933,伊维菌素
Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV
Oleic acid
Cat.No: T2O2668
Synonym: Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸
Target: Apoptosis, ATPase, Others, Endogenous Metabolite
3′,4′,7-Trihydroxyflavone 
Cat.No: TN3209
Synonym:
Target: ATPase, Others, p38 MAPK, NF-κB
11-​Keto-​beta-​boswellic acid
Cat.No: TN1182
Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸
Target: Leukotriene Receptor, NF-κB, Lipoxygenase
Nigericin sodium salt
Cat.No: T3092
Synonym: 尼日利亚菌素,尼日利亚菌素钠盐
Target: Potassium Channel, NOD-like Receptor (NLR), Antibacterial, Antibiotic, NOD
Lupinine
Cat.No: Fr16605
Synonym: 鲁冰花,羽扇豆碱
Target: AChR, AChE
Sodium oleate
Cat.No: T36390
Synonym: Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt
Target: ATPase
δ-Tocotrienol
Cat.No: TMA2474
Synonym: Delta-Tocotrienol,δ-生育三烯酚
Target: ERK, BCL, VEGFR, Akt, PI3K, PDK, p53
Isovalerylcarnitine
Cat.No: T19384
Synonym:
Target: Apoptosis, Cysteine Protease
D-Isoleucine
Cat.No: T9143
Synonym: (2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine
Target: Others
18α-Glycyrrhetinic acid
Cat.No: T2745
Synonym: 18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid
Target: Apoptosis, NF-κB, Proteasome
Carnosol
Cat.No: T6S1302
Synonym:
Target: Nrf2, Endogenous Metabolite, S6 Kinase
24-Hydroxycholesterol
Cat.No: T10086
Synonym: Cholest-5-ene-3beta,24-diol
Target: Liver X Receptor, NMDAR
Methyl syringate
Cat.No: T3727
Synonym: Syringic Acid Methyl Ester,丁香酸甲酯
Target: TRP/TRPV Channel
PHYTOL
Cat.No: T3254
Synonym: 植醇,trans-Phytol,(E)-Phytol
Target: Antibacterial, PPAR, Parasite
Ingenol
Cat.No: T5S2017
Synonym: (-)-Ingenol,巨大戟二萜醇,巨大戟醇
Target: PKC
Pro-xylane
Cat.No: T16579
Synonym: 玻色因,Hydroxypropyl tetrahydropyrantriol
Target: Others
Forskolin
Cat.No: T2939
Synonym: 毛喉素,Coleonol,Colforsin
Target: FXR, Adenylyl cyclase, AChR, Autophagy
Gingerenone A
Cat.No: TN5770
Synonym:
Target: Nrf2
Bisdemethoxycurcumin
Cat.No: TL0007
Synonym: 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin
Target: Epigenetic Reader Domain, Wnt/beta-catenin
Phillyrin
Cat.No: T2854
Synonym: Forsythin,连翘苷
Target: P450, Influenza Virus, AMPK
gamma-Linolenic acid
Cat.No: T4868
Synonym: gamolenic acid,γ-Linolenic acid,γ-亚麻酸
Target: Endogenous Metabolite
Quercetin
Cat.No: T2174
Synonym: 槲皮素,Sophoretin
Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy
Platycodin D
Cat.No: T3889
Synonym:
Target: Prostaglandin Receptor, AMPK
Cucurbitacin D
Cat.No: TN1013
Synonym:
Target: Apoptosis
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Cat. No. Product Name Species Expression System
TMPY-01257 uPAR/PLAUR Protein, Mouse, Recombinant (His)

uPAR,Cd87,u-PAR,plasminogen activator, urokinase re...

Mouse HEK293 Cells
uPAR/PLAUR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is P35456-1.
TMPY-02141 uPAR/PLAUR Protein, Human, Recombinant (His)

UPAR,CD87,plasminogen activator, urokinase receptor...

Human HEK293 Cells
uPAR/PLAUR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q03405-1.
TMPY-00904 Urokinase/uPA Protein, Human, Recombinant (His)

u-PA,QPD,BDPLT5,ATF,UPA,plasminogen activator, urok...

Human HEK293 Cells
Urokinase/uPA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is A0A024QZM9.
TMPJ-00662 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Receptor activator of nuclear factor kappa-B ligand...

Human E. coli
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog...
TMPY-06624 STAT3 Protein, Human, Recombinant (His)

ADMIO,signal transducer and activator of transcript...

Human E. coli
STAT3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 65.31 kDa and the accession number is P40763-1.
TMPY-02603 STAT6 Protein, Human, Recombinant (His)

STAT6C,IL-4-STAT,STAT6B,signal transducer and activator<...

Human Baculovirus Insect Cells
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators...
TMPJ-00607 RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)

Receptor activator of nuclear factor κ-B ligand,Ost...

Mouse HEK293 Cells
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
TMPY-01474 PAI-1 Protein, Human, Recombinant (His)

PAI,SERPINE1,PAI-1,serpin peptidase inhibitor, clade E (nexi...

Human HEK293 Cells
PAI-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is A0A024QYT5.
TMPY-04504 Urokinase/uPA Protein, Rat, Recombinant (His)

plasminogen activator, urokinase

Rat HEK293 Cells
Urokinase/uPA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.3 kDa and the accession number is A6KKR2.
TMPJ-00332 tPA Protein, Human, Recombinant (His)

TPA,T-PA,t-plasminogen activator,Tissue plasminogen...

Human HEK293 Cells
Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs to the peptidase S1 family. The main function of this protein is to convert plasminogen into biologically active plasmin. As a protease, PLAT plays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulating the post-tra...
TMPH-01371 GM2A Protein, Human, Recombinant (His & SUMO)

GM2-AP,Cerebroside sulfate activator protein,Sphing...

Human E. coli
GM2A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 33.6 kDa and the accession number is P17900.
TMPY-00938 tPA Protein, Human, Recombinant

TPA,plasminogen activator, tissue,T-PA

Human HEK293 Cells
tPA Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 28 kDa and the accession number is P00750-1.
TMPH-00833 PAI-1 Protein, Horse, Recombinant

Serpin E1,Plasminogen activator inhibitor 1,PAI-1,E...

Horse P. pastoris (Yeast)
PAI-1 Protein, Horse, Recombinant is expressed in yeast. The predicted molecular weight is 36.2 kDa and the accession number is Q8MI31.
TMPH-02834 PAI-1 Protein, Mouse, Recombinant (His & SUMO)

Endothelial plasminogen activator inhibitor,Serpine...

Mouse E. coli
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of ...
TMPH-02833 PAI-1 Protein, Mouse, Recombinant (His)

Endothelial plasminogen activator inhibitor,Plasmin...

Mouse P. pastoris (Yeast)
PAI-1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 44.9 kDa and the accession number is P22777.
TMPJ-00625 Serpin E1 Protein, Mouse, Recombinant (His)

Pai1,Planh1,Plasminogen activator inhibitor 1,Serpi...

Mouse HEK293 Cells
Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
TMPH-00832 PAI-1 Protein, Horse, Recombinant (E. coli)

Endothelial plasminogen activator inhibitor,PAI-1,P...

Horse E. coli
PAI-1 Protein, Horse, Recombinant (E. coli) is expressed in E. coli expression system. The predicted molecular weight is 32.1 kDa and the accession number is Q8MI31.
TMPH-00356 PAI-1 Protein, Feline, Recombinant

PAI-1,Endothelial plasminogen activator inhibitor,S...

Feline E. coli
PAI-1 Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29.7 kDa and the accession number is A9NJ78.
TMPY-02765 GM2A Protein, Human, Recombinant (His)

GM2 ganglioside activator,SAP-3,GM2-AP

Human Baculovirus Insect Cells
GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexo...
TMPY-03442 MOB4A/MOB1B Protein, Human, Recombinant (GST)

MOB kinase activator 1B,MOBKL1A,MATS2,MOB4A

Human E. coli
MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO...
TMPY-00937 tPA Protein, Human, Recombinant (hFc)

TPA,T-PA,plasminogen activator, tissue

Human HEK293 Cells
tPA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.5 kDa and the accession number is P00750-1.
TMPH-00657 NlpD Protein, E. coli, Recombinant (His & SUMO)

Murein hydrolase activator NlpD,nlpD

E. coli E. coli
Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division.
TMPH-03397 uPAR/PLAUR Protein, Rat, Recombinant (His)

Plaur,Urokinase plasminogen activator surface recep...

Rat E. coli
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. uPAR/PLAUR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.1 kDa and the accession number is P49616.
TMPH-01424 GUCA2B Protein, Human, Recombinant (His)

Guanylate cyclase activator 2B,GUCA2B

Human HEK293 Cells
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661.
TMPH-03722 Coagulase/fibrinolysin Protein, Yersinia pestis, Recombinant (His & Myc)

Plasminogen activator,Pla,Coagulase/fibrinolysin

Yersinia pestis E. coli
Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius). Activates plasminogen by cleaving it.
TMPK-00484 HGFA Protein (pro form), Cynomolgus, Recombinant (His)

MGC138397,Hgfac,HGF activator,HGFA,MGC138395

Cynomolgus HEK293 Cells
HGFA Protein (pro form), Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.47 kDa and the accession number is A0A2K5TZH3.
TMPK-01219 HGFA Protein (pro form), Mouse, Recombinant (His)

HGF activator,MGC138395,MGC138397,Hgfac,HGFA

Mouse HEK293 Cells
HGFA Protein (pro form), Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 67.9 kDa and the accession number is Q9R098.
TMPJ-01003 STAT5B Protein, Human, Recombinant (His)

Signal Transducer and Activator of Transcription 5B...

Human E. coli
Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adul...
TMPU-00004 STAT5A Protein, Human, Recombinant (His)

MGF,Signal transducer and activator of transcriptio...

Human E. coli
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. Many studies have indicated a key role of STAT5a in leukemia, breast, colon, head and neck, and prostate cancer. Until recently, the unique characteristics and function of STAT5a in these cancers have not been delineated from STAT5b, and more research into their differential behavior is warranted. Because of its integral role in immune cell development, STAT5a may contribute to tumor de...
TMPH-01869 PAI-2 Protein, Human, Recombinant (His)

SERPINB2,Urokinase inhibitor,Placental plasminogen activ...

Human HEK293 Cells
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. PAI-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 50.1 kDa and the accession number is P05120.
TMPY-01017 uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc)

plasminogen activator, urokinase receptor,u-PAR,uPA...

Mouse HEK293 Cells
uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 58 kDa and the accession number is P35456-1.
TMPY-02898 tPA Protein, Mouse, Recombinant (hFc)

plasminogen activator, tissue,AU020998,tPA,AW212668...

Mouse HEK293 Cells
tPA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.4 kDa and the accession number is P11214.
TMPH-00280 PRKRA Protein, Bovine, Recombinant (His & Myc)

Protein kinase, interferon-inducible double-stranded RNA-dep...

Bovine E. coli
PRKRA Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.4 kDa and the accession number is Q2HJ92.
TMPY-06353 GUCA2B Protein, Mouse, Recombinant (His)

Ugn,AV066530,Gcap2,guanylate cyclase activator 2B (...

Mouse HEK293 Cells
GUCA2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.55 kDa and the accession number is Q3UWA6-1.
TMPY-02581 STAT4 Protein, Human, Recombinant (His)

signal transducer and activator of transcription 4,...

Human Baculovirus Insect Cells
High expression of STAT4 in gastric cancer predicted a better clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after gastrectomy. Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype.
TMPH-02385 Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)

Minor nucleoprotein VP30,Transcriptional activator ...

MARV E. coli
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary structure at the transcription start site of the first gene.
TMPH-03729 Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)

Transcriptional activator VP30,EbolaVP30,Minor nucl...

ZEBOV E. coli
Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists a...
TMPY-03610 PSME2 Protein, Human, Recombinant (His)

REGβ,proteasome (prosome, macropain) activator subu...

Human E. coli
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit...
TMPH-00545 Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc)

Immediate-early protein Rta,Protein R,Replication and transc...

EBV E. coli
Immediate-early transcription factor that controls the initiation of viral lytic gene expression and lytic reactivation from latency. Triggers lytic replication, and initiates a cellular senescence program in epithelial cells. Upregulates human DCR3/TNFRSF6B by directly binding to its receptor. Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.9 kDa and the accession number is Q3KS...
TMPJ-01335 MOB1A Protein, Human, Recombinant (His)

C2orf6,MOB4B,Mob1A,MOBK1B,Mps One Binder Kinase Activato...

Human E. coli
MOB Kinase Activator 1A (MOB1A) belongs to the MOB1/phocein family, which acts as an activator of LATS1/2 in the Hippo signaling pathway, plays a key role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MOBKL1B stimulates the kinase activity of STK38 and STK38L. MOBKL1B binds to and regulate downstream targets such as the NDR-family protein kinases and LATS1 kinase.
TMPH-01170 CDK5R1 Protein, Human, Recombinant (His)

CDK5 activator 1,CDK5R,NCK5A,CDK5R1,Cyclin-dependen...

Human E. coli
CDK5R1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-03612 PSME1 Protein, Human, Recombinant (His)

proteasome (prosome, macropain) activator subunit 1...

Human E. coli
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit...
TMPJ-00674 RANK/TNFRSF11A Protein, Mouse, Recombinant (His)

Receptor activator of NF-KB,TNFRSF11A,Osteoclast di...

Mouse HEK293 Cells
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br...
TMPJ-00961 STAT1 Protein, Human, Recombinant

Transcription Factor ISGF-3 Components p91/p84,STAT1,Signal ...

Human E. coli
Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul...
TMPJ-00349 RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)

CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O...

Human HEK293 Cells
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive...
TMPJ-01318 TACI Protein, Mouse, Recombinant (hFc)

CD267,Tumor necrosis factor receptor superfamily member 13B,...

Mouse HEK293 Cells
Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI (transmembrane activator and CAML interactor), is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system.
TMPJ-01100 UBE2V1 Protein, Human, Recombinant (His)

TRAF6-Regulated IKK Activator 1 Beta Uev1A,P/OKcl.1...

Human E. coli
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Ly...
TMPH-00887 AHSA1 Protein, Human, Recombinant (GST)

C14orf3,p38,Activator of 90 kDa heat shock protein ...

Human E. coli
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. AHSA1 Protein, Human, Recombinant (GST) is expressed i...
TMPH-00215 SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)

Venombin A,Fibrinogen-clotting enzyme,Snake venom serine pro...

Bothrops jararaca E. coli
Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and activates factor VIII (F8). SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is P81661.
TMPJ-01365 SLAMF8 Protein, Human, Recombinant (His)

CD353,SLAM family member 8,BCM-like membrane protein,B-lymph...

Human HEK293 Cells
SLAM family member 8 (SLAMF8) is a single-pass type I membrane protein and contains 1 Ig-like C2-type domain. SLAMF8 is a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling...
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重组蛋白

uPAR/PLAUR Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01257
Species: Mouse
Expression System: HEK293 Cells
uPAR/PLAUR Protein, Human, Recombinant (His)
Cat.No: TMPY-02141
Species: Human
Expression System: HEK293 Cells
Urokinase/uPA Protein, Human, Recombinant (His)
Cat.No: TMPY-00904
Species: Human
Expression System: HEK293 Cells
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Cat.No: TMPJ-00662
Species: Human
Expression System: E. coli
STAT3 Protein, Human, Recombinant (His)
Cat.No: TMPY-06624
Species: Human
Expression System: E. coli
STAT6 Protein, Human, Recombinant (His)
Cat.No: TMPY-02603
Species: Human
Expression System: Baculovirus Insect Cells
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00607
Species: Mouse
Expression System: HEK293 Cells
PAI-1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01474
Species: Human
Expression System: HEK293 Cells
Urokinase/uPA Protein, Rat, Recombinant (His)
Cat.No: TMPY-04504
Species: Rat
Expression System: HEK293 Cells
tPA Protein, Human, Recombinant (His)
Cat.No: TMPJ-00332
Species: Human
Expression System: HEK293 Cells
GM2A Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01371
Species: Human
Expression System: E. coli
tPA Protein, Human, Recombinant
Cat.No: TMPY-00938
Species: Human
Expression System: HEK293 Cells
PAI-1 Protein, Horse, Recombinant
Cat.No: TMPH-00833
Species: Horse
Expression System: P. pastoris (Yeast)
PAI-1 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02834
Species: Mouse
Expression System: E. coli
PAI-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02833
Species: Mouse
Expression System: P. pastoris (Yeast)
Serpin E1 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00625
Species: Mouse
Expression System: HEK293 Cells
PAI-1 Protein, Horse, Recombinant (E. coli)
Cat.No: TMPH-00832
Species: Horse
Expression System: E. coli
PAI-1 Protein, Feline, Recombinant
Cat.No: TMPH-00356
Species: Feline
Expression System: E. coli
GM2A Protein, Human, Recombinant (His)
Cat.No: TMPY-02765
Species: Human
Expression System: Baculovirus Insect Cells
MOB4A/MOB1B Protein, Human, Recombinant (GST)
Cat.No: TMPY-03442
Species: Human
Expression System: E. coli
tPA Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00937
Species: Human
Expression System: HEK293 Cells
NlpD Protein, E. coli, Recombinant (His & SUMO)
Cat.No: TMPH-00657
Species: E. coli
Expression System: E. coli
uPAR/PLAUR Protein, Rat, Recombinant (His)
Cat.No: TMPH-03397
Species: Rat
Expression System: E. coli
GUCA2B Protein, Human, Recombinant (His)
Cat.No: TMPH-01424
Species: Human
Expression System: HEK293 Cells
Coagulase/fibrinolysin Protein, Yersinia pestis, Recombinant (His & Myc)
Cat.No: TMPH-03722
Species: Yersinia pestis
Expression System: E. coli
HGFA Protein (pro form), Cynomolgus, Recombinant (His)
Cat.No: TMPK-00484
Species: Cynomolgus
Expression System: HEK293 Cells
HGFA Protein (pro form), Mouse, Recombinant (His)
Cat.No: TMPK-01219
Species: Mouse
Expression System: HEK293 Cells
STAT5B Protein, Human, Recombinant (His)
Cat.No: TMPJ-01003
Species: Human
Expression System: E. coli
STAT5A Protein, Human, Recombinant (His)
Cat.No: TMPU-00004
Species: Human
Expression System: E. coli
PAI-2 Protein, Human, Recombinant (His)
Cat.No: TMPH-01869
Species: Human
Expression System: HEK293 Cells
uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc)
Cat.No: TMPY-01017
Species: Mouse
Expression System: HEK293 Cells
tPA Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02898
Species: Mouse
Expression System: HEK293 Cells
PRKRA Protein, Bovine, Recombinant (His & Myc)
Cat.No: TMPH-00280
Species: Bovine
Expression System: E. coli
GUCA2B Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06353
Species: Mouse
Expression System: HEK293 Cells
STAT4 Protein, Human, Recombinant (His)
Cat.No: TMPY-02581
Species: Human
Expression System: Baculovirus Insect Cells
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)
Cat.No: TMPH-02385
Species: MARV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)
Cat.No: TMPH-03729
Species: ZEBOV
Expression System: E. coli
PSME2 Protein, Human, Recombinant (His)
Cat.No: TMPY-03610
Species: Human
Expression System: E. coli
Epstein-Barr virus (strain GD1) BRLF1 Protein (His & Myc)
Cat.No: TMPH-00545
Species: EBV
Expression System: E. coli
MOB1A Protein, Human, Recombinant (His)
Cat.No: TMPJ-01335
Species: Human
Expression System: E. coli
CDK5R1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01170
Species: Human
Expression System: E. coli
PSME1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03612
Species: Human
Expression System: E. coli
RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00674
Species: Mouse
Expression System: HEK293 Cells
STAT1 Protein, Human, Recombinant
Cat.No: TMPJ-00961
Species: Human
Expression System: E. coli
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)
Cat.No: TMPJ-00349
Species: Human
Expression System: HEK293 Cells
TACI Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-01318
Species: Mouse
Expression System: HEK293 Cells
UBE2V1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01100
Species: Human
Expression System: E. coli
AHSA1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-00887
Species: Human
Expression System: E. coli
SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)
Cat.No: TMPH-00215
Species: Bothrops jararaca
Expression System: E. coli
SLAMF8 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01365
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
T27098 Ivacaftor-D9

deutivacaftor,CTP-656

CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
T10279 Alfacalcidol-D6

Others Others
Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.
T13076 Tamoxifen-​d5

ICI 47699-​d5,(Z)-Tamoxifen-​d5,trans-Tamoxifen-​d5

HSP Cytoskeletal Signaling; Metabolism
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.
T11089 Doxercalciferol-D3

Others Others
Doxercalciferol-d3 is the deuterated form of Doxercalciferol and ACTS as vitamin D receptor activator (VDRA), which is a vitamin D2 analogue.
T11152 Edaravone-d5

MCI-186 D5

Others Others
Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits.
T71402 Nicorandil-d4

Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...

同位素标记化合物

Ivacaftor-D9
Cat.No: T27098
Synonym: deutivacaftor,CTP-656
Target:
Alfacalcidol-D6
Cat.No: T10279
Synonym:
Target: Others
Tamoxifen-​d5
Cat.No: T13076
Synonym: ICI 47699-​d5,(Z)-Tamoxifen-​d5,trans-Tamoxifen-​d5
Target: HSP
Doxercalciferol-D3
Cat.No: T11089
Synonym:
Target: Others
Edaravone-d5
Cat.No: T11152
Synonym: MCI-186 D5
Target: Others
Nicorandil-d4
Cat.No: T71402
Synonym:
Target:
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