simufilamum

Name: simufilamum
Brand: TargetMol
SKU: T9569
Rating: 4.5 (1 reviews)

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产品编号 T9569Cas号 1224591-33-6

Simufilam 是一种低毒，口服的 filamin A (FLNA) 激活剂。Simufilam 优先结合大脑中改变的FLNA，恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam 可用于阿尔茨海默症的研究。

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产品编号 T9569Cas号 1224591-33-6

规格	价格	库存	数量
100 mg	¥ 10,996	6-8周
200 mg	¥ 16,625	6-8周

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产品介绍

生物活性

产品描述	Simufilam (PTI-125) is a low toxicity, orally active filamin A ( FLNA ) activator. Simufilam preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam can be used in Alzheimer's disease research[1].
体外活性	Simufilam (1 pM~1 nM) dose-dependently improves Arc expression induced by NMDA/glycine[1]. Simufilam (1 nM, 1 hour) largely restores filamin A to its native conformation and is effective in normalizing receptor activities in AD frontal cortices. Simufilam dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs [1].
体内活性	Simufilam (P.o.; 2 months) restores FLNA to its native conformation. Simufilam (22 mg/kg; p.o.) strongly reduces FLNAea7nAChR/TLR4 associations. Simufilam significantly improves spatial memory. Simufilam significantly improves working memory [1].