Plasminogen is a zymogen secreted as a precursor protein that, when cleaved by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA), is converted into plasmin. Plasmin is a protease with broad specificity, capable of degrading fibrin and various extracellular matrix (ECM) components. Additionally, plasminogen functions as a proinflammatory regulator, promoting the healing of both acute and diabetic wounds. It is utilized in research related to wound healing, inflammation, and hypoplasminogenemia [1] [2].

普拉斯明原(plg)（每天一次，静脉注射，单剂量2 mg，连续16天）能够加快WT小鼠烧伤创面的愈合[1]。同样条件下，普拉斯明原还能提高WT和plg缺陷小鼠受伤皮肤中IL-6的表达，并增强STAT3的激活[1]。普拉斯明原（每天一次，静脉注射，单剂量2 mg，连续24天）显著促进糖尿病小鼠模型中烧伤创面的愈合[1]。