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Penisterpenoid A (Compound 1) 是从柴胡根际真菌青霉属中分离出的一种PINK1/Parkin线粒体自噬信号通路激活剂.在体外和体内实验中,此化合物能有效减少脂质积累并显著改善线粒体功能.
Penisterpenoid A (Compound 1) 是从柴胡根际真菌青霉属中分离出的一种PINK1/Parkin线粒体自噬信号通路激活剂.在体外和体内实验中,此化合物能有效减少脂质积累并显著改善线粒体功能.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Penisterpenoid A (Compound 1), an activator of the PINK1/Parkin mitochondrial autophagy signaling pathway, is derived from the rhizosphere fungi of the medicinal plant Bupleurum. In both in vitro and in vivo settings, Penisterpenoid A effectively reduces lipid accumulation and significantly enhances mitochondrial function. |
体外活性 | Penisterpenoid A (Compound 1) (20 μM, 24 h) 在LO2人类正常肝细胞中通过选择性激活PINK1/Parkin线粒体自噬信号通路来降低脂质积累,显示出其降脂活性. |
体内活性 | Penisterpenoid A(Compound 1)(20 μM;72 h)在非酒精性脂肪性肝病的斑马鱼模型中能降低脂质积累,并且优化线粒体功能. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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