Vacquinol-1

Vacquinol-1 能够激活 MAPK 通路，是MKK4特异性激活剂。它可以诱导肝细胞癌细胞凋亡，在多形性胶质母细胞瘤小鼠模型中特异性诱导人胶质母细胞瘤细胞死亡、减缓肿瘤进展并延长生存期。

产品编号 T7008Cas号 5428-80-8

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纯度:98.67%

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产品编号 T7008别名 Vacquinol 1Cas号 5428-80-8

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实验操作小课堂

生物活性

产品描述	Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
体外活性	Vacquinol-1通过诱导膜褶皱、细胞圆化、大量巨大吞噬性空泡累积、ATP耗竭和细胞质膜破裂等机制，特异性快速引发胶质瘤细胞死亡，其IC50值为3.14 μM。[1]
体内活性	在携带U3013 mg肿瘤的小鼠中，Vacquinol-1（15 μM颅内注射，或20 mg/kg经口给药）减缓了肿瘤生长并延长了存活时间。[1]
激酶实验	1MT enantiomers are solubilized in DMSO containing 0.1N HCl and added at concentrations of 100, 50, and 0 μM to wells containing the reaction mixture with tryptophan (0-200 μM) followed by addition of IDO enzyme. Plates are sealed and incubated 1 hr in a humidified 37°C incubator, after which the reactions are terminated by addition of 12.5 μl 30% TCA per well. Plates are then resealed in plastic wrap, incubated 30 min at 50°C to hydrolyze the reaction product N-formylkynurenine to kynurenine, and centrifuged. Supernatants are transferred to a flat-bottom 96-well plate, mixed with 100 μl Ehrlich reagent and incubated 10 min at room temperature. Absorbance at 490 nm is read[1].
细胞实验	Cell viability is measured using CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer's instructions.(Only for Reference)
别名	Vacquinol 1

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 70 mg/mL (164.4 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO