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Search Results for " non-selective "

Targets Recommended: Adrenergic Receptor

398

抑制剂 & 化合物

14

天然产物

2

化合物库

5

重组蛋白

8

同位素标记化合物

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Cat. No.	Product Name
L2010	高选择性抑制剂库		575 compounds
	575种具有高选择性的抑制剂集合
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；

化合物库

高选择性抑制剂库

Cat.No: L2010

Compounds: 575

共价抑制剂库

Cat.No: L9410

Compounds: 1920

Cat. No.	Product Name	Target	Signaling Pathways
T8580	Bupranolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
T7538	Tetraethylammonium chloride	Potassium Channel	Membrane transporter/Ion channel
	Tetraethylammonium chloride 是非选择性钾通道阻滞剂。它是有机阳离子转运蛋白的良好底物，并具有抗肿瘤特性。
T3474	RO 46-8443	Endothelin Receptor	GPCR/G Protein
	Ro 46-844 是选择性非肽内皮素受体拮抗剂。它对ETB(IC50: 34-69 nM) 的选择性比ETA 受体 (IC50: 6800 nM) 高的100倍以上。
T8459	DNQX disodium salt DNQX Disodium	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	DNQX disodium salt 是一种选择性、强竞争性的非 NMDA 谷氨酸受体 (non-NMDA glutamate receptor) 拮抗剂 (对 AMPA、kainate 和 NMDA 受体的 IC50分别为 0.5、2 和 40 μM)，是一种喹恶啉衍生物。
T7304	DNQX 二硝基喹酮,FG 9041	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	DNQX (FG 9041) 是喹恶啉衍生物，是一种选择性和强竞争性的非 NMDA 谷氨酸受体拮抗剂，对 AMPA、kainate 和 NMDA 受体的IC50分别为 0.5、2 和 40 μM。
T60076	Oritinib SH-1028	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Oritinib (SH-1028) 是一种 EGFR 抑制剂，对 EGFR (wt)、EGFR (L858R)、EGFR (L861Q)、EGFR (L858R/T790M)、EGFR (d746-750) 的 IC50 分别为 18、0.7、4、0.1、1.4 和 0.89 nM , EGFR (d746-750/T790M), 分别。奥瑞替尼可用于治疗非小细胞肺癌的研究。
T9245	TRPM4-IN-1 CBA,4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid	TRP/TRPV Channel	Membrane transporter/Ion channel
	TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) 是一种有效的阳离子通道TRPM4选择性抑制剂，IC50为 1.5 μM。TRPM4-IN-1 在心脏病和前列腺癌中具有研究价值。
T10774	CFM-2	iGluR	Membrane transporter/Ion channel; Neuroscience
	CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
T28197	NS-2710 NS 2710,NS2710	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	NS-2710 是一种非选择性 GABA（A）受体部分激动剂，可用于研究焦虑症。
T9967	MAGL-IN-5	Lipid	Metabolism
	MAGL-IN-5 是一种非选择性脂肪酶抑制剂。
T0327	Fendiline hydrochloride Fendiline HCl,盐酸芬他林	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Fendiline hydrochloride (Fendiline HCl) 是一种非选择性钙通道抑制剂。
TP1929L1	Saralasin acetate(34273-10-4 free base)	RAAS	Endocrinology/Hormones
	Saralasin acetate(34273-10-4 free base) 是一种非选择性血管紧张素 II 拮抗剂。
T2362	QNZ46	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	QNZ46 是一种 NR2C/NR2D 选择性 NMDA 受体非竞争性拮抗剂。
T0821	Iproniazid Phosphate 磷酸异丙烟肼,Isoproniazid phosphate	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Iproniazid Phosphate 是一种非选择性的，不可逆的单胺氧化酶抑制剂，具有抗抑郁作用。
T29096	Vapitadine dihydrochloride Vapitadine 2HCl,R129160,R-129160 2HCl,Vapitadine HCl,R 129160 2HCl,R-129160,R 129160,R129160 2HCl	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Vapitadine dihydrochloride(R-129160 2HCl) 是一种新型强效且具有选择性和非镇静性的化合物，对组胺 H1 具有抑制作用。
T22092	Indomethacin heptyl ester	COX	Immunology/Inflammation; Neuroscience
	Indomethacin heptyl ester 是 COX-1 和 COX-2 的非选择性抑制剂。
T7839	Lasofoxifene Tartrate CP-336156,酒石酸拉索昔芬	Estrogen Receptor/ERR	Endocrinology/Hormones
	Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。
T13689	Ethylene dimethanesulfonate	Apoptosis	Apoptosis
	Ethylene dimethanesulfonate 是温和的烷基化乙二醇非挥发性甲烷磺酸二酯，对 LC 具有选择性的促凋亡作用。
T22692	CPCCOEt	GluR	Neuroscience
	CPCCOEt 是mGluR1b 的一种低亲和力、选择性、非竞争性和可逆性拮抗剂
T22236	Alprenolol hydrochloride 阿普洛尔盐酸盐,盐酸阿普洛尔	5-HT Receptor	GPCR/G Protein; Neuroscience
	Alprenolol hydrochloride 是一种非选择性β受体阻滞剂，也是5-HT1A 受体拮抗剂。
T2375	BX471 BX 471,BX-471,ZK-811752	CCR	Immunology/Inflammation; Microbiology/Virology
	BX471 (BX 471) 是可口服的非多肽 CCR1选择性拮抗剂，Ki 值为 1 nM，对其选择性是对 CCR2、CCR5 和 CXCR4 的 250 倍。
T15246	Esaxerenone 艾沙利酮,XL-550,CS-3150	Glucocorticoid Receptor	Endocrinology/Hormones
	Esaxerenone (XL-550) 是高效的、选择性的非类固醇盐皮质激素受体拮抗剂。
T14666	BL-1249	Potassium Channel	Membrane transporter/Ion channel
	BL-1249 是一种具有选择性和有效性的非甾体钾通道激活剂，具有抗炎活性，可激活 K2P2.1 (TREK-1) 和 K2P10.1 (TREK-2)。
T0484	Deracoxib SC 46,SC 046,地拉考昔,SC 59046	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Deracoxib (SC 46) 是非甾体、非麻醉性抗炎药。它也是选择性 cyclooxygenase-2 抑制剂，IC50 值：70 至 150 μM，抑制 3 种骨肉瘤细胞系。
T6083	AZD8330 ARRY-424704,ARRY-704	ERK; MEK	MAPK
	AZD8330 (ARRY-704) 是非竞争性的 MEK1/MEK2抑制剂，IC50为 7 nM。
T24444	Medifoxamine LG 152,Medifoxamina,LG-152,LG152	Dopamine Receptor; Monoamine Oxidase	GPCR/G Protein; Neuroscience
	Medifoxamine (LG 152) 是一种选择性非单胺氧化酶抑制剂,通过对5 HT 再摄取的抑制展现其抗抑郁活性。Medifoxamine 优先抑制多巴胺再摄取 (dopamine reuptake)。
T15420	GS-9901	PI3K	PI3K/Akt/mTOR signaling
	GS-9901 是一种具有选择性、口服活性和高效性的 PI3Kδ 抑制剂（IC50：1 nM），可用于研究非霍奇金淋巴瘤和慢性淋巴细胞白血病。
T12205	Ned 19	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
T2190	Methiothepin mesylate Ro 8-6837 mesylate,Metitepine mesylate,马来酸甲硫替平	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Methiothepin mesylate (Metitepine mesylate) 是一种有效且非选择性的 5-HT2 受体拮抗剂，用作抗精神病药。
T31860	Fosdevirine GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fosdevirine (GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T6546	IPA-3 IPA3,IPA 3	PAK	Cytoskeletal Signaling
	IPA-3 是一种选择性的非 ATP 竞争性 Pak1 抑制剂，IC50 为 2.5 μM。
T8780	AMG131 INT-131,AMG-131,CHS 131	PPAR	DNA Damage/DNA Repair; Metabolism
	AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂，可用于治疗 2 型糖尿病。
T21766	ML352	AChE	Neuroscience
	ML352 是一种具有选择性和高效性的突触前胆碱转运体 (CHT) 抑制剂，抑制非竞争性胆碱摄取。
T0245	RS 61443 RS61443,吗替麦考酚酯,Mycophenolate mofetil,TM-MMF	Dehydrogenase	Metabolism
	RS 61443 (Mycophenolate mofetil) 是一种免疫抑制剂，一种非竞争性、选择性和可逆的肌苷一磷酸脱氢酶 (IMPDH) 抑制剂。
T12402	Penbutolol sulfate (-)-Terbuclomine,喷布特罗硫酸盐	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Penbutolol sulfate ((-)-Terbuclomine) 是一种非选择性的β阻滞剂，能够结合β-1肾上腺素能受体和β-2肾上腺素能受体 (两种亚型)。Penbutolol 是拟交感神经药，可用于高血压的研究。
T1817	GNF-2 GNF2	SARS-CoV; Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	GNF-2 是一种高选择性的非 ATP 竞争性 Bcr-Abl 抑制剂。它抑制 Ba/F3.p210 增殖，IC50为 138 nM。
T8685	SP-146	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	SP-146 是一种选择性、有效且非 ATP 竞争性的 Aurora B 抑制剂（IC50：0.316 nM）。
T15055	DB04760 MMP-13 Inhibitor	MMP	Proteases/Proteasome
	DB04760 是一种高选择性和有效的 MMP-13 非锌螯合抑制剂（IC50：8 nM）。DB04760 能明显降低紫杉醇的神经毒性，并具有抗癌活性。
T9284	Dexketoprofen trometamol	COX	Immunology/Inflammation; Neuroscience
	Dexketoprofen trometamol 是一种改良的非选择性 COX 抑制剂，起效迅速，可作为口服和非肠道制剂使用。
T72058L	CDD-1102 HCl CDD-1102 HCl(2757619-84-2 Free base)	Epigenetic Reader Domain	Chromatin/Epigenetic
	CDD-1102 HCl 是一种新型BRDT-BD4 / BRD2-BD1302选择性抑制剂，在体内外实验中显示出非激素避孕潜力。
T4560	Alprenolol Alpheprol,阿普洛尔,(RS)-Alprenolol,dl-Alprenolol	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Alprenolol (Alpheprol) 是一种非选择性β受体阻滞剂，也是5-HT1A 受体拮抗剂。
T12441	Phenelzine sulfate 硫酸苯乙肼,苯肼,硫酸盐	Monoamine Oxidase	Neuroscience
	Phenelzine sulfate 是一种非选择性的、不可逆的单胺氧化酶抑制剂 (MAOI)，可用作抗抑郁药和抗焦虑药。
T6374	Alfacalcidol Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol	Others	Others
	Alfacalcidol (Etalpha) 是一种维生素 D3 衍生物，是非选择性的维生素 D 受体活化剂，有用于骨质疏松研究的潜力。
T7323	BCI-215	Phosphatase	Metabolism
	BCI-215 是高效肿瘤细胞选择性的双重特异性磷酸酶DUSP-MKP 抑制剂。它对肿瘤细胞有细胞毒性，但对正常细胞无毒性。
T12481	Pipecuronium bromide RGH-1106	AChR	Neuroscience
	Pipecuronium bromide (RGH-1106)是一种具有选择性和有效性的 nAChR 拮抗剂，也可当作一种非去极化甾体神经肌肉阻滞剂，可使肌肉松弛，常与抗生素一起使用。
T69013	Alaproclate	NMDAR	Neuroscience
	Alaproclate 是一种非竞争性 NMDA 受体拮抗剂，也是一种新的选择性5-HT摄取抑制剂，可用于研究抑郁症和老年痴呆。
T6405	Bepotastine Besilate Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bepotastine Besilate (TAU 284) 是一种选择性可口服的组胺 H1 受体拮抗剂，可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。
T26520	ABP688 ABP-688,ABP 688	GluR	Neuroscience
	ABP688 是一种非竞争性和选择性的 mGluR5 拮抗剂 (Ki = 1.7 nM)。 ABP688 可用作临床成像的 PET 示踪剂。
T12293L	Olcegepant BIBN-4096,BIBN 4096BS	CGRP Receptor	GPCR/G Protein; Neuroscience
	Olcegepant (BIBN-4096) 是一种选择性的降钙素基因相关肽1 (CGRP1) 受体拮抗剂，IC50=0.03 nM，Ki=14.4 pM。
T12159	APNEA (2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol,N6-[2-(4-Aminophenyl)ethyl]adenosine,N6-[2-(4-氨基苯基)乙基]腺嘌呤	Adenosine Receptor	GPCR/G Protein; Neuroscience
	APNEA ((2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol) 是腺苷 A3 受体的非选择性激动剂。

化合物

Cat.No: T8580

Target: Adrenergic Receptor

Tetraethylammonium chloride

Cat.No: T7538

Target: Potassium Channel

Cat.No: T3474

Target: Endothelin Receptor

DNQX disodium salt

Cat.No: T8459

Synonym: DNQX Disodium

Target: NMDAR, iGluR

Cat.No: T7304

Synonym: 二硝基喹酮,FG 9041

Target: GluR, iGluR

Cat.No: T60076

Synonym: SH-1028

Target: EGFR

Cat.No: T9245

Synonym: CBA,4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid

Target: TRP/TRPV Channel

Cat.No: T10774

Target: iGluR

Cat.No: T28197

Synonym: NS 2710,NS2710

Target: GABA Receptor

Cat.No: T9967

Target: Lipid

Fendiline hydrochloride

Cat.No: T0327

Synonym: Fendiline HCl,盐酸芬他林

Target: Calcium Channel

Saralasin acetate(34273-10-4 free base)

Cat.No: TP1929L1

Target: RAAS

Cat.No: T2362

Target: NMDAR, iGluR

Iproniazid Phosphate

Cat.No: T0821

Synonym: 磷酸异丙烟肼,Isoproniazid phosphate

Target: MAO, Monoamine Oxidase

Vapitadine dihydrochloride

Cat.No: T29096

Synonym: Vapitadine 2HCl,R129160,R-129160 2HCl,Vapitadine HCl,R 129160 2HCl,R-129160,R 129160,R129160 2HCl

Target: Histamine Receptor

Indomethacin heptyl ester

Cat.No: T22092

Target: COX

Lasofoxifene Tartrate

Cat.No: T7839

Synonym: CP-336156,酒石酸拉索昔芬

Target: Estrogen Receptor/ERR

Ethylene dimethanesulfonate

Cat.No: T13689

Target: Apoptosis

Cat.No: T22692

Target: GluR

Alprenolol hydrochloride

Cat.No: T22236

Synonym: 阿普洛尔盐酸盐,盐酸阿普洛尔

Target: 5-HT Receptor

Cat.No: T2375

Synonym: BX 471,BX-471,ZK-811752

Target: CCR

Cat.No: T15246

Synonym: 艾沙利酮,XL-550,CS-3150

Target: Glucocorticoid Receptor

Cat.No: T14666

Target: Potassium Channel

Cat.No: T0484

Synonym: SC 46,SC 046,地拉考昔,SC 59046

Target: Apoptosis, COX

Cat.No: T6083

Synonym: ARRY-424704,ARRY-704

Target: ERK, MEK

Cat.No: T24444

Synonym: LG 152,Medifoxamina,LG-152,LG152

Target: Dopamine Receptor, Monoamine Oxidase

Cat.No: T15420

Target: PI3K

Cat.No: T12205

Target: Calcium Channel

Methiothepin mesylate

Cat.No: T2190

Synonym: Ro 8-6837 mesylate,Metitepine mesylate,马来酸甲硫替平

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T31860

Synonym: GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A

Target: HIV Protease

Cat.No: T6546

Synonym: IPA3,IPA 3

Target: PAK

Cat.No: T8780

Synonym: INT-131,AMG-131,CHS 131

Target: PPAR

Cat.No: T21766

Target: AChE

Cat.No: T0245

Synonym: RS61443,吗替麦考酚酯,Mycophenolate mofetil,TM-MMF

Target: Dehydrogenase

Penbutolol sulfate

Cat.No: T12402

Synonym: (-)-Terbuclomine,喷布特罗硫酸盐

Target: Adrenergic Receptor

Cat.No: T1817

Synonym: GNF2

Target: SARS-CoV, Bcr-Abl

Cat.No: T8685

Target: Aurora Kinase

Cat.No: T15055

Synonym: MMP-13 Inhibitor

Target: MMP

Dexketoprofen trometamol

Cat.No: T9284

Target: COX

Cat.No: T72058L

Synonym: CDD-1102 HCl(2757619-84-2 Free base)

Target: Epigenetic Reader Domain

Cat.No: T4560

Synonym: Alpheprol,阿普洛尔,(RS)-Alprenolol,dl-Alprenolol

Target: 5-HT Receptor, Adrenergic Receptor

Phenelzine sulfate

Cat.No: T12441

Synonym: 硫酸苯乙肼,苯肼,硫酸盐

Target: Monoamine Oxidase

Cat.No: T6374

Synonym: Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol

Target: Others

Cat.No: T7323

Target: Phosphatase

Pipecuronium bromide

Cat.No: T12481

Synonym: RGH-1106

Target: AChR

Cat.No: T69013

Target: NMDAR

Bepotastine Besilate

Cat.No: T6405

Synonym: Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate

Target: Histamine Receptor

Cat.No: T26520

Synonym: ABP-688,ABP 688

Target: GluR

Cat.No: T12293L

Synonym: BIBN-4096,BIBN 4096BS

Target: CGRP Receptor

Cat.No: T12159

Synonym: (2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol,N6-[2-(4-Aminophenyl)ethyl]adenosine,N6-[2-(4-氨基苯基)乙基]腺嘌呤

Target: Adenosine Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T1680	Tolazoline hydrochloride Imidaline hydrochloride,苯甲唑啉盐酸盐,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tolazoline hydrochloride (NSC35110(hydrochloride)) 是一种 α 肾上腺素受体抑制剂。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T2922	Phlorizin Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin	ATPase; SGLT	GPCR/G Protein; Membrane transporter/Ion channel
	Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂，也是Na+/K+-ATPase 抑制剂，对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。
T6680	Staurosporine Antibiotic AM-2282,星形孢菌素,AM-2282,CGP 41251,星孢菌素	Apoptosis; PKA; Antibacterial; Antibiotic; Src; PKC; Antifungal	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Staurosporine (AM-2282) 是一种蛋白激酶抑制剂，对 PKC、PKA、c-Fgr、Phosphorylase kinase 和 TAOK2 均有抑制活性 (IC50=6/15/2/3/3000 nM)，具有 ATP 竞争性和非选择性。Staurosporine 也可以诱导凋亡。
TN1416	Ayanin	IL Receptor; P450; PARP; PDE	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂，在呼吸道疾病中有研究的价值，如过敏性哮喘等。
T4S1619	L-Hyoscyamine sulfate Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐	AChR	Neuroscience
	L-Hyoscyamine sulfate (Levsin Sulfate) 是来自山莨菪的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T0962	L-Hyoscyamine Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺	AChR	Neuroscience
	L-Hyoscyamine (Daturine) 是从山莨菪中提取的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T2520	Desloratadine Sch34117,地氯雷他定,NSC 675447	Endogenous Metabolite; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物，可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用，包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂，具有抗过敏和抗炎活性。
T15541	Hyperforin dicyclohexylammonium salt Hyperforin DCHA	Others	Others
	Hyperforin dicyclohexylammonium salt is a transient receptor canonical 6 channel activator with antidepressant effect. It modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels.
T39025	Adenosine 2',5'-diphosphate sodium	Others	Others
	Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.
T16381	Okadaic acid	Others	Others
	Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted from black sponges of the genus Halic
T73202	BChE-IN-11	Others	Others
	BChE-IN-11 是一种有效的、选择性的、非竞争性BChE(丁基胆碱酯酶)抑制剂，其IC50为 2.1 μM。BChE-IN-11 可用于阿尔茨海默病 (AD) 的研究。
T36893	4-oxo Withaferin A	Others	Others
	4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian ca...
T35647	4-oxo-27-TBDMS Withaferin A	Others	Others
	4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of wi...

天然产物

Tolazoline hydrochloride

Cat.No: T1680

Synonym: Imidaline hydrochloride,苯甲唑啉盐酸盐,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)

Target: Adrenergic Receptor

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

Cat.No: T2922

Synonym: Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin

Target: ATPase, SGLT

Cat.No: T6680

Synonym: Antibiotic AM-2282,星形孢菌素,AM-2282,CGP 41251,星孢菌素

Target: Apoptosis, PKA, Antibacterial, Antibiotic, Src, PKC, Antifungal

Cat.No: TN1416

Target: IL Receptor, P450, PARP, PDE

L-Hyoscyamine sulfate

Cat.No: T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐

Target: AChR

Cat.No: T0962

Synonym: Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺

Target: AChR

Cat.No: T2520

Synonym: Sch34117,地氯雷他定,NSC 675447

Target: Endogenous Metabolite, Histamine Receptor

Hyperforin dicyclohexylammonium salt

Cat.No: T15541

Synonym: Hyperforin DCHA

Target: Others

Adenosine 2',5'-diphosphate sodium

Cat.No: T39025

Target: Others

Cat.No: T16381

Target: Others

Cat.No: T73202

Target: Others

4-oxo Withaferin A

Cat.No: T36893

Target: Others

4-oxo-27-TBDMS Withaferin A

Cat.No: T35647

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02292	IGSF11 Protein, Human, Recombinant (His) CT119,immunoglobulin superfamily, member 11,BT-IgSF,Igsf13,C...	Human	HEK293 Cells
	Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hep...
TMPH-01693	MAP3K14 Protein, Human, Recombinant (His & Myc) MAP3K14,Serine/threonine-protein kinase NIK,NF-kappa-beta-in...	Human	E. coli
	Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
TMPH-02905	TRPC1 Protein, Mouse, Recombinant (His) Transient receptor protein 1,Short transient receptor potent...	Mouse	E. coli
	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. TRPC1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 94.0 kDa and the accession number is Q61056.
TMPH-03390	TRPV2 Protein, Rat, Recombinant (His) Transient receptor potential cation channel subfamily V memb...	Rat	E. coli
	Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. TRPV2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 88.2 kDa and th...
TMPH-00616	DNA-binding protein H-NS Protein, E. coli, Recombinant (His) hns,DNA-binding protein H-NS,Protein B1,Protein H1,Heat-stab...	E. coli	E. coli
	A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription. Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Many of these loci were horizontally transfe...

重组蛋白

IGSF11 Protein, Human, Recombinant (His)

Cat.No: TMPY-02292

Species: Human

Expression System: HEK293 Cells

MAP3K14 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01693

Species: Human

Expression System: E. coli

TRPC1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02905

Species: Mouse

Expression System: E. coli

TRPV2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03390

Species: Rat

Expression System: E. coli

DNA-binding protein H-NS Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00616

Species: E. coli

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
T10279	Alfacalcidol-D6	Others	Others
	Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.
T12167	Nadolol-d9 纳多洛尔 D9,SQ-11725 D9,Nadolol D9	Others	Others
	Nadolol D9 is the deuterium labeled Nadolol is a blocker of non-selective beta.
T12023	Mexiletine-d6 hydrochloride KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride	Others	Others
	Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.
T11246	Etoricoxib-d4 MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4	Others	Others
	Etoricoxib D4 is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.Etoricoxib D4 is a deuterium labeled Etoricoxib.
T71141	Fenspiride-d5
	Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ...
TMIJ-0202	Desloratadine-d5
	Desloratadine-d5 是 Desloratadine 的氘代化合物。Desloratadine 的 CAS 号为 100643-71-8。Desloratadine 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物，可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用，包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂，具有抗过敏和抗炎活性。
TMIJ-0317	Nadolol-d9 (Mixture of Diastereomers)
	Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物，是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂，可用于高血压，心绞痛和血管性头痛的研究。

同位素标记化合物

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

Alfacalcidol-D6

Cat.No: T10279

Target: Others

Cat.No: T12167

Synonym: 纳多洛尔 D9,SQ-11725 D9,Nadolol D9

Target: Others

Mexiletine-d6 hydrochloride

Cat.No: T12023

Synonym: KOE-1173 D6 hydrochloride,Mexiletine D6 hydrochloride

Target: Others

Cat.No: T11246

Synonym: MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4

Target: Others

Cat.No: T71141

Desloratadine-d5

Cat.No: TMIJ-0202

Nadolol-d9 (Mixture of Diastereomers)

Cat.No: TMIJ-0317

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