L-873724

Name: L-873724
Brand: TargetMol
SKU: T16092
Price: 99 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T16092Cas号 603139-12-4

L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of 0.5 nM for rabbit cathepsin K.

L-873724

还可以

产品编号 T16092Cas号 603139-12-4

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of 0.5 nM for rabbit cathepsin K.
靶点活性	Cathepsin K:0.2 nM, Cathepsin S:178 nM, Cathepsin B:264 nM, Cathepsin B:5239 nM
体外活性	L-873724 also displays IC50s of 95, 1221, and 4807 nM for Ramos cathepsin S, Hep G2 cathepsin L, Hep G2 cathepsin B[1].
体内活性	In the rhesus monkey bone resorption model, L-873724 is orally bioavailable, non-lysosomotropic, and efficacious[1].