368
137
6
77
13
Cat. No. | Product Name | ||
---|---|---|---|
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; | |||
L8700 | 铁死亡化合物库 | 779 compounds | |
779 种与铁死亡通路相关的化合物,可用于高通量和高内涵筛选; | |||
L7500 | 凝血与抗凝化合物库 | 144 compounds | |
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7700 | 神经再生化合物库 | 524 compounds | |
524 种神经再生相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4700 | 免疫/炎症分子化合物库 | 4720 compounds | |
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83043 |
Anti-MI/R injury agent 1
|
Others | Others |
Anti-MI/R injury agent 1 (compound 18) 是一种口服有效的人参三醇衍生物,专用于抗心肌缺血/再灌注 (MI/R) 损伤。该化合物能增强经氧-葡萄糖剥夺和再灌注 (OGD/R) 诱导心肌细胞损伤模型中的细胞活力,显着缩小大鼠心肌梗死面积,减少循环心肌肌钙蛋白 I (cTnI) 的释放,并减轻心脏组织损害。 | |||
T9073 |
SRS16-86
|
Ferroptosis | Apoptosis |
SRS16-86 是一种铁死亡抑制剂,可研究肾缺血再灌注损伤和脊髓损伤。它在体内比 Ferrostatin-1 对代谢和血浆更稳定。 | |||
T19777 |
ODQ
|
Apoptosis; Others; Guanylate cyclase | Apoptosis; GPCR/G Protein; Others |
ODQ 是一种选择性可溶性的鸟苷酰环化酶抑制剂,可增强顺铂促人间皮瘤细胞凋亡的作用。 | |||
T1880 |
P7C3
|
Others | Others |
P7C3 是一种 aminopropyl carbazole 类化合物,具有口服活性,可透过血脑屏障,具有神经保护作用。它可用于神经退行性疾病,如帕金森病的研究。 | |||
T37596 |
Terevalefim
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Terevalefim 是干细胞生长因子的一种类似物,对c-Met 受体有选择性激活作用。 | |||
T8538 |
ML382
|
MRGPR | GPCR/G Protein |
ML382 是选择性的 Mas 相关 G 蛋白偶联受体 X1MRGPRX1 (MrgX1)正向调节剂,其EC50=190 nM。 | |||
TP1856 |
Colivelin
|
Beta Amyloid; STAT | JAK/STAT signaling; Neuroscience; Stem Cells |
Colivelin 是一种神经保护肽和 STAT3 的激活剂,是一种合成的杂合肽,可增强 humanin (HN) 的神经保护作用。它通过激活 STAT3 在体外抑制神经元死亡,具有潜力用于阿尔茨海默病和缺血性脑损伤的相关研究。 | |||
T20812 |
Azamethiphos
甲基吡啶磷,唑啶磷 |
AChE | Neuroscience |
Azamethiphos 是有机磷杀虫剂和神经毒性物质,能够抑制乙酰胆碱酯酶的活性。 | |||
T40423 |
L48H37
|
Others | Others |
L48H37是Curcumin的一个化学稳定类似物。它对髓系分化蛋白2 (MD2) 表现出强效的抑制性质,作为一个特异性抑制剂。其机制包括抑制LPS-TLR4/MD2的相互作用和信号传导。L48H37主要用于脓血症和肺损伤研究[1]。 | |||
T7946 |
AER-271
|
Aquaporin | Membrane transporter/Ion channel |
AER-271 是一种 AER-270 的膦酸酯前药,是aquaporin-4抑制剂,有用于急性缺血性中风的研究潜力。 | |||
T22537 |
9-Phenanthrol
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
9-Phenanthrol 是瞬时受体电位 melastatin 4 (TRPM) 通道的抑制剂,这是一种 Ca2+ 激活的非选择性阳离子通道。 | |||
T8313 |
HCH6-1
|
Others | Others |
HCH6-1 是甲酰肽受体 1 的竞争性二肽拮抗剂。它能够抑制 fMLF (FPR1激动剂) 特异性激活的人中性粒细胞的趋化性、超氧阴离子生成和弹性酶释放。动物实验中,它对急性肺损伤具有保护作用,可用于研究 FPR1 参与的炎症性肺部疾病。 | |||
T16724 |
Razuprotafib
AKB-9778 |
Phosphatase; Others | Metabolism; Others |
Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂,抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外,它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化,增强 ANG1 诱导的 TIE2 活化,并刺激 TIE2 通路中信号分子的磷酸化。 | |||
T7683 |
Adenosine amine congener
ADAC |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Adenosine amine congener (ADAC) 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。 | |||
T9765 |
TJ-M2010-5
|
MyD88 | Immunology/Inflammation |
TJ-M2010-5 是一种 MyD88 抑制剂,可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。 | |||
T3478 |
Ro 67-7476
|
GluR | Neuroscience |
Ro 67-7476 是mGluR1的正变位调节剂,能增强表达 rat mGluR1a 的 HEK293 细胞中谷氨酸诱导的钙释放,EC50为 60.1 nM。它是 P-ERK1/2 激动剂,可以在外源添加谷氨酸的情况下激活 ERK1/2 磷酸化 (EC50=163.3 nM)。 | |||
T2022 |
CZC-54252
CZC54252,CZC 54252 |
LRRK2 | Autophagy |
CZC-54252 是一种选择性 LRRK2有效抑制剂,对野生型和 G2019S LRRK2的 IC50分别为 1.28 nM 和 1.85 nM。它具有神经保护活性,可减弱由 G2019S LRRK2 诱导的人神经元损伤 ,EC50约为 1 nM。 | |||
T14960 |
Chroman 1
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Chroman 1 是高效的的ROCK 选择性抑制剂,对 ROCK2 (IC50=1 pM) 的抑制作用强于 ROCK1 (IC50=52 pM) 。它对MRCK 也有抑制作用,IC50为 150 nM。 | |||
T4612 |
NS309
|
EGFR; Potassium Channel; HER | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。 | |||
T9232 |
Mitochondrial fusion promoter M1
|
Mitochondrial Metabolism | Metabolism |
Mitochondrial fusion promoter M1 是一种线粒体动态调节剂,能够保持线粒体功能并促进细胞呼吸,减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。 | |||
T39202 |
CZC-54252 hydrochloride
|
LRRK2 | Autophagy |
CZC-54252 hydrochloride 是 LRRK2 的特异性抑制剂,对野生型和 G2019S LRRK2 的 IC50 分别为 1.85 nM 和 1.28 nM。 CZC-54252 hydrochloride 具有神经保护活性,可减轻 G2019S LRRK2 诱导的人类神经元损伤,EC50 为 1 nM。 | |||
T1677 |
Montelukast
孟鲁司特,Singular |
Leukotriene Receptor; Lipoxygenase; LTR | GPCR/G Protein; Immunology/Inflammation; Metabolism |
Montelukast (Singular) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂,可用于研究预防哮喘和肝损伤。它还可减少心脏损伤,在肠缺血-再灌注损伤中也具有抗氧化作用。 | |||
T19659 |
Annaosanchun
雄甾-3,5,6三醇,YC6,YC-6,YC 6 |
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
Annaosanchun (YC-6) 有可能用于治疗急性缺血性中风(AIS)。 | |||
T1677L |
Montelukast sodium
MK0476,孟鲁司特钠 |
Leukotriene Receptor; LTR | GPCR/G Protein; Immunology/Inflammation |
Montelukast sodium (MK0476) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂,可用于研究预防哮喘和肝损伤。它还可减少心脏损伤,在肠缺血-再灌注损伤中也具有抗氧化作用。 | |||
T6576 |
Malotilate
Malotilatum,NKK 105,马洛替酯,Kantec |
Lipoxygenase | Metabolism |
Malotilate (Kantec) 是一种抗纤维化物质,是一种口服活性的促肝药,可选择性抑制5-lipoxygenase (5-LOX)(IC50=4.7 μM)。它通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中,从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。 | |||
T1461 |
Candesartan
CV 11974,坎地沙坦 |
RAAS | Endocrinology/Hormones |
Candesartan (CV 11974) 是一种血管紧张素II 受体拮抗剂(IC50:0.26 nM)。 | |||
T22323 |
Enoxaparin sodium
|
Thrombin | Proteases/Proteasome |
Enoxaparin sodium 是一种低分子量肝素 (LMWH),已获得美国 FDA 批准,可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用,并抑制凝血因子 XIa、IXa、Xa 和 IIa(凝血酶),从而防止血栓形成。 | |||
T1479 |
Isosorbide dinitrate
硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate |
Others; NO Synthase | Immunology/Inflammation; Others |
Isosorbide dinitrate (Isordil) 是 NO 供体,可预防心肌梗死 (MI) 引起的左室重构及心功能退化。 | |||
T0462 |
Cilostazol
西洛他唑,OPC 21,OPC 13013 |
PDE; Autophagy | Autophagy; Metabolism |
Cilostazol (OPC 21) 是一种选择性的心血管系统中磷酸二酯酶 3 亚型PDE 3A 的抑制剂,IC50值为 0.2 μM。 | |||
T19930 |
Nitrosoglutathione
S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO |
RAAS; NO Synthase | Endocrinology/Hormones; Immunology/Inflammation |
Nitrosoglutathione (GSNO) 是一种外源性的 NO 供体,是大鼠酒精脱氢酶III 类同工酶的底物,能够减少脑血管紧张素II 依赖性及非依赖型的 AT1 受体反应。 | |||
T28178 |
NLRP3-IN-9
INF-4E,INF 4E,INF4E |
NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用,以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。 | |||
T2171 |
SEW2871
SEW2871 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
SEW 2871 是一种可口服的高选择性 S1P1激动剂,EC50为 13.8 nM。它减少血液中的淋巴细胞数量,可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路,并诱导 S1P1 内在化和再循环。 | |||
T1090 |
Perphenazine
Perphenazin,Etaperazine,Trilafon,奋乃静 |
CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂,具有止吐和抗精神病特性。它能够抑制5-HT2A 受体,α1A 肾上腺素能受体,多巴胺D2、D3、D2L 受体,以及组胺H1受体,对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。 | |||
T15781 |
LP-935509
|
Serine/threonin kinase; AAK1 (AP2 associated kinase 1) | Cell Cycle/Checkpoint; Metabolism; Neuroscience |
LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂,其 IC50=3.3 nM,Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。 | |||
T6986 |
Sivelestat
ONO5046,EI546,西维来司他,LY544349 |
Others; SARS-CoV; Serine Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂,其 IC50值为 44 nM,Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。 | |||
T22517 |
5,7-Dichlorokynurenic acid
5,7-二氯犬尿喹啉酸,5,7-dichlorokynurenic acid sodium,5,7-DCKA |
NMDAR | Neuroscience |
5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) 是一种专门针对于NMDA 受体甘氨酸位点的竞争性拮抗剂(KB:65 nM)。它是犬尿酸的衍生物,可降低大鼠皮质细胞培养物中 NMDA 诱导的神经元损伤程度。 | |||
T2663 |
GTS-21 dihydrochloride
GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine |
5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂,具有抗炎和增强认知的活性。它也是一种拮抗剂,对人α4β2的 Ki 为20 nM,对5-HT3A 受体的 IC50为3.1 μM。 | |||
T10353 |
APX-115 free base
Ewha-18278 free base |
NADPH-oxidase; NADPH | Immunology/Inflammation; Metabolism |
APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂,对 Nox1,Nox2和 Nox4的 Ki 分别为 1.08 μM,0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。 | |||
T1615 |
Irbesartan
厄贝沙坦,SR-47436,BMS-186295 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂,IC50为1.3 nM。 | |||
TP1016L |
Aviptadil Acetate
醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt |
RAAS; SARS-CoV | Endocrinology/Hormones; Microbiology/Virology |
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物,具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。 | |||
T2131 |
Articaine hydrochloride
Ultracaine,盐酸阿替卡因,阿替卡因,Articaine HCl,Hoe-045 |
Sodium Channel | Membrane transporter/Ion channel |
Articaine hydrochloride (Hoe-045) 一种牙科局部麻醉剂。 | |||
T2047 |
AG-1478
AG1478,NSC 693255,Tyrphostin AG-1478 |
EGFR; HCV Protease; Influenza Virus; HER; PDGFR | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
AG-1478 (NSC-693255) 是一种选择性 EGFR 酪氨酸激酶抑制剂,IC50为 3 nM。它对 HCV 和脑心肌炎病毒有抗病毒作用。 | |||
T33519 |
MTOB
α-keto-γ-Methylthiobutyric acid,4-甲硫基-2-氧丁酸钠,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid |
Others | Others |
MTOB (α-keto-γ-Methylthiobutyric acid) 是 c 末端结合蛋白 (CtBP) 的底物,可干扰 CtBP 在细胞培养物和小鼠中的致癌活性。它还积极调节 TCF-4 信号传导,导致癌症干细胞 (CSC) 生长和自我更新。 | |||
T6595 |
Moexipril hydrochloride
莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的,不含巯基的血管紧张素转化酶抑制剂,可治疗高血压和充血性心力衰竭。 | |||
T27397 |
Gacyclidine
GK 11,OTO311,OTO-311,OTO 311,GK-11 |
NMDAR | Neuroscience |
Gacyclidine (OTO311) 是一种小分子 N-甲基-D-天冬氨酸(NMDA)受体拮抗剂。在耳蜗局部注射加西环定可抑制水杨酸盐引起的耳鸣,可用于治疗脑损伤、脊髓损伤和耳鸣。 | |||
T61933 |
MK-0159
|
CD38 | Immunology/Inflammation |
MK-0159 是一种可口服且具有高效性的 CD38 抑制剂,具有心肌损伤保护作,可用于研究心脏缺血和再灌注损伤。 | |||
T27827 |
Libenzapril
CGS 16617,Abutapril |
Angiotensin-converting Enzyme (ACE) | Metabolism |
Libenzapril (CGS 16617)是一种有效的血管紧张素转换酶抑制剂,可用于研究心肌损伤。 | |||
T22864 |
Immethridine dihydrobromide
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Immethridine dihydrobromide 是一种新型高效且具有选择性的组胺 H3 受体 (H3R) 激动剂,抑制树突状细胞的功能,可缓解实验性自身免疫性脑脊髓炎。Immethridine dihydrobromide MesV 诱导神经元和MMN去极化,可防止心肾损伤。 | |||
T20103 |
Isoxadifen-ethyl
Isoxadifen-ethyl |
Others | Others |
Isoxadifen-ethyl 是除草剂安全剂和农用化学品。 Isoxadifen-ethyl 可有效减轻烟嘧磺隆对玉米的损伤。 | |||
T26483 |
A-65186
A 65186,A65186 |
cholecystokinin | GPCR/G Protein |
A-65186 是一种选择性A型谷氨酸基胆囊收缩素 (CCK) 拮抗剂,可用于研究炎症和胃肠道损伤。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1403 |
Arjunolic acid
|
IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE | Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB |
Arjunolic acid 是分离自蓝莓的皂苷,具有抗氧化、抗菌和抗炎症等多种生物活性,在保护细胞和组织免受活性氧的有害作用中发挥重要作用。 | |||
T5783 |
Rosamultin
野蔷薇苷,罗莎白素 |
Antioxidant; HIV Protease | Microbiology/Virology; oxidation-reduction; Proteases/Proteasome |
Rosamultin 是从Potentilla anserina L 分离的 19 α-羟基型三萜。它抑制 HIV-1 蛋白酶,具有抗氧化、抗炎和镇痛作用。 | |||
T4778 |
3-Hydroxybenzaldehyde
|
Others; Dehydrogenase | Metabolism; Others |
3-Hydroxybenzaldehyde 是很多酚类化合物的前体分子。它是人和大鼠醛脱氢酶 (ALDH) 的底物 (substrate)。它具有血管保护的作用。 | |||
T14002 |
12-Ketodeoxycholic acid
|
Endogenous Metabolite | Metabolism |
12-Ketodeoxycholic acid 是一种胆汁酸,由肾脏代谢产生。它是肾脏损伤的标志物。 | |||
T3S1591 |
Notoginsenoside Fc
三七皂苷 FC,三七皂苷Fc |
Others; Autophagy | Autophagy; Others |
Notoginsenoside Fc 是从三七叶中分离得到的原卟啉二醇型皂苷,可通过促进自噬促进糖尿病大鼠血管损伤后的内皮细胞再生,具有抗血小板聚集的作用。 | |||
TN6490 |
Regaloside C
|
Others | Others |
Regaloside C 是一种从百合属的中分离出来的甘油葡糖苷,具有抗炎作用。 | |||
T8733 |
Antrodin A
(2-氯苯基)二苯基甲醇,camphorataanhydride A |
Others | Others |
Antrodin A (camphorataanhydride A) 是固体发酵樟脑菌菌丝体的一种主要活性成分。它能够增强肝脏的抗炎及抗氧化能力,维持肠道菌群的稳定,避免酒精对肝脏的损伤。 | |||
T3858 |
macranthoidin A
灰毡毛忍冬皂苷甲,金银花 |
Others | Others |
Macranthoidin A 是一种具有口服活性的、提取于金银花中的皂苷。它对四氯化碳,对乙酰氨基酚和镉所致的肝损伤具有保护作用,对耳巴豆油的溶胀具有明显的抑制作用。 | |||
T0610 |
Piceatannol
白皮杉醇,trans-Piceatannol,Astringenin |
Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors |
Piceatannol (Astringenin) 是一种Syk 抑制剂,可降低由 TNF 诱导的 iNOS 表达,可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯,可诱导细胞自噬和凋亡,具有抗癌和抗炎特性。 | |||
T3409 |
Plantamajoside
Y0160,C10485,大车前苷,车前子甙 |
Others | Others |
Plantamajoside (Y0160) 是一种苯丙烷类糖苷,从车前Plantago asiaticaL.中分离出来得到。它对 LPS 诱导的急性肺损伤小鼠模型具有保护作用。它对肺部炎症具有潜在的研究价值。 | |||
T22311 |
Djenkolic Acid
jengkolic acid,Djenkolate,3,3'-(亞甲二硫)雙丙胺酸,S,S'-Methylenebiscysteine |
Others | Others |
Djenkolic Acid (S,S'-Methylenebiscysteine) 是天然存在于东南亚植物 Archidendron jiringa 的 Djenkol 豆中的含硫非蛋白质氨基酸。它是人类急性肾损伤的一个不常见但重要的原因。 | |||
T3890 |
Verbenalin
Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin |
Others | Others |
Verbenalin (Verbenaloside) 是马鞭草苷,具有抗炎、抗真菌、抗病毒等活性。它能减轻脑缺血再灌注损伤。它可用于前列腺炎的研究。 | |||
TN2147 |
Retrorsine
|
P450; OCT | Membrane transporter/Ion channel; Metabolism |
Retrorsine 特异性地抑制肝细胞增殖,并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。 | |||
T2870 |
Matrine
Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine |
Mitophagy; Ferroptosis; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱,可作为一种κ阿片受体激动剂,有抗肿瘤活性。 | |||
T2S1158 |
4,5-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C |
Others; HBV; Endogenous Metabolite | Metabolism; Microbiology/Virology; Others |
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物,有抗病毒、抗肝毒性活性。 | |||
T3033 |
Deoxycorticosterone acetate
醋酸去氧皮质酮,DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate,醋酸脱氧皮质酮 |
Glucocorticoid Receptor; Endogenous Metabolite; Adrenergic Receptor | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience |
Deoxycorticosterone acetate (Cortexone acetate) 是肾上腺产生的类固醇激素,具有盐皮质激素活性,并作为醛固酮的前体。 | |||
T5S1632 |
Barlerin
8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01 |
VEGFR; TNF; NF-κB; Akt; Caspase | Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。 | |||
T5760 |
(-)-Salutaridine
清风藤碱,SINOACUTINE |
Others | Others |
(-)-Salutaridine 是一种生物碱。 | |||
T36857L |
Premarin
共轭雌激素,Estrone 3-sulfate,Estrone sulfate |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Premarin (Estrone 3-sulfate) 是一种硫酸雌激素,在创伤性脑损伤期间具有神经保护作用。 | |||
T2804 |
Panaxatriol
人参三醇,Panaxtriol |
Others | Others |
Panaxatriol (Panaxtriol) 是一种能够减轻由于辐射损伤造成的骨髓抑制的天然产物。 | |||
T6S0105 |
Peiminine
贝母素乙,Zhebeinone,Fritillarine,Raddeanine,Verticinone |
Others; Autophagy | Autophagy; Others |
Peiminine (Raddeanine) 是浙贝母中的一种生物碱,具有抗炎症活性。 | |||
T4S0217 |
HOMOPLANTAGININ
|
TNF; NF-κB | Apoptosis; NF-κB |
Homoplantaginin 是来自中药荔枝草的一种类黄酮,具有抗炎和抗氧化活性。 | |||
TN1984 |
Neoisoliquiritin
|
Others | Others |
Neoisoliquiritin 是一种提取自甘草中的活性物质。 | |||
T2S1008 |
Oxysophoridine
Sophoridine N-oxide,氧化槐定碱 |
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱,具有抗发炎,抗氧化应激和抗凋亡的作用。 | |||
TN1143 |
1-O-Acetyl britannilactone
|
Apoptosis; Antibiotic | Apoptosis; Microbiology/Virology |
1-O-Acetyl britannilactone 是一种农用杀菌剂,可诱导细胞凋亡,可用于研究肝损伤和癌症。 | |||
TN1308 |
6-Hydroxyflavanone
|
Others; Lipoxygenase; COX; GABA Receptor | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
6-Hydroxyflavanone 是从菖蒲叶中提取分离,通过靶向环氧合酶-2(COX-2),5-脂氧合酶(5-LOX)以及阿片类药物和 GABA-A 受体从而具有抗炎和抗神经性疼痛活性。6-Hydroxyflavanone 在链脲佐菌素诱导的糖尿病神经病变模型中具有抗伤害感受特性。 | |||
T5798 |
Euphorbia Factor L2
千金子素L2,euphorbiafactor L2,大戟因子L2 |
Apoptosis; NF-κB | Apoptosis; NF-κB |
Euphorbia Factor L2 是从大戟种子中分离得到的一种赤藓烷二萜,显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡,具有抗癌活性。 | |||
TN4661 |
Nodosin
|
IL Receptor; Autophagy | Autophagy; Immunology/Inflammation |
Nodosin 是一种二萜化合物,从Isodon trichocarpusKudo 和I. JaponicusHARA 中提取得到。 | |||
T5217 |
2-(2-Phenylacetamido)acetic acid
Phenaceturic acid,Phenyl-ac-Gly-OH,苯乙酰甘氨酸,Phenylacetyl glycine |
Others; Endogenous Metabolite | Metabolism; Others |
Phenyl-ac-Gly-OH 是内源性代谢产物的一种,可激活 β2AR,可用于研究缺血/再灌注引起的心脏损伤。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
T3273 |
Bifendate
联苯双酯,Bifendatatum |
HBV; Reverse Transcriptase | Microbiology/Virology |
Bifendate (Bifendatatum) 是 Schisandrin C 的合成中间体,在慢性 B 型肝炎的研究中具有抗HBV 功效,用于治疗病毒性肝炎和药物性肝损伤引起的转氨酶升高。 | |||
T4S2084 |
3'-Methoxypuerarin
3'-甲氧基葛根素,3’- Methoxy Puerarin |
Antioxidant | oxidation-reduction |
3'-Methoxypuerarin 是一种提取自葛根中的异黄酮,具有神经元保护作用。 | |||
T3S0289 |
Araloside X
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi | |||
T2S0500 |
Ilexsaponin A
毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1 |
Others | Others |
Ilexsaponin A (Ilexsaponin A1)1 是分离自冬凌草的根中,利用抗凋亡途径减轻缺血再灌注引起的心肌损伤。它能够减少心肌梗塞的大小,减少 LDH,AST 和 CK-MB 的血清水平,促进细胞活力并抑制缺氧/复氧心肌细胞的凋亡。 | |||
T5S2178 |
Fargesin
辛夷脂素,(+/-)-Fargesin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Fargesin ((+/-)-Fargesin) 是一种活性新木脂素,从木兰植物中分离得到,具有抗高血压和抗炎活性。 | |||
T3861 |
Isobavachalcone
Corylifolinin,Isobacachalcone,补骨脂乙素 |
Apoptosis; Others; Reactive Oxygen Species; Akt; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Others; PI3K/Akt/mTOR signaling |
Isobavachalcone (Corylifolinin) 是来源于补骨脂的一种Akt 信号通路抑制剂,可诱导人类癌细胞凋亡,以IC50值为 7.92 μM 抑制 OVCAR-8 癌细胞生长,具有抗癌和抗增殖活性。它还能诱导 OVCAR-8 细胞中活性氧的产生。 | |||
TN1472 |
Cassiaside
|
Beta-Secretase; BACE | Neuroscience |
Cassiaside 是一种萘甲酮糖苷,抑制 BACE1 (IC50= 4.45 μM; Ki=9.85 μM)。Cassiaside 对半乳糖胺损伤具有明显的肝脏保护作用, 具有潜在的抗阿尔茨海默病 (AD) 活性。 | |||
T3005 |
4-Hydroxychalcone
P-Cinnamoylphenol,4-羟基查尔酮 |
Others; NF-κB | NF-κB; Others |
4-Hydroxychalcone (P-Cinnamoylphenol) 是一种查尔酮代谢物,具有抗血管生成和消炎作用。它抑制 TNF-α 诱导的 NF-κB 途径活化并激活 BMP 信号传导,通过减轻小鼠的醛固酮过多症和肾脏损伤来降低抵抗性高血压。它通过抑制生长因子途径抑制血管生成,无细胞毒性迹象。 | |||
T3900 |
Emodin-8-glucoside
大黄素-8-β-D-吡喃葡萄糖苷,Emodin glucoside B,Anthraglycoside B |
Others | Others |
Emodin-8-glucoside (Anthraglycoside B) 是从芦荟中分离出的蒽醌衍生物,与 DNA 的小沟结合。它具有保护缺血和再灌注引起的局灶性脑损伤的作用。它直接刺激成骨细胞的细胞增殖和分化。 | |||
T3S0401 |
Piceatannol 3'-O-glucoside
白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷 |
Arginase; NO Synthase | Immunology/Inflammation |
Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分,通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶,抑制Arginase I 和Arginase II,IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压,减少肺间质水肿,从而保护肺损伤。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
T3893 |
Forsythoside B
连翘酯苷 B,连翘脂苷B |
TNF; NF-κB | Apoptosis; NF-κB |
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。 | |||
TN1895 |
Luteolinidin chloride
|
CD38 | Immunology/Inflammation |
Luteolinidin chloride 是天然的脱氧花青素,分离自苔藓和蕨类植物中。它是一种有效的 CD38 抑制剂,可以保留 eNOS 功能并预防体内内皮功能障碍,同时可以保护心脏免受 I/R 损伤。 | |||
TN1677 |
Gartanin
1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮,藤黄苷 |
BCL; Caspase; JNK | Apoptosis; MAPK; Proteases/Proteasome |
Gartanin 是山竹果中的一种天然黄酮,具有抗氧化、抗真菌、抗炎、神经保护和抗肿瘤活性。它能够诱导人脑胶质瘤细胞的细胞周期阻滞和自噬,抑制其迁移。 | |||
T6194 |
Fidaxomicin
非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101 |
Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂,具有窄谱活性。它选择性地根除致病性艰难梭菌,对构成正常健康肠道菌群的多种细菌影响很小。 | |||
TN1936 |
Mogroside III-E
罗汉果皂苷ⅢE |
IL Receptor; TNF; TLR | Apoptosis; Immunology/Inflammation |
Mogroside IIIe 是一种葫芦烷型化合物,从罗汉果中分离得到,可抑制 NO 的释放,具有抗肺纤维化作用。 | |||
T3902 |
Atractylenolide III
白术内酯 III,ICodonolactone,8β-Hydroxyasterolide |
Apoptosis | Apoptosis |
Atractylenolide III (ICodonolactone) 是白术根茎主要成分,通过诱导细胞色素 c 的释放、上调 Bax 的表达和易位凋亡诱导因子,是治疗人肺癌的潜力。 | |||
TN1956 |
Mulberrofuran G
|
Phosphatase; HBV; Glucosidase | Metabolism; Microbiology/Virology |
Mulberrofuran G分离自自 Morus alba L.,具有抗乙型肝炎病毒活性,可保护缺血损伤诱导的细胞死亡。Mulberrofuran G 是一种 PTP1B 和 α-葡萄糖苷酶的双重抑制剂,可用于研究阿尔茨海默症。 | |||
T20793 |
Magnesium Lithospermate B
丹參酸B鎂,Monomethyl lithospermate B,丹参酸 B 镁,Lithospermate B |
Others | Others |
Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物,从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究,并且可以防止葡萄糖引起的细胞内氧化损伤。 | |||
T3674 |
Hydroxysafflor yellow A
藏红花,羟基红花黄色素A,HSYA,Safflomin A |
TGF-beta/Smad | Stem Cells |
Hydroxysafflor yellow A (Safflomin A) 是一种黄酮类天然产物,从中药红花中分离得到,具有抗癌作用。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00423 |
TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His)
Hepatitis A virus cellular receptor 1 homolog,HAVcr-1,T cell... |
Mouse | HEK293 Cells |
TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. And may have a role in kidney injury and repair. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hypera... | |||
TMPY-02028 |
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON |
Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... | |||
TMPY-01075 |
Von Willebrand Factor/vWF Protein, Human, Recombinant (His)
von Willebrand factor,VWD,F8VWF |
Human | CHO Cells |
Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thr... | |||
TMPY-02525 |
RGMA Protein, Human, Recombinant (His)
repulsive guidance molecule family member a,RGM |
Human | HEK293 Cells |
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that form... | |||
TMPY-06981 |
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ... |
Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage... | |||
TMPY-02869 |
MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12 |
Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... | |||
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPK-01139 |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His)
KIM1,TIM-1,HAVCR-1,KIM-1,TIM,TIM1,TIMD1,HAVCR,CD365,TIMD-1,H... |
Human | HEK293 Cells |
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 21-295, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 30.58 kDa and the accession numb... | |||
TMPK-00546 |
TIM-1/KIM-1/HAVCR1 Protein, Cynomolgus, Recombinant (His)
CD365,HAVCR1,KIM1,TIMD-1,TIM-1,KIM-1,HAVcr-1,TIM1,HAVCR,TIMD... |
Cynomolgus | HEK293 Cells |
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. TIM-1/KIM-1/HAVCR1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 35.25 kDa and the accession number is ... | |||
TMPH-02249 |
TRIM72 Protein, Human, Recombinant (E. coli, His & Myc)
Mitsugumin-53,Tripartite motif-containing protein 72,TRIM72 |
Human | E. coli |
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch fo... | |||
TMPH-02241 |
TMEM158 Protein, Human, Recombinant (His)
TMEM158,Ras-induced senescence protein 1,40 kDa BINP-binding... |
Human | E. coli |
Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide. | |||
TMPK-00698 |
AGR2 Protein, Mouse, Recombinant (His)
AG2,HPC8,hAG-2,Anterior gradient protein 2 homolog,AG-2,hAG ... |
Mouse | E. coli |
Anterior gradient homolog 2 (AGR2) is a functional protein with critical roles in a diverse range of biological systems, including vertebrate tissue development, inflammatory tissue injury responses, and cancer progression. | |||
TMPK-00138 |
CXCL16 Protein, Mouse, Recombinant (hFc)
SR-PSOX,SCYB16,SRPSOX,CXCLG16,CXCL16 |
Mouse | HEK293 Cells |
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro... | |||
TMPK-00469 |
CXCL16 Protein, Human, Recombinant (hFc)
SR-PSOX,SCYB16,CXCL16,CXCLG16,SRPSOX |
Human | HEK293 Cells |
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro... | |||
TMPH-02974 |
Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc)
Vwf,von Willebrand factor |
Mouse | E. coli |
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand Factor/vWF Protein, Mouse, Recombinant (His & Myc) is expressed in E.... | |||
TMPH-03365 |
REG3A Protein, Rat, Recombinant (E.coli, His)
Lithostathine 3,Reg3a,RegIII,Regenerating islet-derived prot... |
Rat | E. coli |
Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Rat, Recombinant (E.coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P35231. | |||
TMPY-04424 |
MST3 Protein, Human, Recombinant (His)
HEL-S-95,STE20,MST3B,RP11-111L24.5,MST3,STK3,serine/threonin... |
Human | Baculovirus Insect Cells |
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury. | |||
TMPH-02019 |
REG3A Protein, Human, Recombinant (GST)
Regenerating islet-derived protein 3-alpha,REG3A,Regeneratin... |
Human | E. coli |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.6 kDa and the accession number is Q06141. | |||
TMPY-04934 |
Serpin A3n Protein, Rat, Recombinant (His)
serine (or cysteine) peptidase inhibitor, clade A, member 3N |
Rat | HEK293 Cells |
Serpina3n may represent a circulating biomarker of muscle atrophy associated with GC and, broadly, a reflection of dynamic changes in muscle mass. Serpina3n blocks endogenous increases in the activity of select skeletal muscle resident proteases during injury or dystrophic disease, which stabilizes the sarcolemma leading to less myofiber degeneration and increased regeneration. | |||
TMPJ-00572 |
Vasorin Protein, Human, Recombinant (His)
Vasorin,VASN,SLITL2,Protein Slit-Like 2 |
Human | HEK293 Cells |
Vasorin is a Type I membrane protein, which is predominantly expressed in vascular smooth muscle cells in a developmentally regulated pattern. The expression level of Vasorin can be down regulated during vessel repair after arterial injury. Vasorin binds to transforming growth factor beta (TGF-β) and attenuates TGF-β signaling in vitro. | |||
TMPH-01633 |
MMP-12 Protein, Human, Recombinant (His)
MMP12,Macrophage metalloelastase,Matrix metalloproteinase-12... |
Human | E. coli |
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. MMP-12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession number is P39900. | |||
TMPK-00564 |
TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)
TBP1,TNF-RI,TNFAR,p55,p60,p55-R,TNF-R55,FPF,TNF-R1,TNFR1-d2,... |
Cynomolgus | HEK293 Cells |
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling. | |||
TMPJ-00082 |
NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)
Lipocalin-2,SV-40-induced 24P3 protein,Siderocalin LCN2,LCN2... |
Mouse | HEK293 Cells |
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig... | |||
TMPJ-00876 |
FAH Protein, Human, Recombinant (His)
Fumarylacetoacetate Hydrolase,β-Diketonase,FAH,FAA,Fumarylac... |
Human | HEK293 Cells |
Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, ep... | |||
TMPK-01200 |
Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His)
NGR,NOGOR,RTN4R,NgR1,Nogo receptor,Nogo-66 receptor |
Cynomolgus | HEK293 Cells |
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes. | |||
TMPK-00541 |
SEZ6 Protein, Cynomolgus, Recombinant (His)
SEZ-6,BSRPC,BSRP-C,SEZ6 |
Cynomolgus | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig... | |||
TMPH-02733 |
IFI27L2A Protein, Mouse, Recombinant (His)
Interferon-stimulated gene 12 protein,Ifi27l2a,Interferon al... |
Mouse | E. coli |
May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury. IFI27L2A Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 7.3 kDa and the accession number is Q8R412. | |||
TMPY-01099 |
GPT Protein, Rat, Recombinant (His)
Gpt1,ALAT,glutamic-pyruvate transaminase (alanine aminotrans... |
Rat | Baculovirus Insect Cells |
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily. Gpt / Gpt1 / ALT catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. Gpt / Gpt1 / ALT is expressed in the liver, kidney, heart, and skeletal musc... | |||
TMPJ-00942 |
MMP-12 Protein, Mouse, Recombinant (His)
Mme,Mmp12,MMP-12,Mmel,Matrix metalloproteinase-12,Macrophage... |
Mouse | HEK293 Cells |
Matrix metalloproteinase-12(MMP12) is a secreted protein.It contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. It can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | |||
TMPH-02879 |
REG3G Protein, Mouse, Recombinant (His)
Regenerating islet-derived protein III-gamma,Reg3g,Pancreati... |
Mouse | P. pastoris (Yeast) |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regula... | |||
TMPK-01065 |
SEZ6 Protein, Mouse, Recombinant (His)
BSRP-C,SEZ-6,BSRPC,SEZ6 |
Mouse | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00763 |
Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
APOE3,Apo-E,apolipo E,Apolipoprotein E,APOE |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated i... | |||
TMPK-00588 |
Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc)
Apolipoprotein E,Apo-E,apolipo E,APOE4,APOE |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w... | |||
TMPK-00996 |
SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated
BSRPC,BSRP-C,SEZ6,SEZ-6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi... | |||
TMPK-00096 |
FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated
FGF-10,KGF2 |
Human | E. coli |
Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more suscept... | |||
TMPK-00762 |
Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc)
APOE,Apo-E,Apolipoprotein E,APOE3,apolipo E |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w... | |||
TMPH-01796 |
NR4A1 Protein, Human, Recombinant (His & Myc)
ST-59,NR4A1,Nuclear hormone receptor NUR/77,Orphan nuclear r... |
Human | E. coli |
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. NR4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expre... | |||
TMPK-00997 |
SEZ6 Protein, Human, Recombinant (hFc)
SEZ-6,BSRP-C,SEZ6,BSRPC |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is... | |||
TMPY-02201 |
Peroxiredoxin 6 Protein, Human, Recombinant (His)
p29,PRX,1-Cys,HEL-S-128m,peroxiredoxin 6,NSGPx,AOP2,aiPLA2 |
Human | E. coli |
PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and iPLA2 activities,which are concomitantly increased with the expression of PRDX6. PRDX6 promoted lung tumor growth in an in vivo allograft... | |||
TMPY-02491 |
LRRN3 Protein, Human, Recombinant (His)
NLRR3,FIGLER5,leucine rich repeat neuronal 3,NLRR-3 |
Human | Baculovirus Insect Cells |
Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a member of the leucine-rich (LRR) family whose members have significant functions in neural development. Leucine-rich repeats are short sequence motifs present in some proteins with diverse functions and cellular locations. All proteins containing these repeats are thought to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor protein has revealed th... | |||
TMPK-00998 |
SEZ6 Protein, Human, Recombinant (His)
BSRPC,BSRP-C,SEZ-6,SEZ6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00589 |
Apolipoprotein E/APOE4 Protein, Human, Recombinant (His)
APOE,apolipo E,Apo-E,APOE4,Apolipoprotein E |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells w... | |||
TMPK-00788 |
Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc)
apolipo E,Apo-E,Apolipoprotein E,APOE |
Mouse | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells wi... | |||
TMPY-02271 |
TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)
thioredoxin reductase 1,TR1,TXNR,TR,TRXR1,GRIM-12 |
Human | E. coli |
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor th... | |||
TMPK-00744 |
LRP-6 Protein, Human, Recombinant (mFc)
DCAD2,LRP-6,FLJ90421,LRP6,FLJ90062 |
Human | HEK293 Cells |
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it ... | |||
TMPY-03058 |
SLITL2/VASN Protein, Human, Recombinant (His)
SLITL2,vasorin |
Human | HEK293 Cells |
Vasorin is a typical type I membrane protein. It contains 1 EGF-like domain, 1 fibronectin type-III domain, 10 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. Vasorin is predominantly expressed in vascular smooth muscle cells, and that its expression is developmentally regulated. vasorin It directly binds to transforming growth factor (TGF)-β and attenuates TGF-β signaling in vitro. This suggests that down-regulation of vasorin expression contributes to neointimal formation after ... | |||
TMPH-02606 |
CR1L Protein, Mouse, Recombinant (His)
Crry,Complement regulatory protein Crry,Complement component... |
Mouse | E. coli |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion. CR1L Prot... | |||
TMPJ-00753 |
Myoglobin Protein, Human, Recombinant (His)
MGC13548,PVALB,MB,Myoglobin |
Human | E. coli |
Myoglobin(MB) is a cytoplasmic protein expressed in myocytes of the heart and skeletal muscle that reversibly binds oxygen. It belongs to the globin family. Functions of myoglobin include oxygen storage and transport, as well as scavenging of NO and reactive oxygen species. MB serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Myoglobin also serves as a sensitive marker for muscle injury resulting from cardiac infarction. Surprisingly, mice in which myogl... | |||
TMPJ-00921 |
COL8A1 Protein, Human, Recombinant (His)
Vastatin,Endothelial Collagen,Collagen Alpha-1(VIII) Chain,C... |
Human | HEK293 Cells |
Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium o... | |||
TMPJ-00009 |
CCL2 Protein, Human, Recombinant
C-C motif chemokine 2,MCAF,CCL2,MCP-1,Monocyte chemotactic p... |
Human | E. coli |
The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0198 |
Esmolol-d7 HCl
|
||
Esmolol-d7 HCl 是 Esmolol HCl 的氘代化合物。Esmolol HCl 的 CAS 号为 81161-17-3。Esmolol hydrochloride 是一种心脏选择性β受体阻滞剂,用于治疗心律失常和严重高血压。 | |||
TMIJ-0253 |
Benazepril-d5 HCl
|
||
Benazepril-d5 HCl 是 Benazepril HCl 的氘代化合物。Benazepril HCl 的 CAS 号为 86541-74-4。Benazepril hydrochloride 是一种血管紧张素转化酶(ACE)抑制剂,能够作用于高血压。 | |||
TMID-0126 |
Clonidine-d4 Hydrochloride
|
||
Clonidine-d4 Hydrochloride 是 Clonidine Hydrochloride 的氘代化合物。Clonidine Hydrochloride 的 CAS 号为 4205-91-8。Clonidine hydrochloride 是一种α2-adrenoceptor激动剂,是一种抗高血压药。 | |||
TMIJ-0329 |
Montelukast-d6
|
||
Montelukast-d6 是 Montelukast 的氘代化合物。Montelukast 的 CAS 号为 158966-92-8。Montelukast 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂,可用于研究预防哮喘和肝损伤。它还可减少心脏损伤,在肠缺血-再灌注损伤中也具有抗氧化作用。 | |||
TMIH-0095 |
Apigenin-d4
|
||
Apigenin-d4 是 Apigenin 的氘代化合物。Apigenin 的 CAS 号为 520-36-5。Apigenin 是从韩信草中提取的一种天然产物,是一种竞争性CYP2C9抑制剂,Ki为 2 μM。它被用作镇静剂、温和的镇痛剂和安眠药。 | |||
TMIJ-0136 |
Moxifloxacin-d4 HCl
|
||
Moxifloxacin-d4 HCl 是 Moxifloxacin HCl 的氘代化合物。Moxifloxacin HCl 的 CAS 号为 186826-86-8。Moxifloxacin Hydrochloride是一种口服有效的 8-甲氧基喹诺酮类抗菌药物,可研究感染性肺炎,急性细菌性鼻窦炎和慢性支气管炎的急性细菌性加重。 | |||
TMIH-0096 |
Apigenin-d6
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Apigenin-d6 是 Apigenin 的氘代化合物。Apigenin 的 CAS 号为 520-36-5。Apigenin 是从韩信草中提取的一种天然产物,是一种竞争性CYP2C9抑制剂,Ki为 2 μM。它被用作镇静剂、温和的镇痛剂和安眠药。 | |||
TMIJ-0287 |
Meropenem-d6-1
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Meropenem-d6-1 是 Meropenem-1 的氘代化合物。Meropenem-1 的 CAS 号为 96036-03-2。Meropenem是一种具有广谱抗菌活性的碳青霉烯抗生素,对敏感和耐药的淋病奈瑟氏球菌,流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL,0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。 | |||
TMID-0190 |
Milnacipran-d10 Hydrochloride
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Milnacipran-d10 Hydrochloride 是 Milnacipran Hydrochloride 的氘代化合物。Milnacipran Hydrochloride 的 CAS 号为 101152-94-7。Milnacipran hydrochloride 是一种5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),可用于纤维肌痛的研究。 | |||
T71402 |
Nicorandil-d4
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Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =... | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
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Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... | |||
TMID-0254 |
Linalool-d3
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Linalool-d3 是 Linalool 的氘代化合物。Linalool 的 CAS 号为 78-70-6。Linalool 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
TMIJ-0207 |
(S)-Ketoprofen-d3
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(S)-Ketoprofen-d3 是 (S)-Ketoprofen 的氘代化合物。(S)-Ketoprofen 的 CAS 号为 22161-81-5。S-(+)-Ketoprofen 抑制COX-1和COX-2的IC50值分别为 1.9 和 27 nM。 |