购物车
- 全部删除
- 您的购物车当前为空
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 133 | 现货 | |
5 mg | ¥ 215 | 现货 | |
10 mg | ¥ 347 | 现货 | |
25 mg | ¥ 648 | 现货 | |
50 mg | ¥ 1,190 | 现货 | |
100 mg | ¥ 1,730 | 现货 | |
200 mg | ¥ 2,490 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 383 | 现货 |
产品描述 | Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. |
体外活性 | Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM[1]. Sivelestat (ONO-5046) exhibits IC50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively[1]. |
体内活性 | Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase[1]. Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats[2]. Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder[3]. |
别名 | ONO-5046 sodium tetrahydrate, Elaspol, 西维来司钠四水合物, ONO 5046, ONO5046 sodium tetrahydrate, Elaspol sodium tetrahydrate, ONO-5046, Sivelestat Sodium, Sivelestat Sodium Hydrate, ONO5046 |
分子量 | 528.51 |
分子式 | C20H29N2NaO11S |
CAS No. | 201677-61-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 225 mg/mL (425.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
|
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.