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TMPH-01677
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MBD2 Protein, Human, Recombinant (His & KSI)
Methyl-CpG-binding domain protein 2,Methyl...
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Human
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E. coli
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Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
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TMPJ-00998
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MECP2 Protein, Human, Recombinant (His)
Methyl-CpG-binding protein 2,MeCp-2 protein,MECP2
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Human
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HEK293 Cells
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The MeCP2 helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout the body, although it is particularly abundant in brain cells.In the brain, the MeCP2 protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. The alternative splicing of proteins is critical for normal communication between neurons and may ... |
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TMPH-00563
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3-demethoxyubiquinol 3-hydroxylase Protein, E. coli, Recombinant (His)
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hyd...
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E. coli
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E. coli
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Catalyzes the hydroxylation of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis. |
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TMPH-03430
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ECM31 Protein, S. cerevisiae, Recombinant (His)
Extracellular matrix protein 31,Ketopantoate hydroxymeth...
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Saccharomyces cerevisiae
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E. coli
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ECM31 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.5 kDa and the accession number is P38122. |
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TMPH-00711
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BioH Protein, E. coli, Recombinant (His & Myc)
bioB,Carboxylesterase BioH,Biotin synthesis protein BioH,Pim...
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E. coli
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E. coli
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The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes. BioH shows a preference for short chain fatty acid esters (acyl c... |
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TMPH-01394
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GRIN1 Protein, Human, Recombinant (His)
N-methyl-D-aspartate receptor subunit NR1,Glutamate...
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Human
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E. coli
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Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His)... |
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TMPH-03304
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GRIN1 Protein, Rat, Recombinant (His)
Glutamate [NMDA] receptor subunit zeta-1,Glutamate receptor ...
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Rat
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E. coli
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GRIN1 Protein, Rat, Recombinant (His) is expressed in E. coli. |
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TMPH-03475
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MglB Protein, Salmonella typhimurium, Recombinant (His)
D-galactose/D-glucose-binding protein,D-galactose-binding pe...
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Salmonella typhimurium
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P. pastoris (Yeast)
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This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor. MglB Protein, Salmonella typhimurium, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 35.4 kDa and the accession number is P23905. |
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TMPH-00920
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FTO Protein, Human, Recombinant (His & Myc)
U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-d...
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Human
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E. coli
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FTO Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
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TMPJ-01429
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SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)
SARS-CoV 2 nsp14,Guanine-N7 methyltransferase,SARS-...
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SARS-CoV-2
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E. coli
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The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14. |
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TMPH-00313
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tRNA (guanine-N(7)-)-methyltransferase Protein, Brugia malayi, Recombinant (His)
tRNA (guanine-N(7)-)-methyltransferase,tRNA (guanin...
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Brugia malayi
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E. coli
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Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. tRNA (guanine-N(7)-)-methyltransferase Protein, Brugia malayi, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 36.3 kDa and the accession number is A8NFF0. |
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TMPY-00279
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Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His)
chemokine (C-X-C motif) ligand 8
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DENV
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E. coli
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Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35.5 kDa and the accession number is AAC59275.1. |
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TMPY-05693
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SARS-CoV-2 Methyltransferase/ME Protein (His)
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SARS-CoV-2
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E. coli
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Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design ... |
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TMPH-03174
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LecA Protein, Pseudomonas aeruginosa, Recombinant (His)
lecA,PA-I galactophilic lectin,Galactose-binding lectin
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Pseudomonas aeruginosa
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E. coli
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D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity. LecA Protein, Pseudomonas aeruginosa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.8 kDa and the accession number is Q05097. |
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TMPH-00557
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DXP reductoisomerase Protein, E. coli, Recombinant (His & Myc)
1-deoxy-D-xylulose 5-phosphate reductoisomerase,DXP reductoi...
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E. coli
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E. coli
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Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). |
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TMPH-01682
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METTL7B Protein, Human, Recombinant (His)
Methyltransferase-like protein 7B,TMT1B,Thiol S-
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Human
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E. coli
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Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to hydrogen sulfide and other thiol compounds including dithiothreitol, 7alpha-thiospironolactone, L-penicillamine, and captopril. |
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TMPH-00757
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Reticuline oxidase Protein, Eschscholzia californica, Recombinant (His)
BBE1,Tetrahydroprotoberberine synthase,Berberine bridge-form...
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Eschscholzia californica
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E. coli
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Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine. |
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TMPH-01634
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MLYCD Protein, Human, Recombinant (His & Myc)
MLYCD,Malonyl-CoA decarboxylase, mitochondrial
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Human
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E. coli
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Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic ... |
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TMPH-00878
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ASMT Protein, Human, Recombinant (His & Myc)
Hydroxyindole O-methyltransferase,Acetylserotonin O...
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Human
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E. coli
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Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. ASMT Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.9 kDa and the accession number is P46597. |
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TMPH-00893
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AHCY Protein, Human, Recombinant (His & SUMO)
AdoHcyase,S-adenosyl-L-homocysteine hydrolase,SAHH,Adenosylh...
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Human
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E. coli
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Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. AHCY Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.6 kDa and the accession number is P23526. |
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TMPH-02564
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CARNMT1 Protein, Mouse, Recombinant (His & SUMO)
Carnosine N-methyltransferase,Carnmt1
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Mouse
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E. coli
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N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). |
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TMPH-00509
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Protein-L-isoaspartate Protein, Drosophila melanogaster, Recombinant (His & Myc)
Protein-L-isoaspartate(D-aspartate) O-methyltransfe...
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Fruit fly
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E. coli
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Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins. Protein-L-isoaspartate Protein, Drosophila melanogaster, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.0 kDa and the accession number is Q27869. |
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TMPH-01529
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INMT Protein, Human, Recombinant (His & SUMO)
Thioether S-methyltransferase,INMT,Aromatic alkylam...
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Human
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E. coli
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Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Catalyzes the N-methylation of tryptamine and structurally related compounds. |
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TMPH-00611
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DNA helicase II Protein, E. coli, Recombinant
mutU,DNA 3'-5' helicase II,DNA helicase II,recL,rad,pdeB,uvr...
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E. coli
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E. coli
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A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA. DNA helicase II Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 82.0 kDa and the acce... |
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TMPH-00645
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Lactose permease Protein, E. coli, Recombinant (His)
Lactose permease,lacY,Lactose-proton symport
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E. coli
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E. coli
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Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl-1-thio-beta,D-galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate. Lactose permease Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 34.4 kDa... |
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TMPJ-00872
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MGMT Protein, Human, Recombinant (His)
MGMT,6-O-methylguanine-DNAmethyltransferas...
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Human
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E. coli
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MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-met... |
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TMPH-00612
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MutL Protein, E. coli, Recombinant (His)
DNA mismatch repair protein MutL,mutL
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E. coli
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E. coli
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This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA. MutL Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag... |
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TMPH-03460
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ERG26 Protein, S. cerevisiae, Recombinant (His & Myc)
ERG26,Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, deca...
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SVG-Saccharomyces cerevisiae
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E. coli
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Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol. Catalyzes the second step, an oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group. ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The pre... |
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TMPJ-01118
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GNMT Protein, Human, Recombinant (His)
GNMT,Glycine N-Methyltransferase
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Human
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E. coli
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Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cau... |
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TMPJ-01114
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GAMT Protein, Human, Recombinant (His)
Guanidinoacetate N-methyltransferase,TP53I2,PIG2,GA...
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Human
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E. coli
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GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of ... |
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TMPY-03508
|
XTP3TPA Protein, Human, Recombinant (His)
XTP3TPA,dCTP pyrophosphatase 1,RS21C6,CDA03
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Human
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E. coli
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DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. DCTPP1 also hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). DCTPP1 does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP.... |
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TMPY-02340
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HNMT Protein, Human, Recombinant (GST)
HMT,HNMT-S1,HNMT-S2,histamine N-methyltransferase
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Human
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E. coli
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HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabolism of histamine in the rat brain, is potently inhibited by 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Methylation is an important pathway in the biotransformation of many drugs, neurotransmitters, and xenobiotic compounds. Histamine N-methyltransferase (HNMT) catalyzes the N ... |
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TMPY-01692
|
NETO1 Protein, Human, Recombinant (His)
neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTCL1
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Human
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HEK293 Cells
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Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr... |
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