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Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad-spectrum caspase inhibitor, provides a cost-effective, non-toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors.
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Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad-spectrum caspase inhibitor, provides a cost-effective, non-toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,023 | 期货 | |
5 mg | ¥ 2,733 | 期货 | |
10 mg | ¥ 4,533 | 期货 | |
25 mg | ¥ 7,233 | 期货 | |
1 mL x 10 mM (in DMSO) | ¥ 5,163 | 期货 |
产品描述 | Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad-spectrum caspase inhibitor, provides a cost-effective, non-toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. |
体外活性 | It is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk. Q-VD-OPh is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase 12. In addition to the increased effectiveness, Q-VD-OPh was not toxic to cells, even at high concentrations. Q-VD-OPh is equally effective at inhibiting the three major apoptotic pathways, it can inhibit recombinant caspases 1, 3, 8, and 9 with IC50 values ranging from 25 to 400 nM2. The effectiveness of Q-VD-OPh as an apoptotic inhibitor is evidenced by the complete suppression of an apoptotic inducer capable of inducing substantial cell death in less than 4 hours. Q-VD-OPh protected against the substantial apoptosis induced by actinomycin D. In addition, Q-VD-OPh alone exhibited little or no toxicity, even at extremely high concentrations [2]. |
分子量 | 527.52 |
分子式 | C27H27F2N3O6 |
CAS No. | 402592-44-3 |
密度 | 1.297 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | Ethanol: ≥97.4 mg/mL H2O: <1 mg/mL DMSO: ≥26.35 mg/mL |
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