购物车
- 全部删除
- 您的购物车当前为空
SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) 是高选择性非竞争性 mGlu5 受体拮抗剂 (IC50:0.4 μM) 。
为众多的药物研发团队赋能,
让新药发现更简单!
SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) 是高选择性非竞争性 mGlu5 受体拮抗剂 (IC50:0.4 μM) 。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 206 | 现货 | |
5 mg | ¥ 491 | 现货 | |
10 mg | ¥ 768 | 现货 | |
25 mg | ¥ 1,550 | 现货 | |
50 mg | ¥ 2,380 | 现货 | |
100 mg | ¥ 3,450 | 现货 | |
200 mg | ¥ 4,730 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 460 | 现货 |
产品描述 | SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM) |
靶点活性 | mGlu5 (human):0.4 μM |
体内活性 | SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route[1]. |
别名 | 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 |
分子量 | 213.24 |
分子式 | C12H11N3O |
CAS No. | 31993-01-8 |
Smiles | N(=NC1=CC=CC=C1)C2=C(O)C=CC(C)=N2 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 5.5 mg/mL (25.79 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
|
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.
评论内容