Alclometasone (7a-Chloro-16a-methyl prednisolone), a glucocorticoid, inhibits leukocytes from releasing pro-inflammatory mediators. It is effective in treating corticosteroid-responsive dermatoses such as atopic dermatitis, psoriasis, allergic dermatitis, and eczema [1].

The prodrug of alclometasone is alclometasone dipropionate[2]. Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) has no effects on hepatic drug metabolism in female rats or DS strain mice[2].