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Search Results for " g2/m "

Targets Recommended: CDK

194

抑制剂 & 化合物

34

天然产物

1

化合物库

16

重组蛋白

5

同位素标记化合物

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Cat. No.	Product Name
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

细胞周期化合物库

Cat.No: L8100

Compounds: 677

Cat. No.	Product Name	Target	Signaling Pathways
T22260	Aminopurvalanol A	CDK	Cell Cycle/Checkpoint
	Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的Cyclins/Cdk 复合物抑制剂，优先靶向G2/M 期转变进而抑制癌细胞分化。它通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。
T1753	D-64131	Microtubule Associated	Cytoskeletal Signaling
	D64131 是一种微管蛋白聚合抑制剂，IC50 值为 0.53 μM。它具有抗丝分裂活性，可用于癌症研究。
T9812	Tubulin inhibitor 24	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 24 是一种 tubulin 抑制剂，可以抑制微管蛋白聚合，以浓度依赖性方式诱导细胞周期停滞在 G2/M 期，具有抗肿瘤活性且无明显毒性。
T12575	Unesbulin PTC596	Apoptosis; BMI-1	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Unesbulin (PTC596) 是一种口服有效和选择性的 B 细胞特异性莫洛尼氏鼠白血病病毒整合位点 1 抑制剂。它在急性髓细胞白血病细胞中可下调 MCL-1 并诱导不依赖 p53 的线粒体凋亡，具有抗白血病作用。
T19664	ON1231320 GBO-006	Apoptosis; PLK	Apoptosis; Cell Cycle/Checkpoint
	ON1231320 (GBO-006) 是一种高度特异性的 polo 样激酶 2 抑制剂，IC50为 0.31 µM。在有丝分裂 G2/M 期阻断肿瘤细胞周期进程，它可导致细胞凋亡。它是一种芳基磺酰基吡啶并嘧啶酮，具有抗肿瘤活性。
T8342	BRD9876 6-叔丁基-2,3-二氰基萘	Others; Kinesin; Microtubule Associated	Cytoskeletal Signaling; Others
	BRD9876 是一种 MM1S 生长的选择性抑制剂，可将驱动蛋白 5 锁定在增强微管结合的状态，从而导致 MT 的捆绑和稳定。它特异性靶向微管结合的 Eg5，选择性抑制 CD34 细胞的骨髓瘤，有用于多发性骨髓瘤的研究潜力。
T3459	VK3-OCH3 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na	Others	Others
	VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) 是一种通过血红素加氧酶(HO-1) 相关机制的选择性抗肿瘤剂；维生素 K3 类似物。
T10723	CDC25B-IN-1 ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate	Phosphatase	Metabolism
	CDC25B-IN-1 是 CDC25B 的抑制剂，Ki 为 8.5 μM。 CDC25B-IN-1 通过抑制细胞增殖和集落形成来增加 G2/M 期。
T4189	4-Oxofenretinide 3-Keto fenretinide,4-氧代维甲酰酚胺	cell cycle arrest	Cell Cycle/Checkpoint
	4-Oxofenretinide (3-Keto fenretinide) 是一种最近发现的 fenretinide 代谢物，可诱导显着的 G2-M 细胞周期停滞和细胞凋亡。
T3485	Probimane AT-2153,MM-159	Others	Others
	Probimane (AT-2153) 具有抗增殖作用、细胞周期 G2/M 期阻滞和用 MST-16 阻断人类肿瘤细胞系中的染色体分离。
T9595	LP-261	Microtubule Associated	Cytoskeletal Signaling
	LP-261 是一种新型的微管蛋白靶向抗癌剂，可与微管蛋白上的秋水仙碱位点结合，诱导 G2/M 期阻滞，其EC50为 3.2 μM。它可抑制人非小细胞肺癌的生长，可用于癌症研究。
T5699	SSE15206	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	SSE15206 是一种克服多药耐药性的微管聚合抑制剂，其在 HCT116 细胞中的 GI50值为 197 nM。由于癌细胞中纺锤体形成不完整，导致 G2/M 停滞，有丝分裂异常。
T78701	Tubulin inhibitor 32	Apoptosis	Apoptosis
	Tubulin inhibitor 32是一种口服活性的新型微管抑制剂，具有抗增殖和抗肿瘤活性，可抑制微管聚合，可诱导细胞凋亡及在G2/M期引起细胞周期停滞。
T63732	EGFR-IN-3	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-3 是一种 EGFR 抑制剂，具有潜在的抗肿瘤活性。EGFR-IN-3 抑制 EGFRwt-TK，诱导细胞凋亡 (apoptosis)，可使细胞在G2/M期阻滞。
T6864	Ixabepilone BMS 247550,Ixempra,Azaepothilone B,伊沙匹隆,BMS 247550-1	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Ixabepilone (Azaepothilone B) 是一种可口服的微管抑制剂，能够与微管蛋白结合，促进微管蛋白的聚合和微管的稳定，使细胞停滞在 G2-M 期，诱导细胞凋亡。
T64923	Sodium citrate Citrosodine,Natrocitral,柠檬酸钠	Others	Others
	Sodium citrate (Natrocitral) 是柠檬酸的钠盐。Sodium citrate 诱导G2/M 期和S 期细胞凋亡和细胞周期阻滞。Sodium citrate 通过降低抗氧化酶活性引起肝脏氧化损伤。
T60129	MT189 Antiproliferative agent-14	Microtubule Associated	Cytoskeletal Signaling
	MT189 (Antiproliferative agent-14)是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，IC50 为 3.41 μM。MT189 具有优异的抗增殖活性。Antiproliferative agent-14 具有在细胞周期的 G2/M 期阻滞细胞的能力。
T67746	IMS2186	Others	Others
	IMS2186 是一种抗脉络膜新生血管 (CNV) 试剂，可以使癌细胞周期阻滞在 G2/M 期，由此产生抗增殖和抗血管生成作用。IMS2186 能够减少眼睛渗漏和病变细胞的数量，并且无眼内毒性。
T77729	MY-1076	Apoptosis; YAP	Apoptosis; Stem Cells
	MY-1076 是一种高效的 YAP 抑制剂，具有抗胃癌活性。MY-1076 剂量依赖性诱导G2/M期阻滞，诱导 YAP 降解和细胞凋亡，抑制微管蛋白聚合。MY-1076 抑制 MGC-803、SGC-7901、HCT-116 和 KYSE450 细胞增殖。
T23601	ABC1183 ABC 1183,ABC-1183	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	ABC1183是一种抑制GSK3α， GSK3β和CDK9的新型二氨基噻唑。ABC1183通过诱导G2/M 阻滞和改变GSK3、糖原合成酶、β-catenin 磷酸化和MCL1表达降低细胞存活率来抑制多种癌细胞株的生长，并具有口服活性。
T28886	Suprafenacine N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide	Microtubule Associated	Cytoskeletal Signaling
	Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) 是一种细胞渗透性微管去稳定剂，可在 G2/M 期诱导细胞周期停滞和细胞凋亡。它与微管结合并抑制秋水仙碱连接处的聚集。它对癌细胞有选择性，包括耐药癌细胞。
T63081	KS106	Apoptosis; Dehydrogenase	Apoptosis; Metabolism
	KS106 是一种具有选择型和高效性的 ALDH 抑制剂，具有抗增殖和抗癌活性，抑制 ALDH1A1、ALDH2 和 ALDH3A1 ，IC50 分别为 334、2137、360 nM。KS106 促使细胞凋亡，诱导 G2/M 细胞周期停滞增加，可用于研究黑色素瘤和结肠癌。
T16750	Rigosertib ON-01910,瑞格色替	Apoptosis; FLT; PLK; PI3K; Bcr-Abl; CDK; PDGFR; Src	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3K/Akt 途径诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期中的 G2/M 期停滞。它是一种选择性的非 ATP 竞争性PLK1抑制剂，IC50值为 9 nM。
T8756	KRAS inhibitor-9 DUN09716	Apoptosis; Ras	Apoptosis; GPCR/G Protein; MAPK
	KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂，阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合，选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。
T78157	PARP-1-IN-3	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-3 是一种高效的 PARP-1 抑制剂，对 PARP-1 和 PARP-2 具有抑制作用， IC50 值分别为 0.25 nM 和 2.34 nM。PARP-1-IN-3 具有潜在的抗炎活性，促使细胞凋亡并使细胞周期停滞在 G2/M 期。PARP-1-IN-3 可用于研究与癌症相关的疾病。
T77647	Tubulin polymerization-IN-43	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用，通过靶向 Colchicine 位点破坏细胞微管网络，促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。
T4451	Estramustine phosphate sodium Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Estramustine phosphate sodium (Ro 21-8837/001) 是雌二醇类似物，是一种具有口服活性抗微管化疗剂，通过与微管相关蛋白和微管蛋白结合而使微管解聚。它可诱导前列腺癌细胞凋亡，可研究前列腺癌。
T27407	GDC0575 monohydrochloride ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575	Chk	Cell Cycle/Checkpoint
	GDC0575 monohydrochloride (ARRY575) 是一种有效的、选择性的细胞周期检查点激酶 1(Chk1) 抑制剂，IC50 为 1.2 nM。GDC0575 monohydrochloride (ARRY575) 特异性结合并抑制 Chk1；这可能导致肿瘤细胞在 S 期和 G2/M 期绕过 Chk1 依赖性细胞周期停滞，从而允许细胞在进入有丝分裂之前进行 DNA 修复。
T2090	Lexibulin CYT-997	Apoptosis; Reactive Oxygen Species; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂，可诱导细胞凋亡，并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M，在体内外具有高细胞毒性和血管增生阻断作用。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T41163	ZNL 02-096 Pomalidomide-C3-adavosertib	Apoptosis; Wee1	Apoptosis; Cell Cycle/Checkpoint
	ZNL 02-096 (Pomalidomide-C3-adavosertib) 是一种快速和选择性的 Wee1 降解剂 (IC50=3.58 nM)。ZNL 02-096 可在亚摩尔浓度下选择性降解 Wee1，而不损伤 AZD 1775 的二级靶点 PLK1。在体外 MOLT-4 细胞中，ZNL 02-096 可诱导 Wee1 降解、DNA 损伤积累、细胞周期停滞在 G2/M 期和细胞凋亡。ZNL 02-096 在 300 种癌症细胞系中显示出抗增殖作用。
T0009	Flubendazole 氟苯咪唑,Flumoxanal,Flumoxane,NSC 313680,Fluvermal	Apoptosis; Microtubule Associated; Parasite	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology
	Flubendazole (Flumoxane) 是用于治疗人类蠕虫感染的驱虫药。它通过抑制微管功能等机制发挥抗癌作用。它诱导p53介导的细胞凋亡，抑制 G2/M 细胞周期。
T0440	Oxcarbazepine GP 47680,奥卡西平	Apoptosis; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oxcarbazepine (GP 47680) 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。
T19661	8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	8-Chloroadenosine (NSC-354258) 是一种 5' AMP 激活的蛋白激酶激动剂，可能用于治疗慢性淋巴细胞白血病。它的活性与 mTOR 通路的抑制有关。它是一种核苷类似物。在体内代谢为 8-氯-ATP。在转录过程中掺入 RNA 并抑制 RNA 合成。在 MM.1S、RPMI-8226 和 U266 癌细胞系中表现出细胞毒性；在 A549 和 H1299 细胞中诱导 G2/M 细胞周期停滞和有丝分裂灾难。它已被证明可消耗 ATP 并抑制血液恶性肿瘤以及肺癌和乳腺癌细胞系中的肿瘤生长。
T5818	Rigosertib sodium Rigosertib,Estybon,ON-01910	Apoptosis; PLK; PI3K	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling
	Rigosertib sodium (ON-01910) 是一种选择性的非 ATP 竞争性PLK1抑制剂，IC50值为 9 nM。它是一种多激酶抑制剂和选择性抗癌剂，通过抑制PI3K/Akt 途径诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期中的 G2/M 期停滞。
T71259	GNE-900 GNE900,GNE 900	Apoptosis; Chk	Apoptosis; Cell Cycle/Checkpoint
	GNE-900 是一种 ATP 竞争性、选择性和口服活性 ChK1抑制剂，对 ChKl,ChK2的 IC50值分别为为 0.0011，1.5 µM。GNE-900 废除 G2-M 检查点，增强 DNA 损伤，并诱导胞凋亡 (Apoptosis)。gemcitabine 和 GNE-900 给药显示抗肿瘤活性[1]< /sup>。
T13901	SS28	Microtubule Associated	Cytoskeletal Signaling
	SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.
T31004	Compound 8H Compound-8H,Compound 8-H,Compound 343	Others	Others
	Compound 8H is an inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines.
T29449	5-AcTMF 5-ATMF,5-ATAN,5 ATMF	Others	Others
	5-AcTMF is an inducer of G2/M arrest, apoptosis and autophagy in cancer cells.
TQ0016	NKP-1339 IT-139,KP-1339	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
T30768	CB-403 UNII-4V9Q0C88UK,CB403,CB 403	Others	Others
	CB-403 is a cinnamaldehyde derivative that has antitumor effects by blocking cell cycle progression in the G2/M phase.
T23726	WB-308 WB308	Others	Others
	WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis.
T13227	Tubulin inhibitor 1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
T83020	Antiproliferative agent-37	Others	Others
	Antiproliferative agent-37 (compound 10J) 通过诱导细胞周期在G2/M期的阻滞来实现其抗增殖效果。
T73413	Cadein1	Others	Others
	Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和caspase 依赖的凋亡。
T62458	EGFR-IN-56	Others	Others
	EGFR-IN-56 (Compound 13a) 是一种 EGFR 的有效抑制剂，能够作用于 EGFRT790M (IC50: 541.7 nM) 和 EGFRT790M/L858R (IC50: 132.1 nM)。EGFR-IN-56 能够将癌细胞的细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。
T72817	Colibactin 742	Others	Others
	Colibactin 742 是一种稳定的大肠杆菌素衍生物，可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。
T79463	Antitumor agent-110	Apoptosis	Apoptosis
	Antitumor agent-110 (compound 13) 是一种抗癌咪唑四嗪，具备良好的渗透性，能够阻滞细胞周期于G2/M期并诱导apoptosis。
T23817	BPTQ B-P-T-Q	Others	Others
	BPTQ is a typical intercalator of DNA that acts by inducing a dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at the S and G2/M phase.
T61129	Tubulin polymerization-IN-27	Others	Others
	Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the G2/M phase and also induce apoptosis [1].

化合物

Aminopurvalanol A

Cat.No: T22260

Target: CDK

Cat.No: T1753

Target: Microtubule Associated

Tubulin inhibitor 24

Cat.No: T9812

Target: Microtubule Associated

Cat.No: T12575

Synonym: PTC596

Target: Apoptosis, BMI-1

Cat.No: T19664

Synonym: GBO-006

Target: Apoptosis, PLK

Cat.No: T8342

Synonym: 6-叔丁基-2,3-二氰基萘

Target: Others, Kinesin, Microtubule Associated

Cat.No: T3459

Synonym: 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na

Target: Others

Cat.No: T10723

Synonym: ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate

Target: Phosphatase

4-Oxofenretinide

Cat.No: T4189

Synonym: 3-Keto fenretinide,4-氧代维甲酰酚胺

Target: cell cycle arrest

Cat.No: T3485

Synonym: AT-2153,MM-159

Target: Others

Cat.No: T9595

Target: Microtubule Associated

Cat.No: T5699

Target: Apoptosis, Microtubule Associated

Tubulin inhibitor 32

Cat.No: T78701

Target: Apoptosis

Cat.No: T63732

Target: Apoptosis, EGFR

Cat.No: T6864

Synonym: BMS 247550,Ixempra,Azaepothilone B,伊沙匹隆,BMS 247550-1

Target: Apoptosis, Microtubule Associated

Cat.No: T64923

Synonym: Citrosodine,Natrocitral,柠檬酸钠

Target: Others

Cat.No: T60129

Synonym: Antiproliferative agent-14

Target: Microtubule Associated

Cat.No: T67746

Target: Others

Cat.No: T77729

Target: Apoptosis, YAP

Cat.No: T23601

Synonym: ABC 1183,ABC-1183

Target: GSK-3, CDK

Cat.No: T28886

Synonym: N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Target: Microtubule Associated

Cat.No: T63081

Target: Apoptosis, Dehydrogenase

Cat.No: T16750

Synonym: ON-01910,瑞格色替

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

KRAS inhibitor-9

Cat.No: T8756

Synonym: DUN09716

Target: Apoptosis, Ras

Cat.No: T78157

Target: Apoptosis, PARP

Tubulin polymerization-IN-43

Cat.No: T77647

Target: Apoptosis, Microtubule Associated

Estramustine phosphate sodium

Cat.No: T4451

Synonym: Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠

Target: Apoptosis, Microtubule Associated

GDC0575 monohydrochloride

Cat.No: T27407

Synonym: ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575

Target: Chk

Cat.No: T2090

Synonym: CYT-997

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Cat.No: T41163

Synonym: Pomalidomide-C3-adavosertib

Target: Apoptosis, Wee1

Cat.No: T0009

Synonym: 氟苯咪唑,Flumoxanal,Flumoxane,NSC 313680,Fluvermal

Target: Apoptosis, Microtubule Associated, Parasite

Cat.No: T0440

Synonym: GP 47680,奥卡西平

Target: Apoptosis, Sodium Channel

8-Chloroadenosine

Cat.No: T19661

Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷

Target: AMPK

Rigosertib sodium

Cat.No: T5818

Synonym: Rigosertib,Estybon,ON-01910

Target: Apoptosis, PLK, PI3K

Cat.No: T71259

Synonym: GNE900,GNE 900

Target: Apoptosis, Chk

Cat.No: T13901

Target: Microtubule Associated

Cat.No: T31004

Synonym: Compound-8H,Compound 8-H,Compound 343

Target: Others

Cat.No: T29449

Synonym: 5-ATMF,5-ATAN,5 ATMF

Target: Others

Cat.No: TQ0016

Synonym: IT-139,KP-1339

Target: DNA/RNA Synthesis

Cat.No: T30768

Synonym: UNII-4V9Q0C88UK,CB403,CB 403

Target: Others

Cat.No: T23726

Synonym: WB308

Target: Others

Tubulin inhibitor 1

Cat.No: T13227

Target: Microtubule Associated

Antiproliferative agent-37

Cat.No: T83020

Target: Others

Cat.No: T73413

Target: Others

Cat.No: T62458

Target: Others

Cat.No: T72817

Target: Others

Antitumor agent-110

Cat.No: T79463

Target: Apoptosis

Cat.No: T23817

Synonym: B-P-T-Q

Target: Others

Tubulin polymerization-IN-27

Cat.No: T61129

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TQ0089	Juglanin	Apoptosis; JNK; Autophagy	Apoptosis; Autophagy; MAPK
	Juglanin 是来自金鸡脚的一种黄酮类天然产物，是一种 JNK 的激活剂，能诱导人乳腺癌细胞的凋亡和自噬，具有炎症和抗肿瘤活性。
T5669	Citric acid monohydrate	Others	Others
	Citric acid monohydrate 是一种存在于柑橘类水果中的三羧酸。柠檬酸因其抗氧化特性而被用作药物制剂中的赋形剂。它保持活性成分的稳定性并用作防腐剂。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。
T3981	Acacetin 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis; IAP; COX; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Neuroscience
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种来自狗舌草的口服有效类黄酮。它停在 PI3Kγ 的 ATP 结合口袋中，可导致癌细胞周期停滞，并诱导细胞凋亡和自噬。它有抗癌和抗炎活性，有潜力研究疼痛相关疾病。
TN2058	Persicogenin	Anti-infection	Microbiology/Virology
	Persicogenin 是分离自 Rhus retinorrhoea 中，具有抗癌作用。
TN2554	1-Monopalmitin Glyceryl palmitate	Apoptosis	Apoptosis
	1-Monopalmitin (Glyceryl palmitate) 是一种从Mougeotia nummuloides 和 Spirulina major 提取出来的小分子化合物，具有潜在的抗肿瘤活性，抑制A549和SPC-A1细胞增殖，诱导G2/M阻滞和半胱天冬酶依赖性细胞凋亡。
T4S1335	Daphnoretin Dephnoretin,西瑞香素,Thymelol	Influenza Virus; Caspase; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物，具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。
TN2254	Taccalonolide A 根薯酮内酯A,根薯酮内酯 A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Taccalonolide A 是从水田七根茎中分离得到的一种类固醇，具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用，抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂，能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
T5S1952	9-Methoxycamptothecin	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	9-Methoxycamptothecin 是从臭味假柴龙树中分离得到的一种天然产物，通过抑制拓扑异构酶起到抗肿瘤作用，具有强效的诱导 G2/M 期细胞和癌细胞凋亡的作用。
T6S2315	Polyphyllin VI	Apoptosis; Antibacterial; Pyroptosis	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Polyphyllin VI 是一种活性皂甙，诱导 G2/M 细胞周期停滞并引发细胞凋亡，具有抗癌活性。它通过诱导非小细胞肺癌中的 ROS/NF-κB/NLRP3/GSDMD 信号轴来诱导 caspase-1 介导的细胞焦亡。
T5497	AMAROGENTIN 苦杏苷,苦龙胆酯苷	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Amarogentin 是要从 Swertia 和 Gentiana 根中提取的裂环烯醚萜苷，有抗氧化、抗肿瘤和抗糖尿病活性，具有保肝和免疫调节作用。它通过激活 AMPK 发挥有益的血管代谢作用。它促进细胞凋亡，阻止 G2/M 细胞周期和下调 PI3K/Akt/mTOR 信号通路。
T7032	Eupatorin	Others; P450	Metabolism; Others
	Eupatorin 是天然存在的黄酮，可捕获 G2-M 细胞周期，激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解，促使凋亡细胞死亡。
T2966	Beta-Sitosterol Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost	Apoptosis; Lipase; Endogenous Metabolite	Apoptosis; Metabolism
	Beta-Sitosterol (SKF 14463) 属于天然产物，是一种植物甾醇，广泛存在于植物界。Beta-Sitosterol 的摄人量与许多慢性病的发生率有关系，比如具有明显降低血清胆固醇的功效。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。
T0186	Docetaxel trihydrate RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物	Apoptosis; BCL; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂，抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物，能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期，导致细胞凋亡。
T3895	Polyphyllin I 重楼皂苷I,重楼皂甙	Apoptosis; Akt; JNK; PDK; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Polyphyllin I 是从七叶一枝花中提取的生物活性成分，具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂，也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬，G2/M 期阻滞和细胞凋亡。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
TN4154	Gomisin L1	Others	Others
	(-)-Gomisin L1 induces G2/M arrest and apoptosis in human ovarian cancer cells.
T81818	Metachromins X
	Metachromins X，一倍半萜醌类化合物，能阻碍HeLa/Fucci2细胞在S/G2/M期的细胞周期。
T75698	Xylopine	Others	Others
	Xylopine 是一种具有细胞毒活性的阿朴啡生物碱，能诱导癌细胞氧化应激，从而引发 G2/M 细胞周期停滞及细胞凋亡(apoptosis)。
TN6547	Angustifoline 鲁冰花
	Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stimulating G2/M cell cycle arrest.
T72965	Inuviscolide	Others	Others
	Inuviscolide，一种诱导细胞凋亡(apoptosis)的化合物，能够引起人黑素瘤细胞系在G2/M期的停滞，并展现出抗肿瘤和抗炎活性。
TN5336	9-Oxo-10,11-dehydroageraphorone 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮
	9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha
T75569	Xerophilusin B	Others	Others
	Xerophilusin B 是一种从 Isodon xerophilus 中分离得到的抗癌剂，对食管鳞状细胞癌 (ESCC) 细胞系表现出抗增殖作用，可诱导 G2/M 细胞周期停滞，介导细胞凋亡 apoptosis。
TN7449	8-Hydroxy-5,7-dimethoxyflavanone	Others	Others
	8-Hydroxy-5,7-dimethoxyflavanone (PDMF) is a phytochemical with tumor-preventive properties, promoting p53-driven G2/M cell cycle arrest and apoptosis. It is a potent anti-allergic agent for preventing IgE-driven hypersensitivity reactions and possesses anti-inflammatory activity.
TN5190	Tryprostatin A	Topoisomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the G2/M phase.
TN2344	Swainsonine Tridolgosir	Apoptosis; Others; Antibiotic	Apoptosis; Microbiology/Virology; Others
	Swainsonine (Tridolgosir) 是一种从黄芪中分离出来的一种生物碱，是一种强效和可逆的α-甘露糖苷酶抑制剂。Swainsonine 具有抗肿瘤活性，可诱导细胞凋亡和细胞周期停滞在 G2/M 期。
TN1953	Morusinol 桑根皮醇,桑树醇	ERK; MEK; Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Morusinol 是从桑树根皮中提取出的类黄酮。 Morusinol 具有抗血小板和抗癌活性，在体内抑制动脉血栓形成，通过诱导自噬、G2/M 细胞周期阻滞、抑制细胞侵袭和迁移以及靶向 Ras/MEK/ERK 通路发挥抗肿瘤活性。
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one	BCL; Caspase; p53	Apoptosis; Proteases/Proteasome
	Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, these results would be useful for the further utilization of man
T75602	Albanol B	Others	Others
	Albanol B 是一种芳基苯并呋喃衍生物，可从桑葚中分离得到。Albanol B 具有抗阿尔茨海默病、抗菌和抗氧化活性。Albanol B 抑制癌细胞增殖，下调 CDK1表达。Albanol B 还会诱导细胞周期停滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。Albanol B 诱导线粒体 ROS 产生并增加 AKT 和 ERK1/2的磷酸化水平。
T36961	Malformin C	Others	Others
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ...
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

Cat.No: TQ0089

Target: Apoptosis, JNK, Autophagy

Citric acid monohydrate

Cat.No: T5669

Target: Others

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

(S)-10-Hydroxycamptothecin

Cat.No: T2764

Synonym: 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Cat.No: T3981

Synonym: 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Cat.No: TN2058

Target: Anti-infection

Cat.No: TN2554

Synonym: Glyceryl palmitate

Target: Apoptosis

Cat.No: T4S1335

Synonym: Dephnoretin,西瑞香素,Thymelol

Target: Influenza Virus, Caspase, PKC

Taccalonolide A

Cat.No: TN2254

Synonym: 根薯酮内酯A,根薯酮内酯 A

Target: Apoptosis, Microtubule Associated

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

9-Methoxycamptothecin

Cat.No: T5S1952

Target: Apoptosis, Topoisomerase

Cat.No: T6S2315

Target: Apoptosis, Antibacterial, Pyroptosis

Cat.No: T5497

Synonym: 苦杏苷,苦龙胆酯苷

Target: Apoptosis, AMPK

Cat.No: T7032

Target: Others, P450

Beta-Sitosterol

Cat.No: T2966

Synonym: Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Docetaxel trihydrate

Cat.No: T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物

Target: Apoptosis, BCL, Microtubule Associated

Cat.No: T3895

Synonym: 重楼皂苷I,重楼皂甙

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: TN4154

Target: Others

Cat.No: T81818

Cat.No: T75698

Target: Others

Cat.No: TN6547

Synonym: 鲁冰花

Cat.No: T72965

Target: Others

9-Oxo-10,11-dehydroageraphorone

Cat.No: TN5336

Synonym: 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮

Cat.No: T75569

Target: Others

8-Hydroxy-5,7-dimethoxyflavanone

Cat.No: TN7449

Target: Others

Cat.No: TN5190

Target: Topoisomerase, Antifection

Cat.No: TN2344

Synonym: Tridolgosir

Target: Apoptosis, Others, Antibiotic

Cat.No: TN1953

Synonym: 桑根皮醇,桑树醇

Target: ERK, MEK, Autophagy, Ras

Ergosta-4,6,8(14),22-tetraen-3-one

Cat.No: TN1617

Target: BCL, Caspase, p53

Cat.No: T75602

Target: Others

Cat.No: T36961

Target: Others

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00604	CDTA Protein, E. coli, Recombinant (His) Cytolethal distending toxin subunit A,CDTA,CDT A	E. coli	E. coli
	CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for the delivery of CdtB.
TMPH-03269	COMMD5 Protein, Rat, Recombinant (His & Myc) COMM domain-containing protein 5,COMMD5,Hypertension-related...	Rat	E. coli
	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
TMPH-03748	KAT14 Protein, Human, Recombinant (His) KAT14,ADA2A-containing complex subunit 2,Cysteine-rich prote...	Human	E. coli
	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.
TMPH-00605	CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) CDTB,Cytolethal distending toxin subunit B,Deoxyribonuclease...	E. coli	E. coli
	Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement. CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is Q46669.
TMPY-03989	PFDN1 Protein, Human, Recombinant (His) PDF,PFD1,prefoldin subunit 1	Human	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ...
TMPY-02046	PFDN1 Protein, Mouse, Recombinant (His) AU044714,AA408327,2700086I23Rik,prefoldin subunit 1	Mouse	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ...
TMPY-03655	GADD45G Protein, Human, Recombinant GADD45γ,growth arrest and DNA-damage-inducible, γ,DDIT2,grow...	Human	E. coli
	GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45G acts as a new-age tumor suppressor however is being fr...
TMPJ-00988	SEPHS1 Protein, Human, Recombinant (His) water dikinase 1,SELD,Selenophosphate synthase 1,SEPHS1,SPS1...	Human	HEK293 Cells
	Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased, which Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased. SEPHS1 can be activated by phosphate ions and by potassium ions. It can synthesize synthesizes selenophosphate from selenide and ATP....
TMPY-03672	Survivin Protein, Human, Recombinant BIRC5,IAP4,API4,baculoviral IAP repeat containing 5,EPR-1	Human	E. coli
	BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation...
TMPH-00028	Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP) Protein Rep78	AAV-2	E. coli
	Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factors in site-specific integration of the viral genome. Regulates host PKA activity by interacting with host PRKX as a mechanism of i...
TMPH-00536	Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc) Epstein-Barr nuclear antigen 2,EBNA2	EBV	P. pastoris (Yeast)
	Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-ass...
TMPY-02496	Rad6/UBE2A Protein, Human, Recombinant (His) UBC2,HHR6A,MRXS30,MRXSN,RAD6A,ubiquitin-conjugating enzyme E...	Human	E. coli
	Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication repair and induced mutagenesis. UBE2A is described as a CDK2 substrate. It is the human homologue of the product of the Saccharomyces cerevisiae RAD6 / UBC2 gene, a member of the family of ubiquitin-conjugating enzymes. In vivo, HHR6A phosphorylation peaks during the G2/M phase o...
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His) HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST) TPL2,MEKK8,EST,ESTF,COT,Tpl-2,c-COT,AURA2,mitogen-activated ...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform 1 of MAP3K8 is activated specifically during the S and G2/M phases of the...
TMPH-02613	ATF-5 Protein, Mouse, Recombinant (His & Myc) Transcription factor ATFx,Transcription factor-like protein ...	Mouse	E. coli
	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip...

重组蛋白

CDTA Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00604

Species: E. coli

Expression System: E. coli

COMMD5 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03269

Species: Rat

Expression System: E. coli

KAT14 Protein, Human, Recombinant (His)

Cat.No: TMPH-03748

Species: Human

Expression System: E. coli

CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00605

Species: E. coli

Expression System: E. coli

PFDN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03989

Species: Human

Expression System: E. coli

PFDN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02046

Species: Mouse

Expression System: E. coli

GADD45G Protein, Human, Recombinant

Cat.No: TMPY-03655

Species: Human

Expression System: E. coli

SEPHS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00988

Species: Human

Expression System: HEK293 Cells

Survivin Protein, Human, Recombinant

Cat.No: TMPY-03672

Species: Human

Expression System: E. coli

Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)

Cat.No: TMPH-00028

Species: AAV-2

Expression System: E. coli

Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc)

Cat.No: TMPH-00536

Species: EBV

Expression System: P. pastoris (Yeast)

Rad6/UBE2A Protein, Human, Recombinant (His)

Cat.No: TMPY-02496

Species: Human

Expression System: E. coli

PBK/TOPK Protein, Human, Recombinant (His)

Cat.No: TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

MAP3K8 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04389

Species: Human

Expression System: Baculovirus Insect Cells

ATF-5 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02613

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0443	3-Keto Fenretinide-d4
	3-Keto Fenretinide-d4 是 3-Keto Fenretinide 的氘代化合物。3-Keto Fenretinide 的 CAS 号为 865536-65-8。4-Oxofenretinide 是一种最近发现的 fenretinide 代谢物，可诱导显着的 G2-M 细胞周期停滞和细胞凋亡。
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...
TMIJ-0295	Flubendazole-d3 (methyl-d3)
	Flubendazole-d3 (methyl-d3) 是 Flubendazole 的氘代化合物。Flubendazole 的 CAS 号为 31430-15-6。Flubendazole 是用于治疗人类蠕虫感染的驱虫药。它通过抑制微管功能等机制发挥抗癌作用。它诱导p53介导的细胞凋亡，抑制 G2/M 细胞周期。
TMID-0067	Oxcarbazepine-d10
	Oxcarbazepine-d10 是 Oxcarbazepine 的氘代化合物。Oxcarbazepine 的 CAS 号为 28721-07-5。Oxcarbazepine 是一种钠通道阻滞剂，有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡或 G2/M 停滞，具有抗癌和抗惊厥作用。

同位素标记化合物

3-Keto Fenretinide-d4

Cat.No: TMIJ-0443

Cat.No: T70808

Cat.No: T71055

Flubendazole-d3 (methyl-d3)

Cat.No: TMIJ-0295

Oxcarbazepine-d10

Cat.No: TMID-0067

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