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FAK-IN-22 (Compound 26) 是FAK、JAK3和Aurora B的抑制剂,其IC50值分别为50.94 nM、9.99 nM和0.49 nM,有效抑制胰腺导管腺癌 (PDAC) 的肿瘤发生和转移。FAK-IN-22 抑制 PANC-1 细胞的增殖,IC50值为0.15 μM,并通过抑制FAK/PI3K/Akt信号通路,在 PANC-1 细胞中诱导凋亡和 G2/M 期阻滞。
FAK-IN-22 (Compound 26) 是FAK、JAK3和Aurora B的抑制剂,其IC50值分别为50.94 nM、9.99 nM和0.49 nM,有效抑制胰腺导管腺癌 (PDAC) 的肿瘤发生和转移。FAK-IN-22 抑制 PANC-1 细胞的增殖,IC50值为0.15 μM,并通过抑制FAK/PI3K/Akt信号通路,在 PANC-1 细胞中诱导凋亡和 G2/M 期阻滞。
产品描述 | FAK-IN-22 (Compound 26) is an inhibitor of FAK, JAK3, and Aurora B, with IC50 values of 50.94 nM, 9.99 nM, and 0.49 nM, respectively, effectively suppressing tumorigenesis and metastasis in pancreatic ductal adenocarcinoma (PDAC). It inhibits proliferation in PANC-1 cells with an IC50 of 0.15 μM. FAK-IN-22 induces apoptosis and G2/M phase arrest in PANC-1 cells by inhibiting the FAK/PI3K/Akt signaling pathway. |
靶点活性 | FAK:50.94 nM, Aurora B:0.49 nM, JAK3:9.99 nM |
分子量 | 427.38 |
分子式 | C21H16F3N5O2 |
CAS No. | 2703920-02-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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