393
120
20
465
5
Cat. No. | Product Name | ||
---|---|---|---|
L2140 | 癌细胞分化化合物库 | 406 compounds | |
406 个诱导肿瘤细胞分化化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L8000 | 干细胞分化化合物库 | 1197 compounds | |
1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选; | |||
L2630 | 神经元分化化合物库 | 672 compounds | |
672 种与神经元分化相关的化合物,可以用于神经系统疾病药物研发 | |||
L6900 | 稀有天然产物库 | 693 compounds | |
693 种稀有天然产物的集合,可以用于高通量和高内涵筛选; | |||
L4200 | FDA 上市药物库 | 1729 compounds | |
1729 个FDA 批准药物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4000 | 经典已知活性库 | 14439 compounds | |
14439 个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认; | |||
L4010 | 已知活性化合物库 | 22555 compounds | |
22555 个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认; | |||
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L3400 | 临床期小分子药物库 | 3404 compounds | |
3404 个临床期化合物集合,可用于高通量筛选和高内涵筛选; | |||
L4300 | Wnt/Hedgehog/Notch 通路化合物库 | 237 compounds | |
237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。 | |||
L6100 | 天然多酚类化合物库 | 635 compounds | |
635 个天然多酚化合物的独特集合,可用于高通量、高内涵筛选; | |||
L1400 | MAPK 抑制剂库 | 365 compounds | |
365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L6150 | 天然产物共价化合物库 | 583 compounds | |
提供产品的生物学信息和药物学信息,为筛选提供理论方向和研究基础; | |||
L1610 | FDA 上市激酶抑制剂库 | 263 compounds | |
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L6000 | 高通量筛选天然产物库 | 4533 compounds | |
4533 种天然产物的独特集合,是药物开发、药理研究、干细胞分化、指纹图谱研究、质量研究等领域的有力工具,可用于HTS 和HCS; | |||
L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L3510 | 甲基化化合物库 | 128 compounds | |
128 种甲基化相关的化合物,可以用于高通量和高内涵筛选; | |||
L2600 | 神经信号分子库 | 2540 compounds | |
2540 种CNS 相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; | |||
L6740 | 抗结直肠癌中药单体化合物库 | 382 compounds | |
382 种抗结直肠癌相关的中药单体集合,是药物开发、药理研究的有效工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13829 |
Oiligodendrocyte differentiation promoter 1
|
Others | Others |
Oiligodendrocyte differentiation promoter 1 is a promoter of oiligodendrocyte differentiation . | |||
T7693 |
Thiorphan
|
Neprilysin | Metabolism |
Thiorphan 是选择性neprilysin 抑制剂 (IC50:6.9 nM) 。 | |||
T8839 |
ICCB280
|
Apoptosis; Others | Apoptosis; Others |
ICCB280 是一种 C/EBPα诱导剂,通过激活 C/EBPα 并影响其下游靶点,具有终末分化、增殖停滞和凋亡的抗白血病特性。 | |||
T39508 |
KY-02327
|
Others | Others |
KY-02327 是 KY-02061的一种类似物,具有代谢稳定性。KY-02327是Dishevelled (Dvl)-CXXC5相互作用抑制剂。KY-02327激活Wnt/β-catenin 途径,从而促进成骨细胞分化。 | |||
T1748 |
Kartogenin
KGN |
TGF-beta/Smad | Stem Cells |
Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A,破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用,并通过调节 CBFβ-RUNX1 转录程序,诱导软骨形成,可用于研究骨关节炎。 | |||
T2340 |
AC1NS4RE
|
Tyrosinase | Proteases/Proteasome |
是一种化学合成中的砌块 | |||
T2052 |
KY02111
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KY02111 是典型的 WNT 信号抑制剂,能够促进人多潜能干细胞向心肌细胞分化,可用于研究人类心肌细胞再生。 | |||
T9210 |
CD73-IN-4
|
CD73 | Immunology/Inflammation |
CD73-IN-4 是高选择性的亚甲基膦酸 CD73抑制剂,对人 CD73 作用的 IC50值为 2.6 nM,在癌症免疫学中具有研究潜力。 | |||
TP1328 |
TB500
|
Others | Others |
TB500 是一种胸腺素β4活性区域的合成分子。它可促进内皮细胞分化,角质形成细胞迁移,真皮组织中的血管生成,胶原沉积和减少炎症。 | |||
T9243 |
PFI-90
|
Histone Demethylase; Others | Chromatin/Epigenetic; Others |
PFI-90 是组蛋白去甲基化酶 (KDM3B) 的选择性抑制剂,可抑制 PAX3-FOXO1 的作用。它具有抗肿瘤活性的潜力,可诱导细胞凋亡和成肌分化,导致细胞死亡增加。 | |||
T13336 |
VTP50469
|
Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
VTP50469 是一种高选择性和口服活性的Menin-MLL 相互作用抑制剂,具有有效的抗白血病活性,Ki 为 104 pM。 | |||
T10425 |
AZ084
|
CCR | Immunology/Inflammation; Microbiology/Virology |
AZ084 是可口服的选择性 CCR8变构拮抗剂,其Ki 值为 0.9 nM,可研究哮喘。 | |||
T1938 |
FLT3-IN-2
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
FLT3-IN-2 是 FLT3 抑制剂(IC50<1 μM)。 | |||
T1176 |
Racecadotril
Acetorphan,消旋卡多曲 |
Neprilysin; Proteasome | Metabolism; Proteases/Proteasome; Ubiquitination |
Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂,具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性,Ki 分别为 4500 和 6.1 nM。 | |||
T4428 |
CCT241736
|
FLT; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂,还抑制临床相关的 FLT3 耐药突变体,包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物,是治疗人类恶性肿瘤的临床前开发候选物。 | |||
T3079 |
GSK1838705A
|
IGF-1R; JNK; S6 Kinase; ALK | Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
GSK1838705A 是一种高效的、可逆的IGF-IR (IC50:2.0 nM) 和胰岛素受体 (IC50:1.6 nM)抑制剂,也可抑制ALK (IC50:0.5 nM)。 | |||
T11298 |
FLT3-IN-3
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
FLT3-IN-3 是 FLT3抑制剂,能够抑制 FLT3 WT (IC50:13 nM) 和 FLT3 D835Y (IC50:8 nM) 。 | |||
TQ0106 |
Sacubitrilat
LBQ-657 |
Neprilysin | Metabolism |
Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。 | |||
T15612 |
JH-VIII-157-02
|
Microtubule Associated; ALK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
JH-VIII-157-02 是一种 ALK 抑制剂,可抑制棘皮动物微管相关蛋白样 4-ALK (EML4-ALK),对EML4-ALK G1202R、EML4-ALKwt、EML4-ALK C1156Y、EML4-ALK F1174L 和 EML4-ALK F1174L 的 IC50 均为 2 nM。 | |||
T5521 |
Bropirimine
U-54461,溴匹立明 |
TLR | Immunology/Inflammation |
Bropirimine (U-54461) 是 toll 样受体 7(TLR7)的合成激动剂,可通过 TLR7 介导 IFN-β 的产生抑制破骨细胞前体细胞向破骨细胞分化。它是一种生物反应调节剂,通过诱导淋巴因子起作用,在膀胱和上尿路的原位移行细胞癌中具有抗癌活性。 | |||
T9765 |
TJ-M2010-5
|
MyD88 | Immunology/Inflammation |
TJ-M2010-5 是一种 MyD88 抑制剂,可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。 | |||
T2272 |
BPR1J-097
BPR1J097 |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
BPR1-J097 是新型的、强效的FLT3抑制剂 (IC50:11 nM)。 | |||
T22814 |
GSA-10
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
GSA-10是新型的喹啉甲酰胺衍生物,有效激动平滑受体剂,EC50为 1.2 μM。它作用于Smo,促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导,这可能对癌症疾病的再生医学具有研究意义。 | |||
T6756 |
AMG 925
|
FLT; CDK | Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
AMG 925 是一种选择性FLT3/CDK4双重抑制剂,IC50分别为 1 nM 和 3 nM。 | |||
T15335 |
FN-1501
|
FLT; CDK | Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
FN-1501 是一种有效的 FLT3 和 CDK 抑制剂,具有抗肿瘤的活性,对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。 | |||
T16153 |
MS4078
|
ALK; PROTACs | Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors |
MS4078 是一种基于 Cereblon 配体的间变性淋巴瘤激酶 PROTAC ,结合 ALK 的 Kd 为 19 nM。 | |||
T6020 |
Pacritinib
SB1518 |
FLT; Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Pacritinib (SB1518) 是一种野生型 JAK2和 JAK2V617F 突变型抑制剂,IC50分别为 23 和 19 nM。它也抑制 FLT3及其突变型 FLT3D835Y,IC50分别为 22 和 6 nM。 | |||
T3065 |
TG101209
|
Apoptosis; FLT; c-RET; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG101209 是一种选择性有效的 JAK2抑制剂,IC50值为 6 nM。它能抑制 Flt3和RET 的活性,IC50值分别为 25 nM 和 17 nM。 | |||
T3635 |
IQ 1
IQ1,IQ-1 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
IQ 1 有多种作用,如保持小鼠ESCs 的多功能性、降低Wnt 刺激的磷酸化、阻止PP2A/Nkd 的相互作用等等。 | |||
T11254 |
F-1
|
ROS; ALK; ROS Kinase | Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
F-1 是 ALK 和 ROS1 的双重抑制剂,抑制 ALK 的磷酸化及下游通路,可作用于对 ALKWT (IC50:2.1 nM),ROS1WT (IC50:2.3 nM),ALKL1196M (IC50:1.3 nM) 和 ALKG1202R (IC50:3.9 nM)。 | |||
T6138 |
TCS 359
FLT3 Inhibitor |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
TCS 359 (FLT3 Inhibitor) 是 2-酰基氨基噻吩-3-甲酰胺,是选择性FLT3抑制剂(IC50:42 nM),能够抑制 MV4-11 细胞增殖(IC50:340 nM)。 | |||
T9473 |
4SC-203
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
4SC-203 是一种具有潜在的抗肿瘤活性的多激酶抑制剂。它对 FLT3/STK1、 FLT3 的突变形式以及 VEGFRs 具有选择性抑制作用。 | |||
T1962 |
ASP3026
ASP 3026 |
Apoptosis; ALK | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ASP3026 是一种选择性的,具有口服活性的间变性淋巴瘤激酶抑制剂,可诱导肿瘤细胞凋亡,可研究非小细胞肺癌。 | |||
T7673 |
ATH686
ATH 686 |
Apoptosis; FLT | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ATH686 是一种选择性的,ATP 竞争性的FLT3抑制剂,具有抗白血病作用。它靶向突变 FLT3 蛋白激酶活性,并通过诱导凋亡和抑制细胞周期来抑制具有 FLT3 突变的细胞的增殖。 | |||
T8317 |
5'-Fluoroindirubinoxime
5'-FIO |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
5'-Fluoroindirubinoxime (5'-FIO) 是一种 Indirubin 的衍生物,是一种 FLT3 的抑制剂(IC50:15 nM)。 | |||
T12341 |
P-gp inhibitor 1
|
Others; P-gp | Membrane transporter/Ion channel; Neuroscience; Others |
P-gp inhibitor 1 抑制逆转 P-糖蛋白介导的多药耐药性,EC50 为 57.9 nM(K562/A02 细胞)。 | |||
T28036 |
MI-2-2
MI22,MI 2 2 |
Histone Methyltransferase | Chromatin/Epigenetic |
MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂,IC50 为 46 nM。 MI-2-2 与 menin 结合,Kd 为 22 nM。 | |||
TQ0235 |
AC710
|
FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AC710是一种 PDGFR 抑制剂,能够作用于 FLT3 (Kd:0.6),CSF1R (Kd:1.57),KIT (Kd:1),PDGFRα (Kd:1.3) 和 PDGFRβ (Kd:1.0)。 | |||
T16561 |
Polyoxyethylene stearate
POES,聚氧乙烯硬脂酸酯 |
Antibacterial; P-gp | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Polyoxyethylene stearate (POES) 是一种非离子乳化剂。 | |||
T9988 |
Wnt/β-catenin agonist 3
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Wnt/β-catenin agonist 3是一种Wnt/beta-catenin 信号通路激动剂。 | |||
T38562 |
AKN-028
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
AKN-028 是酪氨酸激酶 FLT3的抑制剂,可剂量依赖性的诱导 FLT3的自磷酸化。 | |||
T11071 |
Dofequidar fumarate
MS-209 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Dofequidar fumarate (MS-209) 是口服活性的喹啉化合物,通过抑制 ABCB1/P-gp 和 ABCC1/MDR 相关蛋白 1 来克服 MDR。 | |||
T6115 |
Fostamatinib
R788,福他替尼 |
FLT; Syk; Monoamine Transporter; Adenosine Receptor | Angiogenesis; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors |
Fostamatinib (R788) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的,有效的,ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM,IC50:41 nM),也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。 | |||
T2640 |
Rebastinib
DCC2036,DCC 2036,DCC-2036 |
Apoptosis; FLT; Bcr-Abl; Src | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Rebastinib (DCC-2036) 是一种口服有效的,非 ATP 竞争性的 Bcr-Abl 抑制剂,作用于 Abl1WT 和 Abl1T315I,IC50分别为 0.8 nM 和 4 nM,还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2,对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。 | |||
T6287 |
Tariquidar
XR9576,他立喹达 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Tariquidar (XR9576) 是一种特异性有效的P-糖蛋白抑制剂,Kd 为 5.1 nM。 | |||
T3621 |
Brigatinib
布格替尼,AP-26113 |
EGFR; FLT; ROS; IGF-1R; ALK | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Brigatinib (AP-26113) 是一种有效,选择性的ALK 抑制剂 (IC50:0.6 nM)。 | |||
T8426 |
Encequidar
HM30181,HM30181A |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Encequidar (HM30181A) 是一种选择性 P-糖蛋白抑制剂。 | |||
T4015 |
HG-14-10-04
|
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
HG-14-10-04 是一种特异的 ALK 抑制剂,IC50=20 nM。 | |||
T4409 |
Gilteritinib
吉列替尼,ASP2215 |
FLT; TAM Receptor; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50=0.29 nM),也是一种 AXL 抑制剂 (IC50=0.73 nM),具有 ATP 竞争性、选择性和口服活性。Gilteritinib 具有抗肿瘤活性,可以用于治疗 FLT3 突变阳性的 AML。 | |||
T2620 |
G-749
G749 |
Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
G-749 是一种新型 FLT3 抑制剂,对 FLT3 野生型和突变体有持续的抑制作用,IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3816 |
Velutin
|
NF-κB; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; NF-κB |
Velutin 是一种苷元,提取自槲寄生中,能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。 | |||
TN5888 |
Toddaculin
|
Others | Others |
Toddaculin 是一种天然香豆素,抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡,具有抗炎活性。 | |||
TN1040 |
Skullcapflavone II
|
COX; Antibacterial; TGF-beta/Smad | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells |
Skullcapflavone II 是从黄芩中提取的黄酮,具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。 | |||
T5751 |
Tigogenin
|
Others | Others |
Tigogenin 是甾体皂甙元,普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化,促使成骨细胞的分化。 | |||
TN1124 |
Neoeriocitrin
|
AChE | Neuroscience |
Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂,分离于自百日草,在 MC3T3-E1 中显示出对增殖和成骨分化的活性。 | |||
T2S0712 |
Sinigrin
黑芥子苷,Allylglucosinolate,2-Propenylglucosinolate |
Others; Antioxidant | Others; oxidation-reduction |
Sinigrin 是十字花科植物中主要的硫代葡萄糖苷,具有抗脂肪生成作用。它在芥子油苷的分离和鉴定程序中用作参考材料。Sinigrin 具有有效的抗氧化、抗肿瘤和抗炎作用。 | |||
T8152 |
6-Demethoxytangeretin
|
MAPK; ALK | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
6-Demethoxytangeretin 是一种从柑橘分离的黄酮。它能够促进 CRE 介导的转录 (与海马神经元的学习和记忆相关)。它具有抗炎和抗过敏作用,通过间变性淋巴瘤激酶和丝裂原活化蛋白激酶途径抑制人肥大细胞中 IL-6 的产生和基因表达。 | |||
TN1651 |
Furanodiene
|
Apoptosis; PARP; Reactive Oxygen Species; Caspase; CDK; P-gp | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Proteases/Proteasome |
Furanodiene 是从姜黄中提取的一种萜类天然产物,可抑制外排转运蛋白Pgp 功能并降低 Pgp 蛋白水平。它通过抗血管生成和诱导ROS 产生,DNA 链断裂和细胞凋亡发挥抗癌作用。 | |||
T3S0012 |
coniferyl ferulate
|
P-gp; GST | Membrane transporter/Ion channel; Neuroscience; oxidation-reduction |
Coniferyl ferulate 是从川芎中提取的一种天然产物,是强效的谷胱甘肽 S-转移酶抑制剂,强抑制人胎盘型谷胱甘肽 S-转移酶,IC50为 0.3 μM。它还可逆转多药耐药性并下调 P-糖蛋白。 | |||
T2S0223 |
Isosinensetin
异橙黄酮,6-Demethoxynobiletin |
Antioxidant; HIV Protease; Antibacterial; P-gp | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; oxidation-reduction; Proteases/Proteasome |
Isosinensetin (6-Demethoxynobiletin) 是从青皮中提取的一种甲氧基黄酮,具有抗氧化和抑制 HIV-1 蛋白酶的活性。 | |||
TN4761 |
Phellamurin
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Phellamurin 是一种来自黄檗叶的黄酮糖苷,可诱导细胞凋亡,具有抗肿瘤活性。它抑制肠道 P-糖蛋白,还抑制凤蝶的产卵。 | |||
T3002 |
Piperine
胡椒碱,1-Piperoylpiperidine,Bioperine |
P450; Endogenous Metabolite; P-gp; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Piperine (Bioperine) 是从胡椒中分离的一种生物碱,可以抑制P-糖蛋白和 CYP3A4 的活性,在HeLa 细胞中的IC50值为61.94±0.054 μg/mL。它已用于研究治疗多发性骨髓瘤和吞咽障碍的试验。 | |||
TJS1159 |
Chrysosplenetin
猫眼草黄素,Chrysosptertin B |
P450; Ferroptosis; P-gp | Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Chrysosplenetin 是青蒿和其他几种中草药中的一种多甲氧基化黄酮类天然产物,抑制 P-gp 活性并逆转由青蒿素诱导的上调的 P-gp 和 MDR1 水平。 | |||
T2S0271 |
Voacamine
老刺木胺,Voacanginine |
Cannabinoid Receptor; P-gp | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Voacamine (Voacanginine) 是非洲马铃果中的一种吲哚生物碱,可抑制多药耐药肿瘤细胞中的 P-糖蛋白作用,具有强效的大麻素 CB1受体拮抗活性。 | |||
T6S0033 |
Crotonoside
巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE |
Others; FLT; HDAC | Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors |
Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。 它抑制 FLT3 和 HDAC3/6,有治疗急性髓性白血病 (AML)的研究潜力。 | |||
T2S1200 |
Sinapine
|
Antioxidant; P-gp; AChE | Membrane transporter/Ion channel; Neuroscience; oxidation-reduction |
Sinapine 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
T4034 |
Solamargine
Solamargin,δ-Solanigrine,澳洲茄边碱 |
Apoptosis; p38 MAPK; P-gp; STAT | Apoptosis; JAK/STAT signaling; MAPK; Membrane transporter/Ion channel; Neuroscience; Stem Cells |
Solamargine (δ-Solanigrine) 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,诱导非选择性细胞毒性和 P-gp 抑制作用。它通过下调 MMP-2 和 MMP-9 的表达和活性来显著抑制 HepG2 细胞的迁移和侵袭,在多种癌症中均表现出抗癌活性。 | |||
T3392 |
Sinapine thiocyanate
|
P-gp; AChE | Membrane transporter/Ion channel; Neuroscience |
Sinapine thiocyanate 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
T19676 |
Tributyrin
NSC661583,NSC 661583,NSC-661583,甘油三丁酸酯 |
Apoptosis | Apoptosis |
Tributyrin (Glyceryl tributyrate) 是一种中性短链脂肪酸甘油三酯,是一种稳定且吸收迅速的丁酸前药。 它通过生物膜扩散并被细胞内脂肪酶代谢,在体内将有效的丁酸直接释放到细胞中,有抗增殖、促凋亡和诱导分化作用。 | |||
TJS0328 |
Nordalbergin
6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素 |
Others | Others |
Nordalbergin 是一种香豆素,分离自Dalbergia sissoo的木皮中。 它能够显著性的诱导 HL-60 细胞的分化。 | |||
T13502 |
3-Oxo-5β-cholanoic acid
3-氧代-5β-胆烷酸,Dehydrolithocholic acid |
ROR | Metabolism |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。 | |||
TN1757 |
Hypophyllanthin
叶下珠次素,(7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂 |
Potassium Channel; Calcium Channel; P-gp | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Hypophyllanthin 是珠子草中的一种木脂素,能直接抑制 P-gp 的活性,具有很强的抗炎活性。 | |||
TN1525 |
Convallatoxin
K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷 |
NF-κB; P-gp; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
Convallatoxin 是从铃兰分离得到的一种强心苷。它是 P-糖蛋白底物,并识别 Val982 是参与其转运的重要氨基酸。它是配体诱导的 MOR 胞吞作用的增强剂,通过激活PPARγ和抑制NF-κB 改善结肠炎,具有抗炎和抗增殖特性。 | |||
T2799 |
(20S)-Protopanaxadiol
20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇 |
Apoptosis; Reactive Oxygen Species; P-gp | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) 是人参皂甙的代谢产物,是一种凋亡诱导剂,抑制Akt 活性并诱导多种肿瘤细胞凋亡。 | |||
T1048 |
Estradiol
雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estradiol (E2) 是一种天然的类固醇性激素,对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。 | |||
TCS2336 |
Evodine
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Evodine 是吴茱萸中的主要柠檬苦素,是P-gp 有效抑制剂,可通过保留抗氧化剂防御系统,针对谷氨酸诱导的毒性具有保护作用。 | |||
TN7036 |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路,诱导间充质干细胞成骨分化和随后的骨形成,可用于研究骨质疏松症。 | |||
T4085 |
Paris saponin VII
重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII |
Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位,增加凋亡相关蛋白的表达,并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬,可研究白血病。 | |||
T6627 |
Phosphoramidon Disodium
Phosphoramidon Disodium Salt,磷酰胺二钠 |
RAAS; Neprilysin; Others | Endocrinology/Hormones; Metabolism; Others |
Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ,0.034 和 78 μM。 | |||
T2185 |
L-Ascorbic acid 2-phosphate trisodium
L-抗坏血酸-2-磷酸三钠盐(维生素C),L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐 |
Reactive Oxygen Species; c-Met/HGFR; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB; Tyrosine Kinase/Adaptors |
L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) 是长效的维生素 C 衍生物,能够刺激胶原蛋白的表达和形成。Sodium L-ascorbyl-2-phosphate 提高成骨细胞分化过程中 hASC 中的碱性磷酸酶活性和 runx2A 的表达,因此,能够促进人脂肪干细胞的成骨分化。 | |||
T22644 |
C2 Ceramide
Ceramide |
Others | Others |
A potent modulator of cell proliferation and differentiation. | |||
T3488 |
Tectorigenin
4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素 |
Apoptosis | Apoptosis |
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) 是一种从葛根汤干燥的花中分离出来的植物异黄酮。 | |||
T10886 |
Crocetine dimethyl ester
Dimethylcrocetin |
Antioxidant | oxidation-reduction |
Crocetine dimethyl ester (Dimethylcrocetin) 是一种藏红花素衍生物,具有抗氧化活性,抑制 AChE 活性,抑制细胞生长分化。 | |||
T8015 |
4-METHOXYCHALCONE
2-(4-Methoxybenzal)Acetophenone,4-甲氧基查耳酮 |
Others | Others |
4-METHOXYCHALCONE (2-(4-Methoxybenzal)Acetophenone) 是一种增强脂肪细胞分化的天然化合物。 | |||
T13768 |
(+)-Medicarpin
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It exhibits potent inhibition of osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, which is mediated by the estrogen receptor (ER) β. | |||
T0421 |
i-Inositol
Inositol,myo-Inositol,肌醇,meso-Inositol |
Endogenous Metabolite | Metabolism |
i-Inositol (myo-Inositol) 是一种细胞内磷酸化合物,参与细胞信号传导,可能刺激肿瘤细胞分化。 | |||
T1882 |
Meisoindigo
N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛 |
Apoptosis | Apoptosis |
Meisoindigo (Natura-α) 是 Indirubin 的衍生物,可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞,并诱导凋亡,具有高抗肿瘤活性。 | |||
T3808 |
Icariside I
淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I |
Others | Others |
Icariside I (Lcariside I) 是一种 Icarlin 的代谢产物,具有调节骨重塑的作用,可用于研究骨质疏松。 | |||
TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
T2848 |
Osthole
Osthol,NSC 31868,蛇床子素,Ostol |
Apoptosis; HBV; Parasite; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Osthole (Osthol) 是一种天然抗组胺药替代试剂,可刺激成骨细胞增殖和分化。它可抑制组胺 H1受体活性,还可抑制细胞培养物中 HBV 的分泌。 | |||
T3924 |
Astragaloside II
黄芪皂苷 II,Astrasieversianin VIII |
TGF-beta/Smad | Stem Cells |
Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。 | |||
T6062 |
Brefeldin A
BFA,布雷非德菌素 A,Ascotoxin,Cyanein,Decumbin |
ATPase; Mitophagy; Antibiotic; Autophagy; HSV; CRISPR/Cas9 | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Brefeldin A (Cyanein) 属于大环内酯类抗生素,是一种 ATPase 抑制剂 (IC50=0.2 μM)。Brefeldin A 可以诱导肿瘤细胞分化和凋亡,也具有抑制自噬的活性。 | |||
T3220 |
Euphorbiasteroid
Euphobiasteroid,Euphorbia factor L1,千金子甾醇 |
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
Euphorbiasteroid (Euphobiasteroid) 是续随子中的一种三环二萜,可抑制酪氨酸酶活性,增强AMPK 的磷酸化。它通过减少细胞内甘油三酯的积累来降低 3T3-L1 细胞的分化,具有抗癌、抗病毒、抗肥胖及多重耐药调节作用。 | |||
TQ0198 |
Phorbol 12-myristate 13-acetate
佛波醇12-十四酸酯13-乙酸酯,PMA |
NF-κB; S1P Receptor; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; NF-κB |
Phorbol 12-myristate 13-acetate (PMA) 属于佛波酯类天然产物,是一种 PKC、SphK、NF-κB 的激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP1 细胞分化。 | |||
T3810 |
Saikosaponin B2
柴胡皂苷 B2,柴胡皂甙 B2 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Saikosaponin B2 是从柴胡根中分离得到的一种活性成分,可抑制 HCV 病毒感染的侵入,有抗癌作用。 | |||
T5770 |
Alisol B
|
RANKL/RANK | NF-κB |
Alisol B 是一种具有用于骨科疾病研究潜力的化合物,通过分化破骨细胞发挥其功能。 | |||
T3900 |
Emodin-8-glucoside
大黄素-8-β-D-吡喃葡萄糖苷,Emodin glucoside B,Anthraglycoside B |
Others | Others |
Emodin-8-glucoside (Anthraglycoside B) 是从芦荟中分离出的蒽醌衍生物,与 DNA 的小沟结合。它具有保护缺血和再灌注引起的局灶性脑损伤的作用。它直接刺激成骨细胞的细胞增殖和分化。 | |||
T3925 |
Astragaloside I
黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化,可用于成骨活性研究。 | |||
TN2121 |
3,5,7,3′,4′-Pentamethoxyflavone
栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether |
Others | Others |
3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期,它可以调控转录因子,促进 3T3-L1 前脂肪细胞形成脂肪。 | |||
T1086 |
Vitamin D2
Calciferol,Ergocalciferol,Ercalciol,维生素D2 |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Vitamin D2 (Calciferol) 来源于植物或膳食补充剂,能够用作维生素 D 的补充剂。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02698 |
CD14 Protein, Human, Recombinant (His)
CD14 antigen,monocyte differentiation antigen CD14,... |
Human | HEK293 Cells |
CD14 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P08571. | |||
TMPY-04727 |
GDF-15 Protein, Human, Recombinant (His)
PLAB,PTGFB,NAG-1,MIC1,GDF-15,PDF,MIC-1,growth differenti... |
Human | P. pastoris (Yeast) |
GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988. | |||
TMPY-01073 |
GDF-15 Protein, Human, Recombinant (hFc)
PTGFB,PLAB,MIC-1,MIC1,PDF,NAG-1,growth differentiation |
Human | HEK293 Cells |
GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988. | |||
TMPY-01817 |
GDF-10 Protein, Mouse, Recombinant (hFc)
growth differentiation factor 10,Bmp3b |
Mouse | HEK293 Cells |
BMP-3b / GDF-10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. In th... | |||
TMPH-01416 |
GDF9 Protein, Human, Recombinant (GST)
Growth/differentiation factor 9,GDF9 |
Human | E. coli |
GDF9 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.5 kDa and the accession number is O60383. | |||
TMPJ-00662 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Receptor activator of nuclear factor kappa-B ligand,Receptor... |
Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog... | |||
TMPH-03321 |
KRTDAP Protein, Rat, Recombinant (His & SUMO)
Keratinocyte differentiation-associated protein,Krt... |
Rat | E. coli |
May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. KRTDAP Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 21.5 kDa and the accession number is P85411. | |||
TMPY-03185 |
METRN Protein, Mouse, Recombinant (hFc)
meteorin, glial cell differentiation regulator,Hyra... |
Mouse | HEK293 Cells |
METRN (Meteorin, Glial Cell Differentiation Regulator) is a Protein Coding gene. The encoded protein belongs to the meteorin family. It is broadly expressed in the brain, kidney, and other tissues. Meteorin is a novel secreted protein that is expressed in undifferentiated neural progenitors and the astrocyte lineage, including radial glia. It plays important role in the differentiation of glial cells and also in axonal network formation during neurogenesis. Meteorin selectively promoted astrocyt... | |||
TMPH-01415 |
GDF-8 Protein, Human, Recombinant (His)
Growth/differentiation factor 8,MSTN,Myostatin |
Human | E. coli |
Acts specifically as a negative regulator of skeletal muscle growth. MSTN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.4 kDa and the accession number is O14793. | |||
TMPY-00697 |
CD14 Protein, Human, Recombinant (hFc)
CD14 molecule,CD14 antigen,monocyte differentiation... |
Human | HEK293 Cells |
CD14 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.4 kDa and the accession number is P08571. | |||
TMPH-01723 |
MYD88 Protein, Human, Recombinant (His)
Myeloid differentiation primary response protein My... |
Human | E. coli |
MYD88 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.2 kDa and the accession number is Q99836. | |||
TMPH-00353 |
GDF8 Protein, Feline, Recombinant
Myostatin,MSTN,Growth/differentiation factor 8 |
Feline | E. coli |
GDF-8 Protein, Feline, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 40.7 kDa and the accession number is M3WPT7. | |||
TMPJ-00898 |
CD72 Protein, Human, Recombinant (Trx & His)
Lyb-2,B-Cell Differentiation Antigen CD72,CD72 |
Human | E. coli |
B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells. CD72 is a ligand for CD5. CD72 associates with CD5, interacts with PTPN6/SHP-1 and plays a role in B-cell proliferation and differentiation. CD72 associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulat... | |||
TMPJ-00607 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)
Receptor activator of nuclear factor κ-B ligand,Osteoprotege... |
Mouse | HEK293 Cells |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1. | |||
TMPH-01414 |
GDF2 Protein, Human, Recombinant (His)
Growth/differentiation factor 2,Bone morphogenetic ... |
Human | P. pastoris (Yeast) |
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. GDF2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.3 kDa and the accession number is Q9UK05. | |||
TMPJ-00020 |
IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated
白介素,Eosinophil differentiation factor,B-cell di... |
Human | HEK293 Cells |
IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functi... | |||
TMPH-01413 |
GDF11 Protein, Human, Recombinant (His & SUMO)
Bone morphogenetic protein 11,GDF11,Growth/differentiati... |
Human | E. coli |
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. GDF11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression... | |||
TMPH-03400 |
SLC17A6 Protein, Rat, Recombinant (His)
Slc17a6,Vesicular glutamate transporter 2,Solute carrier fam... |
Rat | P. pastoris (Yeast) |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vessel regression during postnatal development. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. SLC17A6 Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 11.1 kDa an... | |||
TMPH-03118 |
IL-5 Protein, Pig, Recombinant (His)
Eosinophil differentiation factor,Interleukin-5,T-c... |
Sus scrofa (Pig) | P. pastoris (Yeast) |
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. IL-5 Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 15.0 kDa and the accession number is Q9MYM5. | |||
TMPH-03117 |
IL-5 Protein, Pig, Recombinant (E. coli, His)
Interleukin-5,T-cell replacing factor,Eosinophil differe... |
Sus scrofa (Pig) | E. coli |
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. IL-5 Protein, Pig, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.0 kDa and the accession number is Q9MYM5. | |||
TMPJ-00713 |
GDF-11 Protein, Human, Recombinant
Growth/differentiation factor 11,Bone morphogenetic... |
Human | HEK293 Cells |
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The si... | |||
TMPJ-00693 |
EDF1 Protein, Human, Recombinant (His)
Multiprotein-Bridging Factor 1,EDF-1,Endothelial Differe... |
Human | E. coli |
Endothelial Differentiation-Related Factor 1 (EDF1) is a 148 amino acid transcriptional coactivator that contains 1 HTH cro/C1-type DNA-binding domain. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. When endothelial cells are induced to differentiate in vitro, EDF1 is downregulated, leading to inhibition o... | |||
TMPH-01016 |
GDF10 Protein, Human, Recombinant (His)
Bone-inducing protein,Bone morphogenetic protein 3B,GDF10,Gr... |
Human | E. coli |
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. GDF-10 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is P55107. | |||
TMPH-01530 |
INHBA Protein, Human, Recombinant (His & SUMO)
Activin beta-A chain,INHBA,Inhibin beta A chain,Erythroid |
Human | E. coli |
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of a... | |||
TMPJ-00663 |
GDF-8 Protein, Human/Mouse/Rat, Recombinant
骨肉瘤源生长因子,Gdf8,Mstn,GDF-8,Growth/differentiation fac... |
Human,Mouse,Rat | HEK293 Cells |
Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically a... | |||
TMPY-04021 |
NPDC1 Protein, Human, Recombinant (His)
CAB1,CAB,NPDC-1,CAB-1,CAB-,neural proliferation, differe... |
Human | HEK293 Cells |
NPDC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.9 kDa and the accession number is Q9NQX5. | |||
TMPJ-01414 |
GDF-15 Protein, Mouse, Recombinant (His & Flag)
Growth Differentiation Factor 15, Macrophage inhibi... |
Mouse | HEK293 Cells |
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenito... | |||
TMPJ-01131 |
UBE2V2 Protein, Human, Recombinant (His)
Enterocyte Differentiation-Associated Factor 1,Vita... |
Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and... | |||
TMPH-01013 |
BMP-15 Protein, Human, Recombinant (His & Myc)
BMP15,GDF-9B,BMP-15,Bone morphogenetic protein 15,GDF9B,Grow... |
Human | E. coli |
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. BMP-15 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.4 kDa and the accession number is O95972. | |||
TMPJ-00329 |
CD19 Protein, Rhesus macaque, Recombinant (hFc)
B-Lymphocyte Antigen CD19,CD19,Differentiation Anti... |
Rhesus | HEK293 Cells |
CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Sr... | |||
TMPJ-00339 |
ALCAM Protein, Mouse, Recombinant (hFc)
CD6 ligand,CD166 antigen,CD6L,activated leucocyte cell adhes... |
Mouse | HEK293 Cells |
Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM interacts with high affinity with CD6 molecule but weaker homotypic (ALCAM–ALCAM) interactions have also been described. ALCAM–CD6 interactions play an important role in the maintenance of T cell activation, proliferation as well as in formation of immune synapse between an... | |||
TMPJ-00292 |
CD36 Protein, Human, Recombinant (hFc)
FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas... |
Human | HEK293 Cells |
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece... | |||
TMPJ-00775 |
CD74 Protein, Mouse, Recombinant (mFc & His)
HLA class II histocompatibility antigen γ chain,HLA-DR antig... |
Mouse | HEK293 Cells |
Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. | |||
TMPJ-00455 |
SLAMF5 Protein, Mouse, Recombinant (His)
CD84 molecule,SLAM family member 5,Leukocyte differentia... |
Mouse | HEK293 Cells |
CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hemato... | |||
TMPJ-00228 |
SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated
Cell surface antigen MAX.3,SLAMF5,SLAM family member 5,Signa... |
Human | HEK293 Cells |
SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 40-50 KDa and the accession number is Q9UIB8. | |||
TMPJ-00229 |
SLAMF5 Protein, Human, Recombinant (His)
SLAMF5,Signaling lymphocytic activation molecule 5,Hly9-β,Ce... |
Human | HEK293 Cells |
SLAMF5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-43 KDa and the accession number is Q9UIB8. | |||
TMPH-01947 |
PPP1R15A Protein, Human, Recombinant (His)
Growth arrest and DNA damage-inducible protein GADD34,Protei... |
Human | E. coli |
PPP1R15A Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01243 |
ID1 Protein, Human, Recombinant (His & SUMO)
Inhibitor of differentiation 1,Inhibitor of DNA bin... |
Human | E. coli |
ID1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.1 kDa and the accession number is P41134. | |||
TMPH-02264 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His)
Tumor necrosis factor ligand superfamily member 11,Osteoprot... |
Human | HEK293 Cells |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl... | |||
TMPJ-00674 |
RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
Receptor activator of NF-KB,TNFRSF11A,Osteoclast differe... |
Mouse | HEK293 Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br... | |||
TMPH-02960 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His & SUMO)
Tnfsf11,Receptor activator of nuclear factor kappa-B ligand,... |
Mouse | E. coli |
TNFSF11 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.9 kDa and the accession number is O35235. | |||
TMPJ-01472 |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)
Osteoclast differentiation factor,Receptor activato... |
Mouse | HEK293 Cells |
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1. | |||
TMPJ-00966 |
GDF-5 Protein, Human, Recombinant
Lipopolysaccharide-associated protein 4,Cartilage-derived mo... |
Human | E. coli |
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a ty... | |||
TMPJ-00700 |
GADD45B Protein, Human, Recombinant (His)
MYD118,Myeloid Differentiation Primary Response Pro... |
Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC). It m... | |||
TMPH-02736 |
IFIH1 Protein, Mouse, Recombinant (His)
Melanoma differentiation-associated protein 5,Helic... |
Mouse | E. coli |
IFIH1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.5 kDa and the accession number is Q8R5F7. | |||
TMPH-02023 |
Renin receptor Protein, Human, Recombinant (His)
Vacuolar ATP synthase membrane sector-associated protein M8-... |
Human | E. coli |
Renin receptor Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01554 |
IFIH1 Protein, Human, Recombinant (His)
Interferon-induced helicase C domain-containing protein 1,RN... |
Human | E. coli |
IFIH1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.5 kDa and the accession number is Q9BYX4. | |||
TMPJ-00090 |
FGF-9 Protein, Human, Recombinant
Fibroblast Growth Factor 9,Heparin-Binding Growth Factor 9,F... |
Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial c... | |||
TMPY-02575 |
PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,peroxisome pr... |
Human | Baculovirus Insect Cells |
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli... | |||
TMPJ-01466 |
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC... |
Human | HEK293 Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T71328 |
Theobromine-d6
|
||
Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium.... | |||
TMIH-0102 |
Avatrombopag-d8
|
||
Avatrombopag-d8 是 Avatrombopag 的氘代化合物。Avatrombopag 的 CAS 号为 570406-98-3。Avatrombopag 是一种新型口服血小板生成素 (TPO) 受体激动剂,可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。 | |||
TMID-0163 |
myo-Inositol-d6
|
||
myo-Inositol-d6 是 myo-Inositol 的氘代化合物。myo-Inositol 的 CAS 号为 87-89-8。Inositol是一种细胞内磷酸化合物,参与细胞信号传导,可能刺激肿瘤细胞分化。 | |||
T67921 |
Retinoic acid-d5
all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5 |
Retinoid Receptor | Metabolism |
Retinoic acid-d5 (Vitamin A acid-d5)是视黄酸的氘标记形式。视黄酸是一种天然的RAR 核受体激动剂, 对 RARα/β/γ 的 IC50 为 14 nM,与 PPARβ/δ 结合的Kd 为 17 nM。视黄酸是维生素a 的代谢物,在细胞生长、分化和器官发育中起着重要作用。视黄酸通过激活视黄酸受体α作为转录因子Nrf2的抑制剂来发挥作用。 | |||
TMID-0303 |
Vitamin A-d4
Retinol-d4 |
||
Vitamin A-d4 是 Vitamin A 的氘代化合物。Vitamin A 的 CAS 号为 68-26-8。Retinol 及其衍生物,在视网膜的代谢功能、上皮组织的生长和分化、骨骼的生长、生殖和免疫反应中起重要作用。膳食维生素 A 来源于植物中发现的多种类胡萝卜素。它富含肝脏、蛋黄和乳制品的脂肪成分。 |