Encequidar mesylate

产品编号 T11578LCas号 849675-87-2

别名 HM30181 mesylate|||HM30181A mesylate

Encequidar mesylate (HM30181A mesylate) 是竞争性有效的 P-糖蛋白抑制剂。

产品编号 T11578L别名 HM30181 mesylate, HM30181A mesylateCas号 849675-87-2

Encequidar mesylate (HM30181A mesylate) 是竞争性有效的 P-糖蛋白抑制剂。

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生物活性

产品描述	Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
体外活性	Treatment of 0.1 or 1 nM Encequidar lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively [2].
体内活性	The plasma concentrations of Encequidar are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction [1].
别名	HM30181 mesylate, HM30181A mesylate

偶联与修饰

抗原信息

存储 & 运输

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 55 mg/mL (70.08 mM), Sonication is recommended.

溶液配制表

DMSO