|
TMPH-01563
|
IAPP Protein, Human, Recombinant (His)
IAPP,Diabetes-associated peptide,Insulinoma amyloid...
|
Human
|
P. pastoris (Yeast)
|
|
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. |
|
TMPH-01562
|
IAPP Protein, Human, Recombinant (GST)
Insulinoma amyloid peptide,IAPP,Islet amyloid polypeptide,Am...
|
Human
|
E. coli
|
|
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.4 kDa and the accession number is P10997. |
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TMPJ-01125
|
PEA15 Protein, Human, Recombinant
15 kDa Phosphoprotein Enriched in Astrocytes,PEA15,PED,Astro...
|
Human
|
E. coli
|
|
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm... |
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TMPY-00395
|
Insulin Protein, Human, Recombinant
IDDM1,MODY10,ILPR,IDDM2,IRDN,IDDM,insulin,INS
|
Human
|
P. pastoris (Yeast)
|
|
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ... |
|
TMPJ-00071
|
EPO/Erythropoietin Protein, Human, Recombinant (His)
Erythropoietin,EPO,红细胞生长素,Epoetin
|
Human
|
HEK293 Cells
|
|
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP... |
|
TMPK-00369
|
HGF Protein, Human, Recombinant (hFc)
HGF,F-TCF,HGFB,SF,F-TCFB,肝细胞生长因子,DFNB39,Hepatopoietin-A,HPTA
|
Human
|
HEK293 Cells
|
|
Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in β-cell homeostasis; and is capable of modulating the inflammatory response.HGF plays a central role in these metabolic disorders,HGF levels could be employed as a biomarker for disease status/progression, and HGF/c-Met signaling pa... |
|
TMPY-03962
|
AFM Protein, Human, Recombinant (His)
afamin,ALBA,ALB2,ALF
|
Human
|
HEK293 Cells
|
|
Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of... |
|
TMPK-00074
|
IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)
IFN-α-1/13,IFN alpha1,干扰素,Interferon α-1/13,Interferon alpha...
|
Mouse
|
HEK293 Cells
|
|
IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.88 kDa and the accession number is P01572. |
|
TMPK-00075
|
IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)
IFN-α-1/13,IFN α1,IFN alpha1,干扰素,IFNA1,IFN α 1,IFNalpha 1,In...
|
Human
|
HEK293 Cells
|
|
IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.14 kDa and the accession number is P01562. |
|
TMPY-02128
|
Serpin B1 Protein, Human, Recombinant (His)
HEL57,serpin peptidase inhibitor, clade B (ovalbumin), membe...
|
Human
|
Baculovirus Insect Cells
|
|
SerpinB1 is an endogenous inhibitor of serine proteases recognized for its anti-inflammatory and host-protective properties. Serum SerpinB1 levels are elevated in patients with type 2 diabetes compared with that in healthy subjects and are negatively correlated with serum LDL-C. serpinB1 as an endogenous protein that can potentially be harnessed to enhance functional beta cell mass in patients with diabetes. |
|
TMPJ-00742
|
GCG Protein, Human, Recombinant (His)
Glicentin,GRPP,GLP-2,Glucagon-Like Peptide 1,OXM,Glucagon,GL...
|
Human
|
HEK293 Cells
|
|
Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin.... |
|
TMPK-00891
|
GIP Protein, Mouse, Recombinant (His)
GIP,Incretin
|
Mouse
|
HEK293 Cells
|
|
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic use of GIP was dampened by evidence that its insulinotropic activity was reduced in type 2 diabetes and by reports that it increased glucagon secretion and adipose deposition in non-diabetic individuals. GIP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cell... |
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TMPK-00036
|
GIP Protein, Human, Recombinant (His)
Incretin,GIP
|
Human
|
HEK293 Cells
|
|
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic use of GIP was dampened by evidence that its insulinotropic activity was reduced in type 2 diabetes and by reports that it increased glucagon secretion and adipose deposition in non-diabetic individuals. GIP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cell... |
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TMPK-00890
|
GIP Protein, Mouse, Recombinant (hFc)
Incretin,GIP
|
Mouse
|
HEK293 Cells
|
|
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic use of GIP was dampened by evidence that its insulinotropic activity was reduced in type 2 diabetes and by reports that it increased glucagon secretion and adipose deposition in non-diabetic individuals. GIP Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cell... |
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TMPY-03353
|
CEL Protein, Mouse, Recombinant (His)
1810036E18Rik,carboxyl ester lipase,BAL
|
Mouse
|
Baculovirus Insect Cells
|
|
CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activated carboxylic ester lipase (CEL) is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. Carboxyl ester lipase is a digestive pancreatic enzyme encoded by the CEL gene. Mutations in CEL c... |
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TMPJ-01196
|
ANGPTL8 Protein, Human, Recombinant (hFc)
βtrophin,Angiopoietin-like protein 8,Lipasin,Angptl8,Betatro...
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Human
|
HEK293 Cells
|
|
The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proli... |
|
TMPH-00298
|
Resistin Protein, Bovine, Recombinant (His)
Resistin,RETN
|
Bovine
|
E. coli
|
|
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Resistin Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.6 kDa and the accession number is Q762I5. |
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TMPJ-00014
|
Resistin Protein, Human, Recombinant (His)
Resistin,C/EBP-epsilon-regulated myeloid-specific secreted c...
|
Human
|
E. coli
|
|
Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit... |
|
TMPY-02579
|
NRN1 Protein, Human, Recombinant (His)
NRN,dJ380B8.2,MGC44811,neuritin 1
|
Human
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Baculovirus Insect Cells
|
|
Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF), and NT-3. Purified rec... |
|
TMPJ-00380
|
AOC3 Protein, Human, Recombinant (His)
Membrane primary amine oxidase,HPAO,VAP-1,Semicarbazide-sens...
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Human
|
HEK293 Cells
|
|
Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inf... |
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TMPK-01128
|
LRG1 Protein, Mouse, Recombinant (His)
Leucine-rich α-2-glycoprotein,Leucine-rich alpha-2-glycoprot...
|
Mouse
|
HEK293 Cells
|
|
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammali... |
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TMPK-00449
|
HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated
E4ICD,ALS19,ErbB4,4ICD,HER4,p180erbB4,MGC138404
|
Human
|
HEK293 Cells
|
|
Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The... |
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TMPK-00526
|
LRG1 Protein, Cynomolgus, Recombinant (His)
Leucine-rich α-2-glycoprotein,LRG1,LRG,Leucine-rich alpha-2-...
|
Cynomolgus
|
HEK293 Cells
|
|
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ma... |
|
TMPK-00448
|
HER4/ERBB4 Protein, Human, Recombinant (His & Avi)
HER4,ALS19,4ICD,p180erbB4,MGC138404,E4ICD,ErbB4
|
Human
|
HEK293 Cells
|
|
Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted mol... |
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TMPJ-00345
|
IGF2BP-2 Protein, Human, Recombinant (His)
IGF-II mRNA-Binding Protein 2,IGF2 mRNA-Binding Protein 2,He...
|
Human
|
E. coli
|
|
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to the 5'-UTR of the Insulin-Like Growth Factor 2 (IGF2) mRNA. This binding is isoform-specific. IGF2BP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replicat... |
|
TMPY-04388
|
BLK Protein, Human, Recombinant (GST)
MODY11,BLK proto-oncogene, Src family tyrosine kinase
|
Human
|
Baculovirus Insect Cells
|
|
Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and... |
|
TMPK-00299
|
ANGPTL2 Protein, Human, Recombinant (His & Avi), Biotinylated
MGC8889,ANGRP2,angiopoietin-like 2,ANGPTL2,HARP,ARP2
|
Human
|
HEK293 Cells
|
|
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... |
|
TMPK-00298
|
ANGPTL2 Protein, Human, Recombinant (His & Avi)
ANGRP2,ANGPTL2,angiopoietin-like 2,HARP,MGC8889,ARP2
|
Human
|
HEK293 Cells
|
|
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... |
|
TMPY-02924
|
RGS1 Protein, Human, Recombinant (His)
1R20,IER1,BL34,HEL-S-87,regulator of G-protein signaling 1,I...
|
Human
|
E. coli
|
|
RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type I diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs. RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new Multiple myeloma (MM) therapy. The markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that ... |
|
TMPY-03756
|
BBOX1 Protein, Human, Recombinant (His & GST)
butyrobetaine (γ), 2-oxoglutarate dioxygenase (γ-butyrobetai...
|
Human
|
Baculovirus Insect Cells
|
|
BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treatanginaandmyocardial infarctio... |
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TMPJ-00104
|
SOD2 Protein, Human, Recombinant (E. coli, His)
SOD2,Superoxide Dismutase [Mn] Mitochondrial
|
Human
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E. coli
|
|
Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6), idiopathic cardiomyopathy (IDC), sporadic motor neuron dis... |
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TMPJ-00658
|
CYR61/CCN1 Protein, Human, Recombinant (hFc)
Cysteine-rich angiogenic inducer 61,IGFBP10,Insulin-like gro...
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Human
|
HEK293 Cells
|
|
Protein CYR61, also known as CCN family member 1, Cysteine-rich angiogenic inducer 61,Insulin-like growth factor-binding protein 10 , GIG1, CYR61, CCN1 and IGFBP10, belongs to the CCN family, CYR61 is a secreted protein and contains one CTCK (C-terminal cystine knot-like) domain,one IGFBP N-terminal domain,one TSP type-1 domain and one VWFC domain. CYR61 promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. CYR61 plays important roles in inflammation and tissue repair. CYR61 ... |
|
TMPY-04394
|
Glucokinase Protein, Human, Recombinant
glucokinase (hexokinase 4),HXKP,MODY2,FGQTL3,LGLK,HKIV,GLK,H...
|
Human
|
E. coli
|
|
Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but ... |
|
TMPY-02051
|
FABP2 Protein, Human, Recombinant (His)
MGC133132,fatty acid binding protein 2,FABPI,I-FABP
|
Human
|
E. coli
|
|
Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the a... |
|
TMPK-01385
|
CRTAM Protein, Canine, Recombinant (His)
CRTAM,CD355 antigen,CD355
|
Canine
|
HEK293 Cells
|
|
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr... |
|
TMPK-00971
|
CRTAM Protein, Mouse, Recombinant (His)
CRTAM,CD355,CD355 antigen
|
Mouse
|
HEK293 Cells
|
|
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr... |
|
TMPJ-00921
|
COL8A1 Protein, Human, Recombinant (His)
Vastatin,Endothelial Collagen,Collagen Alpha-1(VIII) Chain,C...
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Human
|
HEK293 Cells
|
|
Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endothelium. COL8A1 forms homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrhedron stabilized by central interacting C-terminal NC1 trimers. COL8A1 contains one C1q domain and is primarily expressed in the subendothelium o... |
|
TMPJ-00307
|
BLK Protein, Human, Recombinant (His)
Tyrosine-Protein Kinase Blk,BLK,B Lymphocyte Kinase,p55-Blk
|
Human
|
E. coli
|
|
Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B t... |
|
TMPY-03419
|
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
SMAD family member 3
|
Human,Mouse,Rat
|
Baculovirus Insect Cells
|
|
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice,... |
|
TMPY-02276
|
GPR56 Protein, Human, Recombinant (His)
BFPP,UNQ540/PRO1083,DKFZp781L1398,TM7LN4,adhesion G protein-...
|
Human
|
HEK293 Cells
|
|
ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family with a very long N-terminal stalk and seven transmembrane domains. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. GPR56 may be a target for the treatment of type 2 diabetes. GPR56 inhibits melanoma metastatic growth by impeding the exp... |
|
TMPJ-00052
|
Leptin Protein, Mouse, Recombinant
OB,Obesity Factor,OBS,LEP,Obese Protein,Leptin
|
Mouse
|
E. coli
|
|
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin defici... |
|
TMPY-02952
|
SIAE Protein, Human, Recombinant (His)
CSE-C,AIS6,CSEC,LSE,YSG2,sialic acid acetylesterase
|
Human
|
Baculovirus Insect Cells
|
|
Sialate O-acetylesterase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. It is widely expressed with high expression in the testis, prostate, and colon. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the p... |
|
TMPJ-01199
|
BTN2A1 Protein, Human, Recombinant (His)
BT2.1,BTN2A1,Butyrophilin subfamily 2 member A1,BTF1
|
Human
|
HEK293 Cells
|
|
Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 258 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A1 that lack the first Ig like domain or transmembrane segment as well as isoforms with substitutions and deletion... |
|
TMPY-01229
|
SETD7 Protein, Human, Recombinant (His)
SET7/9,SET domain containing (lysine methyltransferase) 7,SE...
|
Human
|
E. coli
|
|
Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysi... |
|
TMPY-01618
|
GLO1 Protein, Mouse, Recombinant (His)
glyoxalase I,Glo-1r,GLY1,Glo1-r,2510049H23Rik,Glo1-s,AW55064...
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Mouse
|
E. coli
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Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyoxalase I is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellul... |
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TMPJ-00353
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ILDR2 Protein, Human, Recombinant (His)
Angulin-3,immunoglobulin-like domain containing receptor 2,D...
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Human
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HEK293 Cells
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ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23–25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic ce... |
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TMPY-04122
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ATOX1 Protein, Human, Recombinant (His)
HAH1,ATX1,antioxidant 1 copper chaperone
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Human
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E. coli
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ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the trace element copper is essential, but extremely toxic in high concentrations, intracellular copper concentrations are tightly controlled. Once in the cell, copper is distributed by metallochaperones, including the small cytoplasmic protein ATOX1. ATOX1 plays an important role in ... |
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TMPJ-00379
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AOC3 Protein, Human, Recombinant (hFc)
SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas...
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Human
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HEK293 Cells
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Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam... |
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TMPY-04458
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TRIB2 Protein, Human, Recombinant (His & GST)
TRIBBLE,tribbles pseudokinase 2,TRIB2,C5FW,FLJ57420,GS3955,T...
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Human
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Baculovirus Insect Cells
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Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate the activation of some intracellular signalling pathways with roles e... |
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TMPY-01875
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SCGN Protein, Human, Recombinant (His)
SEGN,SECRET,DJ501N12.8,CALBL,secretagogin, EF-hand calcium b...
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Human
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E. coli
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Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes ... |
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